CURRICULUM VITAE Reid J. Robison, MD, MBA POSITION TITLE: Director of Clinical Research OFFICE ADDRESS: Clinical Methods LLC 676 E. Vine St. #5 Salt Lake City, Utah, United States PROFESSIONAL LICENSURE: SPECIALIZATION: CONTACT INFORMATION: Telephone: 801-290-5320 Fax: 801-290-5321 e-Mail: reid@clinicalmethods.com Utah, State License- Physician (MD), #370399-1205 Utah, Controlled Substance-Physician (MD), #370399-8905 Utah, DEA Certificate- Physician (MD), #FR0068052 Idaho, State License- Physician (MD), 10016 exp. 6/30/12 Psychiatrist EDUCATION/TRAINING: DEGREE INSTITUTION AND LOCATION (if applicable) YEAR(s) FIELD OF STUDY University of Utah School of Medicine Salt Lake City, Utah Postdoctoral Fellow 2009-2010 Biomedical informatics NLM training grant University of Utah School of Medicine (Center for Clinical & Translation Science) Salt Lake City, Utah Research Fellow 2008-2009 Clinical Investigation University of Utah Department of Psychiatry Salt Lake City, Utah Co-Chief Resident 2007-2009 Psychiatry University of Utah School of Medicine Salt Lake City, Utah Resident University of Utah School of Medicine Salt Lake City, Utah Intern Univeristy of Utah, Salt Lake City, Utah M.B.A University of Utah School of Medicine Salt Lake City, Utah M.D. Brigham Young University Provo, Utah B.S. Updated 21 Sept 2011 Initials___________________ 2006-2009 Psychiatry 2005-2006 Psychiatry 2001-2005 Business Administration 2001-2005 Medicine 1994-2001 Neuroscience Page 1 of 9 POSITIONS AND EMPLOYMENT: 2011 – Present Partner and Director of Clinical Research, Clinical Methods LLC, Salt Lake City, UT 2011 - Present Medical Director, Consultation-Liaison Psychiatry, Intermountain Medical Center, Murray, UT 2007 – 2010 Consulting Psychiatrist, Discovery Academy Residential Adolescent Treatment Center, Provo, UT 2010 - Present Consulting Psychiatrist, Utah Health & Human Rights Project (Refugees & torture survivors), Salt Lake City, UT 2009 - 2011 Clinical Instructor, University of Utah Department of Psychiatry, Salt Lake City, UT 2009 – 2011 Associate Director, University of Utah Healthcare Psychiatry Research Clinic, Clinical Trials Salt Lake City, UT 2007 - 2009 Consulting Psychiatrist (Youth Sex Offenders), Pinecreek Ranch, Ascent Inc. Springville, UT 2007 - 2009 Consulting Psychiatrist (Youth Substance Abuse), Ascent Country Residential, Ascent Inc., Springville, UT 2007 - 2009 Consulting Psychiatrist (Youth Sex Offenders), Oxbow Academy, (Telepsychiatry) Wales, UT 2006 - 2007 Outpatient Psychiatrist, Comprehensive Psychological Services, Salt Lake City, UT 2006 - 2007 Physician Associate, University of Utah Neuropsychiatric Institute, Salt Lake City, UT 06/01/2010 American Board of Psychiatry & Neurology (Psychiatry), Board Certified OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS: 2009 - Present 2008 - Present 2008 - Present 2008 - 2009 2005 - Present 2005 - Present 2010 - Present 2010 - Present 2008 - 2009 2007 - 2008 2003 - 2004 2006 – Present Updated 21 Sept 2011 Member, American Society of Clinical Psychopharmacology Member, Public Population Project in Genomics Member, International Genetic Epidemiology Society Member, American Society of Human Genetics Member, Utah Psychiatric Association Member, American Psychiatric Association State Refugee Health Committee Member, Utah State Government, Salt Lake City, UT Utah Refugee Conference, Organizing Committee Member Resident Board Representative, Utah Psychiatric Association, Salt Lake City, UT Co-Chief Resident, University of Utah Department of Psychiatry, Salt Lake City, UT Vice-Chair, AMA-MSS Region I, Salt Lake City, UT Utah Medical Association Initials___________________ Page 2 of 9 OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS: ADMINISTRATION 