Lymphedema:
1. A comparison of compression pumps in the treatment of lymphedema. J.J. Bergan,
S. Sparks, N. Angle. Vascular Surgery 1998(32):455-462.
Study size: 35 patients.
In this study, patients were treated with either a single chamber pump, a three chamber pump, and a 10-cell pump with gradient sequential compression. By far the greatest reduction was seen with the 10-chamber pump. Conclusion: Compression therapy systems with many chambers are superior to those with one or few chambers .
2. Treatment of monstrous elephantiasis, F-J Schingale, Lymphlogie in
Forschung und Praxis 1999(3Vj1) Special edition.
Study size: Case report.
Case report describing successful inpatient treatment and outpatient follow-up with manual lymph drainage and Lympha Press Mini in a patient with massive lower limb primary lymphedema . Conclusion: Combination therapy with MLD and Lympha
Press Mini is effective in treating the most extreme cases of lymphedema, and maintains the limb reduction without adverse effect. (German language.)
3. Sequential pneumatic compression for lymphedema. A controlled trial. Richmand
DM, O'Donnell TF Jr, Zelikovski A . Arch Surg 1985 Oct;120(10):1116-1119.
Study Size: 25 patients.
Shows successful inpatient treatment using Lympha Press 103 in patients with upper- and lower- extremity lymphedema, as well as successful maintenance of treatment reduction.
4. Physical treatment of post-mastectomy lymphedema. F. Dubois - C.E.R.T.O. (Centre d'Etude et de Recherche pour le Traitement des Oedemes – Brussels, Belgium.)
Study size: 103 patients.
Compared MLD alone to Lympha Press alone and Lympha Press + MLD together. Showed best results obtained when MLD and Lympha Press are used together, especially in the follow-up period.
5 . Experimental studies on the efficacy of pressure wave massage (Lymphapress) in lymphedema. Partsch H, Mostbeck A, Leitner G. Z Lymphol. 1981 Jul;5(1):35-9.
Study size: Physiological laboratory studies.
Isotopic lymphography was performed on several patients before and after treatment with Lympha Press. Labelled albumen was also injected to determine speed and extent of protein transport. Limb volume was measured before and after treatment.

There was a significant volume reduction. The Lympha Press was tested against the
Jobst singe cell pump, and the tracer was transported much more rapidly than the single cell pump, peaking at 5 minutes of treatment, when the single cell pump took
60 minutes. Tissue albumen was significantly reduced; however, the water was transported more rapidly . Conclusion: Lympha Press massage DOES transport proteins, but not as rapidly as water.
6. The Lympha-Press intermittent sequential pneumatic device for the treatment of lymphoedema: five years of clinical experience. A. Zelikovski, M.
Haddad, R. Reiss, J Cardiovasc Surg, 27(3):288-290.
A review of 5 years' experience with Lympha Press in clinic and hospital, showing it to be an efficient and effective treatment method as well as a preoperative aid for reduction surgery.
7. Clinical Report: Home therapy for lymphedema. Aileen McLeod PT, MCSP,
MCPA, Senior Physiotherapist, Hospital for Sick Children, Toronto, CA. Home
Health Care, Summer 1989.
Study size: 9 patients.
Observation and follow-up on home care for pediatric lymphedema with Lympha
Press. Conclusion: Treatment is effective, with good limb size decrease.
Conclusion: Compression therapy offers a much needed advancement for the medical management of lymphedema.
9. Long-term results of compression treatment for lymphedema. Christos J.
Pappas, MD, and Thomas F. O'Donnell, Jr., MD, FACS, Boston, Mass. J Vasc
Surg 1992;16:555-564.
Study size: 49 patients, followup for 26 months.
The effects of Lympha Press along with elastic stockings and skin care on the longterm reduction of lymhedema and infection control were assessed. Conclusion: The treatment of lymphedema with Lympha Press and compression stockings is associated with long-term maintenance of reduced limb girth in 90% of patients.
10. The Lymphapress - a new pneumatic device for the treatment of lymphedema: clinical trial and results A. Zelikovski, I. Melamed, I. Kott, M. Manoach, and I. Urca.
Folia Angiologica, Vol. XXVIII:165-169 .
Study size: 25 patients.
25 women with postmastectomy lympedema were trated, with recuction of 36 to 70% seen in 60% of the patients. There were almost no side effects.
11. Efficiency of treatment of lymphedema of the upper limb by multicompartment sequential pneumatic compression therapy. Rehabilitacion
(Madr) 1998:32:234-250.

