BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Wu, Elizabeth Yiru Medical Student eRA COMMONS USER NAME (credential, e.g., agency login) EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Toronto, Toronto ON, Canada Johns Hopkins University School of Medicine, Baltimore MD, U.S.A. H.B.Sc. 05/2010 Molecular Biology Chemistry Mathematics In Progress 05/2014 Medicine A. Personal Statement My summer research investigated the effects of metabolic inhibition using 2-deoxyglucose (2DG) on glioma stem cell proliferation, apoptosis, invasion, migration and stemness. I am interested in the concept of novel targeted therapies with milder side effect profiles than currently used chemotherapies. B. Positions and Honors Positions and Employment 2007-2009 Summer Research Assistant: Rancourt Lab, Foothills Medical Centre, University of Calgary 2009-2010 Teaching Assistant: University of Toronto 2009-2010 Thesis student: Sokolowski Lab, University of Toronto Other Experience and Professional Memberships 2010Member, American College of Physicians Honors 2007 Alberta Cancer Board: Summer Studentship. 2007 Canadian Institutes of Health Research (CIHR): Studentship in Skeletal Regenerative Medicine. 2007 Canadian Institutes of Health Research (CIHR): Studentship in musculoskeletal health and arthritis. 2008 Canadian Institutes of Health Research (CIHR): Studentship in musculoskeletal, oral and skin health, and mobility. 2008 Alberta Heritage Foundation for Medical Research (AHFMR): Summer Studentship. 2010 Governor General’s Academic Medal nominee (University of Toronto). 2010 E.A. Robinson Science Medal (Faculty of Science, University of Toronto). C. Selected Peer-reviewed Publications (Selected from 42 peer-reviewed publications) Most relevant to the current application None Additional recent publications of importance to the field (in chronological order) 1. Krawetz R.J., Liu S.Y., Wu Y.E., Cormier J.T., Nishikawa S., and Rancourt D.E. 2007. Embryonic Stem Cell Derived Mesenchymal Progenitor Cells that Develop into Blood, Stroma, and Fat In-Vivo. Stem Cell Network AGM, Toronto, Ontario, Nov 2007. 2. Krawetz, R., Wu, Y.E., Rancourt, D., Matyas, J. (2009). Osteoblasts suppress high bone turnover caused by osteolytic breast cancer in vitro. Experimental Cell Research. 315: 2333-2342. 3. Taiani, J.T., Krawetz, R.J., zur Nieden, N.I., Wu, Y.E., Kallos, M.S., Matyas, J.R., Rancourt, D.E. (2010). Reduced differentiation efficiency of murine embryonic stem cells in stirred suspension bioreactors. Stem Cells and Development. 19(7): 989-998. D. Research Support Ongoing Research Support None Completed Research Support Dean’s Summer Research Funding (Summer 2011)