2010 – Present 2011 – Present 2009 – Present Editorial / Journal 2010 – Present 2009 – Present Medical Director, Free Mental Health Clinic, Polizzi Foundation, Salt Lake City, UT Medical Director, Consultation-Liasion Psychiatry, Intermountain Medical Center, Murray, UT Associate Director, University of Utah Healthcare Psycgiatry Research Clinic, Salt Lake City, UT Ad Hoc Review, Neuropsychopharmacology Ad Hoc Review, ADHD Attention Deficit Hyperactivity Disorder Journal/ HONORS: 2009 - 2010 2009 - 2010 2008 – 2010 2007 - 2008 2007 – 2008 2004 – 2005 2001 - 2002 1999 - 2001 Career Development Institute in Psychiatry (Standford University) Resident Research Award (University of Utah Department of Psychiatry) Chief Resident Service Award (University of Utah Department of Psychiatry) APIRE/Janssen Research Scholars Award (APA/APIRE) Outstanding Resident Award (University of Utah Department of Psychiatry) Outstanding Poster Award (Society for Computer Applications in Radiology) University Honors (Brigham Young University) Dean's List, College of Biology (Brigham Young University) RESEARCH EXPERIENCE: Year 2009-2011 Indication Major Depressive Disorder Role Sub-I 2009 - 2011 Major Depressive Disorder Sub-I 2009 - 2011 Bipolar I Disorder Sub-I 2009 - 2011 Major Depressive Disorder Sub-I 2010 - 2011 Major Depressive Disorder (MDD) Principal Investigator Updated 21 Sept 2011 Research Project A Phase 2, Multicenter, Randomized, Doubl-blind, Placebo-Controlled Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder A Multicenter, Long-term, Open-Label Study to Assess the Safety and Tolerability of OPC-34712 as Adjunctive Therapy in the Treatment of Outpatients with Major Depressive Disorder Study to Assess the Safety and Efficacy of Olanzapine and Fluoxetine Combination versus Placebo in Patients Ages 10-17 in the Treatment of Major Depressive Episodes Associated with Bipolar I Disorder A Phase 2, Multicenter, Open-Label Study to asssess Safey & Tolerability of OPC-34712 as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder An 8-week, randomized, double-blind, placebocontrolled, parallel-group, multi-center study of the efficacy and safety of agomelatine 0.5 mg and 1 mg sublingual tablets administered once daily Initials___________________ Page 3 of 9 2009 - 2011 Bipolar I Disorder Sub-I 2005 - 2011 Major Depressive Disorder Sub-I 2008 - 2011 Bipolar I Depression Sub-I 2009 - 2011 Major Depressive Disorder Sub-I 2008 - 2010 Bipolar I Disorder Sub-I 2008 - 2010 Generalized Anxiety Disorder Sub-I Bipolar I Depression Sub-I 2008 - 2010 2008 - 2010 Adult ADHD 2009 - 2010 Major Depressive Disorder Sub-I 2006 - 2010 Major Depressive Disorder Sub-I 2006 - 2010 Stuttering Sub-I Updated 21 Sept 2011 Principal Investigator in patients with Major Depressive Disorder (MDD) Study to Assess the Safety and Efficacy of Olanzapine and Fluoxetine Combination Versus Placebo in Patients Ages 10 to 17 in the Treatment of Major Depressive Episodes Associated with Bipolar I Disorder A Long-term, Observational, Multi-center patient Outcome Registry to Collect Data in Patients with Treatment-Resistant Depression A Phase II Randomized, Double-Blind, PlaceboControlled, Flexible-Dose Study to Assess the Safety, Tolerability and Efficacy of RG2417 (Uridine) in the Treatment of Bipolar I Depression A Phase 2, Multicenter, Open-Label Study to asssess Safey & Tolerability of OPC-34712 as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder SCA102833: The Evaluation of LAMICTAL as an Add-on Treatment for Bipolar I Disorder in Children and Adolescents, 10 to 17 years of age A Phase 3, Randomized, Double-blind, Parallel Group, 10-week Placebo Controlled Fixed Dose Study of PD 0332334 and Paroxetine Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder A Phase II Randomized, Double-blind, Placebo Controlled, Flexiable Dose Study to Assess the Safety, Tolerability and Efficacy of RG2417 (Uridine) in the Treatment of Bipolar I Depression A Candidate Gene Case-Control Study of Adult ADHD A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Safey & Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder Randomized Comparison of Outcomes in Patients withTreatment-Resistant Depression who Receive VNS Therapy Administered at Different Amounts of Electrical Charge An 8-week, Double-Blind, Randomized, Multicenter, Flexible-Dose, Placebo Controlled Pilot Study of Pagoclone in Patients with Persistent Developmental Stuttering Followed by a 52-Week Open-Label Extension Initials___________________ Page 4 of 9 2005 - 2010 Major Depressive Disorder Sub-I A Long-term, Observational, Multi-center patient Outcome Registry to Collect Data in Patients with Treatment-Resistant Depression 2008 - 2009 Generalized Anxiety Disorder Sub-I A 52-week Open Label Safety Study of PD 0332334 in Subjects with Generalized Anxiety Disorder 2006 - 2009 Adult ADHD 2008 - 2009 Major Depressive Disorder 2007 - 2008 Adult ADHD Sub-I A study to evaluate the efficacy and safety of PF03654746 in adults with ADHD 2007 - 2008 Generalized Anxiety Disorder Sub-I 2006 - 2008 Bipolar I Sub-I 2006 - 2008 Major Depressive Disorder Sub-I 2006 - 2008 Major Depressive Disorder Sub-I 2007 - 2008 Genotyping CoInvestigator A Multicenter, Randomized, Double-Blind, Placebo and Escitalopram Controlled Trial of the Safety and Efficacy of Pexacerfont (BMS-562086) in the Treatment of Outpatients with Generalized Anxiety Disorder (CN148-015) Efficacy of Aripiprazole in Combination with Lithium or Valproate in the Long Term Treatment of Mania in Patients with Bipolar I Disorder Partially Nonresponsive to Lithium or Valproate Monotherapy (CN138-189) A Multi-Centered, Randomized, Double-Blind, Placebo Controlled Study of the Safety and Efficacy of Aripiprazole as adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder A Multicenter, Randomized, Double-Blind, Placebo and Escitalopram Controlled Trial of the Safety and Efficacy of BMS-562086 in the Treatment of Outpatients with Major Depressive Disorder (CN 148-007-017) Autism Gene Discovery 2007 - 2008 Adult ADHD Principal Investigator 2006 - 2007 Opiate Detoxification Sub-I Updated 21 Sept 2011 CoPrincipal Investigator Sub-I Methylphenidate Transdermal System (MTS) in the Treatment in Adult ADHD Randomized, double-blind, placebo- controlled study of Vilazadone Pgx efficacy, safety andbiomarkers of response in major depression disorder Pharmacogenetics of Adult ADHD in Clinical Trials Seed Grant A Phase III, Randomized, Multi-Center, Double Blind, Placebo-Controlled Study of Safety and Efficacy of Lofexidine for Relief of Symptoms in Subjects Undergoing Inpatient Opiate Initials___________________ Page 5 of 9 Detoxification Adult ADHD Sub-I 2004 - 2007 2002 - 2004 Community Health CoPrincipal Investigator 2003 - 2004 Biomedical Informatics Principal Investigator A Randomized, Double-Blind Comparison of Placebo and Atomoxetine Hydrochloride Given Once a Day in Adults with AttentionDeficit/Hyperactivity Disorder: with a Secondary Examination of Impact of Treatment on Family Functioning (B4Z-US-LYCW) The Utah Rural Outreach Program Pfizer/AAMC Caring for Communities Grant, Association of American Medical Colleges Development of an Informatics Tool for Vendorneutral Collection of Radiological Images for Educational Use PUBLICATIONS: 06/22/2011 Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency. Am J Hum