APPENDIX A: EXPERIMENT RECONSTRUCTIONS WITH THUMS Table A1. Reported and predicted peak values for lateral head impact. Physical test1 Measurement Physical test1 THUMS Unpadded-9221 HIC Head CG resultant acceleration (g) Angular acceleration about X THUMS Padded-9217D 1894-3850 3141 473-690 741 276-502 402 115-196 164 2324-6035 8206 3390-4677 3610 11441-14175 1230 2312-5676 5078 7546-11662 10498 6868-7409 5582 33.3-42.5 40.3 25-27 20 (rad/s^2) Angular acceleration about Z (rad/s^2) Impactor force (N) Impactor linear acceleration (g) 1 Reported in McIntosh et al. (1993) 150 McIntosh et al. Simulation 300 Acceleration (g) Acceleration (g) 375 225 150 75 McIntosh et al. Simulation 125 100 75 50 25 0 0 0 0.002 a) 0.004 0.006 0.008 0 0.01 Time (s) 0.002 0.004 0.006 0.008 0.01 0.012 Time (s) b) Figure A1. Head CG resultant accelerations obtained experimentally (one subject per curve) and predicted for THUMS for a) unpadded (9221) and b) padded (9217D) lateral head impacts after McIntosh et al. (1993). Table A2. Cross-correlation analysis results for lateral head impact THUMS vs McIntosh1 Signals compared Response curve Evaluation metric Unpadded-9221 Padded-9217D Head resultant cg acceleration Head resultant cg acceleration Magnitude 0.79 0.75 Shape 0.91 0.96 Phase (ms) 0.05 -0.17 1 Reported in McIntosh et al. (1993) a) b) c) d) Figure A2. Resultant head cg acceleration (a,c) and T1 force (b,d) traces and corridors obtained experimentally and predicted using FEM for inverted head impacts against a horizontal (a,b) (0) and anteriorly inclined (c,d) (15) rigid surface after Nightingale et al. (1996) and reported by Camacho et al. (1997). Table A3. Cross-correlation analysis results for inverted impact THUMS vs Nightingale corridor mean1,2 Signals compared 0 inclination Response curve 15 anterior inclination Head resultant cg accel T1 resultant force Head resultant cg accel T1 resultant force Magnitude 0.26 0.83 0.88 0.79 Shape 0.96 0.92 0.84 0.94 Phase (ms) 0.48 0.01 0.67 0.10 Corridor 0.08 0.50 0.10 0.63 Evaluation metric 1 Test performed by Nightingale et al. (1996) 2 Corridors calculated in Camacho et al. (1997) Toomey et al. Simulation Toomey et al. Simulation 5 75 4 Force (kN) Moment (Nm) 100 50 25 3 2 1 0 0 -25 0 0.004 a) 0.008 0.012 Time (s) 0.016 0 0.02 0.004 0.008 b) 0.012 0.016 0.02 Time (s) Figure A3. T1 sagittal plane moment (a) and resultant force (b) traces obtained experimentally (one subject per curve) and predicted using FEM for inverted head impacts against a laterally inclined (15) rigid surface after Toomey et al. (2009) Table A4. Cross-correlation analysis results for laterally inclined inverted impact THUMS vs Toomey 15 lateral inclination1 Signals compared Test 1 Test 3 T1 sagittal moment T1 resultant force Magnitude 0.79 0.75 Shape 0.85 0.91 Phase (ms) -0.05 -1.2 Response curve Evaluation metric 1 Reported in Toomey et al. (2009) APPENDIX B: SIGNAL CORRELATION ANALYSIS METHODOLOGY The following definitions were used to quantify the similarity between two signals, x(t) and y(t). Magnitude correlation: ∞ 𝑀= ‖𝑥‖ ∫−∞ 𝑥 2 (𝑡)𝑑𝑡 = ‖𝑦‖ ∫∞ 𝑦 2 (𝑡)𝑑𝑡 −∞ where M = 1 corresponds to identical magnitudes. Shape correlation: 𝑆 = 𝑠 2 (𝑥, 𝑦, ℎ) for which h is chosen to maximize s(x,y,h) and where ∞ 𝑠(𝑥, 𝑦, ℎ) = ∫−∞ 𝑥(𝑡)𝑦(𝑡 + ℎ)𝑑𝑡 ∞ ∞ √∫−∞ 𝑥 2 (𝑡)𝑑𝑡 ∫−∞ 𝑦 2 (𝑡)𝑑𝑡 Phase shift: P=h where h is chosen for which s(x,y,h) reaches its maximum value. Corridor rating: 𝑖𝑓 |𝑦(𝑡𝑖 ) − 𝑥(𝑡𝑖 )| < 𝛿𝑖 (𝑡) 1 𝛿𝑜 (𝑡) − |𝑦(𝑡𝑖 ) − 𝑥(𝑡𝑖 )| ) 𝛿𝑜 (𝑡) − 𝛿𝑖 (𝑡) 0 { 𝑘 𝑐𝑖 = ( 𝐶= 𝑤𝑖𝑡ℎ 𝑘 ∈ 𝑁>0 𝑖𝑓 |𝑦(𝑡𝑖 ) − 𝑥(𝑡𝑖 )| > 𝛿𝑜 (𝑡) ∑𝑛𝑖=1 𝑐𝑖 𝑛 Figure 1. Impact vectors (left) and 45 anterolateral setup (right). Figure 2. Boxplots of injury measure outputs (rows) according to impact parameters (columns). Statistical significance (p < 0.05) is identified with grey shading. Figure 3. Boxplots of injury measure outputs (rows) according to impact orientation (columns). Statistical significance (p < 0.05) is identified with grey shading. BrIC lateral BrIC anterolateral T1 axial force anterior BrIC anterior T1 axial force lateral T1 axial force anterolateral Percent of maximum 100% 80% 60% 40% 20% 0% 0 15 30 45 Lateral/Anterior/Anterolateral angle (deg) Figure 4. Peak brain and cervical-spine injury measures according to impact orientation in impacts at 6m/s and 127 mm of displacement. Maximum principal strain Cerebrum 0.5 Cerebellum Brainstem CSDM0.1=0.636 0.4 0.3 0.2 0.1 0 Maximum principal strain 0.5 CSDM0.1=0.131 0.4 0.3 0.2 0.1 0 0 0.02 Time (s) 0.04 Figure 5. Scatter plot of peak strain values recorded for each brain element (n=15212) in simulations with the greatest (top) and least (bottom) CSDM0.1 values. Table 1. Magnitude of factor levels for impact conditions Factor Levels Velocity (m/s) 4, 5, 6 Displacement (mm) 31.75, 63.5, 127 Orientation (deg) Anterior Lateral 0, 15, 30, 45 Anterolateral Note that the 0 angle for each orientation represents the same condition.