IUPUI Research Center for Quantitative Renal Imaging RENAL IMAGING TECHNOLOGY DEVELOPMENT PROGRAM (RITDP) 2015 Call for Proposals Guidelines and Application Questions regarding the ITDP Grant Program should be directed to: renalimg@iupui.edu. Renal Imaging Technology Development Program (RITDP) APPLICATION GUIDELINES OBJECTIVE The objective of the Renal Imaging Technology Development Program (RITDP) is to provide a source of seed funding to foster research activities in the development of new, innovative, renal imaging-related technologies*. The intent of the RITDP is to develop new quantitative renal imaging technologies that will enhance the diagnosis of kidney diseases and the evaluation of the efficacy of therapeutic interventions and not just the utilization of currently available imaging technologies in renal studies. RATIONALE The aim of the Renal Imaging Technology Development Program (RITDP) is to enhance the IUPUI renal research community’s ability to compete successfully for research grants and contracts that require the development and implementation of advanced and novel renal imaging methods. *Definition of Imaging-Related Technology: Any technology associated with the acquisition of images, display of image information, or quantitative analyses of the information contained within an image. ELIGIBILITY CRITERIA All full-time faculty, including tenured/tenure track faculty and faculty in the clinical, research and scientist ranks are eligible to apply as the Principal Investigator. Faculty in visiting ranks and post-doctoral research associates are not eligible. An investigator may not serve as PI on more than one RITDP proposal in a given round. NATURE OF PROPOSALS The intent of the RITDP is to seed pilot projects for the development of new, innovative, renal imagingrelated technologies designed to diagnose kidney disease and evaluate efficacy of therapeutic interventions. It is expected that the funded pilot projects will provide the preliminary studies needed to demonstrate the feasibility of developing and implementing the new renal imaging-related technology resulting in an external grant submission or the successful development of new technology that is now available to other renal imaging investigators. FUNDING AND PROJECT DURATION: A total of $45,000 from the Renal Imaging Technology Development Program is available to fund meritorious proposals. Although there is no specific limit for the total proposed budget (up to $45k), it is strongly recommended the maximum total budget for the submitted proposal not exceed the range of $10k to $15k. Proposals with larger budgets will be subject to increased scrutiny during the review process. The budget cannot include faculty salary or travel. Staff salary, student salary (but not tuition and fees), equipment, imaging costs, animal model costs, patient costs, and supplies costs are permitted. Projects will be limited to one (1) year in duration. Requests for a one (1) year no cost extension must be approved by the IUPUI Research Center for Quantitative Renal Imaging. Funds will not be granted for similar projects currently supported by other internal or external funding mechanisms at the campus or university level. Previously submitted (but un-awarded) RITDP proposals can be resubmitted. Resubmitted proposals will be considered de novo applications. Previous RITDP awardees are ineligible to receive an additional RITDP award unless they have met the requirements in their RITDP award letter (i.e. submitted a final report, submitted evidence of an external grant submission based, in part, on work from the previous RITDP award or the successful development of new technology that is now available to renal imaging investigators). APPLICATION INSTRUCTIONS: Investigators should be aware that reviewers outside of their designated research area may be reviewing the proposals. Therefore, it is important to write the proposal in a manner understandable to non-content experts. Use standard paper size 8 ½ x 11 with at least 1/2 inch margins. Use an Arial, Helvetica, Palatino Linotype, or Georgia typeface, a black font color, and a font size of 11 points or larger. Charts, grafts, figures and so on may be in color. Applications should include the following sections: Section 1. Cover Page Use the Cover Page form provided. A copy of the IRB, IACUC and/or IBC form must be included in the Appendix when these forms are required to conduct the proposed work. For projects requiring initial IRB, IACUC or IBC approval, RITDP uses the Just-In-Time procedure. Section 2. Proposal Abstract State the proposal’s objective(s) and specific aims. Describe concisely the research design and methods for achieving these objectives. Avoid summaries of past accomplishments and the use of the first person. The abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. Do not include proprietary/confidential information. Keep the abstract to a half page in length. Section 3. Key Personnel List all key personnel and their departmental affiliation. Section 4. Budget Page Use the Budget Form page provided. Section 5. Budget Justification Limit budget justification to two (2) pages. Describe