Dispatcher recognition of cardiac arrest GRADE grid Criteria Judgements Benefits & harms of the options Problem ○ No Is there a problem priority? What is the overall certainty of this evidence? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies ○ No included studies ● Very low ○ Low ○ Moderate ○ High Research evidence Additional considerations Failure to recognise cardiac arrest during the initial emergency call results in longer dispatch times and lower survival rates. Kuisma et al (2005, 89) reported that when dispatch times were under 60sec survival to discharge was 39.4%, whereas when dispatch time exceeded 60sec survival was reduced to 32.2%. Berdowski et al (2009, 2096) identified that when cardiac arrest was identified by dispatchers survival at 3 months was 14%, but if cardiac arrest was not recognised survival at 3 months was 5%. Gold et al (2009) showed that survival declines on average 3% per minute that EMS is delayed following collapse. If response times are below 4 minutes survival is not adversely impacted; however if response times exceed 5 min survival declines at 5.2% per minute. Relative importance or values of the outcome of interest Outcome Relative importance Dispatcher recognition of cardiac arrest CRITICAL Certainty of the evidence (GRADE) ⨁◯◯◯ VERY LOW ○ Important uncertainty or variability Is there important uncertainty about how much people value the main outcomes? ○ Possibly important uncertainty or variability There is limited evidence to suggest that many patients believe that should they suffer a cardiac arrest that they Most patients would want early identification of will survive with favourable neurologic outcome (Straney et cardiac arrest with rapid EMNS response. Probably no important uncertainty of al 2014). variability ○ ○ No important uncertainty of variability ● No known Criteria Judgements Research evidence Additional considerations undesirable ○ No Are the desirable anticipated effects large? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Implementation of new dispatch protocols to identify cardiac arrest results in improved recognition rates and increased provision of T-CPR. Heward (2004, 114) recognition increased from 15% before to 50% after. Ropollo (2009, 769) missed cardiac arrest cases reduced from 28% before to 18.8% after. Bohm (2009, 1025) provision of T-CPR increased from 47% before to 68% after. The greatest improvements will be seen where no protocols to identify cardiac arrest exist. If protocols exist incremental improvements will be seen with the introduction of training to recognised agonal breathing, and the implementation of quality assurance programs to improve compliance with dispatch protocols. Berdowski (2009, 2096) identified that a 100% sensitive protocol would result in 76% false positive rate. Increasing the number of cases identified as suspected cardiac arrest may identify a need for increased resourcing. Berdowski (2009, 2096) ○ No Are the undesirable anticipated effects small? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Criteria Judgements Research evidence Additional considerations ○ No Are the desirable effects large relative to undesirable effects? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies ○ No Resource use Are the resources required small? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Patients are likely to favour rapid recognition and response by EMS. Clinicians are aware that time to intervention is critical to positive outcome. This needs to be balanced against the resource requirements and the risk of increased sensitivity increasing the number of false positive cases. May require alteration of dispatch software, training of call centre personnel and ongoing quality control/monitoring to ensure adherence to call script questions. There may be resource issues to consider in those systems that favour very high sensitivity within dispatch algorithms. ○ No Is the incremental cost small relative to the net benefits? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Incremental cost is likely to be small in comparison to system maintenance costs. Criteria Judgements Research evidence Additional considerations Equity ○ Increased What would be the impact on health inequities? ● Probably increased ○ Uncertain ○ Probably reduced ○ Reduced ○ Varies Acceptability ○ No Is the option acceptable to key stakeholders? ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Dispatch protocols are likely to result in improved response to all cardiac arrest patients. Patients, clinicians and commissioners of services are likely to favour increasing survival from OHCA with favourable neurologic outcomes. Central to these improvements are rapid identification and treatment. Improved outcomes from cardiac arrest is dependent upon optimising both sensitivity and specificity of dispatch protocols. Increasing sensitivity alone will increase response requirements, increase costs, waste resources and potentially increase risk. Increasing specificity alone will reduce response requirement and reduce costs but at the expense of increasing the number of patients where cardiac arrest is not recognised. Criteria Judgements Research evidence Additional considerations Feasibility ○ No ○ Probably no ○ Uncertain ● Probably yes ○ Yes ○ Varies Is the option feasible to implement? Most EMS systems have established dispatch centers. Improving recognition requires optimising the dispatch process. Recommendation Balance of consequences Type of recommendation Undesirable consequences clearly outweigh desirable consequences in most settings Undesirable consequences probably outweigh desirable consequences in most settings The balance between desirable and undesirable consequences is closely balanced or uncertain Desirable