Scholar: Akhoon, Shabir Ahmad
Guide: Qazi, Shagufta
Title: Comparative study of intrathecal tramadol Administration on
postoperative analgesia after transurethral resection of
prostate using three different doses of tramadol.
Keywords: Intrathecal Tramadol; Prostatectomy, Transurethral
Degree: M.D
Year:
2010
Institution: : Dept of Anesthesiology & Critical Care,
Sher-i-Kashmir Institute of Medical Sciences.
Abstract
Objectives: 1: To determine the optimal dose requirements of intrathecal Tramadol as
the main postoperative Analgesic.2: To evaluate the side effect profile of various doses
of Intrathecal Tramadol
Study Design & Setting: Prospective Double Blind, Hospital based Study.
Materials & Methods: 87 patients of status ASA I and II, aged between 50-70 years
scheduled for TURP under spinal anesthesia, received 30 mg, (Group I), 40mg (Group II),
and 50mg (Group III) of intrathecal tramadol hydrochloride with 2.5ml of 0.5%
bupivacaine each. VAS score was assessed hourly for the first 8 hours after operation
and every four hourly thereafter for a total of 24 hours. The duration of analgesia in
three groups was obtained from the completion of spinal injection to the time of rescue
analgesic administered on demand or when visual analogue score was =3
Results: There was a statistically significant difference in postoperative pain relief in
group I (14.69±5.85 hours), group II (18.48±6.18 hours) and group III (19.45±4.626
hours). Incidence of vomiting in group III (34.5%), group II (17.2%) and group I (13.8%)
was statistically significant. The Postoperative Visual Analogue Scale score is statistically
significant among the three groups at different time periods.
Conclusions: Tramadol hydrochloride is an effective analgesic agent when administered
intrathecally for postoperative pain.40 mg is an optimum dose for postoperative
analgesia given intrathecally without significant increase in side effects.50 mg of
tramadol can be used with appropriate anti-emetics to reduce the incidence of nausea
and vomiting associated with this dose.