CURRICULUM VITAE Personal Details Name, surname: Jan Korabecny Date and place of birth: 31. 8. 1983/Pardubice Nationality: Czech Address: Hradek 13, 503 15, Czech Republic Mobile No.: +420 724 770 956 E-mail address: korabecny.jan@gmail.com Summary of Education 1997-2003 High school studies at Gymnazium Bozeny Nemcove, Hradec Kralove 2003-2008 MSc. studies at Faculty of Pharmacy in Hradec Kralove, Charles University in Prague (diploma work titled: Synthesis of differently substituted arylguanidines as potential drug candidates VI., supervisor: Dr. Karel Palat) 10/2008-6/2012 Doctoral studies at Faculty of Pharmacy in Hradec Kralove (Charles University in Prague), Department of Pharmaceutical Chemistry and Drug Control in collaboration with Faculty of Military Health Sciences (University of Defence), Department of Toxicology and Military Pharmacy. Doctoral thesis titled: Synthesis of tetrahydroacridine based acetylcholinesterase inhibitors (supervisors: assoc. prof. Veronika Opletalova, prof. Kamil Kuca) Work Experience - - Since 9/2011 Academic worker at Department of Toxicology and Military Pharmacy (Faculty of Military Health Sciences in Hradec Kralove, University of Defence in Brno) Since 5/2012 Academic worker at Center for Biomedical Research (University Hospital in Hradec Kralove) 8/2012-6/2015 Post-doctoral studies at Center for Biomedical Research (University Hospital in Hradec Kralove) Since 5/2014 junior researcher at National Institute of Mental Health (Klecany, Prague) Work Profile - Experience in synthesis and handling of different organic compounds - Development of new agents with potential cholinergic, antitumor, anti-mycotic and anti-tuberculotic activity - Molecular modeling studies and design of novel drugs Abilities and other relevant details - Driving license (group B) - Computer knowledge operating system Microsoft Windows and Mac OS X - MS office (word, excel, power point, publisher) - Programs used for drawing structures and for interpretation of NMR spectra Chemdraw, ChemSketch and ISIS draw, MestreNova, MestreC - Molecular docking software – PyMol viewer, Autodock Tools, Autodock Vina, PoseView Languages French language (basic knowledge) English language (STANAG 2 – 9/2012) Achievements 2008 Award of Penta society for the best diploma thesis at the Department of inorganic and organic chemistry (titled Synthesis of differently substituted arylguaindines as potential drug candidates VI.) 2010 Honored by Czech Neuropsychopharmacological society for the best poster presentation (authors, title: Korabecny, J.; Holas, O.; Musilek, K.; Opletalova, V.; Pohanka, M.; Kuca, K. Newly prepared derivatives of 7-MEOTA. 52. Czech and Slovak psychopharmacological conference, Lazne Jesenik (Czech republic) 6.10.1.2010, Supplementum 1, 2010, p. 45.) 2013 Honored by Czech Neuropsychopharmacological society for the best poster presentation (authors, title: Hroudova, J.; Fisar Z., Raboch, J.; Korabecny, J.; Kuca, K. In vitro účinky inhibitorů acetlycholinestráz na aktzivitu monoaminooxidáz a NADH dehydrogenázy. 55. Czech and Slovak psychopharmacological conference, Lazne Jesenik (Czech republic) 4.-8.1.2013, Supplementum 1, 2013, p. 65.) 2013 Best poster award (authors, title: Kuca, K.; Musilek, K.; Jun, D.; Zdarova-Karasova, J.; Kunes, M.; Soukup, O.; Korabecny, O.; Sepsova, V.; Hrabinova, M. Novel acetylcholinesterase reactivators – antidotes against nerve agents. International Conference on Pharmacology and Drug Development Singapore (Singapore) 9. – 11. 12. 2013.) 2015 Best poster award (authors, title: Svobodova, L.; Nepovimova, E.; Korabecny, J.; Kucerova-Chlupacova, M.; Kuca, K. Tacrine-Benzothiazole Hybrids - Novel Multitarget Agents To Combat Alzheimer’s Disease. EPSA Annual Congress in Toulouse, Science day (Toulouse, France) 30.3.2015 2015 Best publication award for 2014 in neuroscience research awarded by Czech Alzheimer Society (Nepovimova, E.; Uliassi, E.; Korabecny, J.; Peña-Altamira, L.E.; Samez, S.; Pesaresi, A.; Garcia, G.E.; Bartolini, M.; Andrisano, V.; Bergamini, C.; Fato, R.; Lamba, D.; Roberti, M. Kuca, K.; Monti, B.; Bolognesi, M.L. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects. J. Med. Chem. 2014, 57, 8576 8589. IF = 5.480.) Educational stay 4/2011-6/2011Three months internship in Kosice (Slovakia), synthesizing new acetylcholinesterase inhibitors based on 7-methoxytacrine (supervisor Dr. Hamulakova) 6/2013-7/2013Two months internship in Rouen (France), development of new acetylcholinesterase reactivators (supervisors Dr. Ludovic Jean, prof. P. Y. Renard) 4/2014-5/2014Two months internship in Daejeon (South Korea), drug design and synthesis of novel acetylcholinesterase reactivators (supervisor Dr. Y.-S. Jung) 4/2015-6/2015two months internship in Würzburg (Germany), drug design and synthesis of novel anti-malaria agents (supervisor prof. Ulrike Holzgrabe) Projects • Title: Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs (applicant prof. Kamil Kuca, co-applicant Dr. Daniela Ripova) – Grant Agency of Czech Republic, 2011-2015, team-member) • PUBLICATIONS, CONFERENCES AND ORAL PRESENTATIONS Conferences 1. Korabecny, J.; Kuca, K.; Musilek, K.; Opletalova, V.; Karasova, J.; Pohanka, M. Synthesis and evaluation of bis-7-MEOTA compounds as reversible acetylcholinesterase inhibitors. 9th International Conference Alzheimer’s and Parkinson’s Diseases Prague (Czech Republic) 11.