Supplementary Table 1: A list of the 103 modifiers (58 Suppressors, 45 Enhancers) of VAP functions
discovered in our genetic screen. The modifiers are listed in alphabetical order of their Flybase symbol.
Symbol
Ars2
Name
-
Modifier class
Flybase Gene
Number
Enhancer
response toFBgn0033062
arsenic,
Bmcp
Bmcp
Suppressor
FBgn0036199
Bx
Beadex
Enhancer
FBgn0000242
Cdc6
CG10089
CG11560
CG11811
CG12743
Cdc6
ovarian tumor
Enhancer
Suppressor
Suppressor
Suppressor
Enhancer
FBgn0035918
FBgn0036369
FBgn0036249
FBgn0036099
FBgn0003023
CG12822
CG13048
CG13063
CG13075
CG13296
-
Suppressor
Enhancer
Suppressor
Suppressor
Enhancer
FBgn0033229
FBgn0036593
FBgn0036601
FBgn0036563
FBgn0035687
CG13387
embargoed
Enhancer
FBgn0020497
Function
response to arsenic, catalytic step2 spliceosome
negative regulation of viral genome replication
conversion of ds siRNA to ss siRNA involved in
RNA interference
gene silencing by miRNA
nuclear mRNA splicing, via spliceosome
regulation of metabolic process,mitochondrial
transmembrane transport
imaginal disc-derived leg segmentation
leg disc development
locomotor rhythm
response to cocaine
phagocytosis, engulfment
inter-male aggressive behavior
pre-replicative complex assembly
protein dephosphorylation
purine nucleotide metabolic process
female germ-line sex determination,
germ cell development
germ cell development
germ-line cyst formation
germ-line sex determination
oogenesis
chromosome organization
positive regulation of DNA endoreduplication
chitin metabolic process
nucleic acid binding
protein export from nucleus,
multicellular organismal development
protein export from nucleus
protein transport
protein export from nucleus
nuclear export
centriole replication
CG13994
CG14043
CG14125
CG14222
CG14326
CG14435
CG14606
smallminded
-
Enhancer
Suppressor
Suppressor
Enhancer
Suppressor
Enhancer
Suppressor
FBgn0031772
FBgn0031659
FBgn0036232
FBgn0031043
FBgn0038528
FBgn0029911
FBgn0037485
CG14837
CG15160
CG17327
CG17760
-
Suppressor
Enhancer
Suppressor
Suppressor
FBgn0035797
FBgn0032688
FBgn0038107
FBgn0033756
CG17985
CG18110
CG30043
CG30060
CG30161
CG31702
CG31769
CG32437
CG32685
CG32703
CG33090
-
Suppressor
Suppressor
Suppressor
Suppressor
Enhancer
Enhancer
Suppressor
Suppressor
Suppressor
Suppressor
Suppressor
FBgn0033199
FBgn0039677
FBgn0050043
FBgn0050060
FBgn0050161
FBgn0051702
FBgn0051769
FBgn0052437
FBgn0052685
FBgn0052703
FBgn0028916
CG34113
CG3476
-
Enhancer
Suppressor
FBgn0083949
FBgn0031881
CG3500
CG3884
CG3975
CG4169
-
Enhancer
Enhancer
Suppressor
Suppressor
FBgn0034849
FBgn0033786
FBgn0027559
FBgn0250814
CG42255
-
Suppressor
FBgn0259140
CG4627
CG4646
CG5325
CG5733
Nucleoporin 75
Suppressor
Suppressor
Suppressor
Enhancer
FBgn0033808
FBgn0033810
FBgn0032407
FBgn0034310
chitin metabolic process
metabolic process
phagocytosis, engulfment, hexose
transmembrane transport
translation
G-protein coupled receptor protein signaling
pathway, protein ADP-ribosylation
cell wall macromolecule catabolic process
sodium ion transport
proteolysis
neurogenesis
transcription initiation, DNA-dependent
biological_process
protein phosphorylation
bile acid metabolic process,
O-glycoside catabolic process
glucosylceramide catabolic process
acyl carnitine transport,
carnitine transport
mitochondrial transport
transmembrane transport
DNA replication
mitochondrial electron transport, ubiquinol to
cytochrome c,
proteolysis
lipid particle associated
microtubule associated complex
Microtubule associated complex, calcium
binding, metalloendopeptidase
biological_process
nervous system development , peroxisome