the role of each individual on the project and list their %FTE on the project (including %FTE on the project not covered by RITDP funds). List each item of equipment with amount requested separately and justify each purchase. Itemize supplies in separate categories, such as glassware, chemicals, radioisotopes, etc. If animals are to be purchased, state the species and the number to be used. Section 6. Biographical Sketches A biosketch must be included for all key personnel. Use the NIH format excluding the “Personal Statement”. Limit each biographical sketch to four (4) pages. List all current and pending internal and external research support, as well as past support for the previous three years. The NIH form and biosketch sample are available at http://grants1.nih.gov/grants/funding/phs398/phs398.html. Section 7. Research Plan (This section is limited to a maximum of three (3) pages in length. Research Plans longer than 3 pages will not be reviewed.) The Research Plan should include the following: Brief descriptions of 1) Goals/Aims; 2) Rationale/Background; 3) Brief overview of approach; 4) Potential Significance if work is accomplished; 5) Plan for future technology development and external funding strategy. Additional pages permitted for Biosketches, Budget, & Budget Justification. Section 8. References (not included in the 3 page limit) Use the NIH or NSF format to cite your literature. See page 3 of the NIH Biosketch sample referenced in Section 6. (The references do not count toward the 3 page limit for the research plan.) Section 9. Appendix A copy of the IRB, IACUC and/or IBC form must be included when these forms are required to conduct the proposed work. If awarded, no funds will be transferred without the proper approvals. Letters confirming the provision of additional resources and/or partnerships with external stakeholders can be included, if applicable. Description of the facilities available for this project including laboratories, clinical resources, office space, animal quarters, major items of equipment available for this work, etc. REVIEW AND SELECTION OF PROPOSALS Review and selection of the grant proposals will be carried out as follows: Review: Proposals will be reviewed by members of the IUPUI Research Center for Quantitative Renal Imaging and, potentially, other experts within the IUPUI research community, if necessary. Some proposals may be forwarded to the Indiana CTSI PDT Program for further evaluation and development. Review Criteria: Assess potential impact of proposed study on strengthening the development and utilization of advanced and novel renal imaging methods and ability to secure external funding for further development and utilization. KEY DATES RITDP applications due by 5 PM on June 15, 2015. Awarded RITDP funding to begin June 25, 2015. POST AWARD REQUIREMENTS If an award is made, a final 1-page summary must be submitted to the IUPUI Research Center for Quantitative Renal Imaging within 30 days of the termination of the award period. Lists of refereed papers submitted, abstract and presentations funded by the RITDP grant must be provided. Additional follow-up information may be requested outside of the final report submission requirement, to determine the ongoing efficacy of the RITDP mechanism. It is expected that the recipients of an RITDP award will submit a final report as well as submit evidence of an external grant submission based, in part, on work from the RITDP award or the successful development of new technology that is now available to renal imaging investigators. Recipients are reminded to acknowledge receipt of RITDP support in any presentation or publication of work funded by an RITDP grant. SUBMISSION OF APPLICATION The RITDP application submission due date is June 15, 2015. Submit your application in PDF format via email attachment to: renalimg@iupui.edu Questions regarding the ITDP Grant Program should be directed to: renalimg@iupui.edu IUPUI Office of the Vice Chancellor for Research Indiana University Purdue University Indianapolis Leave blank-for internal use only IUPUI Renal Imaging Technology Development Program (RITDP) Grant Application PI Name Campus Address Rank/Title Email Address School Telephone Number Department Fax Number Title of Project Keywords Total Costs Project Start & End Dates Performance Site(s) Research Risk (double-click on the box, use the default value buttons) Include a copy of the approval form in the Appendix. YES NO Human Subjects IRB Study # and Approval Date: Animals IACUC Study # and Approval Date: Biosafety (rDNA) IBC Study # and Approval Date: Principal Investigator Assurance The undersigned agrees to accept responsibility for the scientific and technical conduct of the research project and for submission of the annual and final reports. Signature of Principal Investigator Date Budget Form BUDGET FROM PERSONNEL (Applicant organization only) NAME ROLE ON PROJECT SUBTOTALS EQUIPMENT (Itemize) SUPPLIES (Itemize) PATIENT CARE COSTS (Itemize) OTHER COSTS (Itemize) TOTAL COST TYPE APPT. (months) % EFFORT ON PROJ. THROUGH DOLLAR AMOUNT REQUESTED (omit cents) INST. BASE SALARY SALARY REQUESTED FRINGE BENEFITS TOTAL