Genet, Rope, A. F., Wang, K., Evjenth, R., Xing, J., Johnston, J. J., Swensen, J. J., Johnson, W. E., Moore, B., Huff, C. D., Bird, L. M., Carey, J. C., Opitz, J. M., Stevens, C. A., Jiang, T., Schank, C., Fain, H. D., Robison, R., Dalley, B., Chin, S., South, S 05/01/2011 Methylphenidate transdermal system in adult ADHD and impact on emotional and oppositional symptoms. J Atten Disord, Marchant, B.K., Reimherr, F.W., Robison, R.J., Olsen, J.L., Kondo, D.G. Long-term open-label response to atomoxetine in adult ADHD: influence of sex, emotional dysregulation, and double-blind response to atomoxetine., 2011. Marchant, B., Reimherr, F., Halls, C., Williams, E., Strong, R., Kondo, D., Soni, P., Robison, R. Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees. Mol Autism, Coon, H., Villalobos, M. E., Robison, R. J., Camp, N. J., Cannon, D. S., Allen-Brady, K., Miller, J. S., McMahon, W. M. Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders. Mol Autism, 2010. Cannon, D. S., Miller, J. S., Robison, R. J., Villalobos, M. E., Wahmhoff, N. K., Allen-Brady, K., McMahon, W. M., Coon, H. Personality disorders in ADHD Part 2: The effect of symptoms of personality disorder on response to treatment with OROS methylphenidate in adults with ADHD. Ann Clin Psychiatry. Personality disorder in ADHD Part 1: Assessment of personality disorder in adult ADHD using data from a clinical trial of OROS methylphenidate. Ann Clin Psychiatry. Gender differences in 2 clinical trials of adults with attention-deficit/hyperactivity disorder: a retrospective data analysis. J Clin Psychiatry Page 6 of 9 Informatics in Initials___________________ radiology (infoRAD): Vendor-neutral case input into a server-based 03/07/2011 2010 2010 05/01/2010 05/01/2010 02/01/2008 Updated11/01/2006 21 Sept 2011 01/03/2003 digital teaching file system. Radiographics. Kamauu, A.C., DuVall, S.L., Robison, R.J., Liimatta, A.P., Wiggins, R.H., Avrin, D.E. Effect of central angiotensin II on body weight gain in young rats. Brain Res. Porter, J. P., Anderson, J. M., Robison, R. J., Phillips, A. C. PUBLISHED ABSTRACTS & POSTER PRESENTATIONS: 2010 2009 2009 2009 2009 2009 2009 2009 2009 2009 2008 Updated 21 Sept 2011 Allen-Brady K, Cannon D, Robison R, McMahon WM, Coon H. A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families [Abstract].Autism Res. Keeshin B, Robison R, Pratt A, Sheetz J. Past Childhood Abuse Among Homeless Youth: Prevalence, Perceived Ongoing Effect and Interest In Treatment [Abstract].American Academy of Child and Adolescent Psychiatry. Williams ED, Kondo D, Reimherr FW, Marchant BK, Halls C, Strong RE, Christopherson DC, Robison RJ, Olsen JL. Oppositional Defiant Disorder Symptoms In An Adult ADHD Trial of Methylphenidate Transdermal System (MTS) [Abstract].American Academy of Child and Adolescent Psychiatry. Robison RJ, Matsunami N, Allen-Brady K, Cannon D, Miller J, Hobbs M, Stevens J, Baird L, Varvil T, Pingree C, Leppert MF, McMahon W, Coon H. Inheritance of 15q11-13 Duplications in Autism Pedigrees [Abstract].American Society of Human Genetics. Coon H, Villalobos M, Robison R, Cannon D, Allen-Brady K, Leppert MF, Miller J, McMahon WM. Genome-wide linkage using the Social Reciprocity Scale (SRS) in Utah autism pedigrees [Abstract].American Society of Human Genetics. Cannon D, McMahon, Allen-Brady K, Miller J, Robison R, Coon H. Chromosome 15 linkage analysis of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders [Abstract].American Society of Human Genetics. Allen-Brady K, Cannon C, Robison R, McMahon W, Coon H. A Unified Theory of Autism Revisited: Linkage Evidence Points to the IL1RAPL1 Gene using a High-Risk Subset of AGRE Families [Abstract].American Society of Human Genetics. Reimherr FW, Marchant B, Williams E, Strong RE, Halls C, Soni P, Robison RJ. Methyphenidate Transdermal System in the Treatment of Adults with ADHD: A Preliminary