Moshe Shemesh June 2014 CURRICULUM VITAE Area of expertise Food microbiology, biofilms in the dairy industry, microbial quality and safety of milk products. Positions Held 2011-to date Research Scientist at Agricultural Research Organization The Volcani Center. 2009-2010 Postdoctoral fellow at Harvard University, Department of Molecular and Cellular Biology, Cambridge, MA, USA. 2003-2008 Instructor in Microbiology at The Hebrew University of Jerusalem, Jerusalem, Israel. 1997-2002 Instructor in Life Sciences at Belmonte Science Center, Jerusalem, Israel. Higher Education 2008 Ph.D. at The Hebrew University of Jerusalem. Title of thesis: Expression and Role of Fructosyltransferase in Biofilm. Supervision by: Prof. Doron Steinberg 2001 M.Sc. in Biotechnology at The Hebrew University of Jerusalem. Title of thesis: Establishment of a Physical Map of the Hereditary Inclusion Body Myopathy Locus on Chromosome 9p12-p13. Supervision by: Prof. Stella Mitrani-Rosenbaum 1997 B.Sc. in Life Sciences at The Hebrew University of Jerusalem. Awards 2010 Award for Outstanding Poster from ISM (Israel Society for Microbiology). 2008 Post-Doctoral Award from the Fellowships Committee of The Hebrew University of Jerusalem. 2008 Israeli Nominee of the International Association for Dental Research (IADR)/Unilever Hatton Award at 86th General Session & Exhibition of the IADR in Toronto. 1 2007 The Distinguished Young Scientists' Award from The Jewish Community of Thessaloniki. 2007 The Travel Award to 42nd Meeting of IADR – Continental European Division and Israeli Division in Thessaloniki. 2006 IADR Norton M. Ross International Fellowship. 2006 Golda Meir Fellowship for Outstanding Ph.D. Student. 2005-2008 The Hebrew University of Jerusalem Rector's Price for Excellence in Ph.D. Studies and Research. 2004 The Travel Award to the Joint Meeting of the Continental European Division, Scandinavian Division and Israeli Division of IADR in Istanbul. Teaching and Training 2013-to date Visiting Lecturer in "Biofilms in the food industry" course at The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot. 2013 ARO International R&D Course on Postharvest Physiology, Pathology and Handling of Fresh Commodities (Invited lecture). 2012 "Biofilms in the food industry" course at the Hebrew University of Jerusalem (Invited Lecture). 2011, 2013 "Oral Microbial Ecology" course at the Hebrew University of Jerusalem (Invited Lecture). 2011, 2013 ARO course for engineers and technicians on selected topics in Postharvest and Food-Science (Invited lecture). 2003-2008 "Oral Microbiology" course at The Hebrew University of Jerusalem (Instructor of dentistry students). Students guidance 2012-to date Svetlana Ogiy, M.Sc., Development of a molecular technique to follow the dynamics of Lactobacilli (lactic acid bacteria) population in ensiled crops, in progress, guidance with Prof. Zvi Weinberg. 2012-to date Danielle Assaf, M.Sc., The effect of milk components on biofilm formation of Streptococcus species, in progress, guidance with Prof. Doron Steinberg. 2 2012-2013 Dr. Ronit Pasvolsky, postdoctoral training, Regulation of biofilm formation of Bacillus species within milk. 2013-to date Hilla Oknin, M. Sc., Developing of novel technology to prevent biofilm formation of Bacillus species, in progress, guidance with Prof. Doron Steinberg. 2014-to date Ievgeniia Ostrov, Ph.D., Regulation of biofilm formation problem in the dairy industry, in progress, guidance with Prof. Doron Steinberg. Editorial Responsibilities 2009 – to date Reviewer (ad-hoc) of manuscripts for BMC genomics. 2013 – to date Reviewer editor of Frontiers in Microbial Physiology and Metabolism. 