Jinja Regional Referral Hospital Paediatric Placement A Helpful Guide for the New Intern -------------2015-2016 EMERGENCY Signs Priority Signs Queue (Children with none of these signs) 1 ABC ASSESSMENT DURING LIFE SUPPORT 2 Welcome to Jinja Regional Referral Hospital Paediatrics Department - ‘Nalufenya’! Welcome to a busy and interesting placement! The hospital consists of an outpatient department, emergency ward, two general wards, a neonatal room off Ward 1, a large malnutrition unit, an isolation room for tetanus patients off Ward 2, a laboratory, a research unit (iNO), a small private wing and outpatient HIV services. On the main hospital site there is the Special Care Baby Unit next to maternity. You will be rotating around the hospital wards with one week in Emergency ward, one week in Ward 1 (general inpatients prolonged stay), one week in Ward 2 (predominantly short stay patients), one week in Malnutrition Ward and one week in the Special Care Baby Unit. Your normal day starts at 8:30 am. Tuesday and Thursday mornings are Continuing Medical Education presentations. During your 3 month rotation you will be expected to give one presentation on a clinically topical subject. Lunch at Taso (main hospital) is subsidised. If you are having a busy day, you can ask Agnes to put aside a plate for you so that you can have a late lunch (see her contact number below). One night in five you will be on-call which means you will return to hospital for the afternoon, evening and night shift. There is an intern’s office in which you stay overnight. One weekend in five you will be first on-call where you are on-call day and night for emergencies. One weekend in five you will be second-on-call covering the wards. The intern who has been covering Special Care for the week should also pass by there on the weekend. You may find you are on call for both in which case you should pass by to see Special Care patients first in the morning. Please remember that this guide is not a replacement of the Ugandan Paediatric Guidelines or WHO guidelines. We have arranged to have a copy of the latter on the Emergency ward and in OPD where you see patients at night. There are also soft copies of these and many other resources on the intern USB flash drive as well as on the computer in the intern room. 3 GENERAL ADVICE - - - - - Look through this guide and other resources on the USB and computer so that you know where you can find help if you do not have senior support Always remember supportive care: adequate and appropriate feeding or fluids, oxygen in unwell neonates and severely malnourished children, analgesia for children in pain (trauma, sickle cell disease) Explain to the caretakers what you are doing and why. Always be polite and respectful and take the time to explore their beliefs and concerns. This will lead to better care of the child and will ensure that the caretaker returns to hospital in the future. Remember handwashing or use alcohol gel between patients and explain to them the importance of handwashing! This is especially important in small babies and immunocompromised children (malnutrition, HIV) Remember to write clear discharge and followup plans for any child with chronic disease Be on time – for work and for meetings Help each other – it is a busy but very rewarding rotation. FOR EACH PATIENT, ALWAYS CHECK: - Weight (if it does not seem accurate, reweigh and recalculate dosages) HIV status (RCT) Immunisation status (see schedule on following page) – if incomplete, direct the child to YCC on discharge MUAC (mid upper arm circumference) done for any child with suspected malnutrition Sickle cell screening for all newborns and any other child you suspect (for example, an anaemic child who is MPS negative) OPD The outpatient department is primarily run by a charity called Global. They staff and supply the medications for the outpatient department as well as support the emergency department. They check the emergency ward Resuscitation Equipment and Drugs Bag twice every day to ensure it is stocked (you can find this bag on the door inside the emergency ward). 4 If you are looking for out of stock medications, medications for chronic disease or for certain types of equipment eg cannulas, NG tubes, you can check whether they have them in OPD. For those families that cannot afford important investigations, necessary medications or referrals, please note that in OPD there is a hardship fund that can help to fund these cases. Please ask the Global nurses (especially Sarah) in OPD if you need to use this. CLINICS Mondays – Sickle cell, HIV Wednesdays – Epilepsy, Cerebral Palsyand TB 2nd Thursday of every month – HIV adolescent clinic Thursday morning at main hospital – Paediatric Physiotherapy clinic Weds – Surgical / orthopaedic clinic. Thurs and Friday morning to see surgical consultant WARDS Emergency Ward The expectation is that you see all patients on Emergency Ward. If there is a Senior Paediatrician that day, you will see some or all of the patients with them. If you are on call, the expectation is that you will add the file of any child that has died in the last 24 hours to the mortality database on the intern computer. There is a box for you to put (and find) these files in the little room off of the emergency ward Suggestions: On your week covering the Emergency Ward, ask the Student Nurses and Sister in Charge to take Observations of all the children before you start the round. This includes Temperature, Respiratory Rate, Heart Rate and Oxygen Saturation. This will also help you prioritise which children you need to see first. Look at the blackboard to see who the nurses think are the sickest See the sickest child first. Learn the normal range of observations for children of different ages. Please also find the table at the back of this booklet for easy reference. We have not included Blood Pressure as this is currently not available to do for all children. Please do remember to measure blood pressure (ask Sister 5 in Charge or researchers in INO to use their machine) for children with suspected hypertension (eg renal). Malnutrition Ward Suggestions: On your week covering the Malnutrition Ward, ask the nurses to take Observations of any child they are worried about including Temperature, Respiratory Rate, Heart Rate and perhaps most importantly, Oxygen Saturation. Remember that some children will need to be seen every day and some are stable in nutritional rehabilitation. These children are potentially some of the sickest children with the least reserve. If a child is not improving or deteriorating despite treatment, ask advice of your seniors. This can also be by phone. Move the child to Emergency if they need oxygen. Ward 1 and 2 Suggestions: There may be a high turnover of patients, especially on Ward 2 so make sure that you are clear on your discharge plan for common presentations such as Pneumonia, Malaria, Anaemia and Sickle cell disease. If you have a complicated patient, inform your senior early on. If you have prepared a summary (it can be verbal), it makes it easier for your senior to direct advice if they do not have time to see the patient on that day. Also use the resources available in the resource pack. You could write down any names of patients that need a review somewhere on the ward so that if your senior comes at a time when you are not there, they know which patients you wanted them to see. If children deteriorate, do not hesitate in bringing them back to emergency. If you do, make sure you hand them over properly to the staff in emergency and ensure there is a plan in place. Whichever ward you are covering that week, make sure to help each other as it can be busy and stressful – remember: ‘a problem shared is a problem halved’ or ‘two minds are greater than one’. 