-15.3.2009, Neurodegenerative Diseases 2009, 6 (S1), p. 2109, ISBN 978-3-8055-9118-8. 2. Pohanka, M.; Musilek, K.; Zdarova-Karasova, J.; Korabecny, J.; Drtinova, L.; Kassa, J.; Kuca, K. In vitro evaluation of two Alzheimer’s disease drugs tacrine and 7methoxytacrine using electrochemical biosensor with immobilized acetylcholinesterase. 9th International Conference Alzheimer’s and Parkinson’s Diseases Prague (Czech Republic) 11.-15.3.2009, Neurodegenerative Diseases 2009, 6 (S1), p. 2149, ISBN 978-3-8055-9118-8. 3. Stodulka, P.; Pohanka, M.; Musilek, K.; Korabecny, J.; Kuca, K.; Zdarova--Karasova, J. In vitro study of passive drug transport through blood-brain barrier using HPLC techniques. 9th International Conference Alzheimer’s and Parkinson’s Diseases Prague (Czech Republic) 11.-15.3.2009, Neurodegenerative Diseases 2009, 6 (S1), p. 2112, ISBN 978-3-8055-9118-8. 4. Binder, J.; Holas, O.; Opletalova, V.; Kuca, K.; Musilek, K.; Korabecny, J.; Jun, D. Design, synthesis and biological evaluation of new effective acetylcholinesterase inhibitors. 10th International Meeting on Cholinesterases Sibenik (Croatia) 20.25.9.2009, Book of abstracts, P3-5, p. 92. 5. Korabecny, J.; Holas, O.; Opletalova, V.; Kuca, K.; Musilek, K.; Zdarova-Karasova, J.; Synthesis amd evaluation of various N-methyl quarternary salts of 7methoxytacrine compounds as acetylcholinesterase inhibitors. 10th International 21, p. 100. 6. Pohanka; M.; Drobik; Krenkova; Zdarova-Karasova, J.; Holas, O.; Kasalova; Korabecny, J.; Marek, J.; Kuca, K.; Musilek, K. Electrochemical evaluation of acetylcholinesterase activity and construction of biosensor suitable for anticholinergic compounds assay. The 104th National Meeting of the Korean Chemical Society Daejeon (Korea) 28.-30.10.2009, Abstract book p 255. 7. Binder, J.; Kuca, K.; Jun, D.; Korabecny, J.; Opletalova V. Design, syntéza a biologické testování nových inhibitorů acetylcholinesterasy. 38. konference Syntéza a analýza léčiv Hradec Králové (Česká republika) 14.-16.9.2009, Sborník p. 68. 8. Korabecny, J.; Holas, O.; Opletalova, V.; Musilek, K.; Kuca, K. Syntéza a in vitro stanovení sekundárních alkyl-aminoderivátů odvozených od 7-MEOTA. 38. konference Syntéza a analýza léčiv Hradec Králové (Česká republika) 14.-16.9.2009, Sborník p. 102. 9. Korabecny, J.; Holas, O.; Musilek, K.; Opletalova, V.; Binder, J.; Pohanka, M.; Zdarova-Karasova J.; Kuca, K. Syntéza a in vitro evaluace centrálně účinných inhibitorů acetylcholinesterázy odvozených od struktury 7-MEOTA. 9. konference odborné Společnosti vojenských lékařů, farmaceutů a veterinárních lékařů ČLS JEP Hradec Králové (Česká republika) 26.-27.11.2009, Sborník příspěvků, p. 80-83. 10. Korabecny, J.; Holas, O.; Musilek, K.; Opletalova, V.; Pohanka, M.; Kuca, K. Nově připravené deriváty látky 7-MEOTA. 52. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 6.-10.1.2010, Supplementum 1, 2010, p. 45. 11. Korabecny, J.; Holas, O.; Patocka, J.; Zdarova-Karasova J.; Pohanka, M.; Opletalova, V.; Musilek, K.; Kuca, K. Syntéza a in vitro testování strukturně odlišných alkylaminoderivátů odvozených od látky 7-MEOTA. 52. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 6.-10.1.2010, Supplementum 1, 2010, p. 45. 12. Zdarova-Karasova, J.; Komloova, M.; Korabecny, J.; Musilek, K.; Kuca, K. Hodnocení schopnosti prostupu léčiv, inhibitorů acetylcholinesterázy, přes hematoencefalickou bariéru pomocí in vitro metodiky. 52. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 6. -10. 1. 2010, Supplementum 1, 2010, p. 47. 13. Korabecny, J.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Musilek, K.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K. Syntéza a in vitro hodnocení duálních inhibitorů cholinesteras se strukturním základem 7-MEOTA. 39. konference Syntéza a analýza liečiv Modra-Harmónia (Slovenská republika) 2. -4. 9. 2010 zborník, p. 84. 14. Korabecny, J.; Holas, O.; Zemek, F.; Marek, J.; Musilek, K.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K. Syntéza a hodnocení biologické účinnosti nových takrinových derivátů jako potenciálních agens pro Alzheimerovu chorobu. 53. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 5. -9. 1. 2010, Supplementum 1, 2011, p. 55 15. Kuca, K.; Korabecny, J.; Holas, O.; Zemek, F.; Musilek, K.; Pohanka, M.; Opletalova, V.; Dohnal, V. Syntéza a in vitro hodnocení N-alkyl-7-methoxytakrin hydrochloridů jako potenciálních inhibitorů cholinesteras při Alzheimerově chorobě. 53. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 5. -9. 1. 2010, Supplementum 1, 2011, p. 56 16. Hroudova, J.; Fisar, Z.; Korabecny, J.; Kuca, K. In vitro účinky takrinu, 7-MEOTA a oximů na aktivitu MAO-A, MAO-B a komplexu I dýchacího řetězce. 53. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 5. -9. 1. 2010, Supplementum 1, 2011, p. 55 17. Musilek, K.; Korabecny, J.; Holas, O.; Horova, A.; Patocka, J.; Kuca, K. 7-MEOTA – cholinesterase inhibitor with valuable pharmacological profile. 10th International Conference Alzheimer’s and Parkinson’s Diseases Barcelona (Spain) 9. -13.3.2011, p. 73. 18. Korabecny, J.; Musilek, K.; Holas, O.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Hroudova, J.; Jun, D.; Fisar, Z.; Karasova, J.; Patocka, J.; Kuca, K. Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential antiAlzheimer`s disease agents. 10th International Conference Alzheimer’s and Parkinson’s Diseases Barcelona (Spain) 9. -13.3.2011, p. 74. 