2013 – to date Reviewer (ad-hoc) of manuscripts for PloS ONE. 2014 – to date Reviewer (ad-hoc) of manuscripts for Journal of Dairy Science. Selected Presentations 2014 The 24th International ICFMH Conference - Food Micro 2014. Nantes, France. 2014 (Invited lecture) IDF WORLD DAIRY SUMMIT, Tel Aviv, Israel. 2014 (Invited lecture) Work Group 1 of the COST Action FA1202 - Experts meeting on harmonization of tools for the analysis of colonization patterns. Jerusalem, Israel. 2013 1st BacFoodNet Conference - A European Network for Mitigating Bacterial Colonization and Persistence on Foods and Food Processing Environments. Prague, Czech Republic. 2013 (Invited lecture) Annual Meeting of milking equipment and cleaning solution providers for dairy farms, Caesarea, Israel. 2013 EUROBIOFILMS 2013 Third European Congress on Microbial Biofilms - Basic and Clinical Aspects, Ghent, Belgium. 2013 Nobel Conference on Biofilm Formation, its clinical impact and potential treatment, Stockholm, Sweden. 2013 Annual Meeting of Cattle Sciences, Jerusalem, Israel. 2013 (Invited lecture) Annual Meeting of Israel Society for Microbiology, Ramat-Gan, Israel. 2013 2nd MC Meeting and WG Workshops of the COST Action FA1202, Potsdam, Germany. 3 2012 Molecular Microbiology Meeting, Würzburg, Germany. 2011 The EMBO Meeting, Vienna, Austria. 2011 Annual Meeting of Israel Society for Microbiology, Ramat-Gan, Israel. 2010 Israel Society for Microbiology - Fall Workshop on Microbial Biofilms, Ginosar, Israel. 2008 The 86th General Session & Exhibition of the International Association for Dental Research (IADR), Toronto, Canada. 2008 (Invited lecture) The Annual Research Day of the Faculty of Dental Medicine, Maale Hamisha, Israel. 2007 The 42nd Meeting of IADR – Continental European Division and Israeli Division Thessaloniki, Greece. 2006 The 84th General Session & Exhibition of the IADR, Brisbane, Australia. 2004 Joint Meeting of the Continental European Division, Scandinavian Division and Israeli Division of IADR, Istanbul, Turkey. Membership in Professional Societies 2012-to date COST (European Cooperation in Science and Technology), MC member and leader of Task2 of WG2. 2012-to date The American Society for Microbiology (ASM). 2012-to date International Association for Food Protection (IAFP). 2012-2013 Israel Association for Veterinary Microbiology and Immunology 2011-to date Israel Society for Microbiology (ISM) 2003 – 2008 The International Association for Dental Research (IADR) Contribution to the Scientific Community 2013-to date Member of a judging committee of the Chief Scientist of the Ministry of Agriculture grant. 2013-to date Member of a judging committee of the Israeli Dairy Board grant for udder health and milk quality. 2012-to date Participation in Professional Forum for Udder Health and Milk Quality of Israel Dairy Board. 4 2012-2013 Participation in organizing institutional seminars in the Institute for Postharvest and Food Sciences. 2011 Participation in a selecting committee for the best poster competition of Israel Society for Microbiology (ISM) Annual Meeting. List of publications 1. Shemesh M., Pasvolsky R., Zakin V. External pH is a cue for the behavioral switch that determines surface motility and biofilm formation of Alicyclobacillus acidoterrestris. J. Food Prot. (in press). 2. Pasvolsky R., Zakin V., Ostrova I., Shemesh M. (2014). Butyric acid released during milk lipolysis triggers biofilm formation of Bacillus species. Int. J. Food Microbiol. 181C:19-27. 3. Shemesh M., Pasvolsky R., Sela N., Green S.J., Zakin V. (2013). Draft genome sequence of Alicyclobacillus acidoterrestris strain ATCC 49025. Genome Announc. 1(5). 