6 Helpful phone numbers as of August 2015 Dr Ajuna Patrick (HIV/general paeds) Ambulance drivers Look on the noticeboard for daily rota of drivers and their numbers CoRSU hospital in Entebbe Orthopaedic and Plastic Surgery 0794900131 (Ward) / 0794900106 (Admin) / 0794900158 (OPD) / 0794900111 (General Inquiries) CURE hospital in Mbale Hydrocephalus, Spina Bifida, Brain Tumours / Neurosurgery 0454435273 / 0772778813 / 0454435356 / info@cureuganda.org / ug.info@cure.org EEG at Mulago Hospital – Olga 0772601603 Green’s Pharmacy (you can also SMS your question regarding availability, dosage and price), Main Street near Post Office – NB they have ATS 0794473367 Hospice – eg for morphine Esther 0773444363 Head of Paediatric Dept – Dr Harriet Nambuya 0772448247 Laboratory / Mr Bakimbi / Geofrey (lab tech) 0772832102 / 0772832102 / 0776284501 / 0704774197 Medicare Jinja Diagnostic Centre – for cultures 0702559991 Mulago Hospital - Cancer Institute (Dr Noleb Mugisha) 0414 540 410 / 0706599544 / 0712123889 Mulago Hospital - Heart Institute (Dr Emmanuel Tenywa) 0782840944 Mulago Hospital - Surgical Referrals (Mr Ssekabira) Nicholas – NDI (nurse and engineer for oxygen machines and inverter) 7 0782222560 Ophthalmology Referral (Dr Kikira) 0772536520 Orthopaedic Referrals (Mr Magada) 0772410875 Pharmacy (Mr Kiganda) 0772953491 Rapha 0752068737 Rippon 0434 120200 Sister in Charge – Margaret Oboke 0776187833 Soft Power Health NGO (Allan Stone Community Health Clinic, Bujagali) 0779933303 Surgery (Main hospital) Mr Ekwaro 0772446402 Taso (Lunch – Agnes) 0784588732 TUSC (Transporting Ugandan Sick Children) – Yakub 0779153378 Please note that there is a hospital phone that may be available for use – ask the Sister in Charge. Please add any other useful numbers below: 8 Referrals and points of advice or support CORSU hospital, Entebbe – for orthopaedics or plastics: fixed club foot (refer in the first month of life), cleft lip / palate (refer at 2 to 3 months of age, or sooner if they are not able to feed well), osteomyelitis, bow legs, congenital dislocation of hip, congenital abnormalities, severe contractures e.g. after a stroke or post-burns. Surgery and other treatments are free for children at CORSU, but they charge 8000 per consultation plus the costs of lab tests/xrays and 18,000 per night of hospital stay. CURE hospital, Mbale – paediatric neurosurgery – eg for congenital hydrocephalus, spina bifida, myelomeningocoele, brain tumours. They charge around 1 million shillings spread over 12 months as a maximum (e.g. for children needing surgery). They have financial counsellors and price plans to make this affordable and no child in need who could benefit is turned away. Mulago hospital, Kampala – cardiac lesions, oncology patients for diagnostic investigations and chemotherapy, complicated paediatric surgical cases e.g. surgical jaundice (pale stools and dark urine, high total and direct bilirubins – MUST refer ASAP eg before 5 weeks of age, as could be biliary atresia). If you have children for surgical referral, e.g. to Mulago, please first send to Ward 9 at the Main Hospital. Make sure you have spoken to the interns doing Surgery as well as the Surgical Consultant. If you need a consultant surgical opinion, the best days to refer are clinic day (Wednesday) or Thursday and Friday mornings. If you have a neonate or child with a suspected cardiac lesion, they are likely to need an Echocardiogram. Based on the results of this, they may then need to be seen at the Heart Institute in Kampala. Please also note that Dr Tenywa who works at the Uganda Heart Institute also works at Nalufenya on Fridays, Saturdays and Sundays and is happy to be contacted for advice. He can see cardiac patients at Nalufenya in OPD on a Friday (or at SoftPower on a Sat). 9 Also remember to use Transport for Ugandan Sick Children (contact Yakub) to arrange free transport to other hospitals including Cure Hospital in Mbale, Mulago Hospital in Kampala and CORSU in Entebbe. The Allan Stone Community Health Clinic at Bujagali is part of the Soft Power Health NGO. For a small membership fee they subsidise some medical costs, and arrange TUSC transport, so for patients who need referral to Mulago or other hospitals it can help make this more affordable. In particular, the Ugandan heart institute is very expensive and is a privately run organisation (an echo costs 44,000) and so patients can benefit by going through Soft Power Health. If you need to transfer a patient to the main hospital you can contact the Driver / Ambulance (look on noticeboard for daily rota of drivers). If the patient needs to be seen by the surgical team but needs to go with oxygen, you may be able to take one of the concentrators with you. Check with Sister in charge if this would be possible. If a child has weakness, spasticity or muscle atrophy following cerebral malaria, stroke, tetanus or trauma, refer to paediatric physiotherapy which is on Thursday mornings at main hospital. For any child with a terminal illness, you can refer to the hospice, which is based on the site of the DHO’s office, but runs a home visiting service. The hospice also provides morphine to any medical establishment that has a need of it, on receipt of 2 copies of a signed requisition letter (must be stamped with the departmental stamp which is kept in the head of department’s office). There are examples of this type of requisition letter in the sister in charge’s files – if the hospital ever runs out of morphine, ask the in-charge and they should be able to get more supplies through the hospice. The Uganda Cancer Institute in Kampala sees children daily for diagnosis, investigation and treatment of cancers. The services are all free unless the child needs any investigation that is not available at