19. Pohanka, M.; Novotny, L.; Sobotka, J.; Korabecny, J.; Kuca, K. Metrifonate (trichlorfon), an inhibitor of acetylcholinesterase is implicited in cerebral cortex oxidative stress modulation. 10th International Conference Alzheimer’s and Parkinson’s Diseases Barcelona (Spain) 9. -13.3.2011, p. 72. 20. Korabecny, J.; Musilek, K.; Holas, O.; Opletalova, V.; Dohnal, V.; Hroudova, J.; Fisar, Z.; Patocka, J.; Kuca, K. 7-MEOTA derivatives based human cholinesterase inhibitors. 12th Annual Network Conference Alzheimer’s Research UK Leeds (United Kingdom) 16. – 17. 3. 2011, p. 36. 21. Musilek, K.; Korabecny, J.; Holas, O.; Horova, A.; Patocka, J.; Kuca, K. 7-MEOTA – cholinesterase inhibitor with improved pharmacological properties. 12th Annual Network Conference Alzheimer’s Research UK Leeds (United Kingdom) 16. – 17. 3. 2011, p. 46. 22. Korabecny, J.; Marek, J.; Musilek, K.; Kuca, K. Development of new 7-MEOTA compounds: molecular modelling, synthesis and in vitro data. Twelfth Tetrahedron Symposium Sitges (Spain) 21. -24. 6. 2011. 23. Korabecny, J.; Janovec, L.; Musilek, K.; Zemek, F.; Horova, A.; Nepovimova, E.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y.-S.; Kuca, K. Comparison of novel tacrine and 7-MEOTA derivatives with aromatic and alicyclic residues: synthesis, biological evaluation and docking studies. 63. Zjazd Chemikov Vysoké Tatry, Tatranské Matliare (Slovenská republika) 5. – 9. 9. 2011, Erratum. 24. Kuca, K.; Musilek, K.; Jun, D.; Pohanka, M.; Zdarova-Karasova, J.; Soukup, O.; Marek, J.; Korabecny, J.; Hrabinova, M.; Kassa, J. Vývoj nových reaktivátorů acetylcholinesterázy – antidot pro případ otrav organofosforovými pesticidy. 63. Zjazd Chemikov Vysoké Tatry, Tatranské Matliare (Slovenská republika) 5. – 9. 9. 2011, p 225. 25. Marek, J.; Korabecny, J.; Musilek, K.; Cabal, J.; Kuca, K. Development of novel quaternary detergents as part of decontamination and disinfection means. 63. Zjazd Chemikov Vysoké Tatry, Tatranské Matliare (Slovenská republika) 5. – 9. 9. 2011, p 228. 26. Hroudova, J.; Fisar, Z.; Jirak, R.; Korabecny, J.; Kuca, K.; Raboch, J. Changes of cellular respiration in patients with Alzheimer’s disease. 20. Evropský psychiatrický kongres Praha (Česká republika) 3. 3. – 6. 3. 2012. 27. Korabecny, J.; Janovec, L.; Musilek, K.; Zemek, F.; Horova, A.; Nepovimova, E.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y.-S.; Kuca, K. Comparison of novel tacrine and 7-MEOTA derivatives with aromatic and alicyclic residues: synthesis, biological evaluation and docking studies. 11. Conference Odborné společnosti vojenských lékařů, farmaceutů a veterinárních lékařů ČLS Hradec Králové (Česká republika) 18. – 19. 10. 2011, Blok V : Postery. 28. Hroudova, J.; Fisar, Z.; Jirak, R.; Korabecny, J.; Raboch, J. Změny bunečného dýchání u pacientů s Alzheimerovou chorobou a osob v depresivní episodě. 54. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4. -8. 1. 2012. 29. Korabecny, J.; Musilek, K.; Zemek, F.; Horova, A.; Holas, O.; Nepovimova, E.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y.-S.; Kuca, K. Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine – new tacrine derivative with cholinergic properties. 54. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4. -8. 1. 2012. 30. Korabecny, J.; Musilek, K.; Zemek, F.; Horova, A.; Nepovimova, A.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y.-S.; Kuca, K. Monosubstitued N-alkylated-tacrine derivatives: synthesis, biological evaluation and molecular modeling. 54. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4. -8. 1. 2012. 31. Spilovska, K.; Hamuľakova, S.; Korabecny, J.; Musilek, K.; Kuca, K.; Imrich, J. Synthesis and biological evaluation of tacrine-coumarine heterodimers as potential cholinesterase inhibitors in Alzheimer's disease therapy. 54. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4. -8. 1. 2012. 32. Hroudova, J.; Fisar, Z.; Kitzlerova E., Zverova, M.; Korabecny, J.; Kuca, K., Raboch, J. Changes of cellular respiration in patients with depression. World Psychiatric Association International Congress 2012. Praha (Česká republika) 17. – 21. 10. 2012. 33. Musilek, K.; Benek, O.; Korabecny, J.; Kuca, K.; Gunn-More, F. Analogues of benzothiazole ureas as potential inhibitors of mitochondrial enzymes with implications for AD. Alzheimer’s Research UK Conference 2012 Birmingham (United Kingdom) 27. – 28. 3. 2012, p. 64. 34. Korabecny, J.; Musilek, K.; Zemek, F.; Horova, A.; Holas, O.; Nepovimova, E.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y.-S.; Kuca, K. Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine – new tacrine derivative with cholinergic properties. Alzheimer’s Research UK Conference 2012 Birmingham (United Kingdom) 27. – 28. 3. 2012, p. 46. 35. Korabecny, J.; Hamuľakova, S.; Babkova, K.; Horova, A.; Musilek, K.; Spilovska, K.; Imrich, J.; Opletalova, V.; Gazova Z.; Karasova-Zdarova J.; Hroudova J.; Fisar Z.; Gaľa L.; Valko M.; Kassa J.; Kuca K.; Synthesis, biological assessment and molecular modeling of novel tacrine-7 methoxytacrine heterodimers for Alzheimer disease treatment. 12th International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy Stockholm (Sweden) 9. – 12. 5. 2012, p. 80E. 36. Ricny, J.; Kristofikova Z.; Korabecny, J.; Kuca, K.; Musilek, K.; Proska, J.; Ripova, D. Methoxytacrine analogues (N-alkyl-7-methoxytacrine hydrochlorides) as acetylcholinesterase inhibitors with potential therapeutic use in Alzheimer disease. 