Curriculum vitae
MSc. Katarína Špilovská
PhD student
+420 737 042 545
k.spilovska@gmail.com
Katarína obtained her MSc. in 2011 at the Faculty of Science in Kosice, Pavol Jozef Safarik
University. The main goal of the diploma thesis was the synthesis and biological evaluation of
tacrine a coumarin derivatives as potential cholinesterase inhibitors. Currently, she is a PhD
student at the Department of Toxicology and Military Pharmacy, Faculty of Military Health
Sciences, University of Defence. Her PhD thesis is preparation of novel cholinesterase
inhibitors with central action and their in vitro testing.
Education:
Bsc. (2009)
Pavol Jozef Safarik University, Faculty of Science, Kosice, Slovakia
Bachelor thesis: „Acridine and acridone derivatives, their biological efficacy
and methods of synthesis“.
MSc. (2011) Pavol Jozef Safarik University, Faculty of Science, Kosice, Slovakia
Diploma thesis: „Synthesis and biological evaluation of tacrine and coumarin
derivatives as potential cholinesterase inhibitors“.
Research Focus:
Synthesis and biological testing of potential cholinesterase inhibitors in Alzheimer’s disease
therapy.
Professional training:
Since 2011
PhD student, Department of Toxicology and Military Pharmacy, Faculty of
Military Health Sciences in Hradec Kralove, University of Defence
Since 1.7.2013
Researcher, University Hospital Hradec Kralove
Since 1.4.2014
Researcher, National Institute of Mental Health, Klecany
Projects:
Title:
Synthesis and testing of derivatives with potential prophylactic effects against
Nerve agents and Alzheimer’s disease.
Funding:
Ministry of Education, Youth and Sports (SV/FVZ201201)
Schedule:
2012-2014
Role:
principal investigator
Cooperation:
Since 2011
Pavol Jozef Safarik University, Faculty of Science, Kosice, Slovakia
Publicaton activity:
Author or co-author of 3 scientific publications in journals with review process and 5
publications in journal with IF.
(dated 10/2015)
Selected Publications:
2015
Spilovska, K.; Korabecny, J.; Horova, A.; Musilek, K.; Nepovimova, E.; Drtinova, L.;
Gazova, Z.; Siposova, K.; Dolezal, R.; Jun, D.; Kuca, K. Design, synthesis and in vitro testing
of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment
of Alzheimer’s disease. Med. Chem. Res. 2015, 24, 2645-55.
2014
Hamulakova, S.; Janovec, L.; Hrabinova, M.; Spilovska, K.; Korabecny, J.; Kristian, P.;
Kuca, K.; Imrich, J. Synthesis and biological evaluation of novel tacrine derivatives and
tacrine-coumaric hybrids as cholinesterase inhibitors. J. Med. Chem. 2014, 57, 7073-84.
Korabecny, J.; Dolezal, R.; Cabelova, P.; Horova, A.; Hruba, E.; Ricny, J.; Sedlacek, L.;
Nepovimova, E.; Spilovska, K.; Andrs, M.; Musilek, K.; Opletalova, V.; Sepsova, V.; Ripova,
D.; Kuca, K. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis,
pharmacological evaluation, molecular modeling and QSAR studies. Eur. J. Med. Chem.
2014, 82, 426-38.
Korabecny, J.; Soukup, O.; Dolezal, R.; Spilovska, K.; Nepovimova, E.; Andrs, M,; Nguyen,
T.D.; Jun, D.; Musilek, K.; Kucerova-Chlupacova, M.; Kuca, K. From pyridinium-based to
centrally active acetylcholinesterase reactivators. Mini. Rev. Med. Chem. 2014, 14, 215-21.
2013
Spilovska, K.; Korabecny, J.; Kral, J.; Horova, A.; Musilek, K.; Soukup, O.; Drtinova, L.;
Gazova, Z.; Siposova, K.; Kuca, K. 7-Methoxytacrine-adamantylamine heterodimers as
cholinesterase inhibitors in Alzheimrr’s disease treatment – synthesis, biological evaluation
and molecular modeling studies. Molecules 2013, 18, 2397-2418.
2012
Spilovska, K.; Korabecny, J.; Kuca, K.; Musilek, K. Gamma-secretase inhibitors in
Alzheimer’s disease therapy. Ceska Slov. Farm. 2012, 61, 93-100.
Korabecny, J.; Spilovska, K.; Benek, O.; Musilek, K.; Soukup, O.; Kuca, K. Tacrine and its
derivatives in the therapy of Alzheimers disease. Ceska Slov. Farm. 2012, 61, 210-221.
Korabecny, J.; Hruba, E.; Soukup, O.; Zemek, F.; Musilek, K.; Nepovimova, E.; Spilovska,
K.; Opletalova, V.; Kuca, K. Intended pharmacotherapeutical approaches of Alzheimer’s
disease therapy. Ceska Slov. Farm. 2012, 61, 4-10.