the institute. The institute however does not have inpatient facilities and therefore the caretaker must bring small funds for upkeep. Contact TUSC to arrange transport for the child – Yakub will normally leave very early in the morning so that the child will be seen at the beginning of clinic day. 10 Malnutrition ward – outpatient programme. There is an “OTC” programme of outpatient care for children with moderate or severe malnutrition who are clinically well and able to eat plumpynut (plumpynut = RUTF). Advice on specific patient cases. If you have access to the internet there is an NGO which provides an email advice service for doctors working in Africa. You can email Md2ndopinion@aol.com stating your professional background and job, a brief outline of the case, and the clinical question that you have, and they normally reply within 48 hours with advice. You can include photos as well (and it is for any patient, not just paediatrics). There are some world leading experts that give advice through this NGO, all for free. Seniors including the head of department are happy to be called for advice if they are not on site. And of course, you can always email the authors of this induction booklet, Dr Johanna and Dr Jenny. 11 General tips regarding medications: Never forget that many of the most life-saving medications can be given IM as well as IV so if you are struggling to get access, do not delay in giving treatment while you keep trying. Also remember that everything that can be given IV can also be given via intra-osseous route. Drugs are restocked on Tuesdays. This means that there can sometimes be stock-outs on Mondays and over the weekend. Please discuss any patterns you see with the Sister in Charge and Pharmacist in Charge Mr Kiganda. You may also consider keeping a log in the intern computer as an audit. When you are choosing antibiotics, first determine what is available on the ward as it is better to prescribe something that is available than the child does not get any treatment. If your choice of antibiotic is unavailable, make sure that the family can afford to buy the type that you have prescribed. We recommend that you write 6hrly, 8hrly, 12hrly to make communication clear. If the drug sheet is becoming congested, please get a new one and cross through the old one. This simple action can actually save lives! As the wards and nurses can get very busy, it is important to empower the parents to remind them of the times for treatment, especially if the child is having regular painkillers (for example in sickle cell, tetanus). Use the BNF and formulary (both attached in Emergency ward) and make sure to help student nurses if they have questions regarding drugs. Use the special tetanus treatment sheets for tetanus patients. If babies need 2 hourly IV fluids consider drawing up a personalised fluid chart for them and empowering the nursing staff to give them 2 hourly. Put their names on the blackboard. 12 Medications Please find common dosages for most medications that you will use. Adrenaline (for resuscitation if pulse absent or <60bpm with inadequate breathing) Ampoules come as 1mg adrenaline in 1 ml solution = 1:1000 strength. Add 1ml of adrenaline from the vial (1:1000 solution) + 9mls normal saline = 1mg adrenaline in 10mls total solution (1:10000) GIVE INTRAVENOUSLY 0.1mls / kg of 1:10,000 solution Repeat after 2 minutes if no improvement Aciclovir (oral) for herpes encephalitis Child 1 month–2 years 200 mg 4 times daily for 21 days Child 2–6 years 400 mg 4 times daily for 21 days Child 6–12 years 800 mg 4 times daily for 21 days Albendazole <2 years: 200mg one dose ≥2 years: 400mg one dose Aminophylline (respiratory stimulant, can be used for apnoea of prematurity and asthma) All ages: Loading dose (oral or IV) 6mg/kg (maximum 300mg) Neonates: Maintenance dose (oral or IV) 2.5mg/kg 12 hourly Older babies and children: Maintenance dose 5mg/kg 6 hourly Ampicillin (a broad spectrum antibiotic, first line to treat neonatal sepsis) Neonates (<7 days old): 50mg/kg IV 12 hourly Neonates 8 days to 28 days old: 50mg/kg IV 8 hourly Older babies and children: 50mg/kg IV 6 hourly Ampiclox (a combined antibiotic containing Ampicillin and Cloxacillin) <1 year: 75mg 8 hourly IV 1 to 2 years: 250mg 6 hourly IV or oral 2 to 10 years: 250 – 500mg 6 hourly IV or oral More than 10 years: 500mg – 1g 6 hourly IV or oral 13 Artesunate (an antimalarial, first line in severe / complicated malaria) Weight <20kg: 3mg/kg at 0,12,24 hours IV or IM Weight>20kg: 2.4mg/kg at 0,12,24 hours. Give 3 IV / IM doses over 24 hours irrespective of patient’s ability to tolerate oral treatment. If unable to take oral medication, continue IV or IM treatment once a day for a maximum of 7 days. Remember, this must be followed by 3 days of oral Coartem (below). X Pen = Benzylpenicillin (Remember: iu/mega-u/mg are NOT the same) 50,000 iu / kg IV or IM 6 hourly is 0.05 mega units/kg IV or IM 6 hourly is 30mg/kg IV or IM 6 hourly Note: in severe infection dose can be doubled to 100,000 iu/kg 6 hourly Carbamazepine 1month – 12 years: Initially 5mg/kg at night, increased as necessary by 2.55mg/kg every 3-7 days; usual maintenance dose 5mg/kg 2-3 times daily. The dose needs to be titrated up slowly and the drug should not be stopped suddenly as it may cause side effects. Ceftriaxone (a broad spectrum antibiotic used to treat meningitis and severe pneumonia) 100mg/kg once a day IV or IM Chloramphenicol (broad spectrum antibiotic) 12.5mg /kg 6 hourly IV (can be doubled to 25mg/kg 6 hourly in sepsis/meningitis/epiglottitis) Chlorpromazine (CPZ) (a sedative used for tetanus patients) All ages: 12.5 to 25mg every 6 hours IV/IM/PO/NGT Alternate with diazepam so one sedative is given every 3 hrs Ciprofloxacin (antibiotic in bloody diarrhoea) 10mg/kg 8 hourly IV Cloxacillin (broad spectrum antibiotic used in meningitis, severe skin infections, a second line for neonatal sepsis) Neonatal sepsis: 50mg/kg every 12 hours IV All children and babies above 28 days old: 50mg/kg every 6 hours IV 14 Co-artem (combined anti-malarial 20mg/120mg which should always be given after Artesunate). <15kg: 1 tab BD for 3 days. 15 – 30 kg: 2 tabs BD for 3 days. >30kg: 3 tabs BD for 3 days. Diazepam (anti-convulsant and sedative used in tetanus) Remember that this is a potent sedative. Be especially careful in children with reduced consciousness as the risk of apnoea and respiratory depression is high (use a smaller dose and if using IV route, GIVE DOSE SLOWLY OVER AT LEAST 5 MINUTES SLOW IV PUSH). If respiratory depression occurs, the child may need help (bagging) for a number of hours as the main effect of the drug wears off. Rectal suppository for convulsions: 0.5mg/kg It is also safe and effective to give the undiluted IV solution of diazepam by rectum. Can repeat after 10 mins if needed. For convulsions: 0.2 – 0.3mg / kg IV given SLOWLY. If needed repeat after 10 minutes then PRN for a total maximum of 3 doses (max 2 doses if also given phenobarbitone within 24 hours) For tetanus spasms: 0.2mg/kg IV 6 hourly given SLOWLY. Give IV until spasms mild/infrequent. 