For Examiner Only Case Diabetic Ketoacidosis Author: Chris Kyriakedes, MD Reviewer: Michael Bohrn, MD Approved: 1/10/06 ORAL CASE SUMMARY CONTENT AREA Endocrine Emergencies SYNOPSIS OF CASE Patient presents with clinical signs and symptoms of DKA. Early recognition and aggressive treatment with fluids and insulin while monitoring the patient's electrolytes, acid-base status and vitals will successfully resusitate this patient. SYNOPSIS OF HISTORY Patient brought in by family with weakness and confusion. Patient is oriented to person, place and time but cannot give any other history. Family relates patient drank ETOH up to one month ago and stopped to lose weight. Since then has had intermittent blurry vision. In the past week has had flu like symptoms of anorexia but no vomiting or diarrhea. Denies fever or chills. ROS: no cardiopulmonary or neurological complaints. Denies known drug use or trauma. Found this am in this condition. SYNOPSIS OF PHYSICAL A&Ox3 but confused and barely cooperative. Parched mucous membranes. Lungs clear but Kussmaul respirations. Heart tachycardic. Obese, soft abdomen with bowel sounds present. Poor skin turgor, good skin tone and color. No focal findings on neurological exam' CRITICAL ACTIONS 1. Fluid Hydration and labs drawn 2. Monitor & EKG for hyperkalemia 3. IV Insulin Therapy 4. Finger stick glucose 5. Admission to ICU 6. ABG or venous pH 7. SCORING GUIDELINES (Critical Action No.) Number 4 & 6 should be ordered while fluid hydration is started and labs are drawn(1). Monitor and EKG should follow shortly thereafter(2). Labs confirm DKA, insulin drip(3) is initiated and close monitoring of electrolytes(2) and finally admission to ICU(5). FOR EXAMINER ONLY For Examiner Only PLAY OF CASE GUIDELINES (Critical Action No.) Aggressive fluid hydration with Normal Saline initially IV insulin: (bolus optional) insulin drip: 0.1 units/kg/hr Repeat glucose and K+ one hour after therapy was initiated Bicarbonate therapy: usually withheld for pH > 7.1 Acidosis will correct with hydration and insulin therapy. Use of bicarbonate would be indicated if hyperkalemia is clinically symptomatic ..not in this case - EKG has no peaked T-waves. Patients should be placed on a monitor, a large-bore IV should be established. A second line of ½ N/S should be at a keep open rate. Labs sent should include: electrolytes, CBC, phosphorous, calcium, magnesium, consider blood/urine cultures, and a ABG in critically ill patient or venous pH. Use the second line to adjust for potassium therapy: if < 3.3 hold insulin for 30 minutes and infuse K+, if 3.3-5.0 start insulin drip, if > 5.0 start fluids and insulin drip and stat recheck K+. Potassium should be held until there is adequate urine output. Give 3-4 liters (70kg) over first 4 hours of treatment. Discussion: The importance of early treatment with fluids in very important. Recognition of DKA and subsequent rule out of hyperkalemia is also critical. The ability of the resident to determine that there is no need for treatment of hyperkalemia because it is asymptomatic is important. FOR EXAMINER ONLY For Examiner Only Critical Actions 1. This critical action is met by Fluid Hydration Cueing Guideline: Parched mucosa, tachycardia 2. This critical action is met by Monitor & EKG for hyperkalemia Cueing Guideline: Tachycardia with DKA in diffdx think K+ imbalance 3. This critical action is met by IV Insulin Therapy Cueing Guideline: Kussmaul respirations and lab support 4. This critical action is met by Finger Stick Glucose Cueing Guideline: Kussmaul respirations 5. This critical action is met by Admission to ICU Cueing Guideline: Kussmaul respirations, tachycardia 6. This critical action is met by ABG or venous pH Cueing Guideline: Kussmaul respiration, tachycardia 7. This critical action is met by Cueing Guideline: For Examiner Only History Data Panel Age: 44 Sex: Male Name: Hodge Stone Method of Transportation: Family Presenting complaint: Weakness and confusion Onset and Description of Complaint: this am Past Medical History Allergies: NKA Medical: none Surgical: none Last Meal: not known Habits Smoking: none Drugs: no Alcohol: yes, up to one month ago, quit Family Medical History Father: hypertension, NIDDM Mother: none Siblings: none Social History Married: yes Children: 2 Employed: yes Education: high school PMD: no Person giving information: Patient, Family For Examiner Only Physical Data Panel General Appearance: alert, but confused and barely cooperative Vital Signs: BP : P : R : T : O2Sat : Glucose : 150/80 120 24 37 98 finger stick > 500 Neurological: no focal findings, A & O x 3, moves all extremities Mental Status: confused, but barely cooperative Head: normocephalic, no trauma Eyes: PERRL Ears: TM clear, normal cone of light, normal external canal Mouth: mucosa membranes parched Neck: supple Skin: warm and dry, poor skin turgor Chest: lungs clear (Kussmaul respirations) Heart: tachycardic, good S1, S2, no rub murmur or gallop Abdomen: obese, soft with bowel sounds present, no mass or organomegaly Extremities: full ROM, good skin color Rectal: guiac negative, good tone Pelvic: not done Back: normal spinal alignment Other exam findings: none For Examiner Only Lab Data Panel Stimulus #2 – CBC WBC 10.2 Hgb 13.1 Hct 39.4 Platelets 260 Differential Segs 57 Lymphs 42 Monos 1 Eos 0 /mm3 g/dL % /mm3 % % % % Stimulus #3 – Chemistry Na+ 130 mEq/L K+ 5.6 mEq/L HCO35 mEq/L Cl98 mEq/L Glucose 674 mg/dL BUN 20 mg/dL Creatinine 3.6 mg/dL Stimulus #4 – Urinalysis Color Yellow Sp Gravity 1.035 Glucose >1000 Protein Negative Ketone large Leuk. Est. Negative Nitrite Negative WBC 1-5 /HPF RBC 0-3 /HPF pH 5 Bacteria few Stimulus #5 – Ca++ 8.3, PT/PTT 12.4/28 INR 1.0 Stimulus #6 – Thyroid Panel TSH 2.1 (nl 0.34-4.82), T4 8 (nl 5-11.4), T3 22 (nl 19-38) Stimulus #7 – Hepatic ProfileHep Profile: Bili 0.9, ALT 22, AST 20, LDH 99, Alk Ph 30 Stimulus #8 – ABG: pH 7.005, PCO2 16, PO2, 167, HCO3 40 O2 Sat 98.5%, Lactic Acid 1.7 (nl 0.5-2.2) Stimulus #9 – Tox Screen: Theo <0.1, ASA < 0.2, APAP 0 S. Acetone: Positive (1:32) Stimulus #10 – Acetone: positive (1:32) Stimulus #11 – ETOH negative VERBAL REPORTS Chest xray: normal without infiltrate EKG: tachycardia, non ischemic For Examiner Only Stimulus Inventory Stimulus #1 – Emergency Admitting Form Stimulus #2 – CBC Stimulus #3 – Chemistry Stimulus #4 – Urinalysis Stimulus #5 – Stimulus #6 – Stimulus #7 – Stimulus #8 – Stimulus #9 – Stimulus #10 – Stimulus #11 – FOR EXAMINER ONLY Mock Oral Feedback Form – ABEM model Date: Examiner: Examinee: Data acquisition Worst 1 NOTES 2 3 4 5 6 7 8 Best Problem solving Worst 1 NOTES 2 3 4 5 6 7 8 Best Patient management Worst 1 2 NOTES 3 4 5 6 7 8 Best Resource utilization Worst 1 2 NOTES 3 4 5 6 7 8 Best Health care provided Worst 1 2 NOTES 3 4 5 6 7 8 Best 4 5 6 7 8 Best Comprehension of path physiology Worst 1 2 3 4 NOTES 5 6 7 8 Best Clinical competence (overall) Worst 1 2 3 NOTES 5 6 7 8 Best Patient Interpersonal relations Worst 1 2 3 NOTES 4 Critical Actions Dangerous actions 1. Fluid hydration and labs and omissions 2. Monitor and ECG for hyperkalemia 3. Insulin therapy 4. Fingerstick glucose 5. Admission to ICU 6. ABG 7. FOR EXAMINER ONLY Mock Oral Feedback Form – Core Competencies Date: Examiner: Does not meet expectations Examinee: Meets Expectations Exceeds Expectations 1. Patient care 2. Medical knowledge 3. Interpersonal skills and communication 4. Professionalism 5. Practice-based learning and improvement 6. Systems-based practice Critical Actions Dangerous actions 1. Fluid hydration and labs and omissions 2. Monitor and ECG for hyperkalemia 3. Insulin therapy 4. Fingerstick glucose 5. Admission to ICU 6. ABG 7. FOR EXAMINER ONLY Stimulus #1 ABEM General Hospital Emergency Admitting Form Name : Age : Sex : Method of Transportation : Person giving information : Presenting complaint : Background: Chief Complaint: “Weakness and confusion” History: Patient brought in by family with weakness and confusion. Patient is oriented to person, place and time but cannot give any other history. Family relates patient drank ETOH up to one month ago and stopped to lose weight. Since then has had intermittent blurry vision. In the past week has had flu like symptoms of anorexia but no vomiting or diarrhea. Denies fever or chills. ROS: no cardiopulmonary or neurological complaints. Denies known drug use or trauma. Found this am in this condition. Vital Signs T 36 BP 150/80 P 120 R 24 Stimulus #2 – CBC WBC Hgb Hct Platelets Differential Segs Lymphs Monos Eos /mm3 g/dL % /mm3 % % % % Stimulus #3 – Chemistry Na+ mEq/L K+ mEq/L HCO3mEq/L ClmEq/L Glucose mg/dL BUN mg/dL Creatinine mg/dL Stimulus #4 – Urinalysis Color Yellow Sp Gravity 1. Glucose Negative Protein Negative Ketone Negative Leuk. Est. Negative Nitrite Negative WBC /HPF RBC /HPF Stimulus #5 – Ca++ 8.3, PT/PTT 12.4/28 INR 1.0 Stimulus #6 – Thyroid Panel TSH 2.1 (nl 0.34-4.82), T4 8 (nl 5-11.4), T3 22 (nl 19-38) Stimulus #7 – Hepatic ProfileHep Profile: Bili 0.9, ALT 22, AST 20, LDH 99, Alk Ph 30 Stimulus #8 – ABG: pH 7.005, PCO2 16, PO2, 167, HCO3 40 O2 Sat 98.5%, Lactic Acid 1.7 (nl 0.5-2.2) Stimulus #9 – Tox Screen: Theo <0.1, ASA < 0.2, APAP 0 S. Acetone: Positive (1:32) Stimulus #10 – Acetone: positive (1:32) Stimulus #11 – ETOH negative Stimulus #12 ECG Stimulus #13 – Chest X Ray