12th International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy Stockholm (Sweden) 9. – 12. 5. 2012, p. 120E. 37. Drtinova, L.; Pohanka, M.; Sepsova, V.; Zemek, F.; Zdarova-Karasova, J.; Krenkova, Z.; Misik, J.; Korabecny, J. HI-6 and obidoxime implication in oxidative stress: guinea pig model. 11th international Meeting on Cholinesterases Kazan (Russia) 4. – 9. 6. 2012, p 2-9. 38. Korabecny, J.; Hamuľakova, S.; Babkova, K.; Horova, A.; Musilek, K.; Spilovska, K.; Imrich, J.; Opletalova, V.; Gazova Z.; Karasova-Zdarova J.; Hroudova J.; Fisar Z.; Gaľa L.; Valko M.; Kassa J.; Kuca K.; Synthesis, biological assessment and molecular modeling of novel tacrine-7 methoxytacrine heterodimers for Alzheimer disease treatment. 11th international Meeting on Cholinesterases Kazan (Russia) 4. – 9. 6. 2012, p 2-14. 39. Korabecny, J.; Nepovimova, E.; Janovec, L.; Horova, A.; Zemek, F.; Musilek, K.; Spilovska, K.; Opletalova, V.; Kuca, K. Novel and re-evaluated activities in the series of N-alkylated-tacrine derivatives: Synthesis, biological evaluation and molecular modelling. 11th international Meeting on Cholinesterases Kazan (Russia) 4. – 9. 6. 2012, p 2-19. 40. Sepsova, V.; Krusek, J.; Soukup, O.; Zemek, F.; Drtinova, L.; Korabecny, J.; Krenkova, Z.; Zdarova-Karasova, J. The interaction of reversible acetylcholinesterase inhibitors with the nicotinic receptors – in vitro testing. 11th international Meeting on Cholinesterases Kazan (Russia) 4. – 9. 6. 2012, p 7-10. 41. Hroudová J., Fišar Z., Kitzlerová E., Zvěřová M., Korábečný J., Kuča K., Raboch J. Changes of cellular respiration in patients with depression. WPA International Congress 2012, 17. – 21. 10. 2012 Prague (Czech Republic). Čes a slov Psychiat 2012; 108 (Suppl 1): 246. ISSN 1212-0383. 42. Zemek, F.; Sepsova, V.; Drtinova, L.; Korabecny, J.; Pohanka, M.; Zdarova-Karasova, J.; Kuca, K. Interaction of acetylcholinesterase reactivators with albumin. P.8.b. Other topcis (basic), P.8.b.001; Eur. Neuropsychopharm. S439-S440. (IF2011 = 4.046) 25th ECNP Congress, 13-17 October 2012, Vienna, Austria 43. Zdarova-Karasova, J.; Hroch, M.; Korabecny, J.; Zemek, F.; Hrabinova, M.; Sepsova, V.; Kuca, K. Takrin a jeho deriváty 7-MEOTA a KB-38: Hodnocení základních farmakokinetických parametrů po i.m. podání u potkana. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 65. 44. Hroudova, J.; Fisar, Z.; Raboch, J.; Korabecny, J.; Kuca, K. In vitro účinky inhibitorů acetylcholinesteráz na aktivitu monoaminooxidáz a NADH dehydrogenázy. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 65. 45. Spilovska, K.; Korabecny, J.; Musilek, K.; Horova, A.; benek, O.; Kuca, K. Synthesis and biological testing of 7-methoxytacrine-adamantylamine heterodimers as potential cholinesterase inhibitors in Alzheimer disease. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 66. 46. Sepsova, V.; Soukup, O.; Drtinova, L.; Korabecny, J.; Spilovska, K.; ZdarovaKarasova, J. Vliv inhibitorů acetylcholinesterasy na cholinergní system. 55. ČeskoSlovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.8.1.2013, Supplementum 1, 2013, p. 66. 47. Korabecny, J.; Babkova, K.; Hamulakova, S.; Cabelova, P.; Nepovimova, E.; Andrs, M.; Spilovska, K.; Benek, O.; Musilek, K.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Kuca, K. Synthesis, biological assessment and molecular modeling of novel tacrine-7methoxytacrine heterodimers for Alzheimer disease treatment. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 67. 48. Cabelova, P.; Korabecny, J.; Babkova, K.; Nepovimova, E.; Andrs, M.; Spilovska, K.; Benek, O.; Musilek, K.; Opletalova, V.; Hroduova, J.; Fisar, Z.; Kuca, K. Synthesis, biological properties and in silico studies in the series of novel 7-methoxytacrinedonepezil-like compounds. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 67. 49. Marek, J.; Korabecny, J.; Babkova, K.; Hamulakova, S.; Cabelova, P.; Nepovimova, E.; Andrs, M.; Spilovska, K.; Benek, O.; Musilek, K.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Kuca, K. Comparative study in the N-alkylated desries of tacrine and 7methoxytacrine derivatives. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 68. 50. Korabecny, J.; Babkova, K.; Hamulakova, S.; Cabelova, P.; Nepovimova, E.; Andrs, M.; Spilovska, K.; Benek, O.; Musilek, K.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Kuca, K. 7-methoxytacrine analogues as candidates for Alzheimer disease treatment. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 68. 51. Benek, O.; Musilek, K.; Kuca, K.; Korabecny, J.; Spilovska, K.; Gunn-Moore, F. Benzothiazolyl urea analogues as inhibitors of ABAD-Aβ interaction in Alzheimer disease. 55. Česko-Slovenská psychofarmakologická konference Lázně Jeseník (Česká republika) 4.-8.1.2013, Supplementum 1, 2013, p. 68. 52. Korabecny, J.; Cabelova, P.; Babkova, K.; nepovimova, E.; Andrs, M.; Spilovska, K.; Benek, O.; Musilek, K.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Kuca, K. Synthesis, biological properties and in silico studies in the series of novel 7-methoxytacrinedonepezil like compounds. 11th International Conference On Alzheimer’s and Parkinson’s Diseases Florence (Italy) 6. -10. 3. 