0.5 – 1mg/kg PO/NGT 6 hourly (alternate with CPZ so one sedative is given every 3 hours). Digoxin (250 microgram tablets)(used as a cardiac inotrope) All ages: Load with 15 micrograms/kg stat, then 6 hours later start the maintenance which is 5 micrograms/kg BD. NB Digoxin is TOXIC in overdose, and it has a narrow therapeutic range. It may be impossible in small babies to give a safe dose of oral digoxin using the 250microgram tablets we have available – in that case ask the parents to buy 62.5 microgram tablets. Diclofenac All children> 1 year: 1mg/kg IM TDS (max dose 50mg) Fluconazole (anti fungal: second line for oral thrush, first line for HIV thrush or oesophageal thrush). Syrup is 50mg/5ml. All ages: 6mg/kg on the first day, then 3mg/kg daily for 7 – 14 days Furosemide (a diuretic for heart failure, or given at the start of blood transfusion to prevent heart failure if at risk eg. SAM) 15 Neonate: 0.5 - 1mg/kg, 12 - 24 hourly IV Older babies and children: 0.5 – 2mg/kg, 8 – 24 hourly IV Gentamicin (a broad spectrum antibiotic, first line to treat neonatal sepsis) Preterm / low birth weight less than 2.5kg: 3mg / kg od IV or IM. Term neonate: 5mg / kg once a day IV/IM. Older babies and children: 7.5mg/kg once a day IV / IM Iron (for anaemic children and preterm babies on discharge) 200mg Ferrous sulphate tabs or 140mg/5mls Ferrous fumarate syrup Weight 200 mg tabs 140mg/5mls (twice daily) syrup (twice daily) 3-6kg 2.5mls 7-9kg ¼ 5mls 10-14kg ½ 10mls 15-20kg ½ 15mls Ketoconazole Use only as second line if nystatin or fluconazole fails or is not available (1 in 1000 suffer severe liver toxicity as a side effect). Children 2 years and above: 3 to 6mg/kg od. (Can give 5 – 10mg/kg od in severe mucocutaneous candidiasis with AIDS.) Mebendazole >1 year: 100mg bd for 3 days or 500mg one dose Metronidazole (an antibiotic that covers anaerobic bacteria. Used in tetanus) Dose: 7.5mg/kg every 8 hours. Nevirapine syrup for infants born exposed to HIV Less than 2.5kg: 1ml od. More than 2.5kg: 1.5ml od Nystatin 100,000 iu/ml. Give 1ml 6 hourly after breastfeeds for 7 – 14 days Phenobarbitone (used to stop convulsions that persist for more than 5 minutes, or multiple short convulsions within 30 minutes. First line in neonatal convulsions. Can also be used for breakthrough spasms in tetanus) Neonate loading dose (IM / IV) 20mg/kg. If convulsions do not stop after 30 minutes can give further 10mg/kg. Max dose in 24 hours is 40mg/kg. 16 Paediatric loading dose: 15mg/kg IM / IV Neonate and Paediatric maintenance dose: 5mg/kg once a day PO or IV Prednisolone 5mg tablets For treatment in asthma: 1mg/kg daily for 3-5 days For nephrotic syndrome: 2mg/kg/day for 6 weeks (max 60mg). Then 1.5 mg/kg on alternate days for 6 weeks (max 40mg). Then stop (do not wean). For TB pericarditis: 1mg/kg od for 4 weeks then 0.5mg/kg od for 4 weeks, then 0.25mg/kg od for 2 weeks then 0.08mg/kg od for 1 week. For TB meningitis: Prednisolone 4mg/kg/day (OR dexamethasone IV or oral 0.6mg/kg/day) for 4 weeks, then a tapering course over 4 weeks. Salbutamol nebulisers (a bronchodilator for wheeze) < 5 years: 2.5mg. > 5 years and over: 2.5 to 5mg Can repeat up to every 10 minutes maximum Maintenance dose: depending on improvement but between 6-8 hourly TB Medications Use RHZ for 2 months then RH for 4 months as standard pulmonary TB therapy. In cases of HIV positive or exposed with pulmonary TB, use RHZE for 2 months then RH for 4 months TB Meningitis / spinal TB / abdominal TB: 2 months RHZE, 10 months RH Tabs available: RHZ 60/30/150, RHZE 150/75/400/275, RH 60/30 Watch for liver toxicity. Dose ranges: Rifampicin (R): 10 – 20mg/kg od [max 600mg] Isoniazid (H): 7 – 15mg/kg od [max 300mg] Pyrazinamide (Z): 30 – 40mg/kg od Ethambutol (E): 15 – 25mg/kg od *NB Ethambutol can cause visual loss (optic neuritis) so do not exceed the maximum safe ethambutol dose – if necessary, reduce doses of other drugs. Number of tabs of RH or RHZ for kg ranges as follows: 4 – 6kg: 1 tab od / 7 – 10kg: 2 tabs od / 11 – 14kg: 3 tabs od / 15 – 19kg: 4 tabs od / 20 – 24kg: 5 tabs od Number of tabs of RHZE for kg ranges as follows: 4 – 6kg: ¼ tab od / 7 – 10kg: ½ tab od / 11 – 14kg: 1 tabs od / 15 – 19kg: 1 and ¼ tabs od / 20 – 24kg: 1 and ½ tabs od 17 RHZE continued – Go with the child and caretaker if you are starting a child with suspected TB on treatment to make sure that the drugs are available, dispensed and the caretaker knows correct number and dosage of pills.You need to make sure the child has an exercise book before the pharmacy will issue them anti TBs. (NB the drugs are dispensed directly from the pharmacists, not through Global / OPD). Tetanus Antitoxin (Anti-Tetanus Serum = ATS - Neutralises tetanus toxin) Dose: 1500 units initial dose - give IM split into 2 sites, or give slowly IV Can repeat doses up to a total of 10,000 units (but this is expensive!) They are available at Green’s Pharmacy on Main Street. The cost is around 60,000 USH for 1,500 units – please approach Global in OPD if the family is unable to afford this. Zinc: <6 months 10mg od for 10 days. >6 months 20mg od for 10 days. In severe acutely malnourished children, you do not need to supplement Zinc as it is part of the WHO F75 and F100 in sufficient and safe doses. Too much zinc can be toxic. Paracetamol All children >3months 15mg/kg 6 hourly* (max 20mg/kg 6 hourly in severe pain) PO Ibuprofen All children >3months 10mg/kg 8 hourly PO Diclofenac All children >6months 0.3 – 1mg/kg 8 hourly PO. * Can also be given IM. Morphine All children >6months: 0.2 – 0.3mg/kg 4 – 6 hourly PO 18 Maintenance IV fluids For children at risk of hypoglycaemia eg malnourished, NPO: Add 50 mls of 50% Dextrose to 450 mls Ringer’s Lactate to make 5% Dextrose + Ringer’s Lactate maintenance fluids. Give 100mls for every kg up to the first 10kg bodyweight plus give 50mls for every kg between 10 and 20kg bodyweight plus give 25mls for every kg above 20kg Eg for a 34kg child give (100mls x 10) + (50mls x 10) + (25mls x 14) = 1850mls IV fluid is required every 24 hours as “maintenance”. Drip rate = Rate in mls per hour x 15 3600 Number of drops per second = 1 ÷ drip rate E.g. 1 ÷ 0.125 = 8. There should be 1 drop every 8 seconds (i.e. there should be 8 seconds between each drop that falls through the giving set chamber) 24 hour fluid maintenance by weight 2kg 200mls 18kg 1400mls 4kg 400mls 20kg 1500mls 6kg 600mls 22kg 1550mls 8kg 800mls 24kg 1600mls 10kg 1000mls 26kg 1650mls 12kg 1100mls 28kg 