Human Genetics – BIO 275
Mondays and Wednesdays 3:30 – 4:45 pm
August 31st to December 9th, 2015
Classroom: MLS 105
Book: Human Genetics (10th Edition) by Lewis
ISBN: 0073525308
Dr. Amanda Yonan
amanda.yonan@uvm.edu
802-656-0454
102 Marsh Life Science
Office Hours:
Tuesday
11:30 to 2 pm
Wednesday 2 to 3:30 pm
Thursday
11:30 to 2 pm
Grades:
Homework 20 x 10
Exams
3 x 100
Final
Pedigree
Paper presentation
190
300
200
50
50
790
24%
38%
25%
6%
6%
100%
Homeworks will be assigned in class, worth 10 points each. Homework will be collected
at the beginning of the next class and will be graded for completion and correctness. I
will drop the lowest scoring homework. Because of this there will be no make-ups and
no late homework allowed, under any circumstances.
There will be three exams throughout the semester, worth 100 points each.
The final will be cumulative and will be worth 200 points.
There will be a pedigree assignment worth a possible 50 points, this assignment will be
discussed in class.
Each student will have to present one primary literature paper to the class during the
semester. The details of this assignment will be discussed in class and the date of the
presentation will be dependent on student’s last name, the schedule will be finalized
after the add/drop date has passed.
Schedule (subject to change):
Date
31-Aug
2-Sep
Day
M
W
Chapter
1
3
Topic
Introduction and Genetics Review
Human Development
7-Sep
9-Sep
M
W
4
Labor Day Holiday
Mendelian Genetics
Non-mendelian Genetics and
Student Presentations
Linkage Analysis
14-Sep
16-Sep
M
5
W
handout
21-Sep
M
-
W
6
28-Sep
30-Sep
M
W
7
Exam 1 (Chapters 1-6)
Multifactoral Traits
5-Oct
M
8
W
11
Behavorial Traits
Gene Expression and
Student Presentations
M
-
Epigenetics
W
12 and 13
Mutations and Chromosomes
19-Oct
21-Oct
M
W
13
-
Chromosomal Abnormalities
Student Presentations
26-Oct
M
-
Exam 2 (Chapters 7, 8, 11-13)
W
14 and 15
Alleles Constant and Changing
M
-
W
16
Population Genetics
Human Evolution and
Student Presentations
9-Nov
11-Nov
M
W
17
18
Immunity
Cancer
16-Nov
18-Nov
M
W
-
Student Presentations
Exam 3 (Chapters 14-18)
23-Nov
25-Nov
M
W
-
Thanksgiving Break
Thanksgiving Break
30-Nov
M
20
W
21
Gene Therapy
Reproductive Tech and
Student Presentations
7-Dec
9-Dec
M
W
22
-
Human Genomics
Final Review
14-Dec
M @ 10:30
All
FINAL EXAM (Chapters 1-22)
23-Sep
7-Oct
12-Oct
14-Oct
28-Oct
2-Nov
4-Nov
2-Dec
Discuss Pedigrees
Linkage Analysis - Homework
Influence of Sex and
Student Presentations
Pedigrees Due
Grade of:
A+
> 99%
A
= 92 to 98.9%
A= 90 to 91.9%
B+
= 88 to 89.9%
B
= 80 to 87.9%
B= 78 to 79.9%
C+
= 76 to 77.9%
C
= 69 to 75.9%
C= 67 to 68.9%
D+
= 65 to 66.9%
D
= 57 to 64.9%
D= 55 to 56.9%
F will be anything less than 55%
Accommodations:
If you have a disability and need accommodations, please contact ACCESS for an
accommodation letter and see me during the first few class sessions to discuss details.
Behaviors:
This is a college course, as so I expect every student to be an adult and to act as one in
class. Some examples include but are not limited to:
Treat each other and myself with respect.
Turn off cell phones before class.
Turn off any iPOD or music and remove headphones before class.