2013 53. Soukup, O.; Korabecny, J.; Musilek, K.; Jun, D.; Misik, J.; Zdarova-Karasova, J.; Kamil, K. Hybrids of AChE inhibitor and memantine derivatives as candidates for Alzheimer’s disease treatment. Neuroscience 2013 San Diego (California, USA) 9. – 13. 11. 2013. 54. Kuca, K.; Musilek, K.; Jun, D.; Zdarova-Karasova, J.; Kunes, M.; Soukup, O.; Korabecny, O.; Sepsova, V.; Hrabinova, M. Novel acetylcholinesterase reactivators – antidotes against nerve agents. International Conference on Pharmacology and Drug Development Singapore (Singapore) 9. – 11. 12. 2013. 55. Korabecny, J.; Cabelova, P.; Nepovimova, E.; Andrs, M.; Spilovska, K.; Musilek, K.; Opletalova, V.; Kuca, K. 7-MEOTA-DONEPEZIL-LIKE COMPOUNDS FOR ALZHEIMER’S DISEASE TREATMENT. XXIII International Symposium on Medicinal Chemistry Lisbon (Portugal) 7.-11.9.2014. 56. Andrs, M.; Korabecny, J.; Babkova, K.; Musilek, K.; Kuca, K. Synthesis, biological assessment and molecular modelling of tacrine-7-methoxytacrine heterodimers for Alzheimer’s disease treatment. TOXCON, Stará Lesná, Vysoké Tatry (Slovakia) 24.26.11.2014. 57. Drtinova, L.; Pohanka, M.; Spilovska, K.; Korabecny, J.; Sepsova, V.; Nepovimova, E.; Kuca, K. New cholinestearse inhibitors 7-methoxytacrine-adamantylamine heterodimers as inhibitors of BACE and amyloid beta 1-40. TOXCON, Stará Lesná, Vysoké Tatry (Slovakia) 24.-26.11.2014. 58. Misik, J.; Korabecny, J.; Nepovimova, E.; Kassa, J. Therapeutic effect of novel Nalkylated tacrine analogues on cognitive deficit induced by 3-quinicidinyl benzilate in rats performing the water maze. TOXCON, Stará Lesná, Vysoké Tatry (Slovakia) 24.26.11.2014. 59. Nepovimova, E.; Korabecny, J.; Dolezal, R.; Cabelova, P.; Musilek, K.; Kuca, K. 7 MEOTA-donepezil like compounds – novel agents to combat Alzheimer’s disease. TOXCON, Stará Lesná, Vysoké Tatry (Slovakia) 24.-26.11.2014. 60. Korabecny, J.; Nepovimova, E.; Soukup, O.; Sepsova, V.; Bolognesi, M.L.; Kuca, K.; Bartolini, M. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects. NEURODEGENERATIVE DISEASES: BIOLOGY & THERAPEUTICS, Cold Spring Harbor, New York (USA) 3.-6.12.2014. 61. Patocka, J.; Korabecny, J.; Soukup, O.; Sepsova, V.; Nepovimova, E.; Jun, D.; Kuca, K. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. NEURODEGENERATIVE DISEASES: BIOLOGY & THERAPEUTICS, Cold Spring Harbor, New York (USA) 3.-6.12.2014. 62. Nepovimova, E.; Korabecny, J.; Cabelova, P.; Soukup, O.; Sepsova, V.; Kuca, K. 7MEOTA-donepezil like compounds – novel agents to combat Alzheimer’s disease. NEURODEGENERATIVE DISEASES: BIOLOGY & THERAPEUTICS, Cold Spring Harbor, New York (USA) 3.-6.12.2014. 63. Sepsova, V.; Nepovimova, E.; Korabecny, J.; Krusek, J.; Tobin, G.; Zdarova, J.; Kuca, K.; Soukup. O.; New 7-MEOTA-donepezil derivatives modulate acetylcholinesterase and cholinergic receptors. NEURODEGENERATIVE DISEASES: BIOLOGY & THERAPEUTICS, Cold Spring Harbor, New York (USA) 3.-6.12.2014. 64. Soukup. O.; Sepsova, V.; Korabecny, J; Nepovimova, E.; Kuca, K. A resurrection of 7-MEOTA? A comparison with tacrine. NEURODEGENERATIVE DISEASES: BIOLOGY & THERAPEUTICS, Cold Spring Harbor, New York (USA) 3.6.12.2014. 65. Nepovimova, E.; Korabecny, J.; Bartolini, M.; Bergamini, C.; Lamba, D.; Roberti, M.; Monti, B.; Kuca, K.; Bolognesi, M.L. Multitarget drug design strategy: Quinonetacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects. 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PDTM 2015), Nice, France, 18-22.3.2015. 66. Korabecny, J.; Cabelova, P.; Dolezal, R.; Nepovimova, E.; Babkova, K.; Spilovska, K.; Andrs, M.; Musilek, K.; Soukup, O.; Kuca, K. 7-MEOTA-donepezil like compounds – novel agents to combat Alzheimer’s disease. 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PDTM 2015), Nice, France, 18-22.3.2015. 67. Korabecny, J.; Cabelova, P.; Dolezal, R.; Nepovimova, E.; Babkova, K.; Spilovska, K.; Andrs, M.; Musilek, K.; Soukup, O.; Kuca, K. 7-MEOTA-donepezil like compounds – novel agents to combat Alzheimer’s disease. 12th International Meeting on Cholinesterases-Sixth International Conference on Paraoxonases, Alicante, Spain, 27.9.-2.10.2015. Oral presentations 1. Korabecny, J. Nové deriváty 7-methoxytakrinu jako potenciální léčiva Alzheimerovy choroby; 26. 10. 2011, Košice. 2. Korabecny, J. Syntéza, biologické hodnocení a molekulární docking nových takrin-7methoxytakrin heterodimerů pro léčbu Alzheimerovy choroby; Studentská vědecká konference, 1. 2. 2012, Hradec Králové. 3. Korabecny, J.; Hamulakova, S.; Kuca, K.; Musilek, K.; Kassa, J. Syntéza, biologické vlastnosti a molekulově modelovací studie takrin-7-methoxytakrin heterodimerů v terapii Alzheimerovy choroby; Květinův den 2012, 31. 5. 2012, Brno. 4. Korabecny, J.; Hamulakova, S.; Babkova, K.; Horova, A.; Musilek, K.; Spilovska, K.; Imrich, J.; Opletalova, V.; Gazova, Z.; Hroudova, J.; Fisar, Z.; Gala, L.; Valko, M.; Kassa, J.; Kuca, K. Synthesis, biological assessment and molecular modelling of tacrine-7-methoxytacrine heterodimers for Alzheimer disease treatment. 2nd Meeting of the Paul Ehrlich MedChem Euro-PhD Network 2012, O-37, 9. 9. -11. 9. 2012 Ljubljana, Slovenia. 5. Korabecny, J. Design and synthesis of uncharged reactivators against organophosphorus nerve agents poisoned cholinesterases. Institut Francais de Prague, 7. 4. 2013, Prague, Czech Republic. 6. Korabecny, J.; Nepovimova, E.; Spilovska, K.; Andrs, M.; Babkova, K.; Musilek, K.; Kassa, J.; Kuca, K. Development of tacrine derivatives for Alzheimer’s disease at the department of toxicology in Hradec Kralove. TOXCON, Interdisciplinary Toxicology. 