4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT The Stethoscope No Longer Holds a Monopoly over Our Hearts Medicine Almost two centuries after its invention, the doctors’ undisputed symbol is about to be replaced by the ultrasound device. Victory of the technological progress? Distance from the patient’s body? Practitioners seem divided. NATHANIEL HERZBERG Close your eyes, hold your breath and imagine. He is a doctor, with a George Clooney smile, wearing a white coat. And around his neck … nothing. No rubber tube hanging from his ears or ostensibly coming out of his pocket. You can breathe now, because you will have to get used to it. The stethoscope, due to celebrate its 200th anniversary in two years, is no longer doing very well. If we are to believe some, it is even doomed. A matter of time, they say. But their forecast leaves no room for doubt: in one generation, at most, the doctors’ undisputed symbol, which in itself sets them apart from other white-coat caregivers, will have disappeared. The diagnosis, as it often happens, was made by Americans. One after the other, Global Heart, the journal of the World Heart Federation, and the prestigious New England Journal of Medicine published editorials writing the obituary of the celebrated tool. "As certainly as cassettes and CDs in music," professors Jagat Narula and Bret Nelson, a cardiologist and an emergency medicine physician at Mount Sinai Hospital in New York, respectively, claimed in Global Heart, stethoscopes are headed for certain death. On the forums, doctors lashed out at each other, some swearing never to give up their precious aid, others professing allegiance to the new king. And this is the very crux of the matter. The stethoscope braces itself against the attack of a younger, more efficient, more reliable rival, a competitor that, as a sign of the times, resembles a smart phone, with a flip cover and a screen. In one gesture, the doctor opens it and places the probe on the patient’s chest or abdomen and gains access to the movements of the heart, details of the lung, or the condition of the bladder. Introduced 5 years ago, this ultraportable ultrasound device was tested by some US hospitals. It has become common practice in medical schools, on the other side of the Atlantic. In Europe, its use continues to remain modest. The market leader, General Electric, sold 3,000 Vscan devices, mainly in Germany, Italy, Spain, and Great Britain. France comes next with 200 scanners. "But this is a new market, and it is growing very well," says the US manufacturer. In Europe, this movement continues to remain modest. General Electric sold 3,000 of its Vscan devices, of which only 200 were in France. 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT This change impacts other specialties. in addition to obstetrician/gynecologists and cardiologists, who were the first ones to take ultrasound out of radiology practices. Urologists, pulmonologists, internists, and above all emergency-medicine and intensive-care physicians are discovering the potential of these compact tools. "It’s eight months since I got one. and it has completely changed my practice, says Jean-Luc Dinet, emergency medicine physician at Sens (Yonne) and vice-president of SOS Médecins. It is a considerable aid in decision-making. After one week of using the device, I examined a young girl who was feeling tired and presenting significant weight gain. I felt her thyroid, then I did an ultrasound. She had nodules. Three days later, she had a scan, and the following week she had surgery. Before, I would have done a check-up and told her to see her general practitioner ... How much time would we have lost?" Managing time. Detect the emergency and correctly guide patients. Jean-Luc Dinet continues: "There was hardly any equipment to help us with pulmonary pathologies. Coughing and fever: we could prescribe antibiotics, order a chest X-ray ... and we could have missed it. Now, we make a diagnosis. It’s even truer for elderly people. You get a call on Friday at 6 p.m., a patient with swollen legs. No phlebology office open until Monday. Should you send her to the emergency room? If it is phlebitis, yes. Otherwise, you will make her go there, wait for hours and undergo examinations for nothing. And this would overcrowd the hospital. too. Now, I have the answer." "It took us a while at first, doctor Xavier Bobbia, emergency medicine physician at the Nîmes University Hospital Center, elaborates. But now, it takes two minutes per examination to answer the simple questions we are asking. And the diagnosis is clear." Or very likely, at any rate. In a study carried out in the United States and published in the American Journal of Cardiology, first-year medical students faced with sixty-one patients identified 75% of existing heart pathologies with the help of a small ultrasound device. Equipped with just a stethoscope, qualified cardiologists had identified only 49%. Another study carried out on the liver led to similar results. Is the