OIE Collaborating Centre Reports Activities in 2013 Title of Collaborating Centre: Address of Collaborating Centre: Food Safety The University of Tokyo Graduate School of Agricultural and Life Sciences 1-1-1 Yayoi, Bunkyo-ku, Toyo 113-8657 Japan Tel.: +81-3-5841-5383 Fax: +81-3-5841-5191 e-mail address: website: aksugiur@mail.ecc.u-tokyo.ac.jp http://www.frc.a.u-tokyo.ac.jp/ Name of Director of Institute (Responsible Official): Professor Tsutomu Sekizaki Name (including Title and Position) of Head of the Collaborating Centre (formally OIE Contact Point): Professor Katsuaki Sugiura Name (including Title and Position) of writer of this report (if different from above) Annual reports of OIE Reference Centres, 2013 1 Food Safety Summary of activities specifically related to the mandate of OIE Collaborating Centres ToR: To provide services to the OIE, in particular within the region, in the designated specialty, in support of the implementation of OIE policies and, where required, seek for collaboration with OIE Reference Laboratories ToR: To identify and maintain existing expertise, in particular within its region 1. Activities as a centre of research, expertise, standardisation and dissemination of techniques within the remit of the mandate given by the OIE Disease control Epidemiology, surveillance, risk assessment, modelling Training, capacity building Zoonoses Wildlife Avian diseases Aquatic animal diseases Animal welfare Diagnosis, biotechnology and laboratory Veterinary medicinal products Vaccines Food safety Feed safety Other (Name the category: ) DIAGNOSIS, BIOTECHNOLOGY AND LABORATORY Dissemination of techniques Prof. Hirokazu Tsubone gave a lecture on 'Surveillance of mycotoxin contamination in food in Japan and experimental studies on toxicities of deoxynivalenol and T2 toxin', in a seminar for collaboration between the University of Tokyo and Konkuk University in veteinary medical siciences, held at Konkuk University, Korea on 23 December 2013 Prof. Takashi Onodera gave a lecture about 'Food Safety System for new emerging viral disease in Japan', on August 13, in Harbin Veterinary Research Institute, Harbin, China, and gave a slide seminar for Akabane and PRRS diseases. Prof. Takashi Onodera gave a lecture about 'Japanese Food Safety Commission activity', on August 21, in University of Tokyo Liaison Office in Beijing. Audiences were University Officers in Beijing University ,Tsinghua University, and University of Tokyo Aluminum Society in Beijing. 2 Annual reports of OIE Reference Centres, 2013 Food Safety ToR: To propose or develop methods and procedures that facilitate harmonisation of international standards and guidelines applicable to the designated specialty 2. Proposal or development of any procedure that will facilitate harmonisation of international regulations applicable to the surveillance and control of animal diseases, food safety or animal welfare Proposal title Non Scope/Content Applicable area Non Surveillance and control of animal diseases Food safety Animal welfare ToR: To establish and maintain a network with other OIE Collaborating Centres designated for the same specialty, and should the need arise, with Collaborating Centres in other disciplines ToR: To carry out and/or coordinate scientific and technical studies in collaboration with other centres, laboratories or organisations 3. Did your Collaborating Centre maintain a network with other OIE Collaborating Centres (CC), Reference Laboratories (RL), or organisations designated for the same specialty, to coordinate scientific and technical studies? Yes 4. No Did your Collaborating Centre maintain a network with other OIE Collaborating Centres, Reference laboratories, or organisations in other disciplines, to coordinate scientific and technical studies? Yes No ToR: To place expert consultants at the disposal of the OIE. 5. Did your Collaborating Centre place expert consultants at the disposal of the OIE? Yes ToR: No Name of expert Kind of consultancy Subject Dr Kazuhiro Hirayama Participation in workshop Participation and presentation on 'Trends in bacterial food-borne diseases and possible control by normal and beneficial bacteria' in APHCA-OIE Workshop: Zoonoses, Food-borne Diseases and Antimicrobial Resistance Incidence, Impact and Interventions in the Asia-Pacific Region, held in Thimphur, Bhutan on 24-25 September 2013 To provide, within the designated specialty, scientific and technical training to personnel from OIE Member Countries Annual reports of OIE Reference Centres, 2013 3 Food Safety 6. Did your Collaborating Centre provide scientific and technical training, within the remit of the mandate given by the OIE, to personnel from OIE Member Countries? Yes No If the answer is yes, please provide the total number of trained persons for each of the following categories: a) Technical visits: ................................................................ 0 b) Seminars: ......................................................................... 0 c) Hands-on training courses: .............................................. 0 d) Internships (>1 month): ................................................... 