PEDIATRIC PATHOLOGY ROTATION GOALS AND OBJECTIVES UAMS PATHOLOGY GOALS 1. The trainee will have skills in specimen handling, clinician interaction, and case evaluation that are appropriate and effective for pediatric patient care. 2. The trainee will demonstrate medical knowledge in perinatal pathology, congenital and metabolic disease, pediatric neoplasia, cytogenetics, and pediatric surgical pathology. 3. The trainee will exhibit practice-based learning and improvement in pediatric pathology as demonstrated by effective presentations at pathology and interdisciplinary conferences, composition of surgical pathology reports, and successful performance of a personal karyotype. 4. The trainee will demonstrate effective interpersonal and communication skills in his/her dealings with transcriptionists, histologists, clinicians, and pathology faculty. 5. The trainee will demonstrate professionalism by effective working habits and timely report generation. 6. The trainee will demonstrate an understanding of the systems-based practice of medicine by his/her ability to utilize clinical and radiological data, work with the hospital information system, and read patient charts as necessary for effective surgical pathology and cytogenetic diagnosis and report-writing. SPECIFIC OBJECTIVES 1. Show proficiency in accurately describing, measuring gross lesions and the appropriate selection of sections for microscopic evaluation (practice, patient care). 2. Describe the principles/reasons for tissue fixation in the preparation of sections for light microscopic, ultrastructural or immunofluorescence microscopic evaluation (practice, patient care). 3. Describe the process and sequence of specimen processing from specimen fixation, embedding, sectioning and staining (practice, patient care). 4. Enumerate potential areas of specimen contamination along the processing pathway and discuss ways of troubleshooting for any errors that may arise (practice, patient care, professionalism). 1 5. Give a classification of pediatric renal tumors (medical knowledge, practice, patient care). 6. Discuss the histopathologic features of Wilms’ Tumor and list the features that indicate favorable prognosis (medical knowledge, practice, patient care). 7. Discuss the molecular biology, cytogenetics and the syndromes/associations seen in Wilms’ Tumor (medical knowledge, practice, patient care). 8. Describe the histopathologic features of the primitive neural tumors of childhood (peripheral neuroepithelioma, neuroblastoma, neuroendocrine) (medical knowledge, practice, patient care). 9. Discuss the pathologic features and genetic abnormalities of Ewing’s sarcoma (medical knowledge, practice, patient care). 10. Give a classification of rhabdomyosarcoma and describe the histopathologic features of each sub-type (medical knowledge, practice, patient care). 11. Discuss the immunohistochemical staining and the genetic abnormality of rhabdomyosarcoma (medical knowledge, practice, patient care). 12. Give a classification of pediatric brain and spinal cord tumors. Describe the histopathologic features of the common childhood brain tumors (juvenile pilocytic astrocytoma, medulloblastoma, astrocytoma, ependymoma, oligodendroglioma) (medical knowledge, practice, patient care). 13. Describe the histopathologic features of benign soft tissue lesions (nodular fasciitis, proliferative fasciitis, fibromatosis colli, soft tissue myofibroblastoma, inflammatory myofibroblastic tumor, fibrohistiocytic tumors, xanthoma, and others) (medical knowledge, practice, patient care) 14. Give a classification of vascular lesions (hemangioma, venous malformations, arterio-venous malformation, carvenous hemangioma, lymphangioma, hemangioendothelioma, and others (medical knowledge, practice, patient care) 15. List and discuss the common benign and malignant bone tumors of childhood (medical knowledge, practice, patient care). 16. Classify and discuss the pathologic features of childhood germ cell tumors (medical knowledge, practice, patient care). 17. Give a classification of childhood lymphoma and describe their histopathologic and genetic/chromosomal aberrations (medical knowledge, practice, patient care). 2 18. Describe the benign and malignant tumors of the liver (hepatoblastoma, hepatocellular carcinoma, hepatic adenoma, focal nodular hyperplasia, hamartoma, and others) (medical knowledge, practice, patient care). 19. List and discuss the common tumors and lesions of the thyroid gland (medical knowledge, practice, patient care). 20. List and discuss the common congenital lesions and neoplasms of the respiratory system (juvenile laryngotracheobronchial papillomatosis, hamartoma, pleuropulmonary blastoma, desmoplastic small round cell tumor, and others) (medical knowledge, practice, patient care). 21. List and discuss disorders and diseases associated with the perinatal period, particularly their pertinent clinical and morphologic features, e.g. SIDS, hyaline membrane disease, viral and bacterial sepsis, cerebral palsy, intrauterine growth retardation, meconium aspiration and peritonitis, necrotizing enterocolitis, hypoxic lesions (medical knowledge, practice, patient care). 22. List and discuss the common congenital anomalies of childhood, particularly their pertinent clinical, morphologic, and genetic features, e.g. branchial cleft anomalies, testicular regression, intersex disorders, tracheoesophageal fistulas, imperforate anus, trisomies, chromosomal deletion syndromes, sex chromosome abnormalities, hernias (medical knowledge, practice, patient care). 23. List and discuss common metabolic disorders of childhood, particularly their pertinent clinical, morphologic, and genetic features, e.g. galactosemia, amino acid abnormalies, electron chain disorders and other mitochondrial diseases, lysosomal storage disorders, glycogenoses, cystic fibrosis (medical knowledge, practice, patient care). 24. List and discuss the complications of organ transplantation in children, particularly their pertinent clinical and morphologic features, e.g. graft vs host disease, lymphoproliferative disease, infections, transplant rejection, effects of preparative therapy, effects of prolonged organ transport (medical knowledge, practice, patient care). 25. List and discuss the surgical pathology and cytology of common pediatric lung diseases, e.g. asthma, aspiration, bacterial pneumonia, viral pneumonia, sequestrations, adenomatoid lesions, bronchopulmonary dysplasia (medical knowledge, practice, patient care). 26. List and discuss the morphologic and clinical features of common pediatric gastrointestinal diseases, e.g. reflux, gastritis, duodenitis, colitis, infectious lesions, appendicitis, hepatitis, biliary atresia, paucity of intrahepatic ducts (medical knowledge, practice, patient care). 3 27. List and discuss the morphologic and clinical features of common pediatric infections, e.g. candidiasis, mycoses, CMV, EBV, HSV, HPV, meningitis, staph and strep infections, coliform infections, anaerobic infections, giardiasis, helminths (medical knowledge, practice, patient care). 28. List and discuss the morphologic, clinical, and genetic features of common immunodeficiency disease of childhood, e.g. chronic granulomatous disease, DiGeorge syndrome, SCIDS, chemotherapeutic complications (medical knowledge, practice, patient care). 4