SMAD protein nuclear translocation,NLSbearing substrate import into nucleus
CG5953
CG6048
CG6220
Enhancer of
Polycomb
-
Suppressor
Suppressor
Enhancer
FBgn0032587
FBgn0029827
FBgn0033865
proteolysis
-
Suppressor
FBgn0037816
CG6502
Enhancer of
zeste
Enhancer
FBgn0000629
CG6674
CG6885
CG6950
CG7306
CG7564
CG7564
(Alsin2)
obstructor-F
-
Enhancer
Suppressor
Suppressor
Enhancer
Enhancer
Suppressor
FBgn0036063
FBgn0036810
FBgn0037955
FBgn0036947
FBgn0036734
FBgn0037116
CG7776
CG8219
CG8571
CG8863
CG9172
DnaJ-like-2
-
Enhancer
Enhancer
Enhancer
Enhancer
Enhancer
FBgn0000581
FBgn0035693
FBgn0016983
FBgn0038145
FBgn0030718
CG9391
CG9638
Ada2b
Enhancer
Enhancer
FBgn0037063
FBgn0037555
CG9953
-
Enhancer
FBgn0035726
regulation of cyclin-dependent protein kinase
activity,tRNA modification
histone methylation,
chromatin silencing
histone methylation
syncytial blastoderm mitotic cell cycle
axon guidance
muscle organ development
dendrite morphogenesis
neurogenesis
histone H3-K27 methylation
histone H3-K27 methylation
histone H3-K9 methylation
histone methylation
cuticle hydrocarbon biosynthetic process
biosynthetic process
chitin metabolic process
nuclear mRNA splicing, via spliceosome
Rab guanyl-nucleotide exchange factor
activity,Regulator of chromosome condensation,
RCC1; Vacuolar sorting protein 9
chromatin organization
protein import into nucleus, nuclear pore
protein folding, response to heat
mitochondrial electron transport, NADH to
ubiquinone,
determination of adult lifespan
mitochondrial respiratory chain complex I
assembly
response to reactive oxygen species
dephosphorylation
positive regulation of histone acetylation,
regulation of transcription , SAGA complex,
polytene chromosome
chromatin remodeling
cell proliferation
histone H3 acetylation
eye pigment metabolic process
proteolysis
CG6345
Cyp4ac1
Cyp4ac1
Suppressor
FBgn0031693
Cyp6a19
Cyp6a2
Cyp6a19
Cytochrome
P450-6a2
Cytochrome
P450-9b2
dilatory
Suppressor
Suppressor
FBgn0033979
FBgn0000473
Suppressor
FBgn0015039
Suppressor
FBgn0033447
dynactinsubunit-p25
ENL/AF9related
Enhancer
FBgn0040228
Suppressor
FBgn0026441
Elongation
factor 1 beta
eIF2B-delta
Enhancer
FBgn0028737
transcription initiation from RNA polymerase II
promoter,regulation of transcription, DNAdependent
translational elongation
Enhancer
FBgn0034858
translational initiation, neurogenesis
epsilonCOP
Suppressor
FBgn0027496
Glycogen
phosphorylase
Heat shock
protein 83
Icln
Suppressor
FBgn0004507
retrograde vesicle-mediated transport, Golgi to
ER
glycogen catabolic process, flight
Suppressor
FBgn0001233
Spermatogenesis,
Enhancer
FBgn0029079
Iron regulatory
protein 1B
Karyopherin
beta 3
lethal (1) G0222
lethal (2) 35Cc
mitochondrial
ribosomal
protein S34
myospheroid
Suppressor
FBgn0024957
cell volume homeostasis , chloride transport ,
volume sensitive anion channel
regulation of translational initiation by iron
Enhancer
FBgn0087013
protein import into nucleus
Suppressor
Enhancer
Enhancer
FBgn0028343
FBgn0259982
FBgn0260460
unfolded protein binding,protein folding
mitochondrial small ribosomal subunit
Enhancer
FBgn0004657
central nervous system development,cell
migration
midgut development
muscle attachment
calcium-dependent cell-cell adhesion
calcium-dependent cell-matrix adhesion
cell-matrix adhesion
heterophilic cell-cell adhesion
apposition of dorsal and ventral imaginal discderived wing surfaces
cell adhesion
Cyp9b2
dila
dyn-p25
ear
Ef1beta
eIF2Bdelta
epsilonCO
P
GlyP
Hsp83
icln
Irp-1B
Karybeta3
l(1)G0222
l(2)35Cc
mRpS34
mys
hormone metabolic process, insecticide catabolic