4. Poverenov E., Shemesh M., Gulino A., Cristaldi D.A., Zakin V., Tatiana Yefremov T., Granit R. (2013). Durable Contact Active Antimicrobial Materials Formed by a One-Step Covalent Modification of Polyvinyl Alcohol, Cellulose and Glass Surfaces. Colloids Surf B Biointerfaces. 112C:356-361. 5. Shemesh M., Chai Y. (2013). A combination of glycerol and manganese promotes biofilm formation in Bacillus subtilis via the histidine kinase KinD signaling. J. Bacteriol. 195:2747-2754. 6. Shemesh, M., Kolter, R., Losick, R. (2010). The Biocide Chlorine Dioxide Stimulates Biofilm Formation in Bacillus subtilis by Activation of the Histidine Kinase KinC. J. Bacteriol. 192:6352-6356. 7. Feldman, M., Weiss, E., Ofek, I., Shemesh, M., Steinberg, D. (2010). In vitro realtime interactions of cranberry constituents with immobilized fructosyltransferase. J. Med. Food. 2010 13:1153-1160. 8. Shemesh, M., Tam, A., Aharoni, R., Steinberg, D. (2010). Genetic adaptation of Streptococcus mutans during biofilm formation on different types of surfaces. BMC Microbiol. 10:51. 5 9. Feldman, M., Weiss, E., Shemesh, M., Ofek, I., Bachrach, G., Rozen, R., Steinberg, D. (2009). Cranberry constituents affect fructosyltransferase expression in Streptococcus mutans. Altern. Ther. Health Med. 15:32-38. 10. Shemesh, M., Tam, A., Kott-Gutkowski, M., Feldman, M., Steinberg, D. (2008). DNA-microarrays identification of Streptococcus mutans genes associated with biofilm thickness. BMC Microbiol. 8:236. 11. Steinberg, D., Moreinos, D., Featherstone, J., Shemesh, M., Feuerstein, O. (2008). Genetic and physiological effects of noncoherent visible light combined with hydrogen peroxide on Streptococcus mutans in biofilm. Antimicrob. Agents. Chemother. 52:2626-2631. 12. Shemesh, M., Tam, A., Steinberg, D. (2007). Expression of biofilm associated genes of Streptococcus mutans as response to glucose and sucrose. J. Med. Microbiol. 56:1528-1535. 13. Shemesh, M., Tam, A., Steinberg, D. (2007). Differential Gene Expression Profiling of Streptococcus mutans cultivated under Biofilm and Planktonic Conditions. Microbiology 153:1307-1317. 14. Jabbour, A., Shemesh, M., Srebnik, M., Zaks, B., Steinberg, D. (2007). Effect of oxazaborolidines on immobilized fructosyltransferase analyzed by surface plasmon resonance. Biosens. Bioelectron. 22:1658-1663. 15. Shemesh, M., Tam, A., Feldman, M., Steinberg, D. (2006). Differential expression profiles of Streptococcus mutans and ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases. Carbohydr. Res. 341:20902097. 16. Tam A., Shemesh M., Wormser U., Sintov A., Steinberg D. (2006). Effect of different Iodine formulations on expression and activity of Streptococcus mutans glucosyltransferase and fructosyltransferase in biofilm and planktonic environment. J. Antimicrob. Chemother. 57:865-871. 17. Shemesh, M., Steinberg, D. (2006). Surface plasmon resonance for real-time evaluation of immobilized fructosyltransferase activity. J. Microbiol. Methods 64:411415. 6 18. Shemesh, M., Steinberg, D. (2006). In vitro binding interactions of oral bacteria with immobilized fructosyltransferase. J. Appl. Microbiol. 100:871-877. 19. Eisenberg, I., Avidan, N., Potikha, T., Hochner, H., Chen, M., Olender, T., Barash, M., Shemesh, M., Sadeh, M., Grabov-Nardini, G., Shmilevich, I., Friedmann, A., Karpati, G., Bradley, W.G., Baumbach, L., Lancet, D., Asher, E.B., Beckmann, J.S., Argov, Z., Mitrani-Rosenbaum, S. (2001). The UDP-N-acetylglucosamine 2 epimerase/Nacetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy. Nat. Genet. 29:83-87. 20. Eisenberg, I., Hochner, H., Shemesh, M., Levi, T., Potikha, T., Sadeh, M., Argov, Z., Jackson, C.L., Mitrani-Rosenbaum, S. (2001). Physical and transcriptional map of the hereditary inclusion body myopathy locus on chromosome 9p12-p13. Eur. J. Hum. Genet. 9:501-509. 7