1700mls 14kg 1200mls 30kg 1750mls 16kg 1300mls 19 20 Special Care Baby Unit Neonate: Up to 28 days (4 weeks) of life Normal birth weight = ≥2.5kg Low birth weight = 1.5kg – 2.5kg Very low birth weight = <1.5kg Extremely low birth weight = <1kg Resuscitation of a Newborn (see previous page): Remember that most babies will not need any resuscitation, some babies will only need stimulation, a few babies will need help with ventilation (via bag-valve-mask) and it is rare to need to do cardiac compressions and give medications. Also remember that most newborn babies respond very well to resuscitation so it is ALWAYS worth trying – EVEN if the baby is not breathing at all, or has a weak or absent pulse. Ward round expectations On special care it is expected on ward rounds that you document: Age of baby in days Gestation at birth Weight at birth if <1.5kg Fluids plan including mls of milk mother should give, and whether by cup/tube, and whether to breastfeed. Temperatures over the previous 24 hours (see the parental temperature chart) and a plan for thermal care eg Kangaroo Oxygen sats and how many litres the baby is receiving There are some things that are especially important to monitor in babies – temperatures and the baby’s weights (weigh on day 0, 3, 5, 7, then twice a week). Mothers of any baby weighing <2kg should take the baby’s temperature 4 times a day and record it on the parental recording chart. Temperatures of less than 36.5 in a neonate increase the baby’s mortality, and temperatures of 35.4 or less are very dangerous. 21 The temperature charts have a section on the back for the doctor to fill in to communicate clearly to the parents how many mls of milk they should be giving and how often, and how much kangaroo to do. Please fill it in daily. Remember – cold babies are sick babies. Temp<36.5 is too cold! Breastfeeding Any child >1.5kg should be initiated on breastfeeding as long as they are not unwell. Make sure that you are happy to explain to mothers how to achieve good attachment when breastfeeding. This includes supporting the baby’s body well, holding the baby chest to chest, encourage the baby to open the mouth wide to take both nipple and areola (especially below the nipple). See picture below. Explain to the mother the importance of exclusive breastfeeding for the first six months of life (in accordance with WHO guidelines). You can furthermore explain to her the benefits of breastmilk over formula feeds better immunity, fewer infections and improved neurodevelopmental outcome. If a baby is failing to thrive on cow’s milk or formula feeds, review the type and amount of powder the mother is adding as it may be too dilute. 22 Expressing Breastmilk Mothers can start trying to express from month 7 of pregnancy - this will make it easier for the milk to come when the baby is born. Advise the mother to express from both breasts (this is also the advice if she has breast engorgement). Neonatal Fluids and Feeding In premature and low birth weight babies, the fluids should be gradually increased over the first week of life. Please refer to the tables on the following page: the total volume of fluids per day as well as standard feeding regimens for babies between 0.8kg and 2.5kg. Keep in mind that the smallest babies might need 2 hourly feeds to decrease the risk of hypoglycaemia and because their stomachs are too small to fit the larger volumes (as in 3 hourly feeds). Always use 10% Dextrose as the IV fluid in the first 48 hours. Then change to fluids with added electrolytes = 1/3 Ringer’s Lactate + 2/3 10% Dextrose Neonatal antibiotics Ampicillin and Gentamicin are first-line antibiotics. Add Metronidazole IV if suspecting Necrotising Enterocolitis. Start Ceftriaxone IV if suspecting Neonatal Meningitis. Start Benzylpenicillin if suspected congenital infection as the only one that is easy to cure is Congenital Syphilis (hepatosplenomegaly, thrombocytopenia). Babies born to HIV positive mothers: Start on Nevirapine 1.5ml OD(above 2.5kg) or 1ml OD (below 2.5kg) for 6 weeks only. Explain the importance of exclusive breastfeeding in decreasing risk of transmission. All exposed children should be started on Cotrimoxazole prophylaxis (Septrin) from 6 weeks of age, and brought back to EID (HIV) clinic at Nalufenya at 6 weeks of age for testing. Hypoglycaemia There is a glucometer in the Special Care Baby Unit, but strips are expensive so use them wisely. In most cases, treat any unwell baby who may be hypoglycaemic with an immediate breast-, cup or NG feed or give 5ml/kg 10% Dextrose IV. Make sure to have an ongoing feeding or fluid plan to maintain the baby’s sugar level as the baby continues to be at risk of hypoglycaemia. 23 24 Kangaroo Mother Care The ideal is to do it all the time both day and night – however, the amount of time the mother is willing and able to do it may vary a great deal between mothers. We normally start trying 2 hours x1 or x2 in a day, and increase to 2hours x4. On discharge, explain to mothers that they can practice KMC at night and when they are performing their normal chores and activities. Explain also that they can breastfeed during Kangaroo, and can also express breastmilk whilst the baby remains of Kangaroo. Cup feeds are easier when not on Kangaroo, but it’s easy to do NGT feeds on Kangaroo. It’s easy also to put twins onto Kangaroo with the same caregiver, as long as each baby is a small premature they can fit together on Kangaroo very well. Make sure you are happy to explain to the mother how to do Kangaroo – mother takes off shirt and then places the baby (dressed only in nappy, hat and socks) in the frog position (arms and legs bent) with baby facing the mother and positioned between mother’s breasts. Add one or more thick blanketsfolded on top of the baby if the baby is cold or is less than 1.5kg. Finally, wrap a long cloth around the baby and mother and secure it well by tying it on her back NG feeding NGT feeding is standard in any baby too weak to breastfeed / cupfeed, for example severe birth asphyxia, and premature babies weighing less than 1.2kg. Babies of 1.2 – 2.0kg may be able to take cup feeds instead of NGT feeds, however it is still very important to give extra milk to these small babies as they won’t naturally be able to take enough from the breast. Many parents are frightened of the feeding tube. Take the time (it will save time in the long run) to explain to them the following points: - Premature babies are small and weak and their suck is not strong. This means they cannot take enough milk directly from the breast and we need to give extra so that they can grow. - Babies with difficulty in breathing often do not have the energy to feed well, and in fact trying to breastfeed a child who has breathing distress can easily make the breathing much worse - Babies in a coma will be too weak to suckle and cup feeds are dangerous as there is a significant risk of milk or food passing into the lungs. This can lead to a type of pneumonia which is difficult to treat and makes a sick baby even sicker. - Describe (using the poster if possible) how the tube passes down the throat into the stomach and helps protect the lungs by allowing food to pass directly into the stomach past the lungs. 