Gene Therapy Publications
1.
Aoi, A., et al., Herpes Simplex Virus Thymidine Kinase-Mediated Suicide Gene Therapy Using
Nano/Microbubbles and Ultrasound. Ultrasound Med Biol, 2007.
2.
Benaron, D.A., P.R. Contag, and C.H. Contag, Imaging brain structure and function, infection and gene
expression in the body using light. Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences, 1997. 352(1354): p. 755-61.
3.
Bertoni, C., et al., Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed
plasmid integration. PNAS, 2006. 103(2): p. 419-424.
4.
Bins, A.D., et al., A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen
expression. Nat Med, 2005. 11(8): p. 899-904.
5.
Brian T. Feeley, A.H.C.O.S.L.K.I.S.Y.C.J.R.L., In vivo molecular imaging of adenoviral versus lentiviral
gene therapy in two bone formation models. Journal of Orthopaedic Research, 2006. 24(8): p. 17091721.
6.
Cooper, L.J., et al., Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by
cotransfer of T cells modified to present influenza MP1. Blood, 2005. 105(4): p. 1622-31.
7.
De, A., X.Z. Lewis, and S.S. Gambhir, Noninvasive imaging of lentiviral-mediated reporter gene
expression in living mice. Mol Ther, 2003. 7(5 Pt 1): p. 681-91.
8.
Deroose, C.M., et al., Noninvasive Monitoring of Long-Term Lentiviral Vector-Mediated Gene Expression
in Rodent Brain with Bioluminescence Imaging. Molecular Therapy, 2006. In Press, Corrected Proof.
9.
Dickson, P.V., et al., Intravascular administration of tumor tropic neural progenitor cells permits
targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated
neuroblastoma. J Pediatr Surg, 2007. 42(1): p. 48-53.
10. Dunn, C.A., et al., BMP gene delivery for alveolar bone engineering at dental implant defects. Molecular
Therapy, 2005. 11(2): p. 294-9.
11. Elia, L., et al., CD4+CD25+ regulatory T-cell-inactivation in combination with adenovirus vaccines
enhances T-cell responses and protects mice from tumor challenge. Cancer Gene Ther, 2007. 14(2): p.
201-10.
12. Fan, S., et al., Valproic acid enhances gene expression from viral gene transfer vectors. J Virol
Methods, 2005. 125(1): p. 23-33.
13. Griesenbach, U., et al., In vivo imaging of gene transfer to the respiratory tract. Biomaterials, 2007.
14. Gross, S. and D. Piwnica-Worms, Spying on cancer: molecular imaging in vivo with genetically encoded
reporters. Cancer Cell, 2005. 7(1): p. 5-15.
15. Guse, K., et al., Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses. Mol
Cancer Ther, 2007. 6(10): p. 2728-36.
16. Hung, C.F., et al., Vaccinia virus preferentially infects and controls human and murine ovarian tumors in
mice. Gene Ther, 2007. 14(1): p. 20-9.
17. Iyer, M., et al., Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter
genes in living mice. Molecular Therapy, 2002. 6(4): p. 555-62.
18. Iyer, M., et al., Noninvasive imaging of enhanced prostate-specific gene expression using a two-step
transcriptional amplification-based lentivirus vector. Molecular Therapy, 2004. 10(3): p. 545-52.
19. Iyer, M., et al., Two-step transcriptional amplification as a method for imaging reporter gene
expression using weak promoters. Proc Natl Acad Sci U S A, 2001. 98(25): p. 14595-600.
20. Johnson, M., et al., Differential Biodistribution of Adenoviral Vector In Vivo as Monitored by
Bioluminescence Imaging and Quantitative Polymerase Chain Reaction. Hum Gene Ther, 2006.
21. Kanerva, A., et al., Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptortargeted oncolytic adenovirus. Molecular Therapy, 2003. 8(3): p. 449-58.