die cast? Are we going to actually witness the disappearance of the tool invented by René-Théoplile-Hyacinthe Laennec in 1816, after watching two children play in the courtyard of the Louvre? Are we going to stop teaching this incredible semiology, which is exhausting to students but enthralling to poets? The "sibilant" resembling "the air released by piercing an opening into a balloon," typical of asthma; the "rhonchus," "a deeper sibilant, as if blowing into a bottle," indicating bronchial obstruction or an infectious lung disease; the "crepitation" and its "sound of salt in the fire or footsteps in the snow," sign of an infection or pulmonary edema; not to be confused with the "subcrepitation," which is specific to excessive bronchial mucus, closer to "popping popcorn." And what will take the place of the rite of passage for new students when the newcomer’s stethoscope earpieces are plugged with cotton before asking them to detect a suspicious noise? 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT "It is certainly the way the world is going, Nicolas Danchin, professor of cardiology at the Georges-Pompidou European Hospital, admits. The enema syringe is gone, the stethoscope may be gone one day, too. In a department like ours, we use it less and less. But it does allow us to correct certain diagnoses. Aortic stenosis, for example. It looks very severe on the ultrasound, but through the stethoscope, if you can still hear the second heart murmur, you can state that it is not as tight as that." At the pulmonary section of the Regional Hospital Center of Créteil, the ultrasound device has become "a critical working tool," Professor Bruno Housset insists. Every resident passing through this section is trained to use it by doctor Gilles Mangiapan. The latter, however, dampens his boss’s enthusiasm. "It’s true, in all pleural pathologies, pleural effusion [fluid in the pleural cavity], pneumothorax [air in the pleural space], the ultrasound device has replaced the stethoscope, he explains. But, in pneumonia, the images are not specific enough, whereas a crepitant rale is heard immediately." But there is another warning that this early fan wants to issue. Basically, the following: "The ultrasound must complement, enrich the examination. Ever since Laennec, the clinical examination has been palpation-percussion-auscultation and it should become palpation-percussion-auscultation-visualization. We can miss asthma, because we do not auscultate the patient. Or we can overlook a tumor, because we haven’t performed palpation." Do not deprive yourself of a technique which "was based on two hundred years of medical practice." And, above all, preserve "the complexity of the examination." A general practitioner and writer, Martin Winckler also calls for caution. "We look at the patient, we listen to the patient and touch him. His posture. How he walks. It is the person in its entirety that we are examining. In a direct relationship. And it is because it actually brings us closer to the patient, because it is an extension of our ear, that the stethoscope is so valuable." Is Martin Winckler a bit of a fetishist? Like everybody else, he remembers his first stethoscope, the one that his father, a pulmonologist, had given him; then the second one, "with a red tube to entertain the children." He has kept it to this day. "To be honest, I am not attached to symbols. My concern is that technology should not distance us from the patients." A pioneer of nuclear imaging, physician and philosopher, Henri Atlan adds: "We cannot afford to be afraid of technology. Technology has facilitated considerable progress in medicine. Healthcare is better, a lot better now than before. But these technologies that show everything, sometimes show too much. We may think that something is pathological, when in fact it is simply a case of individual variation." As for André Grimaldi, former head of the Diabetes Section at the Pitié-Salpêtrière Hospital, opponent of the “hospital as a business” concept and of "industrial medicine," he puts it in even stronger terms: "The power of medicine is not only costly, but also potentially dangerous. The multiplication of examinations may easily lead to mistakes. Perform a pancreas scan on the entire population and you will find many suspicious lumps. But is it cancer? How far should we go with the checkups? Don’t we end up artificially creating 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT patients? Medicine is not about that. It is a process made up of hypotheses and inferences, and above all. a unique dialogue, an exchange with the person before us." "A new technology becomes necessary when the old one is approximate, painful or dangerous. Which is not the case here." MARTIN WINCKLER General Practitioner The history of medical progress is also the history of separation from the patient, Céline Lefève recalls. The assistant professor of the philosophy of medicine at the Paris-Diderot University quotes Michel Foucault (Message or noise? 