Do not talk excessively or loudly while someone else is speaking
If you arrive to class late or need to leave early please move as quietly as possible, walk
behind the projector, sit in the back of class or near the aisle, in general please try to not
be an interruption to the other students who have arrived on time.
Cheating:
Cheating is completely unacceptable under any circumstances and will result in your
immediate failure from my class. You are responsible for having read the “Code of
Academic Integrity” and for abiding by its rules in this classroom and on this campus:
Offenses against academic integrity are any acts which would have the effect of unfairly
promoting or enhancing one's academic standing within the entire community of learners.
Such acts are serious offenses, which insult the integrity of the entire academic community
of the University. Any suspected violations of the policy will not be tolerated and all
allegations will be forwarded to the Center for Student Ethics & Standards.
http://www.uvm.edu/~cses/
Presentation Schedule (Will most likely change):
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
Date
14-Sep
14-Sep
14-Sep
14-Sep
23-Sep
23-Sep
23-Sep
23-Sep
7-Oct
7-Oct
7-Oct
7-Oct
21-Oct
21-Oct
21-Oct
21-Oct
21-Oct
21-Oct
4-Nov
4-Nov
4-Nov
4-Nov
16-Nov
16-Nov
16-Nov
16-Nov
16-Nov
16-Nov
2-Dec
2-Dec
2-Dec
2-Dec
Paper - Author
Mendel
Collins
Ottman et al
Cookson et al
Mayuex
Gilliam et al
McCarthy
Savic et al
White et al
Cohn et al
Joober et al.
Gejman et al
Borgatti et al
Beckmann et al
Arai et al
Messenger et al
Brooks et al
Gatchel et al
Yonan et al
Yood et al
Sakate te al
Bauduer et al
Knight
Jirincy
Bartek et al
Tadic et al
Noble
Onishi et al
Simpson et al.
Bank
Antonarakis et al.
Peterson
Paper - Title
http://www.mendelweb.org/Mendel.html
Genetics of Cystic Fibrosis
LG1 mutations in autosomal…
How Genetic Research …
Mapping the new frontier…
...linked to Huntington's disease
Sexual Differentiation of the Brain
**click on link on Bb
Human eye color
Heterozygotes for CF
Genetics of developmental…
Genetics of Schizophrenia
characterization of promoter sequences
Copy number variants and genetic…
Transgenerational epigenetics
A missense mutation in…
…monosomy 13q and trisomy 16q…
Diseases of unstable repeat…
Hardy-Weinberg disequilibrium…
Racial differences LDL goals
Mapping of chimpanzee full-length…
The Basques: a review of…
…Immune response
Multifaceted Mismatch Repair..
The Stress of finding NEMO
A monoamine oxidase B gene…
Immunogenetics of type 1 diabetes
Epigenetic regulation...pluripotency
PGD for hertiable neoplasia
Hematopoietic stem cell gene therapy…
Mendelian disorders deserve…
ART equal access…
Student
Hurlburt, Vicky V.
Kostin, Susan F.
McElroy, Kendall A.
McGarvey, Daniel R.
McHale, Ian J.
Miller, Zach D.
Mitchell, Megan J.
O'Hayre, Shannon J.
Overton, Katrina A.
Peets Ii, Mark A.
Provencher, Curtis A.
Richer, Julie A.
Ryan, Mackenzie H.
Shafique, Sonya
Solcz, Dana R.
Apfelbaum, Hannah L.
Ayer, Mitchel
Banfer, Brittney L.
Belanger-Deloge, Ray M.
Brugger, Ryan T.
Bullock, Sarah A.
Campbell, Libby L.
Casey, Ursula M.
Caveney, Brennen C.
Cayton, Colby P.
Chamberland, Lisa
Cooke, Patrick T.
Curran, Eric J.
DeVito, Breanna M.
Fredericksen, Rachel M.
Gomella, Michael G.
Hulbert, Samantha