0 ToR: To organise and participate in scientific meetings and other activities on behalf of the OIE 7. Did your Collaborating Centre organise or participate in the organisation of scientific meetings on behalf of the OIE? Yes No ToR: To collect, process, analyse, publish and disseminate data and information relevant to the designated specialty 8. Publication and dissemination of any information within the remit of the mandate given by the OIE that may be useful to Member Countries of the OIE (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: ................. 21 Ohkochi M, Koseki S, Kunou M, Sugiura K, Tsubone H. Growth modeling of Listeria monocytogenes in pasteurized liquid egg. J Food Prot. 2013 Sep;76(9):1549-56. doi: 10.4315/0362-028X.JFP-12-524. Hosoi Y, Asai T, Koike R, Tsuyuki M, Sugiura K. Use of veterinary antimicrobial agents from 2005 to 2010 in Japan. Int J Antimicrob Agents. 41:489, 2013. Lee KI, Kobayashi N, Watanabe M, Sugita-Konishi Y, Tsubone H, Kumagai S, Hara-Kudo Y. Spread and change in stress resistance of Shiga toxin-producing Escherichia coli O157 on fungal colonies. Microb Biotechnol. 2013 Aug 6. doi: 10.1111/1751-7915.12071. Ngampongsa S, Hanafusa M, Ando K, Ito K, Kuwahara M, Yamamoto Y, Yamashita M, Tsuru Y, Tsubone H. Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats. J Toxicol Sci. 2013;38(3):495-502. Sakudo, A. and Onodera, T.: Bovine spongiform encephalopathy agent. Manual of Security Sensitive Microbe and Toxins. Chapter 53, Edited by Dongyou Liu, CRC Press, pp. 611-624, 2013. Onodera, T. and Sakudo, A.: Prions, Molecular Biology of Foodborne Viral Pathogens, CRC Press, Edited by Don Liu, 2013. Ano, Y., Sakudo, A., Uraki, R., Kono, J., Yukawa, M., and Onodera, T.: Intestinal transmission of prion proteins and role of exosomes in enterocytes. Food Safety 1(1): p2013005, 2013. Nah,J., Pyo, J.O., Jung, S., Yoo, S.M., Kam,T.I., Chang, J., Han, J., An, S.S.A, Onodera, T. and Jung, Y.K.: BECN1/Beclin1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β42. Autophagy 9: (12)1-13, 2013. 4 Annual reports of OIE Reference Centres, 2013 Food Safety Uchio-Yamada, K. Sawada, K., Tamura, Katayama, S., Sonobe, Yamamoto, Y., Ogura, A., Manabe, N. Tenc1 deficient mice develop glomerular disease in a strain-specific manner. Nephron, 123: 22-33, 2013. Tamura, K., Uchio-Yamada, K., Manabe, N., Noto, T., Hirota, R., Matsumoto, M., Miyamae, Y. Gene expression analysis detected low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice. Nephron, 123: 34-45, 2013. Tsubone, H., Hanafusa, M., Endo, Manabe, N., Hiraga, A., Aida, H. Effect of treadmill exercise and hydrogenrich water intake on serum oxidative and antioxidative metabolites in serum of thoroughbred horses. J. Equ. Sci. 24: 1-8, 2013. Hori, Y., Ozaki, Y., Ito, S., Yamada, Y., Tozaki, T., Manabe, N., Murayama, K., Fujita, F. Breed differences in dopamine receptor D4 gene (DRD4) in horses. J. Equ. Sci. 24: 31-36, 2013. Hori, Y., Ozaki, Y., Ito, S., Yamada, Y., Tozaki, T., Manabe, N., Murayama, K., Fujita, F. Analysis of oxytocin receptor gene polymorphism in horses. J. Gene Polymorph. 21: 35-38, 2013. Rátky, J., Egerszegi, I., Toth, P., Keonuchan, P., Nagai, T., Kikuchi, K., Manabe, N. Saving genetic resources of native pigs in occidental and oriental countries: Practical examples of the characterization and utilization of native pigs in Hungary and Laos. J. Reprod. Dev. 59: 437-441, 2013. Linh, N., Kikuchi, K., Nakai, M., Noguchi, J., Kaneko, T., Dang-Nguyen, Q., Somfai, T., Nguyen, B., Nagai, T., Manabe, N. Fertilization ability of porcine oocytes reconstructed from ooplasmic fragments produced and characterized after serial centrifugations. J. Reprod. Dev. 59: 549-556, 2013. Manabe, N., Wongpanit, K., Jin, H., Taniguchi, K., Jin, H. Abnormalities of ovarian and testicular function in senescence accelerated mice. In: The Senescence-Accelerated Mouse (SAM): Achievements and Future Directions, Takeda, T. eds, Elsevier Science Publishers, The Nederland, pp273-286, total page580, 2013. Manabe, N., Takahashi, T., Onoyama, I., Endo, M., Li, J. Changes in the transfer of fallout radiocesium from pasture harvested in Ibaraki Prefecture, Japan, to cow milk two months after the Fukushima Daiichi nuclear power plant accident. In: Agricultural Implications of the Fukushima Nuclear Accident. Nakanishi, T. eds., Springer, , Germany, pp 87-95, total page 204, 2013. Sato, S., Takata Y., Kondo, S., Kotoda, A., Hongo, N., Kodama, M. Quantitative ELISA kit for Paralytic Shellfish Toxins coupled with sample pretreatment. JAOAC in press Islam S., Kusakabe M., Horiguchi K., Iino S., Nakamura T., Iwanaga K., Hashimoto H., Matsumoto S., Murata T., Hori M., Ozaki H., PDGF and TGF-beta promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice, British J Pharmacol., 2013, in press Ookubo T., Inoue Y., Kim D., Ohsaki H., Mashiko Y., Kusakabe M., Sekino M., Characteristics of Magnetic Probes for Identifying Sentinel Lymph Node. Conf Proc IEEE Eng Med Biol Soc., (2013), 2013:5485-5488. Shiozawa M., Lefor AT., Hozumi Y., Kurihara K., Sata N., Yasuda Y., Kusakabe M., Sentinel lymph node biopsy in patients with breast cancer using superparamagnetic iron oxide and a magnetometer. Breast Cancer. (2013) 20:223-229 b) International conference presentations: ......................... 0 c) National conference presentations: ................................ 0 d) Other: ............................................................................... 0 _______________ Annual reports of OIE Reference Centres, 2013 5