1966): "When doing his job, the physician does not deal with a sick person, or with someone in pain, and least of all, thank God, with a “human being.” He does not have to deal with the body, or with the soul, or with the two taken together or combined. He deals with noise. And through that noise, he must hear the elements of a message." As such, the ultrasound device; in Ms. Lefève’s opinion; "comes as a continuation of the stethoscope, not as a break from it." It all depends on how it is used. It is what Jacques Lucas, vice-president of the French Medical Council, cardiologist and manager of new technology, admits to as well: "The image presents the risk-creating distance from the patients. Or, on the contrary, it can also be an opportunity to get closer. We can explain an image to a patient, we couldn’t have him listen through the stethoscope. However, doctors must be trained in this respect." Training. The buzz word, or rather the big gap. For Jacques Lucas, "it is certain that in a few years’ time, the initial training of general practitioners will include the use of ultrasound devices as a first resort." Meanwhile, it is limited to the teaching of certain specialties: radiology, cardiology, gynecology ... and to the emergency-medicine physicians at state-of-theart university hospital centers, such as Amiens or Nîmes. "If we settle this issue, we will have removed one of the two main obstacles in replacing the stethoscope by the ultrasound device," states doctor Xavier Bobbia, who is in charge of teaching these subjects at Nîmes. The second one? "The price," he says smiling. “Now, you have to spend between 7,000 and 10,000 euros to purchase an ultraportable ultrasound device. One hundred times the cost of a stethoscope.” Which makes Martin Winckler smile: "The manufacturers may very well claim that this device will be perfect for the Indian countryside doctor, far away from any ultrasound center. But how is he going to pay for it? A new technology becomes necessary when the old one is approximate, painful, or dangerous, which is not the case here. And the strength of the stethoscope lies in its simplicity." He ponders: "Will books disappear because of iPads? I don’t think so. It’s the same here. Let’s not be too quick to bury the stethoscope, it will hang in there for the time being." A writer’s faith, and a doctor’s. 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT [photo caption:] At the Museum of Medicine, in Paris, a modern stethoscope, next to the prototypes invented by Laennec, including a notebook rolled up into a cylinder. ÉMILE LOREAUX FOR "LE MONDE" FILE TWO "The Role of the Physical Examination is being Eroded" Bret Nelson is an emergency medicine physician and a professor at the Mount Sinai Hospital in New York City. In December 2013, he co-signed an article announcing the death of the stethoscope, which was published in the American journal Global Heart. How was your editorial in the "Global Heart" received? In a, let’s say ... controversial manner. Those who were already using mobile ultrasound devices supported us. Others, in love with their stethoscopes, resisted this change, and they gained the support of a third category, made up mainly of radiologists and cardiologists, worried to see the technology that they had spent years learning become accessible to everybody. But, at the end of the 19th century, when the use of the stethoscope was truly democratized, the specialists of that time reacted in the same manner. Are all students at the Icahn School of Medicine of Mount Sinai Hospital, trained to use the ultrasound device? Yes. Just like at the University of California at Irvine, at the University of South Carolina, at the University of Ohio, and also at several others ... It is used as a visualization method in the firstyear anatomy course, but also in learning physical examination in the first and second years, together with the stethoscope. Many students find the ultrasound device more practical, more accurate, and more reliable. With this new device, don’t we run the risk of distancing the patient from the doctor even more? I think it’s exactly the opposite. The scans and tests that were done outside the medical office had this effect. Because they are more reliable than simple auscultation, they have actually contributed to eroding the role of the physical examinations for thirty or forty years. Ultrasound can, on the contrary, bring the patient and the practitioner closer together. They will look at the 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT images, assess the results, discuss the consequences together, and the examination becomes all the more valuable as it is done by the very person who knows the patient and his history. It is also a symbol that you suggest should disappear ... I remember that once, here in the United States, one of the physicians’ symbols was the circular mirror they used to wear on their head to examine the throat. It is gone. Physicians in the United Kingdom no longer wear white