2014; Vol. 7(Suppl. 1), 7, 24.-26.9.2014, Stará Lesná, Vysoké Tatry, Slovakia. 7. Korabecny, J. Drug development for Alzheimer’s disease in Hradec Kralove. Workshop on Italy-Czech cooperation on AD and other related topics., 28.-30.9.2014, Bologna, Italy. 8. Korabecny, J. Development of Novel Multi-Target Directed Ligands for Alzheimer’s Disease. Biomedical Research Center group meeting, Rusalka, Malá Úpa, 15.17.1.2015, Czech Republic. 9. Korabecny, J.; Nepovimova, E.; Spilovska, K.; Andrs, M.; Babkova, K.; Musilek, K.; Soukup, O.; Kuca, K. Drug Design and Development of Novel Drugs for Alzheimer’s Disease Treatment. 5th PhD and 3rd Postdoc Conference FaF UK, 3.-4.2.2015, Hradec Králové, Czech Republic. 10. Kuca, K.; Novotny,M.; Uhrikova, A.; Sevimli, A.; Soukup, O.; Rousar, T.; Jost, P.; Jun, D.; Korabecny, J.; Musilek, K. Modified bisquaternary monooximes were found to be effective reactivators of human AChE inhibited by organophosphates. 1st International Scientific Conference, CBRN, Research & Innovation, 16.-18.3.2015, Antibes - Juan-les-Pins, France. 11. Kuca, K.; Hamulakova, S.; Janovec, L.; Hrabinova, M.; Spilovska, K.; Korabecny, J.; Kristian, P.; Nepovimova, E.; Maresova, P.; Imrich, J. Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors. Drug Discovery and Therapy World Congress 2015, 22.-25.7.2015, Boston, MA, USA Book chapters 1. Korabecny, J.; Zemek, F.; Soukup, O.; Spilovska, K.; Musilek, K.; Jun, D.; Nepovimova, E.; Kuca, K. Current treatment and perspectives in pharmacotherapy of Alzheimer`s disease. Frontiers in Drug Discovery, 2014, 6, 702 738. 2. Musilek, K.; Korabecny, J.; Jun, D.; Kassa, J.; Kuca, K. Novel cholinesterase inhibitors. Handbook of Toxicology of Chemical Warfare Agents. 2015, 1071 1087. Published papers 1. Pohanka, M.; Zdarova Karasova, J.; Kuca, K.; Pikula, J.; Holas, O.; Korabecny, J.; Cabal, J. Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX. Talanta. 2010, 81, 621 624. IF = 3.722 2. Korabecny, J.; Musilek, K.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K. Synthesis and in vitro evaluation of N alkyl-7methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg. Med. Chem. Lett. 2010, 20, 6093 6095. IF = 2.661 3. Kuca, K.; Marek, J.; Zdarova Karasova, J.; Pohanka, M.; Korabecny, J.; Kalasz, H. Novel Acetylcholinesterase reactivator – oxime K048 – reactivation activity in vitro. Med. Chem. 2010, 1 5. 4. Korabecny, J.; Holas, O.; Musilek, K.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K. Synthesis and in vitro evaluation of new tacrine derivates-bis- alkylene linked 7-MEOTA. Lett. Org. Chem. 2010, 7, 327 331. IF = 0.774 5. Marek, J.; Stodulka, P.; Cabal, J.; Soukup, O.; Pohanka, M.; Korabecny, J.; Musilek, K.; Kuca, K. Preparation of the pyridinium salts differing in the length of the N-alkyl substituent. Molecules 2010, 15, 1967 1972. 6. Korabecny, J.; Musilek, K.; Holas, O.; Nepovimova, E.; Jun, D.; Zemek, F.; Opletalova, V.; Patocka, J.; Dohnal, V.; Nachon, F.; Hroudova, J.; Fisar, Z.; Kuca, K. Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer’s dinase treatment. Molecules 2010, 15, 8804 8812. IF = 1.738 7. Fisar, Z.; Hroudova, J.; Korabecny, J.; Musilek, K.; Kuca, K. In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity. Toxicol. Lett. 2011, 201, 176 180. 8. Jun, D.; Musilek, K.; Kassa, J.; Cabal, J.; Zdarova-Karasova, J.; Pohanka, M.; Bajgar, J.; Marek, J.; Komloova, M.; Soukup, O.; Holas, O.; Korabecny, J.; Dolezal, B.; Kuca, K. Vývoj univerzálního antidota otrav nervově paralytickými látkami na bázi reaktivátorů cholinesteráz: Od substance k autoinjektoru. Urgentní medicína 2010, 4, 15 19. 9. Hroudova, J.; Fisar, Z.; Korabecny, J.; Kuca, K. In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. Neuroendocrinol. Lett. 2011; 32, 259 263. 10. Korabecny, J.; Musilek, K.; Horova, A.; Holas, O.; Nepovimova, E.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y. S.; Kuca, K. Synthesis and in vitro evaluation of 7methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine - new tacrine derivate with cholinergic properties. Bioorg. Med. Chem. Lett. 2011; 21, 6563 6566. 11. Korabecny, J.; Janovec, L.; Musilek, K.; Zemek, F.; Horova, A.; Nepovimova, E.; Dolezal, R.; Opletalova, V.; Hroudova, J.; Fisar, Z.; Jung, Y. S.; Kuca, K. Comparison of novel tacrine and 7-MEOTA derivatives with aromatic and alicyclic residues: Synthesis, biological evaluation and docking studies. Lett. Org. Chem. 2013; 10, 291 297. 12. Zdarova-Karasova, J.; Korabecny. J.; Pohanka, M.; Zemek, F.; Sepsova, V.; Kuca, K. Acetylcholinesterase inhibitors used or tested in Alzheimer Disease therapy; their passive diffusion through blood brain barrier: In vitro study. Afr. J. Pharm. Pharmaco. 2013, 7, 1471-1481. 13. Korabecny, J.; Hruba, E.; Soukup. O.; Zemek, F.; Musilek, K.; Nepovimova, E.; Spilovska, K.; Opletalova, V.; Kuca, K. Zvažovane farmakoterapeutické přístupy léčby Alzheimerovy choroby. Česk. slov. Farm. 2012, 61, 4 10. 14. Soukup, O.; Jun, D.; Karasova-Zdarova, J.; Patocka, J.; Musilek, K.; Korabecny, J.; Krusek, J.; Kaniakova, M.; Sepsova, V.; Mandikova, J.; Trejtnar, F.; Pohanka, M.; Drtinova, L.; Pavlik, M.; Tobin, G.; Kuca, K. A resurrection of 7-MEOTA: a comparison with tacrine. Curr. Alzheimer Res. 2013, 10, 893-906. IF = 3.796 15. Spilovska, K.; Korabecny, J.; Kuca, K.; Musilek, K. Inhibítory gamma sekretázy v terapii Alzheimerovej choroby. Ceska Slov. Farm. 2012, 61, 93 100. 