Boston University School of Public Health
Department of Global Health – Culminating Experience
Option One – Policy Brief
Title: Examining the differences in ART adherence among adolescents in South Africa:
A gender stratified analysis
Organization: N/A
Problem and Purpose
At the end of 2012, the United Nations Children’s Fund (UNICEF) estimated that
2.1 million adolescents, youth aged ten to nineteen, were living with HIV/AIDS
worldwide. Approximately 85% of these infections among adolescents were in subSaharan Africa (1). These statistics include adolescents who acquired HIV/AIDS
behaviorally, and also those who became ill through mother-to-child transmission, either
perinatally or postnatal transmission through breastfeeding. While there is a vast amount
of information on HIV/AIDS in children and youth ages 15 to 24, respectively,
adolescents are often excluded from research for a variety of reasons, including their
changing physical and emotional states, the potential for reproductive decision-making,
and the trying transition from pediatric to adult care. These difficulties are seldom
documented in the United States (2), let alone in less developed countries such as South
Africa.
This policy brief will examine the differences in adherence to antiretroviral
therapy (ART) among adolescents in South Africa, specifically, if there is a difference in
adherence among males and females. A systematic review of studies from 53 countries
reported that adolescence can be characterized by high-risk sexual behavior, a lack of
interaction with health services, and a desire to fit in with their peers in social situations
(3); these circumstances, among others, will likely lead to a decrease in adherence to
ART during adolescence. Based on the current research, this policy brief will make
recommendations at a systems level on ways to improve adherence to ART among male
and female adolescents in South Africa.
References
1.
Idele P, Gillespie A, Porth T, Suzuki C, Mahy M, Kasedde S, et al. Epidemiology
of HIV and AIDS among adolescents: current status, inequities, and data gaps. J
Acquir Immune Defic Syndr [Internet]. 2014 Jul 1;66 Suppl 2:S144–53. Available
from: http://www.ncbi.nlm.nih.gov/pubmed/24918590
2.
Village EG. Transitioning HIV-infected youth into adult health care. Pediatrics
[Internet]. 2013 Jul [cited 2014 Sep 12];132(1):192–7. Available from:
http://www.ncbi.nlm.nih.gov/pubmed/23796739
3.
Kim S-H, Gerver SM, Fidler S, Ward H. Adherence to antiretroviral therapy in
adolescents living with HIV: systematic review and meta-analysis. AIDS
[Internet]. 2014 May 16 [cited 2014 Sep 10];(April). Available from:
http://www.ncbi.nlm.nih.gov/pubmed/24845154
Working Outline
I.
II.
Introduction
a. Define the problem – present basic facts about HIV/AIDS among
adolescents worldwide, discuss the issues of adolescence and matters of
adherence to ART
b. Describe the problem in the context of South Africa – In July 2014, South
Africa raised the CD4 count to 500, greatly increasing the number of
people who are eligible for ART, many of these will likely be adolescents
c. Answer the “so what?” question – why is this research
importantAdolescence is already a rocky time period, further
compounded by HIV/AIDS, need to ensure that support services are in
place to smooth this transition and maintain proper adherence
Current Situation
a. Number of adolescents living with HIV/AIDS in South Africa
b. Current sex-aggregated data on adherence to ART if available – total
number on treatment
III.
IV.
V.
c. Programs in place to improve adherence among adolescents –
success/failures?
d. Transition from pediatric to adult HIV care
Potential Solutions
a. Identify approaches to address the problem – mHealth applications to
encourage adherence, support groups, etc.
b. Describe the target population – different recommendations based on sex?
See what the evidence recommends
Discussion and Recommendations
a. Examine cost and benefits – have actual costs for the program
b. Whether or not intervention has been successful in South Africa or in a
similar country
c. Look at feasibility – what would the South African Ministry of Health
actually implement
i. Identify the administrative department that would be responsible
for implementation
d. Monitoring and evaluation – when and how will the program be evaluated
Conclusion
a. Stress the importance of implementing these programs – further note the
stress associated with a typical adolescent period, which is made harder by
having a chronic disease
b. Remind the audience of the urgency – adherence is a major issue and
needs to be treated as one
Work Plan for Submitting Drafts
In order to complete the GH Culminating Experience by the fall semester deadline, the
following drafts will be submitted on or before the corresponding dates:
PPS and CE Contract: September 12, 2014
Draft 1: October 10, 2014
Draft 2: November 7, 2014
Draft 3: December 5, 2014
Final Draft: December 19, 2014
Working Bibliography
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