Size, Phase: Dependent Studies of Synthesis and
Characterization of Iron Oxide Nanoparticles for
Biomedical Applications
Nooris H. Momin1*, Radha S1
1
Department of Physics, University of Mumbai, Kalina-400098, India
e-mail:noorismomin@gmail.com, Tel.: +91-9022368716
Abstract: We report the synthesis, characterization and
phases of iron oxide nanoparticles with and without different
coatings. The synthesized particles are characterized by XRD,
FTIR, Raman, UV-Visible spectroscopy and BET. Magnetic
behaviour at room temperature was studied using a pulsed
field B-H loop tracer and its biomedical application. Changes
in the particle size, strain and dislocation density is observed.
Keywords: Chemical co-precipitation; iron oxide; coatings,
phases; biocompatibility
F2
F3
F4
7.59
19.89
8.18
36
34
51
F5
5.16
30
206,239
320,358
293,392
F6
9.65
44
273,234
F7
6.74
γ-Fe2O3
α-Fe2O3
Fe3O4,γ
-Fe2O3
Fe3O4,γ
-Fe2O3
Fe3O4,γ
-Fe2O3
Fe3O4
371,222
1.29x1014
0.13x1014
1.21x1014
1.88x1014
0.84x1014
4.15x1014
F1
Introduction: Iron oxide nanoparticles are popular for
Experiment : Iron oxide nanoparticles are synthesized
by chemical reduction of FeCl3 and FeCl2 in presence of
NH4OH with vigorously stirring. γ-Fe2O3 are obtain by
heating these synthesized Fe3O4 nanoparticles at 250oC
for 3hours.α-Fe2O3 are formed by heating these
synthesized Fe3O4 nanoparticles at 800oC for 3 hours.
Other, variations of iron oxide coated nanoparticles are
made in physical conditions of precursor solvents, in
addition of different reducing and stabilizers,
temperature etc. From XRD analysis we cannot identify
phases of iron oxide i.e.Fe2O3 and Fe3O4 because their
lines are very close and from Raman spectroscopy we
can differentiate the phases of iron oxide.
F1-synthesized iron oxide nanoparticles;F2- synthesized
iron oxide nanoparticles at 250oC for 2 hours; F3synthesized iron oxide nanoparticles at 800oC for 3
hours; F4-Oliec acid coated iron oxide nanoparticles;F5Citric acid coated iron oxide nanoparticles;F6-Diethyl
amine coated iron oxide nanoparticles;F7-PEG-6000
coated iron oxide nanoparticles.
Table: Experimental details of the sample preparation,
characterization used in this study.
Sample
F1
XRD
(nm)
5.47
DLS
(nm)
16
UV
(nm)
-
Formed
Phases
Fe3O4
Dislocation
Density
1.79x1014
180
311
160
120
140
100
120
200
80
60
422
320
531
Intensity
Intensity
their applications in a variety of fields. Different routes
for synthesis of magnetic nanoparticles are reported. For
example chemical methods are co-precipitation, reverse
micelle mechanism, chemical vapour condensation etc.
The formation of Fe3O4 particles by co-precipitation of
Fe2+ and Fe3+ by alkali is fairly well known and it is
widely used.
F2
311
140
100
440
220
80
422
60
40
532
400
40
20
20
0
0
-20
-20
10
20
30
40
50
60
70
2 theta (degrees)
10
20
30
40
50
60
70
2 Theta (degrees)
Fig: XRD pattern of F1 and F2.
Conclusion:
Iron oxide nanoparticles
was
successfully synthesized by co-precipitation route at pH
neutral for biomedical applications. Size and phase
dependent characterization are comparatively studied
with coated and uncoated particles.
Acknowledgment: We thank the Head of Department
of Physics and UGC for Maulana Azad National
Fellowship.
References
[1] J.A. Lopez, F. Gonzalez, F.A. Bonilla, G. Zambrano,
M.E. Gomez, “Synthesis and Characterization of Fe3O4
nanoparticles
Magnetic
Nanofluid”,
Revista
Latinoamericana de Metalurgia Y Materials, 30(1),
2010,pp.60-66.
[2] J. Sun, S Zhou, P. Hou, Y. Yang, J. Weng, X. Li, M.
Li, “Synthesis and characterization of biocompatible
Fe3O4 nanoparticles ” ,J.Biomedical Materials Research
PartA,2006.
[3] S. Gupta, S.Singh, P. Sharma, “Doping Effect Of
Nickel On Cobalt Ferrite At Varying Temperatures:
Synthesis and Morphology Studies”, Int.J.Engineering
Research & Technology, 2(4), 2013, pp.2629-2633.