16. Zemek, F.; Korabecny, J.; Sepsova, V.; Karasova-Zdarova, J.; Musilek, K.; Kuca, K. Albumin and Alpha 1-Acid Glycoprotein; An Old Acquaintance. Expert Opin. Drug Metab. Toxicol. 2013, 9, 943-954. 17. Sepsova, V.; Zdarova-Karasova, J.; Korabecny, J.; Zemek, F.; Bennion, B.J.; Kuca, K. Oximes: Inhibitors of human acetylcholinesterase – a structure-activity relationship (SAR) study. Int. J. Mol. Sci. 2013, 14, 16882-16900. 18. Spilovska, K.; Korabecny, J.; Kral, J.; Horova, A.; Musilek, K.; Drtinova, L.; Gazova, Z.; Siposova, K.; Kuca, K. 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in AD treatment – synthesis, biological evaluation and molecular modeling studies. Molecules, 2013, 18, 2397-2418. IF = 2.428 19. Korabecny, J.; Spilovska, K.; Benek, O.; Musilek, K.; Soukup, O.; Kuca, K. Takrin a jeho deriváty v terapii Alzheimerovy choroby. Cesk. Slov. Farm. 2012, 61, 210-221. 20. Pohanka, M.; Cabal, J.; Bartosova, L.; Stetina, R.; Svobodova, H.; Zdarova-Karasova, J.; Kracmarova, A.; Drtinova, L.; Pavlik, M.; Korabecny, J.; Sespova, V.; Kassa, J. Vybrané laboratorní postupy v toxikologii. Studijní texty FVZ UO v Hradci Králové. 2012. 21. Zemek, F.; Sepsova, V.; Drtinova, L.; Nepovimova, E., Korabecny, J.; Kuca, K. Outcomes of Alzheimer diseases therapy with acetylcholinesterase inhibitors and memantine. Expert Opin. Drug Saf. 2014, 13, 759 774. IF = 2.735 22. Korabecny, J.; Soukup, O.; Dolezal, R.; Spilovka, K.; Nepovimova, E.; Andrs, M.; Nguyen, T.D.; Jun, D.; Musilek, K.; Kucerova-Chlupacova, M.; Kuca, K. From pyridinium-based to centrally active acetylcholinesterase reactivators. Mini-Rev. Med. Chem. 2014, 14, 215 221. IF = 3.186 23. Valis, M.; Koci, J.; Tucek, D.; Lutonsky, O.; Kopova, J.; Barton, P.; Vysata, O.; Krajickova, D.; Korabecny, J.; Masopust, J.; Klzo, L. Common yew intoxication: a case report. Journal of Medical Case Reports. 2014, 8, 4. 24. Kassa, J.; Korabecny, J.; Sepsova, V.; Tumova, M. The evaluation of prophylactic efficacy of newly developed reversible inhibitors of acetylcholinesterase in somanpoisoned mice – a comparison with commonly used pyridostigmine. Bas. Clin. Pharmacol. Toxicol. 2014, 115, 571-576. IF = 2.294 25. Korabecny, J.; Dolezal, R.; Cabelova, P.; Horova, A.; Hruba, E.; Ricny, J.; Sedlacek, L.; Nepovimova, E.; Spilovska, K.; Andrs, M.; Musilek, K.; Opletalova, V.; Sepsova, V.; Ripova, D.; Kuca, K. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modelling and QSAR studies. Eur. J. Med. Chem. 2014, 82, 426 438. IF = 3.447 26. Spilovska, K.; Korabecny, J.; Horova, A.; Musilek, K.; Nepovimova, E.; Drtinova, L.; Gazova, Z.; Siposova, K.; Dolezal, R.; Kuca, K. Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: A novel cholinesterase inhibitors for the treatment of Alzheimer’s disease. Med. Chem. Res. 2015, 24, 2645-2655. IF = 1.402. 27. Nepovimova, E.; Korabecny, J.; Horova, A.; Musilek, K.; Dolezal, R.; Jung, Y.-S.; Kuca, K. N-alkylated tacrine analogues as potential drugs for Alzheimer’s disease. Drug. Des. Devel. Ther. 2015, submitted. 28. Sepsova, V.; Zdarova-Karasova, J.; Tobin, G.; Jun, D.; Korabecny, J.; Cabelova, P.; Janska, K.; Krusek, J.; Kuca, K.; Soukup, O. Cholinergic properties of new 7 methoxytacrine-donepezil derivatives. Gen. Physiol. Biophys. 2015, 34, 189 200. IF= 0.875. 29. Andrs, M.; Korabecny, J.; Jun, D.; Hodny, Z.; Bartek, J.; Kuca, K. Phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: the importance of the morpholine ring. J. Med. Chem. 2015, 58, 41 71. IF = 5.480. 30. Andrs, M.; Korabecny, J.; Jun, D.; Kuca, K. The development of ataxia telangiectasia mutated kinase inhibitors. Mini-Rev. Med. Chem. 2014, 14, 805 811. IF = 3.186 31. Dolezal, R.; Korabecny, J.; Honegr, J.; Malinak, D.; Musilek, K.; Kuca, K. Ligandbased 3D QSAR analysis of reactivation potency of mono- and bis- pyridinium oximes toward VX-inhibited rat acetylcholinesterase. J. Mol. Graphics Model. 2015, 56, 113 129. IF = 2.022. 32. Korabecny, J.; Nepovimova, E.; Dolezal, R.; Malinak, D.; Soukup, O.; Andrs, M.; babkova, K.; Sepsova, V.; Benek, O.; Hroch, L.; Kracmarova, A.; Hrabinova, M.; Hrabcova, V.; Zemek, F.; Marek, J.; Honegr, J.; Jun, D.; Musilek, K.; Kuca, K. Donepezil–from cholinesterase inhibitor to multi-target-directedligands. Prog. Neurobiol., 2015, submitted. 33. Malinak, D.; Salajkova, S.; Dolezal, R.; Marek, J.; Soukup, O.; Vejsova, M.; Korabecny, J.; Honegr, J.; Penhaker, M.; Musilek, K.; Kuca, K. Synthesis, biological evaluation and LC-MS analysis of 6-hydroxyquinolinium salts differing in the length of a side alkyl chain. Bioorg. Med. Chem. Lett. 2014, 24, 5238 5241. IF = 2.331 34. Hamulakova, S.; Janovec, L.; Hrabinova, M.; Spilovska, K.; Korabecny, J.; Kristian, P.; Kuca, K.; Imrich, J. Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors. J. Med. Chem. 2014, 57, 7073 7084. IF = 5.480. 35. Guest, P.; Benek, O.; Aitken, L.; Smith, T.K.; Korabecny, J.; Soukup, O.; Jun, D.; Kuca, K.; Yan, S.S.; Gunn-Moore, F.; Musilek, K. The design, synthesis and evaluation of benzothiazolylurea analogues as inhibitors of the amyloid binding alcohol dehydrogenase / 17β-hydroxysteroid dehydrogenase type 10 enzyme. J. Med. Chem. 2015 Submitted. 36. Nepovimova, E.; Uliassi, E.; Korabecny, J.; Peña-Altamira, L.E.; Samez, S.; Pesaresi, A.; Garcia, G.E.; Bartolini, M.; Andrisano, V.; Bergamini, C.; Fato, R.; Lamba, D.; Roberti, M. Kuca, K.; Monti, B.; Bolognesi, M.L. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects. J. Med. Chem. 2014, 57, 8576 8589. IF = 5.480. 37. Lee, S.K.; Park, M.K.; Yi, J.; Nahm, K.; Cho, D.W.; Ra, C.S.; Musilek, K.; Horova, A.; Korabecny, J.; Dolezal, R.; Jun, D.; Kuca, K. Preparation of 7-methoxy tacrine dimer analogues and their in vitro/in silico evaluation as potential cholinesterase inhibitors. B. Korean Chem. Soc. 2015, 35(6), 1654-1660. IF = 0.835. 38. Andrs, M.; Korabecny, J.; Nepovimova, E.; Jun, D.; Hodny, Z.; Bartek, J.; Kuca, K. Small molecules targeting ATR kinase: an emerging way to enhance existing cancer therapy. Curr Cancer Drug target. 2015, just accepted. IF = 3.522. 39. Kuca, K.; Musilek, K.; Jun, D.; Soukup, O.; Korabecny, J. Oxime K074 – in vitro reactivation of acetylcholinesterase inhibited by nerve agents and pesticides. J. Enzym. Inhib. Med. Ch. 2015, submitted. 40. Misik, J.; Korabecny, J.; Nepovimova, E.; Cabelova, P.; Kassa, J. Effects of novel 7MEOTA-donepezil like hybrids and N alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T maze test. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 2015, just accepted. IF = 1.661. 41. Soukup, O.; Korabecny, J.; Honegr, J.; Kuca, K. Nové trendy ve vývoji nových léčiv Alzheimerovy nemoci. Acta Medicinae, 2014, 11, 66-68. 42. Kuca, K.; Musilek, K.; Korabecny, J.; Zdarova-Karasova, J.; Soukup, O.; Hrabinova, M.; Jun, D. Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes – antidotes against nerve agents. Journal of Environmental Immunology and Toxicology, 2014, 1, 41-43 43. Malinak, D.; Gonda, J.; Korabecny, J.; Dolezal, R.; Honegr, J.; Soukup, O.; Buzga, M.; Kuca, K. A review of total synthesis of (+) lactacystin and its analogs. Curr. Org. Chem. 2015, 19 (20), 1980-2001. IF = 2.157. 44. Misik, J.; Korabecny, J.; Nepovimova, E.; Kracmarova, A.; Kassa, J. Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilateinduced cognitive deficit in rats - is there a potential for Alzheimer's disease treatment? Neurosci. Lett. 2015, submitted. 45. Nunes Lemes, L.F.; de Andrade Ramos, G.; de Oliveira, S.; R.da Silva, F.M.; de Castro Couto, G.; da Silva Boni, M.; Guimarães, M.J.; O. Souza, I.N.; Bartolini, M.; Andrisano, V.; do Nascimento Nogueira, P.C.; Rocha Silveira, E.; Soukup, O.; Korabecny, J.; C. Romeiro, N.; G. Castro, N.; Bolognesi, M.L.; Soares Romeiro, L.A. Cardanol-derived AChE inhibitors: towards the development of dual binding derivatives for Alzheimer’s disease. Eur. J. Med. Chem. 2015, submitted. 46. Nepovimova, E.; Korabecny, J.; Dolezal, R. babkova, K.; Ondrejicek, A.; Jun, D.; Sepsova, V.; Horova, A.; Hrabinova, M.; Soukup, O.; Bukum, N.; Jost, P; Muckova, L.; Kassa, J.; Malinak, D.; Andrs, M.; Kuca, K. Tacrine – trolox hybrids: A novel class of centrally active, non-hepatotoxic multi-target-directed ligands exerting anticholinesterase and antioxidant activities with low in vivo toxicity. J. Med. Chem. 2015, submitted. 47. Prati, F.; Bergamini, C.; Fato, R.; Soukup, O.; Korabecny, J.; Andrisano, M.; Bartolini, M.; Bolognesi, M.L. Novel 8-hydroxyquinoline derivatives as multitarget compounds for the treatment of Alzheimer’s Disease. ChemMedChem., 2015, submitted. 48. Spilovska, K.; Zemek, F.; Korabecny, J.; Nepovimova, E.; Soukup, O.; Windisch, M.; Kuca, K. Adamantane – a lead structure for drugs in clinical practice. Expert Opin. Drug Saf. 2015, submitted. 49. Andrs, M.; Muthna, D.; Rezacova, M.; Siman, P.; Korabecny, J.; Benek, O.; Dolezal, R.; Soukup, O.; Jun, D.; Kuca, K. Novel caffeine derivatives with antiproliferative activity. MedChemComm. 2015, submitted. 50. Kuca, K.; Soukup, O.; Maresova, P.; Korabecny, J.; Nepovimova, E.; Klimova, B.; Honegr, J.; Ramalho, T.; Costa Franca, T. New trends in development of novel drugs for Alzheimer’s disease. J. Braz. Chem. Soc. 2015, submitted. 51. Korabecny, J.; Andrs, M.; Nepovimova, E.; Dolezal, R.; Babkova, K.; Horova, A.; Malinak, D.; Gorecki, L.; Mezeiova, E.; Sepsova, V.; Hrabinova, M.; Soukup, O.; Jun, D.; Kuca, K. 7-Methoxytacrine-p-Anisidine Dimers as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Molecules, 2015, submitted. 52. Zdarova-Karasova, J.; Soukup, O.; Korabecny, J.; Hroch, M.; Sepsova, V.; Kuca, K. Tacrine and its 7-methoxy derivate; significant differences in absorption and bloodbrain barrier penetration after oral application. J. Appl. Biomed. 2015, submitted. 53. Soukup, O.; Dolezal, R.; Malinak, M.; Marek, J.; Salajkova, S.; Pasdiorova, M.; Honegr, J.; Korabecny, J.; Nachtigal, P.; Nachon, F.; Jun, D.; Kuca, K. Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety. Bioorg. Med. Chem. Lett. 2015, submitted. Conference contributions 1. Dolezal, R.; Bodnarova, A.; Cimler, R.; Husakova, M.; Najman, L.; Racakova, V.; Krenek, J.; Korabecny, J.; Kuca, K.; Krejcar, O. Variable elimination approaches for data-noise reduction in 3D QSAR calculations. 17th Portuguese Conference on Artificial Intelligence (EPIA-2015), 2015, 313-325, 8. -11. 9. 2015, Coimbra, Portugal 2. Balik, L.; Horalek, J.; Hornig, O.; Sobeslav, V.; Dolezal, R.; Korabecny, J.; Kuca, K. Endpoint firewall for local security hardening in academic research environment. ICCCI 2015 : 7th International Conference on Computational Collective Intelligence Technologies and Applications. 21. – 23. 9. 2015, Madrid, Spain.