Infectious Disease – PHAS 310
Instructional Objectives
Upon completion of this course, the student will be able to:
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Describe the interplay between host and microorganism that lead to infection and
resolution to include:
a.
host immune factors
b.
host response to infection
c.
diagnosis and treatment of infectious disease
Explain the indications and techniques of specimen collection for examination
and the importance of specimen identification to include:
a.
blood
b.
sputum
c.
urine
d.
wound
e.
spinal fluid
Describe the indications and technique used to obtain:
a.
gram stains
b.
India ink stains
c.
acid fast stains
Identify and treat common ambulatory infectious diseases to include:
a.
pharyngitis
d.
soft tissue infections
b.
conjunctivitis
e.
otitis media
c.
URIs
f.
community acquired
pneumonia
Discuss community acquired pneumonias, contrast their:
a.
etiologic agent/risk factors
b.
clinical presentation/course
c.
laboratory manifestations
d.
treatment
Differentiate UTIs, cystitis, prostatitis with regard to:
a.
diagnostic criteria
b.
significance of bacteriuria
c.
responsible pathogens
d.
significance of recurrent UTIs
e.
treatment and management
Define nosocomial infections, list the most common causative pathogens, host
factors and modes of nosocomial infection transmission.
List the most common hospital acquired infections, their prevention, mode of
transmission, etiologic agents and treatment to include:
a.
UTIs
b.
wound infections
c.
bacteremia
d.
pneumonia
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Discuss the risk of transmission of HIV and Hepatitis B, not only to patients, but
also hospital personnel. Discuss the significance of "universal precautions".
Describe the clinical presentation, diagnostic evaluation, treatment management
of common enteric infections to include:
a.
Salmonella
b.
Shigella
c.
Campylobacter
d.
"traveler's diarrhea" (enterotoxigenic E. coli)
e.
C. difficile
Describe the clinical presentation, diagnostic evaluation, treatment of common
protozoan enteric infections to include:
a.
Giardia
b.
Cryptosporidiosis
c.
Trichinosis
d.
Schistosomiasis
e.
Amebiasis
f.
Toxoplasmosis
Describe the clinical presentation, diagnostic evaluation and treatment of common
helminthic infections to include:
a.
enterobiasis
b.
toxocariasis
c.
hookworms
d.
tapeworms
Discuss the fluid and electrolyte replacement requirements with regards to profuse
or prolonged diarrheal states.
Identify common superficial skin infections, name the causative microbial agent,
clinical course and treatment for:
a.
impetigo
b.
erysipelas
c.
cellulitis
Identify the presentation and treatment of anaerobic skin and soft tissue infections
in include:
a.
crepitant cellulitis
b.
gangrene
c.
necrotizing fascitis
d.
skin abscesses
Describe the clinical presentation, differential diagnosis, laboratory findings and
complications of bacterial meningitis.
List the three most common bacterial agents responsible for meningitis, their
epidemiology, clinical settings and treatment for each.
Differentiate between various viral disease of the CNS and their etiologies to
include:
a.
aseptic meningitis
b.
encephalitis (primary and post infectious)
c.
Creutzfeldt-Jakob Disease
d.
subacute sclerosing panencephalitis
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List CNS conditions associated with AIDS to include:
a.
viral agents (CMV, HSV, AML)
b.
Cryptococcal meningitis
c.
Toxoplasmosis
d.
AIDS dementia
Discuss the clinical manifestation, laboratory workup and treatment for each of
the above.
Discuss the pathogenesis, etiology, clinical
manifestations, treatment and prognosis of brain abscesses.
Define endocarditis and list the three classifications. Discuss the clinical
manifestations, laboratory features, diagnosis and treatment of each.
Discuss surgical management and the role of antimicrobial prophylaxis in
endocarditis.
List the types of exanthems caused by:
a.
viruses
a.
bacteria
Describe the assessment and manifestation of each.
Differentiate between infectious causes of vesicles/bullae and their treatment to
include:
a.
varicella
b.
herpes I & II
c.
staph infections
Discuss the etiology, clinical presentation, laboratory findings and treatment of
toxic shock syndrome.
Discuss Lyme Disease. Identify and describe the causative organism,
epidemiology, clinical manifestations (in three stages), treatment, prognosis and
prevention.
Define Rocky Mountain Spotted Fever. Discuss its etiology, clinical
manifestations, differential diagnosis, complications, treatment and prevention.
Describe osteomyelitis and its pathogenesis. List the hallmark of acute vs.
chronic osteomyelitis. Discuss its clinical manifestations, diagnosis and
treatment.
Differentiate between syphilis, genital herpes, chancroid, Donovanosis, and LGV.
Identify the etiologic agent, clinical manifestation, diagnosis, clinical course and
treatment of each.
List the most common etiologic agent, clinical manifestation, diagnosis and
treatment for the following disorders:
a.
urethritis (gonococcal & non-gonococcal)
b.
epididymitis
c.
cystitis
g.
proctitis
d.
cervicitis
h.
acute arthritis
e.
vulvovaginitis
i.
genital warts
f.
PID
j.
scabies
Define AIDS, list the etiologic agent and risk factors. Describe its
pathophysiology and immunopathogenesis.
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List commonly encountered opportunistic infections and their treatment
associated with AIDS.
Discuss the diagnosis, treatment, prevention and prognosis of AIDS.
Discuss tuberculosis. List the possible modes of
transmission, pathogenesis,
clinical manifestation and diagnosis.
List drugs used to treat TB and the major side effects of each.
Discuss extrapulmonary manifestations of TB.
Discuss multidrug resistant tuberculosis and alternative treatments used.
Define Leprosy and identify the etiologic agent. Discuss the clinicopathologic
classification, clinical manifestations, diagnosis and treatment.
Discuss mycobacterium avium-intracellulare with regard to clinical manifestation,
diagnosis and treatment.
List pathogens commonly associated with immunocompromised patients to
include:
a.
the asplenic patient
b.
secondary to chemotherapy
c.
secondary to organ transplant
d.
secondary to corticosteroid therapy
e.
the cancer patient
f.
the elderly
g.
pregnancy