25 - Explain that the tube is thin and flexible and made of soft plastic, and doesn’t damage any internal structures. It will be removed in a few days or weeks once the baby is bigger or stronger and they can still breastfeed with the tube inside, as they start to recover. - Feeding well will increasing the child’s strength and help to recover from their illness. Apnoea of Prematurity Babies less than 34 weeks gestation may have apnoeas where they stop breathing for many seconds. They need to be stimulated and occasionally resuscitated with the ambubag. Give prophylactic Aminophylline to all premature babies of 7months gestation or less (around 1.5kg or less). Always ensure the baby is treated for other possible causes of apnoeas like RDS, sepsis, hypoglycaemia and hypothermia. Respiratory Distress Syndrome Respiratory Distress Syndrome (RDS) is one of the most common causes of respiratory distress in the premature baby and is caused by immaturity of the lungs and insufficient surfactant production. Treatment is with CPAP and oxygen and it improves slowly over time. Neonatal seizures These can be subtle and may present with nystagmus of the eyes, twitching of the lips or fingers, or sucking movements when there is nothing in the baby’s mouth. If you are not sure then try to stop the abnormal movement if you cannot, then it is likely the baby is having a seizure. Remember that seizures may be caused by hypoxic-ischaemic encephalopathy (‘birth asphyxia’), hypoglycaemia or meningitis. Always check the RBS or give 10% Dextrose to correct for possible hypoglycaemia and give 2nd line antibiotics (ceftriaxone and cloxacillin) for possible meningitis. Start Phenobarbitone IV loading dose (20mg/kg) if seizure persists for more than 3 minutes, or multiple frequent convulsions each shorter than 3 minutes. If convulsions do not stop after 30 minutes can give further 10mg/kg dose. Diazepam can be used as second line (rectal dose is safest) if continuing to convulse despite Phenobarbitone. Neonatal jaundice Physiological jaundice - delayed neonatal conjugation and clearance of bilirubin. Happens 3-5 days after birth (not in the first 24 hours) and will rarely rises to dangerous levels. In a preterm baby, the physiological 26 jaundice is exaggerated as the preterm baby is less able to conjugate and clear the bilirubin. Furthermore, the neonatal brain is at more risk of kernicterus (high levels of bilirubin causing brain damage) so it is important to recognise and start treatment quickly. A sensitive way to check jaundice levels and more importantly, the risk of kernicterus is to check whether it has reached the baby’s palms and soles of feet (rubbing the bottom of the foot shows the underlying colour). Start phototherapy (blue light therapy available both in SCBU and in the Neonatal room at Nalufenya). Undress the baby so it is only in a nappy. Cover the eyes to prevent eye damage. Make sure the baby is warm and well hydrated as this is important in clearing the bilirubin. Remember that breastfeeding /NG / cup feeding should continue as normal – but add 10ml/kg/day to the total daily fluid requirements. Necrotising Enterocolitis Premature babies who have started feeding are at risk of developing necrotising enterocolitis. Babies may present with intolerance of feeds, temperature instability (high or low), bilious vomiting (green), blood in stools and abdominal distension with shiny skin. Treatment: put babies nil per os for at least 48 hours (make sure to explain to caretaker the importance of not feeding), put NG tube on free drainage and start IV fluids per fluids chart. Start triple antibiotics (Ampicillin, Gentamicin, and Metronidazole for 10 days) and consider getting an abdominal X-ray. If you suspect that the baby has perforated the intestine, you need to discuss with Paediatric surgeons at main hospital. Consider discussing with the Paediatric Surgical team at Mulago as well. Cardiac failure Presents with respiratory distress + hepatomegaly + oedema and depending on the size of the lesion, a murmur (if the lesion is very large, a murmur may not be present). Treat with Oxygen, Furosemide, Digoxin, fluid restriction and positioning. The baby will require an Echocardiogram and referral to the cardiac institute at Mulago Hospital. Congenital abnormalities Examine babies with failure to breastfeed for cleft palate. Advise mothers on best way to feed the baby – some will tolerate breast, others cup or spoon feeds – and refer to Mulago hospital for repair. 27 Exomphalos, gastroschisis, imperforate anus – these babies need referrals to the Surgical team (at main hospital or Mulago). Do not initiate feeds for these babies, instead insert an NG tube which is placed on free drainage (tape a glove to the free end to act as container) and start them on IV fluids until they have been seen by the surgical team. Remember to replace fluid losses and consider starting on prophylactic antibiotics. Follow up Weight Remember that babies normally lose up to 10% of their birth weight in the first week but should regain their birth weight by day 14. When preterm babies come for follow up, you should expect them to have gained 20 to 30 grams per day (the calculation is current weight in grams – previous weight in grams / number of days between the two weights). Ask about the feeding pattern (duration and frequency) and what it is composed of. How many times in the day do they give cup feeds? How often each night do they give by cup or do they only breastfeed at night? Does the baby ever vomit? If there is poor weight gain concentrate on encouraging the mother to give additional cupfeeds. If it is severely poor weight gain <10grams per day, the baby should be admitted for NGT feeds. We recommend delaying bathing in very small babies <1.2kg for around 2 weeks, and for any small baby <2kg it’s important to be careful to keep the baby warm when they are bathed. Kangaroo: Is the mother doing KMC? How many times a day, and does she do it overnight? For babies on follow up, encourage mothers to do at least 2hours x 4 in the day, as well as overnight. Is the mother aware she can do her daily tasks whilst the baby is on Kangaroo? What is the temperature at follow up, does the mother know how to check the baby’s hands and feet to see if it’s too cold? Has baby gone for immunisations (same timetable for prematures as term babies)? Does the baby sleep under a mosquito net at night? Medication - give Haemofort or Sytron (Ferrous fumarate) 2.5ml OD and Grovit 0.3ml OD until 6 months of age 28 Severely Impaired Circulation (Shock) without Diarrhoea 29 30 31 32 CONVULSIONS AND EPILEPSY Convulsions are common in our setting. The most common paediatric causes of convulsions seen in the Emergency ward are Cerebral Malaria and Meningitis. Do not forget to start Oxygen therapy for these children When a child comes in with convulsions, establish whether or not the child is known to have convulsions and if they are on regular anti-epileptic medications. If they do, take a full seizure history and make sure you know what doses of medications they take. What is the child’s functional baseline? Look in their book to see what was noted at the last clinic appointment. Ask the caretaker to describe how many types of tablets she gives as well as the number (or half, or quarter). It may be that the child is having a smaller or bigger dose than originally prescribed. Investigate and treat other potential causes of increased seizure frequency (see below) dosage for weight (is it up to date?) any signs of intercurrent illness started new medications (possible interaction) degenerative condition During admission, you can give the child 3 days of Phenobarbitone or Diazepam to interrupt the current increase in seizure activity. First line treatment of Epilepsy is Carbamazepine for focal / partial convulsions and phenobarbitone for Generalised Tonic Clonic seizures Remember to explain to the caretaker that some children will never be entirely free of convulsions. Investigation Blood transfusion Xray Ultrasound CBC RFT, LFT Lumbar puncture CSF protein, cell count Hb estimation MPS and RDT RCT Glucose Echo 33 Where available Paediatric lab Main hospital Main hospital Main hospital Main hospital Main hospital (Medicare on Main St does CSF culture) Paediatric lab Paediatric lab Paediatric lab Paediatric ward and lab Mulago hospital heart institute Diarrhoea and Dehydration 34 35 Pneumonia When a child presents in respiratory distress, independent of the cause, they should be put upright (the back of two of the beds in emergency ward can be put up) to increase the potential gas exchange in the lungs. You should also take the opportunity to place a feeding tube early on as the child will have difficulty meeting their fluid and feed requirement. Remember, the flow rate and inspired oxygen concentration you can give is: 35-45% O2 concentration via nasal cannula (maximum rates 2L/min for neonate, 4L/min for preschool children, 6L/min for school children), 40-60% via well-fitted face mask (Neonate/Infant/Child: 5-6L/min) and 80-90% if you are using a face mask with reservoir bag (Neonate/Infant/Child: 10-15L/min). *If you are struggling to meet the child’s oxygen requirement, you can use both nasal cannula and face mask to deliver more. 36 HOW TO USE PULSE OXIMETER If a child requires oxygen (SaO2 <90%), it is important to recheck saturation after oxygen therapy has been started to ensure that it is sufficient. In children who have improved you have to turn off the oxygen for a few minutes before you can get an accurate saturation reading. 37 HOW TO USE RESERVOIR BAG To use the face mask with reservoir bag, you must first inflate the reservoir bag. This is done by pressing on the valve inside the mask where it attaches to the reservoir bag. HOW TO USE BUBBLE CPAP If you have a neonate with respiratory distress that is not improving despite using oxygen therapy, you can start the child on CPAP. You can create bubble CPAP (continuous positive airway pressure) system: take an empty and clean plastic bottle, fill it two thirds of the way with tap water. Take the CPAP nasal cannula tube (it has one tied end and one cut-off end). Put the cut-off end into the water bottle so that it is about 3cm under the surface of the water. Attach the nasal cannula to the child and make sure there is a good seal. You may have to tape the cannula to the nose of the child. Once you have achieved this, you will see bubbles from the tubing inside the bottle – this is where the name ‘bubble CPAP’ comes from. HOW TO USE OXYGEN CONCENTRATORS (Devilbiss) The oxygen concentrators have two outlets – one that delivers up to 5L/min and one that delivers up to 2L/min. If the machine starts alarming, this usually refers to a specific number of issues (you can troubleshoot): It may be that the machine is overloaded (designed to maximum deliver 5L/min) Flowmeter is set too low Low power (power fluctuation) Blocked or defective humidifier bottles – make sure there is water in the bottle. Blocked or defective nasal cannula, oxygen tubing or face mask The filter at the back of the concentrator can easily be taken out and cleaned of dust. Always check that the tubing is connected to a child, otherwise turn off the oxygen or concentrator. These efforts may improve how long the machine lasts and mean they require less maintenance. (Note that usually turning the machine off and on again will stop the alarm.) POWERCUT / LOAD SHEDDING The inverter system in both Nalufenya (and soon) SCBU have been installed to start working when there are power cuts (load shedding). They will provide electricity to the lights (you must switch on lights by button in OPD), the fridge for blood products, the microscope and the concentrators 38 in the emergency ward. When the inverter batteries are fully charged, there will be enough electricity for around 8-12 hours. If the power has been off for a long time, check whether there is fuel for the generator. Discuss with sister in charge if there is not – this can then be organised in time. TETANUS Caused by spores from gram positive bacillus Clostridium tetani. Clean out suspected wound. Nurse in a quiet, dark room (off Ward 2). Sedate the child with Diazepam / Chlorpromazine (alternate doses every 3 hours). Please use the Tetanus Treatment chart to ensure these medications are given (copies should be in the Emergency Ward and in Sister’s office, otherwise there is a soft copy on the USB and intern computer). Insert NG tube straight away for feeding. Try to avoid triggering spasms during NGT insertion, if it does occur give further Diazepam / CPZ and try again after the child is more sleepy. Treat with Anti-tetanus serum (ATS) 1500 units by giving half of the injection IM in each thigh. They are available at Green’s Pharmacy on Main Street. The cost is around 60,000 USH for 1,500 units. Immunise the child on recovery as they do not have immunity. Also please note: there is a tetanus jobaid on the door of the tetanus room. SICKLE CELL DISEASE Newborn sickle cell screening has started in JRRH and is done in YCC. All