22. Kanerva, A., et al., Noninvasive dual modality in vivo monitoring of the persistence and potency of a
tumor targeted conditionally replicating adenovirus. Gene Ther, 2005. 12(1): p. 87-94.
23. Kesarwala, A.H., et al., Second-generation triple reporter for bioluminescence, micro-positron emission
tomography, and fluorescence imaging. Mol Imaging, 2006. 5(4): p. 465-74.
24. Kim, Y.J., et al., Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a
tri-fusion reporter gene. Molecular Imaging and Biology, 2004. 6(5): p. 331-40.
25. Kimura, T., et al., Lentiviral Vectors with CMV or MHCII Promoters Administered In Vivo: Immune
Reactivity Versus Persistence of Expression. Mol Ther, 2007.
26. Krom, Y., et al., Efficient in vivo knock-down of estrogen receptor alpha: application of recombinant
adenovirus vectors for delivery of short hairpin RNA. BMC Biotechnology, 2006. 6(11): p. 1-10.
27. Kutschka, I., et al., Adenoviral Human BCL-2 Transgene Expression Attenuates Early Donor Cell Death
After Cardiomyoblast Transplantation Into Ischemic Rat Hearts. Circulation, 2006. 114(1_suppl): p. I174-180.
28. Lee, J.Y., et al., Development of a Dual-Luciferase Reporter System for In Vivo Visualization of
MicroRNA Biogenesis and Posttranscriptional Regulation. J Nucl Med, 2008. 49(2): p. 285-294.
29. Leo, B.M., et al., In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell
transplantation in the intervertebral disc. Spine, 2004. 29(8): p. 838-44.
30. Liang, Q., et al., Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus
receptor-epidermal growth factor (sCAR-EGF) fusion protein. Molecular Imaging and Biology, 2004.
6(6): p. 385-94.
31. Liang, Q., et al., Noninvasive imaging of transcriptionally restricted transgene expression following
intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene. Mol
Imaging Biol, 2004. 6(6): p. 395-404.
32. Lin, J., et al., Inhibition of Lymphogenous Metastasis Using Adeno-Associated Virus-Mediated Gene
Transfer of a Soluble VEGFR-3 Decoy Receptor. Cancer Res, 2005. 65(15): p. 6901-6909.
33. Lipshutz, G.S., et al., In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer
produces long-term expression. Molecular Therapy, 2001. 3(3): p. 284-92.
34. Lipshutz, G.S., et al., Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in
utero. Mol Ther, 2003. 8(1): p. 90-8.
35. Liu, S., et al., Enhancement of Cancer Radiation Therapy by Use of Adenovirus-Mediated Secretable
Glucose-Regulated Protein 94/gp96 Expression. Cancer Res, 2005. 65(20): p. 9126-9131.
36. Liu, Y., et al., High intensity focused ultrasound-induced gene activation in solid tumors. J Acoust Soc
Am, 2006. 120(1): p. 492-501.
37. Lockley, M., et al., Activity of the Adenoviral E1A Deletion Mutant dl922-947 in Ovarian Cancer:
Comparison with E1A Wild-type Viruses, Bioluminescence Monitoring, and Intraperitoneal Delivery in
Icodextrin. Cancer Res, 2006. 66(2): p. 989-998.
38. McCaffrey, A., M.A. Kay, and C.H. Contag, Advancing molecular therapies through in vivo
bioluminescent imaging. Mol Imaging, 2003. 2(2): p. 75-86.
39. McCaffrey, A.P., et al., A potent and specific morpholino antisense inhibitor of hepatitis C translation in
mice. Hepatology, 2003. 38(2): p. 503-8.
40. Mocanu, J., et al., Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene
Therapy. Mol Ther, 2007.
41. Mocanu, J.D., et al., Combined in vivo bioluminescence and fluorescence imaging for cancer gene
therapy. Mol Imaging, 2004. 3(4): p. 352-5.
42. Nakajima, A., Application of cellular gene therapy for rheumatoid arthritis. Mod Rheumatol, 2006.
16(5): p. 269-75.