process
oxidation-reduction process
response to insecticide, response to caffeine,
oxidation-reduction process
microsome
adult locomotory behavior, cilium axoneme
assembly, spermatogenesis, peripheral nervous
system neuron development
microtubule-based movement
NaPi-T
Nlp
Osi20
pallidin
porin
PrBP
Prx5
snama
SOD1
ssh
Na[+]dependent
inorganic
phosphate
cotransporter
Nucleoplasmin
Osiris 20
pallidin
porin
Suppressor
FBgn0016684
Enhancer
Suppressor
Enhancer
Enhancer
FBgn0016685
FBgn0037430
FBgn0036192
FBgn0004363
Prenyl-binding
protein
Peroxiredoxin 5
Enhancer
FBgn0032059
Suppressor
FBgn0038570
something that
sticks like glue
Superoxide
dismutase
Suppressor
FBgn0086129
Suppressor
FBgn0003462
slingshot
Enhancer
FBgn0029157
regulation of cell shape
axon guidance
dorsal closure
epithelial cell migration, open tracheal system
tracheal outgrowth, open tracheal system
maintenance of epithelial integrity, open tracheal
system
hemocyte migration
substrate-dependent cell migration, cell
extension,
determination of adult lifespan
germ-line stem cell maintenance
sensory perception of smell
imaginal disc-derived male genitalia
morphogenesis
cell-substrate adhesion
integrin-mediated signaling pathway
cell-matrix adhesion
phosphate transport
nucleosome positioning
biological_process unknown
mitochondrial transport ,
mitochondrial transport
ion transport
phototransduction
sperm individualization
mitochondrion organization
sperm mitochondrion organization
transmembrane transport
Enhancer regulation of anion transport
mushroom body development,visual perception ,
3',5'-cyclic-GMP phosphodiesterase activity
response to oxidative stress, peroxisome,
mitochondrion, cell redox homeostasis
Superoxide dismutase (Cu/Zn) / chaperones;
Superoxide dismutase, copper/zinc binding
domain; Superoxide dismutase, copper/zinc,
binding site, response to oxidative stress
protein dephosphorylation,
actin cytoskeleton organization
Su(P)
Suppressor of
ref(2)P sterility
TBPH
Suppressor
FBgn0004465
Suppressor
FBgn0025790
tectonic
tmod
Tor
tectonic
tropomodulin
Target of
rapamycin
Suppressor
Suppressor
Enhancer
FBgn0261697
FBgn0082582
FBgn0021796
torp4a
Tsp2A
Use1
torp4a
Tetraspanin 2A
Use1
Suppressor
Enhancer
Suppressor
FBgn0025615
FBgn0024361
FBgn0035965
Zif
Zinc-finger
protein
zye
Enhancer
FBgn0037446
Suppressor
FBgn0036985
TBPH
zye
regulation of actin polymerization or
depolymerization
mushroom body development
regulation of axonogenesis
regulation of lamellipodium assembly
mitotic cell cycle
protein dephosphorylation
cell redox homeostasis, protein disulfide
oxidoreductase
neuromuscular junction development,adult
locomotory behavior, RNA metabolism
regulation of smoothened signaling pathway
cytoskeleton organization
Growth,
response to nutrient
phosphorylation
detection of nutrient
positive regulation of cell size
positive regulation of organ growth
positive regulation of cell growth
positive regulation of multicellular organism
growth
determination of adult lifespan
autophagy
multicellular organism growth
gonad development
positive regulation of cell growth
endocytic recycling
regulation of cell growth
positive regulation of cell size
positive regulation of ribosome biogenesis
response to DNA damage stimulus
dendrite morphogenesis
protein folding, Endoplasmic reticulum lumen
integral to membrane
Golgi organization, neurogenesis, protein
secretion
establishment or maintenance of neuroblast
polarity, neuroblast proliferation
regulation of embryonic cell shape, filamentous
actin
cell-matrix adhesion
actin filament organization