Report [Abstract].American Psychiatric Association. Robison RJ, Farley MA, Cannon D, Allen-Brady K, Matsunami N, Stevens J, Baird L, Pingree C, Leppert MF, McMahon W, Coon H. Initial Evaluation of Copy Number Variation in a Follow-up of Adults with Autistic Spectrum Disorders: a Behavioral Phenotype-Genotype Study [Abstract].APA Junior Investigator Research Colloquium. Reimherr FW, Marchant BK, Wender P, Roessler M, Robison RJ. Emotional Dysregulation and Oppositional Defiant Disorder in a Clinical Trial of Methyphenidate Transdermal System in the Treatment of Adults with ADHD [Abstract].2nd International Congress on ADHD. Allen-Brady K, Matsunami N, Stevens J, Baird L, Robison R, Cannon D, Miller J, Leppert T, Pingree C, Leppert MF, McMahon W, Coon H. Follow-up of Five Linkage Peaks For Autism in Extended Utah Kindreds [Abstract].American Society of Human Genetics. Initials___________________ Page 7 of 9 2008 Gale P, Reimherr F, Marchant B, Robison R, Williams E, Strong R, Halls C, Soni P. The Effect of Symptoms of Personality Disorder on in Adult ADHD [Abstract].Biological Psychiatry. 2008 Robison R, Reimherr F, Marchant B, Gale P, Williams E, Strong R, Halls C, Soni P. Assessing Personality Disorder in Adults with ADHD, and Its Effects on Response to Treatment with OROS Methylphenidate (OROS MPH) [Abstract].NCDEU. Robison R, Reimherr F, Faraone S, Marchant B, Adler L, Strong, Soni P. Gender Differences in ADHD Adults During Clinical Trials with Atomoxetine [Abstract].American Psychiatric Association. Blanch R, Robison R, Avrin D, Wiggins R, Liimatta A. Synchronized Digital Teaching Files on a PDA: an Educational Tool [Abstract].Society for Computer Applications in Radiology. 2005 2004 ORAL PRESENTATIONS: Meeting Presentations 2011 2011 2010 2009 2009 2009 2009 2006 2003 2003 2003 Grand Rounds Presentations 2010 2010 2009 Updated 21 Sept 2011 Reimherr F, Marchant B, Olsen J, Wender P, Robison R. Oppositional Defiant Disorder in Adults with ADHD. In-Press Medications after Traumatic Brain Injury, University of Utah Healthcare Genetics of Suicidal Behaviors- Generations Conference Genetics of Suicide. Oral Platform Presentation, Career Development Institute for Psychiatry, Stanford University, Palo Alto, CA, USA Initial Evaluation of Copy Number Variation in a Follow-up of Adults with Autism Spectrum Disorders: a Behavioral Phenotype-Genotype Study. American Psychiatric Institute Junior Investigator Research Colloquium, San Francisco, CA, USA Whole exome sequencing in Autism pedigrees- University of Utah, Department of Biomedical Informatics, Translational Research in Progress Personalized medicine in a digital age- University of Utah, Department of Biomedical Informatics, Clinical Informatics Course Enhancing Employee Satisfaction, Communication and Productivity in the Workplace. Hunter Douglas, Inc. West Valley City, UT Vendor-neutral Case Input to a Server-based Digital Teaching File System. Radiological Society of North American, Scientific Session Server-based Digital Teaching File Database Synchronization with a PDA. Radiological Society of North America, Radiology Informatics Session. Improving the Shortage of Rural Physicians by Targeting High School and Medical Students. Rural Emergency Medicine Summit, Albuquerque, NM, USA "Neuropsychiatric Genetics: The Search for Genes Underlying Autism Spectrum Disorder." Brigham Young University Neuroscience Center "Psychiatric Genetics, Bioinformatics, and the Future of Personalized Psychiatry" University of Utah, Department of Psychiatry Copy Number Variation in Psychiatric Disorders. University of Utah, Initials___________________ Page 8 of 9 Department of Psychiatry, Salt Lake City, UT, USA Updated 21 Sept 2011 Initials___________________ Page 9 of 9