Appendix C—Included RCTs Title Author Journal Impact of alendronate on quality of life in children with osteogenesis imperfecta. Seikaly et al. Continuous passive motion versus immobilisation in a cast after surgical treatment of idiopathic club foot in infants: a prospective, blinded, randomised, clinical study. Comparison of 1-stage versus 2-stage anterior and posterior spinal fusion for severe and rigid idiopathic scoliosis--a randomized prospective study. Allograft versus no graft with a posterior multisegmented hook system for the treatment of idiopathic scoliosis Comparison of short and long arm plaster casts for displaced fractures in the distal third of the forearm in children Above and below-the-elbow plaster casts for distal forearm fractures in children. A randomized controlled trial. Zeifang et al. Journal of Pediatric Orthopedics. 25(6):786-91. Journal of Bone & Joint Surgery - British Volume. 87(12):16635. Shen et al. Spine. 31(22):2525-8. 2006 Betz et al. Spine. 31(2):121-7. 2006 Webb et al. 2006 Axillary block for analgesia during manipulation of forearm fractures in the pediatric emergency department a prospective randomized comparative trial. Effects of a two-school-year multifactorial back education program in elementary schoolchildren. The effect of dynamic ankle foot orthoses on function in children with cerebral palsy. Kriwanek et al. Journal of Bone &Joint Surgery - American Volume. 88(1):9-17. Journal of Bone & Joint Surgery American Volume. 88(1):1-8. Journal of Pediatric Orthopedics. 26(6):737-40. Geldhof et al. Spine. 31(17):196573. 2006 Bjornson et al. Journal of Pediatric Orthopedics. 26(6):773-6. Spine. 31(15):164651. 2006 2007 Labelle et al. Journal of Bone & Joint Surgery American Volume. 89(4):706-12. Spine. 32(8):835-43. Liu et al. Journal of Pediatric 2007 Postoperative analgesia after anterior correction of thoracic scoliosis: a prospective randomized study comparing continuous double epidural catheter technique with intravenous morphine. Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial Preliminary evaluation of a computer-assisted tool for the design and adjustment of braces in idiopathic scoliosis: a prospective and randomized study. A randomized prospective study of music Bohm et al. Blumenthal et al. Kocher et al. Year of Publication 2005 2005 2006 2006 2006 2007 therapy for reducing anxiety during cast room procedures. Acute correction of proximal tibial deformities in adolescents using Ilizarov external fixator: focal-dome versus straightcut osteotomy. Effect of low-dose ketamine on voltage requirement for transcranial electrical motor evoked potentials in children. Are surgeons' preferences for instrumentation related to patient outcomes? A randomized clinical trial of two implants for idiopathic scoliosis. Treatment of clubfoot with the Ponseti method: a comparison of casting materials El-Rosasy M, and Ayoub M. 2007 Zaarour et al. Spine. 32(22):E62730. 2007 Wright et al. Journal of Bone &Joint Surgery - American Volume. 89(12):268493. Journal of Pediatric Orthopedics. 28(2):250-3. Journal of Pediatric Orthopedics. 28(4):410-6. 2007 2008 Wong et al. Journal of Bone & Joint Surgery American Volume. 90(3):463-70. Journal of Bone & Joint Surgery American Volume. 90(1):23-33 . Journal of Bone & Joint Surgery - British Volume. 90(6):801-2. Spine. 33(12):1360-5. Ahlqwist et al. Spine. 33(20):E721-7. 2008 Wright et al. Journal of Bone and Joint SurgeryAmerican Volume 90:722-30 Journal of Pediatric Orthopedics. 29(6):626-8. 2008 Journal of Pediatric Orthopedics. 29(7):741-8. 2009 Pittner et al. Comparing the effectiveness of modified forearm and conventional minidose intravenous regional anesthesia for reduction of distal forearm fractures in children. Acute patellar dislocation in children and adolescents: a randomized clinical trial. Werk et al. Does botulinum toxin a combined with bracing prevent hip displacement in children with cerebral palsy and "hips at risk"? A randomized, controlled trial Is there a role for lengthening flexor hallucis and flexor digitorum longus tendons in surgery for club foot?: a preliminary report. The effect of rigid versus flexible spinal orthosis on the clinical efficacy and acceptance of the patients with adolescent idiopathic scoliosis. Physical therapy treatment of back complaints on children and adolescents. A Randomized Clinical Trial Comparing Intralesional Bone Marrow and Steroid Injections for Simple Bone Cysts Graham et al. Coaptive film versus subcuticular suture: comparing skin closure time following identical, single-session, bilateral limb surgery in children. A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. Orthopedics. 27(7):831-3. Journal of Pediatric Orthopaedics, Part B. 16(2):113-9. Palmu et al Lahoti O and Bajaj S. Rebello et al. Gudas et al. 2008 2008 2008 2008 2008 2009 Prospective, surgeon-randomized evaluation of crossed pins versus lateral pins for unstable supracondylar humerus fractures in children. Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. Impact of cycling on hip subluxation in children with spinal cord injury. Tripuraneni et al. Journal of Pediatric Orthopaedics, Part B. 18(2):93-8. Journal of Pediatric Orthopedics. 29(6):588-93. Journal of Pediatric Orthopedics. 29(4):402-5. Journal of Pediatric Orthopedics. 29(3):275-80. 2009 Minimizing tourniquet pressure in pediatric anterior cruciate ligament reconstructive surgery: a blinded, prospective randomized controlled trial. The effectiveness of botulinum A toxin as an adjunct to the treatment of clubfeet by the Ponseti method: a randomized, double blind, placebo controlled study. Coaptive film versus subcuticular suture: comparing skin closure time after posterior spinal instrumented fusion in pediatric patients with spinal deformity. Oral midazolam for removal of Kirschner wires in the children's orthopaedic outpatient department: a randomized controlled trial. Effect of high-frequency, low-magnitude vibration on bone and muscle in children with cerebral palsy. Effectiveness of an anesthetic continuousinfusion device in children with cerebral palsy undergoing orthopaedic surgery. Medial and lateral pin versus lateral-entry pin fixation for Type 3 supracondylar fractures in children: a prospective, surgeon-randomized study. Improving schoolchildren's knowledge of methods for the prevention and management of low back pain: a cluster randomized controlled trial. Dexamethasone therapy for septic arthritis in children: results of a randomized double-blind placebo-controlled study. Ultrasonographic examination of the radial and ulnar nerves after percutaneous crosswiring of supracondylar humerus fractures in children: a prospective, randomized controlled study. An accelerated Ponseti versus the standard Ponseti method: a prospective randomized controlled trial. Reilly et al. Cummings Journal of Pediatric Orthopedics. 29(6):564-9. 2009 Grottkau et al. Spine. 35(23):2027-9. 2010 Templeton et al. Journal of Pediatric Orthopedics. 30(2):130-4. Journal of Pediatric Orthopedics. 30(7):732-8. Journal of Pediatric Orthopedics. 30(8):840-5. Journal of Pediatric Orthopedics. 30(8):799-806. 2010 Kovacs et al. Spine. 36(8):E505-12. 2011 Harel et al. Journal of Pediatric Orthopedics. 31(2):211-5. Journal of Pediatric Orthopaedics, Part B. 20(5):334-40. 2011 Journal of Bone & Joint Surgery - British Volume. 93(3):404-8. 2011 Gauger et al. Johnston et al. Wren et al. Muthusamy et al. Gaston et al. Altay et al. Harnett et al. 2009 2009 2009 2010 2010 2010 2011