consequences probably outweigh undesirable consequences in most settings Desirable consequences clearly outweigh undesirable consequences in most settings ○ ○ ○ ○ ● We recommend against offering this option We suggest not offering this option We suggest offering this option We recommend offering this option ○ ○ ○ ● We recommend EMS call takers determine if a patient is unconsciousness with abnormal breathing. If the victim is unresponsive with abnormal breathing it is reasonable to assume that the patient is in cardiac arrest at the time of the call. Recommendation We recommend dispatchers are educated to identify unconsciousness with abnormal breathing. This education should include recognition and significance of agonal breathing across a range of clinical presentations. STRONG recommendation. VERY LOW quality evidence Two observational studies (Kuisma 2005, 89; Berdowski 2009, 2096) indicate that when cardiac arrest is not recognised, dispatch intervals are longer and survival to discharge is reduced. Seven observational studies (Eisenberg 1985, 47; Cairns 2008, 349; Deakin 2010, 853; Flynn 2006, 72; Garza 2003, 955; Ma 2007, 236 and Vaillancourt 2007, 877) report that sensitivity of dispatch protocols to recognise cardiac arrest ranges from 38% to 96.9%, two of these same studies indicate that specificity exceeds 99% (Deakin 2010, 853 & Flynn 2006, 72). Positive predictive values range from 45.2% to 97.9% (Cairns 2008, 349; Deakin 2010, 853; Flynn 2006, 72; and Ma 2007, 236), while the negative predictive value approaches 100% (Deakin 2010, 853; Flynn 2006, 72). A case control study (Berdowski 2009, 2096) reported that 29% of cardiac arrest calls were not identified during the initial call, and furthermore that 24% of calls categorised as cardiac arrest were in fact not cardiac arrest cases. A cluster randomised controlled trial determined that dispatchers ‘gut feeling’ did not compare well with AMPDS triage (Weiser 2013, 883). Scripted dispatch protocols to identify patients who are unconscious with abnormal breathing help to increase cardiac arrest recognition. In one observational study recognition increased from 15 to 50% (Heward 2004, 115), while in another the provision of dispatcher-prompted CPR rose from 45% to 56% (Eisenberg 1985, 47). More recently, a before-after study reported increased rates of telephone CPR (9.9% to 22.5%) after introduction of a rigid new protocol (Stipulante 2014, 177). Modifying existing seizure protocols to identify abnormal breathing may also be beneficial; in one study a new question added to the seizure protocol resulted in an increase in ‘high acuity’ calls from 53% to 77% and increased provision of telephone CPR (Clawson 2008, 257). Justification Recognition of unconsciousness with abnormal breathing is central to dispatcher recognition of cardiac arrest. Many terms may be used to describe abnormal breathing: difficulty breathing, poorly breathing, gasping breathing, wheezing , breathing, impaired breathing (Bång 2003, 25), occasional breathing, barely/hardly breathing, heavy breathing, laboured or noisy breathing, sighing, strange breathing (Berdowski 2009, 2096). Agonal breathing has been reported in approximately 30% of cases (Bohm 2007, 256) which can make obtaining an accurate description of the patients breathing pattern challenging for call takers. One study identified that agonal breathing was present in 50% of non-identified cardiac arrest calls (Vaillancourt 2007, 877), while another (Clark 1994, 1022) noted that patients were reported to be conscious and breathing in 27/117 cardiac arrest cases. Other terms that may help identify possible cardiac arrest cases include “dead”, “is dead”, “cold and stiff”, “blue”, “grey” or “pale”. The aforementioned descriptions may however be limited owing to cultural influences and language translation limitations (Bång 1999, 175). Educating call takers to recognise patients who are unconscious with abnormal breathing assists call takers to recognise those patients who may be in cardiac arrest. A before-after study demonstrated an increase in the provision of telephone CPR from 47% to 68% (Bohm 2009, 1025). Two further observational studies indicate that educating call takers to recognise unconsciousness and abnormal breathing reduce the incidence where telephone CPR was not provided by more than 32% (Ropollo 2009, 769; Tanaka 2012, 1235). Failure to recognise cardiac arrest may be associated with failure to follow protocol and ask questions about consciousness and breathing (Castren 2001, 265; Hallstrom 2003, 123; Dami 2010, 848). One study reported an 83% identification rate overall (80% when abnormal breathing, 89% when breathing was absent), however when breathing was not described to the dispatcher this was reduced to 69% (Nurmi 2006, 463). Strict adherence to dispatch protocol would have resulted in a 74% false positive rate in one study (Berdowski 2009, 2096). Subgroup considerations Implementation considerations Training call takers/dispatchers to recognise and understand the significance of agonal breathing. Monitoring and evaluation Audit of protocol compliance and monitoring of appropriate dispatch coding should be encouraged. High quality data from randomized controlled trials are currently lacking. Further studies are required to determine: Research possibilities Which key words used by callers are associated with cardiac arrest? Impact of adherence to/failure to follow dispatch protocols Most appropriate educational content to ensure dispatchers are able to recognise the significance of abnormal and agonal breathing Most appropriate refresher training interval for dispatchers Is there a difference in recognition rates between dispatchers with a clinical background vs those without a clinical background?