coats for fear that they carry infections – another symbol that is extinct. In Star Trek, doctor McCoy prepared us already in the 1960s, to see a physician waving a wand over a patient: the ultrasound device matches this image perfectly. REMARKS COLLECTED BY N.H. FILE THREE Inspired by child’s game, Laennec lays the foundation of modern medicine To invent something, all you need to do is look in the right direction. And, if possible, outside your field of competence. The invention of the stethoscope by René Laennec is a perfect illustration of this principle. One day, in 1816, as he was walking across the courtyard of the Louvre, the doctor observed two children playing around a wooden beam. One of them tapped its end with a pin; the other one, his ear pressed against the other end, listened closely. Sometime later, consulting "a young woman presenting the general symptoms of heart disease, in whose case the application of the hand and the percussion yielded poor results due to her being overweight," Laennec remembered the two children. He grabbed a notebook, rolled it up and placed the cylinder formed this way on the patient’s chest. "I was both surprised and pleased to hear the heartbeats in a manner that was both clearer and more distinct than I had ever been able to hear them by the immediate application of the ear." The stethoscope was born. A year later, Laennec was developing his technique and reviewing various materials. On February 23, 1818, he presented his invention at the Academy of Science: a 30 cm x 3 cm wooden cylinder, with a 6 mm central channel and the shape of a funnel, with the end intended for the patient. In time, he added a shutter to adjust his instrument: cylindrical to listen to the voice and the heart, and funnel-shaped for the lungs. As for the name, it was one of his students who came up with it, from the Greek works stethos (chest) and scopio (to examine). A trained ear 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT In 1819, the first edition of his major work was published: L’Auscultation médiate ou Traité du diagnostic des maladies des poumons et du cœur, fondé principalement sur ce nouveau moyen d’exploration [On Indirect auscultation or Treatise on the diagnosis of diseases of the lungs and heart, Based mainly on this new means of examination]. Nearly one thousand pages of classification and examination methods of pulmonary, respiratory and vocal pathologies. To achieve that, Laennec multiplied his auscultations, but also his corpse dissections. Convinced that every disease has an organic cause and that each abnormal sound results from an injury, he set out to establish the connections. A skilled flute player, Laennec took advantage of his trained ear to achieve descriptions of rare accuracy. Here is how he described the auscultation of a woman presenting "some signs of tuberculosis." Listening to the right carotid artery, he heard "instead of the noise of bellows, the sound of a musical instrument playing a rather monotonous tune (...). At first, I thought that there was someone playing in the apartment located below. I strained my ear; I placed the stethoscope on other points: I could not hear anything. After making sure that the sound came from the artery, I studied the tune: it unfolded on three notes forming an interval close to a major third; the highest note was off-key and a little too deep, but not enough to be marked with a flat." In the manuscript, he even goes as far as to write staffs, where he indicates notes and times. He does not stop, however, at drawing on his experience as a musician. Further on, he mentions a wheezing sound similar to "the voice of a ventriloquist or of a chimney-sweeper heard from afar, without being able to make out the words, due to the narrowing of the flue of the chimney." This new method, this new vocabulary, contributed to the foundation of modern medicine. The physician can now describe an injury without any contribution from the patient. The patient takes second place to the disease. The work was enthusiastically received, with a few exceptions, among whom François Broussais. A Breton, like Laennec, as much of a republican and an atheist as Laennec was a Catholic and a monarchist, Broussais, was convinced that the seat of the disease was "an irritation," roared "the man with the horn." Except that, a few years later, Laennec’s work prevailed. The treatise was translated into several languages. As for the stethoscope, it continued to evolve. It became bell-shaped in 1828, flexible in 1832, binaural in 1870 ... many innovations that the physician, who became a professor at the Collège de France, did not live to witness. In 1826, after having also discovered melanoma and cirrhosis, he died of the disease he had spent his entire life fighting: tuberculosis. The story goes that he contracted it during a dissection and that it was his cousin, Meriadec, who diagnosed it, using his very own stethoscope. N. H. 4 Le Monde Wednesday November 26 2014 SCIENCE & MEDICINE EVENT