43. Nakajima, A., et al., Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin
Invest, 2001. 107(10): p. 1293-301.
44. Niu, G., et al., In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector
encoding firefly luciferase reporter gene. Mol Imaging Biol, 2007. 9(3): p. 126-34.
45. Nyati, M.K., et al., The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy
in an intrahepatic colon cancer model Gene Therapy, 2002. 9(13): p. 844-849.
46. Ohlfest, J.R., et al., Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the
Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing
Intracranial Human Glioblastoma. Molecular Therapy, 2005. 12(5): p. 778-788.
47. Park, C.Y., et al., Periocular triamcinolone enhances intraocular gene expression after delivery by
adenovirus. Invest Ophthalmol Vis Sci, 2008. 49(1): p. 399-406.
48. Ponomarev, V., et al., A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent,
and nuclear noninvasive imaging. European Journal of Nuclear Medicine and Molecular Imaging, 2004.
31(5): p. 740-51.
49. Power, A.T., et al., Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity.
Mol Ther, 2007. 15(1): p. 123-30.
50. Prasad, K.M., et al., Topoisomerase Inhibition Accelerates Gene Expression after Adeno-associated
Virus-mediated Gene Transfer to the Mammalian Heart. Mol Ther, 2007. 15(4): p. 764-71.
51. Qiu, Z., et al., Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide
gene therapy for neuroblastomas compared to herpes simplex virus VP22. J Virol, 2004. 78(8): p.
4224-33.
52. Raki, M., et al., Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3
receptor targeted oncolytic adenovirus. Gene Ther, 2007. 14(19): p. 1380-1388.
53. Ramesh, N., et al., CG0070, a Conditionally Replicating Granulocyte Macrophage Colony-Stimulating
Factor-Armed Oncolytic Adenovirus for the Treatment of Bladder Cancer. Clin Cancer Res, 2006. 12(1):
p. 305-313.
54. Ranki, T., et al., A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta24, for
the treatment of advanced breast cancer. Gene Ther, 2007. 14(1): p. 58-67.
55. Ray, P., et al., Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res,
2004. 64(4): p. 1323-30.
56. Ray, P., R. Tsien, and S.S. Gambhir, Construction and validation of improved triple fusion reporter gene
vectors for molecular imaging of living subjects. Cancer Res, 2007. 67(7): p. 3085-93.
57. Rehemtulla, A., et al., Molecular imaging of gene expression and efficacy following adenoviral-mediated
brain tumor gene therapy. Mol Imaging, 2002. 1(1): p. 43-55.
58. Ryman, K.D., et al., Early restriction of alphavirus replication and dissemination contributes to agedependent attenuation of systemic hyperinflammatory disease. J Gen Virol, 2007. 88(Pt 2): p. 518-29.
59. Sarkioja, M., et al., Noninvasive imaging for evaluation of the systemic delivery of capsid-modified
adenoviruses in an orthotopic model of advanced lung cancer. Cancer, 2006. 107(7): p. 1578-88.
60. Sato, M., et al., Functionality of Androgen Receptor-Based Gene Expression Imaging in Hormone
Refractory Prostate Cancer. Clin Cancer Res, 2005. 11(10): p. 3743-3749.
61. Sato, M., et al., Optimization of adenoviral vectors to direct highly amplified prostate-specific
expression for imaging and gene therapy. Mol Ther, 2003. 8(5): p. 726-37.
62. Schweichel, D., et al., Evaluation of DNA vaccination with recombinant adenoviruses using
bioluminescence imaging of antigen expression: impact of application routes and delivery with dendritic
cells. J Gene Med, 2006. 8(10): p. 1243-50.
63. Slavin, A.J., et al., Adoptive cellular gene therapy of autoimmune disease. Autoimmun Rev, 2002. 1(4):
p. 213-9.
64. Smith, P.G., et al., Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging.
2005.
65. Streck, C.J., et al., Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-{beta} Combined
with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models. Clin
Cancer Res, 2005. 11(16): p. 6020-6029.