children suspected of having sickle cell disease should also be tested (for example, children with dactylitis or with BS negative anaemia). Remember that children with sickle cell disease have high levels of morbidity and mortality and you should therefore have a low threshold to admit and treat. Also remember that they are at increased risk of infection due to hyposplenism. Admit children with sickle cell that have pain which is not controlled by adequate analgesia (if they are requiring morphine they should be admitted), not drinking/not tolerating oral fluids, significant anaemia (Hb<5g/dl), breathlessness or exhaustion, jaundice or evidence of haemolysis, priapism (>2 hours), chest pain, headaches, stroke, abnormal neurology, chest pain, abdominal pain or distension or fever with tachypnoea/tachycardia. Always look for signs of dehydration and shock. A fever in a child with sickle cell disease may be due to malaria, septicaemia, meningitis, pneumonia, osteomyelitis. For most sickle cell presentations, the initial management is the same: Admit the child. Check BS, Hb and Xmatch to transfuse 10ml/kg if Hb<10g/dl. Treat with oxygen if SaO2 < 90%. Treat malaria as per normal 39 protocol. Start broad-spectrum antibiotics eg. Ceftriaxone and Gentamicin if signs of infection. In painful crises, encourage oral fluids (give 150% maintenance fluids as ORS or IV Ringer’s Lactate if unable to drink. Consider changing to Ciprofloxacin after 48 hours. Remember analgesia (make sure there is a supply of morphine!) Acute anaemia is most commonly due to splenic sequestration or aplastic anaemia secondary to parvovirus B19 infection. The child will present with an acute drop in haemoglobin and splenomegaly (document the size clearly in the notes in order to demonstrate improvement). These children need urgent blood transfusions to maintain the Hb close to 10g/dl. Children with sickle cell disease should attend clinic every month (Mondays) and be prescribed: Folic acid 5mg OD Fansidar tablets once a month (<2yrs – ¼ tablet, 2-5 years – ½ tablet, 5-10 years – 1 tablet, 10-15 years 2 tablets, >15 years 3 tablets) Paracetamol 15mg/kg 4-6 hourly for pain or fever 3 days ORS – 3-6 packets (encouraged to drink plenty of fluids) Penicillin V <3 years 125mg bd, 3-5 years 250mg bd daily Pneumococcal vaccine at 2 years + every 5 years after that STROKE Many children may have neurological sequelae following cerebral malaria or suffer a stroke as a complication of sickle cell disease. Any child admitted with suspected stroke, examine neurology in an ageappropriate manner. Knowing your neuroanatomy (and common stroke presentations) can be helpful both in diagnosis but also to assess recovery. Remember to test if the child has any deficit of expressive or receptive speech – this may be most effective if you ask the mother to give the commands. Check whether there is homozygous hemianopia or neglect by bringing your hand from the periphery – does the child blink? Will the child follow an object you are holding with your eyes? Make sure you are familiar with the Blantyre Coma Scale and Glasgow Coma Scale as they can be important indicators of improvement or deterioration and will be your way of demonstrating progress. It is very important to stress to the caretakers the importance of the NG tube to safely feed the child if they are showing any signs of aspirating 40 when they feed eg. Coughing after swallowing.. The child also needs to be placed upright when feeding to minimise the risk of aspiration pneumonia. Use the NG visual aid poster to help explain to the parents and to reassure them that feeding by tube is not dangerous and is not permanent (see the section on NG feeding above if you want further advice). PHYSIOTHERAPY When the child is waiting to be seen by the Physiotherapist (Thursday mornings at main hospital) or as they are being discharged, you can give the caretaker some helpful advice: Children’s brains have a great deal of neural plasticity and there is an important period of recovery and rehabilitation following brain injury. It requires consistent and patient work and both the caretaker and child have to engage. It may therefore be a good idea for the caretaker to set aside some time every day to concentrate on exercises with their child or to incorporate them into the daily chores and activities. It is also important for the child to engage. This means the task has to be appropriate (not too easy, not too difficult) and as much as possible interesting and fun if it can be made into a game, it is more likely to keep the child’s attention. Remember that contractures can be very painful and the best treatment is to prevent them! Make sure you stretch each of the affected muscle groups – both passive and if able, active movements. Soft splints or orthotics can also be used, especially for things like foot drop which can affect the child’s mobility. If the child has right sided weakness and does not seem to understand commands, the stroke may be affecting Wernicke’s language area (receptive). If he is unable to speak but seems to be understanding, the stroke may be affecting Broca’s area. Remember (and explain to the caretaker) that this will be very distressing to the child as they will not understand what has happened. Example: you can tell the caretaker to tie a string with bottle caps on the unaffected arm. Then you can set the child a game or task during which they cannot make any noise. This means they will have to use their unaffected hand as using their stronger, unaffected hand would make noise. 41 42 Treatment of Malnutrition 43 NOTES 44 NOTES 45 Please find many more useful resources on the laptop in the intern office. These include the WHO Pocketbook, MCAI book, the ETAT+ lectures and posters, lectures and guidelines prepared by previous Global Links volunteers, health videos prepared by MAF and Global Community Health. You can also get a free WHO Pocketbook 2013 if you go into the WHO office in Kampala and explain that you are a healthcare provider. This booklet was prepared by Dr Johanna Gaiottino and Dr Jenny Woodruff with reference and thanks to work done by previous Global Links volunteers Dr Jessica Morgan, Dr Colin Powell, Dr Yetunde Odutolu and Dr Sarah Magowan. Please feel free to contact us on the following emails: Dr Johanna Gaiottino - johanna.gaiottino@gmail.com Dr Jenny Woodruff - jkwoodruff@gmail.com 46 Normal Paediatric Observations Age <3 months 6 months 1 year – 4 year 6 year – 12 year Heart Rate 110-170 105-165 85-150 70-135 Respiratory Rate 25-60 25-55 20-40 16-34 AVPU assessment of consciousness A – Alert V – responds to Voice P – responds appropriately to Pain (localises to pain pushes away hand) U – Unresponsive From the Textbook of Paediatrics – Malawi A Faces Pain Scale 47