Study size: 14 patients, upper limb lymphedema.
!4 patients were treated with Lympha Press Mini. Volumetric and circumferential measurements were taken before and after treatment. A statistically significant reduction was observed. Conclusion: A small but important study due to the accuracy of the measurements, and careful statistical analysis, showing the effectiveness of Lympha Press Mini in treating postmastectomy lymphedema.
12. A retrospective study of the effects of the Lymphapress pump on lymphedema in a pediatric population. Hassall A, Graveline C, Hilliard P.
Lymphology. 2001 Dec;34(4):156-65.
Study size: 16 children. Study assessing the effects of Lympha Press Mini treatment on childrem with lymphedema. Conclusion: 93% of patients showed sustained maintenance or continued reduction. Most patients experienced no complications.
Lympha Press Mini in Laparoscopic Surgery:
1. Central and peripheral adverse hemodynamic changes during laparoscopic surgery and their reversal with a novel intermittent sequential pneumatic compression device. Alishahi S, Francis N, Crofts S, Duncan L, Bickel A,
Cuschieri A. Ann Surg. 2001 Feb;233(2):176-82.
Positive pressure pneumoperitonium (inflation of abdomen with gas to provide sufficient room for surgery) is known to cause adverse changes in the central and peripheral circulatory system. This study attempts to quantify these adverse changes and to assess the effect of Lympha Press Mini on reducing these adverse hemodynamic changes during the surgery. Conclusion: Significant changes in the central and peripheral circulation are encountered during laparoscopic surgery.
These negative effects are reversed by Lympha Press Mini.
Phlebo Press DVT for prevention of postoperative deep vein thrombosis:
1. Venous hemodynamic alteration induced by the Venopress (a new intermittent compression pneumatic device for prevention of deep vein thrombosis). A. Zelikovski,
I. Ben-Tov, A. Koren, E. Stelman and M. Haddad . Phlebology (1995) Suppl. 1: 701-703
Note: The name "Venopress" has since been switched to Phlebo Press DVT.
Study size: 20 patients, laboratory study. Venous velocity was monitored before and after induction of general anesthesia. Prior to anesthesia, venous velocity was increased two to four times from baseline. During anesthesia, a further rise of 10 to
30% was seen Conclusion: The Phlebo Press DVT is highly efficient at augmenting venous flow velocity, especially during general anesthesia.
2. Changes in femoral blood flow velocity by intermittent pneumatic compression: Calf compression device versus plantar-calf sequential compression device. H. Iwama, S. Obara, H. Ohmizo. J. Anesth (2004)18:232-
233.

Study size: 10 volunteers, laboratory study.
Phlebo Press DVT and a well-known competitor device were tested. Phlebo Press
DVT performed equivalently to the competitor device.
Sports applications:
1. Use of the Muscle Pump Activator* for Increasing Lower Limb Venous Flow
Velocity. A. Zelikovski, A. Koren, E. Stelman, A. Avrahami, J. Cohen and M.
Haddad. Phlebology (1999) 14:123-125. *AKA Lympha Wave
Study size: 11 volunteers
The Lympha Press Mini (wave cycle) was tested to see if it could shorten recovery time after exercise. The volunteers performed exercise to exhaustion. During a 20minute rest period, half the volunteers were treated with Lympha Press. The volunteers then performed another subsequent exercise bout. Conclusion: the volunteers treated with Lympha Press immediately after exercise showed a 45% improvement in their ability to perform a subsequent exercise bout.
2.Enhancement of tibialis anterior recovery by intermittent sequential pneumatic compression of the legs. A. Wiener, J. Mizrahi, O. Verbitsky.Basic
Appl Myol 11 (2): 87-90, 2001.
Study size: 8 volunteers
Volunteers exercised to exhaustion and were then treated on one leg with the Lympha
Press, wave cycle. Performance after treatment was measured, and EMG studies were performed on the tibialis anterior muscles of both legs. Conclusion: The application of Lympha Press to both legs substantially improved performance. The tibialis anterior muscle of the treated leg achieved higher levels of muscular power than the passively recovering leg.