66. Svensson, R.U., et al., Chemotherapeutic agents up-regulate the cytomegalovirus promoter:
implications for bioluminescence imaging of tumor response to therapy. Cancer Res, 2007. 67(21): p.
10445-54.
67. Tarantal, A.F., et al., Fetal Gene Transfer Using Lentiviral Vectors: In Vivo Detection of Gene Expression
by microPET and Optical Imaging in Fetal and Infant Monkeys. Hum Gene Ther, 2006.
68. Tarner, I.H., et al., Treatment of autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad
Sci, 2003. 998: p. 512-9.
69. Taubes, G., Firefly gene lights up lab animals from inside out. Science, 1997. 276(5321): p. 1993.
70. Thorne, S.H., R.S. Negrin, and C.H. Contag, Synergistic Antitumor Effects of Immune Cell-Viral
Biotherapy. Science, 2006. 311(5768): p. 1780-1784.
71. Toelen, J., et al., Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a
rat model. Am J Obstet Gynecol, 2007. 196(4): p. 352 e1-6.
72. Tseng, J.C., et al., Using sindbis viral vectors for specific detection and suppression of advanced
ovarian cancer in animal models. Cancer Res, 2004. 64(18): p. 6684-92.
73. Tseng, J.C., et al., Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol, 2004.
22(1): p. 70-7.
74. Tseng, J.C., et al., Restricted tissue tropism and acquired resistance to Sindbis viral vector expression
in the absence of innate and adaptive immunity. Gene Ther, 2007. 14(15): p. 1166-74.
75. Vera, M., et al., Liver transduction with a simian virus 40 vector encoding insulin-like growth factor I
reduces hepatic damage and the development of liver cirrhosis. Gene Ther, 2007. 14(3): p. 203-10.
76. Verra, N.C., et al., Human telomerase reverse transcriptase-transduced human cytotoxic T cells
suppress the growth of human melanoma in immunodeficient mice. Cancer Res, 2004. 64(6): p. 215361.
77. Wang, Q., et al., Small Hairpin RNAs Efficiently Inhibit Hepatitis C IRES-Mediated Gene Expression in
Human Tissue Culture Cells and a Mouse Model. Molecular Therapy, 2005. In Press, Corrected
Proof.
78. Wang, Y., et al., Noninvasive monitoring of target gene expression by imaging reporter gene
expression in living animals using improved bicistronic vectors. J Nucl Med, 2005. 46(4): p. 667-74.
79. Wang, Y., et al., A Novel Method for Viral Gene Delivery in Solid Tumors. Cancer Res, 2005. 65(17): p.
7541-7545.
80. Wang, Y., et al., Characterisation of systemic dissemination of nonreplicating adenoviral vectors from
tumours in local gene delivery. Br J Cancer, 2005. 92(8): p. 1414-20.
81. Wilber, A., et al., Dynamic Gene Expression After Systemic Delivery of Plasmid DNA as Determined by
In Vivo Bioluminescence Imaging. Human Gene Therapy, 2005. 16(11): p. 1325-1332.
82. Winkeler, A., et al., Switching on the lights for gene therapy. PLoS ONE, 2007. 2(6): p. e528.
83. Wu, J.C., et al., Optical imaging of cardiac reporter gene expression in living rats. Circulation, 2002.
105(14): p. 1631-4.
84. Yoshimitsu, M., et al., Bioluminescent imaging of a marking transgene and correction of Fabry mice by
neonatal injection of recombinant lentiviral vectors. Proc Natl Acad Sci U S A, 2004. 101(48): p. 1690914.
85. Zinn, K.R., et al., Noninvasive bioluminescence imaging in small animals. Ilar J, 2008. 49(1): p. 103-15.
86. Zinn, K.R., et al., Bioluminescence imaging reveals a significant role for complement in liver
transduction following intravenous delivery of adenovirus. Gene Ther, 2004. 11(19): p. 1482-6.