Center for Environmental Genetics Symposium
Tuesday, May 21, 2013
10:00 a.m. – 3:00 p.m.
Kehoe Auditorium, Kettering Laboratory
Morning Session:
Dr. Shuk-Mei Ho, Chair and Introductions
10:00 – 11:00
Gregory A. Grabowski
The human genome: Era of clinical genomics and personalized medicine
Dr. Grabowski has been Professor of Pediatrics, and Molecular Genetics, Biochemistry and
Microbiology at UCCOM and Director of the Division of Human Genetics (DHG) at CCHMC
since July 1992. He has built the DHG from 2 faculty to 33 that represent major aspects of
Human Genetics clinically and at a basic level. His primary interest is in the field of lysosomal
disease and glycosphingolipid metabolism in which he has published over 300 scientific
papers. He currently serves as a Member (Treasurer) of the American College of Genetics and
Genomics. He also has philanthropic activities in Egypt, China, Cuba, and South America. Dr.
Grabowski's talk will focus on basic introduction to genomic structure, translation, transcription,
and the evolving concepts of genomic organization and gene expression.
11:00 – 12:00
Daniel W. Nebert
Genetics, genomics, and predicting risk in 'personalized medicine’
Daniel W Nebert has been professor in the Department of Environmental Health since
December, 1989. He also has been Adjunct Professor in the Department of Pediatrics and
Molecular Developmental Biology since 1991 and in the Division of Human Genetics, headed
by Professor Grabowski, when it was initially formed. Author and coauthor of more than 600
publications, Dr. Nebert has written numerous reviews and given international and national symposium talks on
the topics of "human pharmacogenetics" (gene-drug interactions) since the 1970s and "human
pharmacogenomics" (interactions of drugs with the entire human genome) since the end of the 1990s. His talk
will explore the feasibility of predicting genetic risk of susceptibility to drug toxicity, as well as environmental
toxicant toxicity, in the individual patient, worker or volunteer subject.
12:00 – 1:00 Lunch
Afternoon Session:
Pilot Projects—Drs. Jagjit Yadav and Aimin Chen, Chairs
1:00
Mario Medvedovic
1:20
Sohaib Khan
1:40
2:00
Ying Xia
Eileen Alexander
2:20
Erin Haynes
Statistical methods and computational infrastructure for gene-environment
interaction studies utilizing mRNA-seq data
Bisphenol-A exposure and epigenetic changes during developing mouse
mammary gland
Developmental toxicity of endocrine disrupting chemicals
Environmental and genetic contributions to the risk of eosinophilic
esophagitis by analysis of families and twins
Community-engaged research in East Liverpool, Ohio
For more information contact Elizabeth Kopras at koprasej@uc.edu or 513-558-3625.