Lesson 12: Single Gene Inheritance Before you begin! Homework Name o Your ideas: Be prepared to share with your peers What is a gene and how does that relate to a chromosome? In what fundamental way is meiosis different from mitosis (what is achieved)? In a Punnett square, what information goes on the outside? On the inside? What is 1/2 x 1/2 ? In humans, hair texture shows incomplete dominance. What kind(s) of kids can a curly haired man have with a straight haired woman (three phenotypes – curly, wave, and straight)? o Previously learned material What is the molecular basis of the word “allele”? What are some genes important for us to study with regard to mood-altering drugs? Required Reading: Introductory biology textbook or internet review is fine Chapter(s) or section(s) on Meiosis (specific to sperm production in A&P text, pg. 643) and Punnett Squares (watch Beginner’s Guide from Bozeman Science here https://www.youtube.com/watch?v=Y1PCwxUDTl8) Chapter(s) section(s) on Mendel – single gene traits, dominant, recessive, incomplete dominance (some information in A&P text, section 20-8 p. 634 Internet http://learn.genetics.utah.edu/content/begin/tour/ (introduction to heredity) http://anthro.palomar.edu/mendel/mendel_2.htm (introduction to Punnett squares) http://www.biology.arizona.edu/cell_bio/tutorials/meiosis/main.html (introduction to meiosis) https://www.youtube.com/watch?v=qCLmR9-YY7o Crash Course Biology on Meiosis (6 min.) https://www.youtube.com/watch?v=CBezq1fFUEA Crash Course: Heredity- good review Supplemental Reading For anyone requiring a little back-to-basics on genes, heredity, chromosomes. http://www.youtube.com/watch?v=eOvMNOMRRm8&feature=related For a reminder of what meiosis can do that mitosis cannot, visit http://www.pbs.org/wgbh/nova/baby/divi_flash.html Guiding Questions 1. How does DNA relate to genes and to chromosomes? 2. How are chromosomes divided during meiosis? 3. How are chromosomes reunited during fertilization? 4. 5. 6. 7. What rules enable us to make predictions for specific matings? What is dominance? What are some alternatives to dominance? How are Punnett squares helpful for solving genetics problems? How are Pedigrees helpful for solving genetics problems? Key Terms Diploid Haploid Heterozygous Homozygous Dominant Recessive Chromosome Trisomy Sex Chromosome Autosome Incomplete dominance Activity One: Web Site Review: Homework Please review the Web sites below. To consider heredity visit http://learn.genetics.utah.edu/content/begin/tour/ and select the tutorial called “What is Heredity”. While there, also visit “What are Traits” which is very long. Repeatedly press “next” until the thumb icon (hitchhikers thumb) is highlighted. Give two examples of both a physical and a behavioral trait. One example should be NOT found in the tutorial. How do parents pass traits on to their children? Of the parental chromosomes, what proportion of them are passed to children? How does one define a dominant allele? What are two ways that traits can be more complicated than ones like hitchhiker’s thumb? To consider Punnett Squares http://anthro.palomar.edu/mendel/mendel_2.htm and/or https://www.youtube.com/watch?v=Y1PCwxUDTl8 What do the single-letter symbols mean – “G” or “Y”? How do you fill in the boxes of a Punnett Square? How can the Punnett Square be used to predict probabilities of genetic outcomes? How is cystic fibrosis inherited? What is an example of a dominantly inherited trait? In Lecture: Respond to discussion questions Nucleotides, DNA, genes, chromosomes, and codons are all terms used to describe our genetic information. Take each pair of terms and describe their relationship. Nucleotides and genes Genes and Chromosomes DNA and codons Chromosomes and DNA Share your responses with your table partner Where do your chromosomes come from? How are they passed along? What did Mendel figure out, even though he did not know about Genes or DNA? Use white boards or paper for genetics problems Need reinforcement of Punnett squares? Try these optional practice problems: Activity Nine: Practice Problems Genetics is an area of biology that some students find challenging because it is more problem solving than memorization. To give yourself practice with this type of approach to studying, do as many practice problems as you can. In the sites below, you will find an interactive quiz for genetics problems. http://anthro.palomar.edu/mendel/quizzes/mendqui2.htmhttp://anthro.palomar.edu/mendel/mendel_3.htm