Oncology Publications
1.
Zhang, N., et al., An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of antiinflammatory compounds in transgenic mice. J Immunol, 2003. 170(12): p. 6307-19.
2.
Zhang, L., et al., Interrogating androgen receptor function in recurrent prostate cancer. Cancer Res,
2003. 63(15): p. 4552-60.
3.
Wang, W. and W.S. El-Deiry, Bioluminescent molecular imaging of endogenous and exogenous p53-
mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model.
Cancer Biol Ther, 2003. 2(2): p. 196-202.
4.
Wang, S. and W.S. El-Deiry, Requirement of p53 targets in chemosensitization of colonic carcinoma to
death ligand therapy. Proc Natl Acad Sci U S A, 2003. 100(25): p. 15095-100.
5.
Sato, M., et al., Optimization of adenoviral vectors to direct highly amplified prostate-specific
expression for imaging and gene therapy. Mol Ther, 2003. 8(5): p. 726-37.
6.
Safran, M., et al., Mouse reporter strain for noninvasive bioluminescent imaging of cells that have
undergone Cre-mediated recombination. Mol Imaging, 2003. 2(4): p. 297-302.
7.
Rubin, J.B., et al., A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain
tumors. Proc Natl Acad Sci U S A, 2003. 100(23): p. 13513-8.
8.
Rosol, T.J., et al., Animal models of bone metastasis. Cancer, 2003. 97(3 Suppl): p. 748-57.
9.
Ray, P., A.M. Wu, and S.S. Gambhir, Optical bioluminescence and positron emission tomography
imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Res, 2003. 63(6): p.
1160-5.
10. Paulmurugan, R. and S.S. Gambhir, Monitoring protein-protein interactions using split synthetic renilla
luciferase protein-fragment-assisted complementation. Anal Chem, 2003. 75(7): p. 1584-9.
11. Murray, L.J., et al., SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an
experimental breast cancer bone metastasis model. Clin Exp Metastasis, 2003. 20(8): p. 757-66.
12. Mendel, D.B., et al., In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting
vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a
pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res, 2003. 9(1): p. 327-37.
13. Malley, R., et al., Recognition of pneumolysin by Toll-like receptor 4 confers resistance to
pneumococcal infection. Proc Natl Acad Sci U S A, 2003. 100(4): p. 1966-71.
14. Lyons, S.K., et al., The generation of a conditional reporter that enables bioluminescence imaging of
Cre/loxP-dependent tumorigenesis in mice. Cancer Res, 2003. 63(21): p. 7042-6.
15. Luker, G.D., et al., Imaging 26S proteasome activity and inhibition in living mice. Nat Med, 2003. 9(7):
p. 969-73.
16. Kanerva, A., et al., Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptortargeted oncolytic adenovirus. Molecular Therapy, 2003. 8(3): p. 449-58.
17. Jenkins, D.E., et al., In vivo monitoring of tumor relapse and metastasis using bioluminescent PC-3Mluc-C6 cells in murine models of human prostate cancer. Clin Exp Metastasis, 2003. 20(8): p. 745-56.
18. Jenkins, D.E., et al., Bioluminescent imaging (BLI) to improve and refine traditional murine models of
tumor growth and metastasis. Clin Exp Metastasis, 2003. 20(8): p. 733-44.
19. Hildebrandt, I.J., et al., Optical imaging of transferrin targeted PEI/DNA complexes in living subjects.
Gene Ther, 2003. 10(9): p. 758-64.
20. Edinger, M., et al., Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo
bioluminescence imaging. Blood, 2003. 101(2): p. 640-8.
21. De, A., X.Z. Lewis, and S.S. Gambhir, Noninvasive imaging of lentiviral-mediated reporter gene
expression in living mice. Mol Ther, 2003. 7(5 Pt 1): p. 681-91.
22. Collisson, E.A., et al., Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human
melanoma cells. Molecular Cancer Therapy, 2003. 2(10): p. 941-8.
23. Choy, G., P. Choyke, and S.K. Libutti, Current advances in molecular imaging: noninvasive in vivo
bioluminescent and fluorescent optical imaging in cancer research. Molecular Imaging, 2003. 2(4): p.
303-12.
24. Burgos, J.S., et al., Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in
nude mice. Biotechniques, 2003. 34(6): p. 1184-8.
25. Blasberg, R.G., In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations.
Nuclear Medicine and Biology, 2003. 30(8): p. 879-88.
26. Armstrong, S.A., et al., Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene
expression based classification. Cancer Cell, 2003. 3(2): p. 173-83.
27. Abrams, T.J., et al., Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent
and in combination with "standard of care" therapeutic agents for the treatment of breast cancer.
Molecular Cancer Therapy, 2003. 2(10): p. 1011-21.
28. Vooijs, M., et al., Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in
mice. Cancer Res, 2002. 62(6): p. 1862-7.
29. Schuetz, E., et al., Development of a real-time in vivo transcription assay: application reveals pregnane
X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol Pharmacol, 2002.
62(3): p. 439-45.
30. Scheffold, C., et al., Visualization of effective tumor targeting by CD8+ natural killer T cells redirected
with bispecific antibody F(ab')(2)HER2xCD3. Cancer Res, 2002. 62(20): p. 5785-91.
31. Rehemtulla, A., et al., Molecular imaging of gene expression and efficacy following adenoviral-mediated
brain tumor gene therapy. Mol Imaging, 2002. 1(1): p. 43-55.
32. Paulmurugan, R., Y. Umezawa, and S.S. Gambhir, Noninvasive imaging of protein-protein interactions
in living subjects by using reporter protein complementation and reconstitution strategies. Proc Natl
Acad Sci U S A, 2002. 99(24): p. 15608-13.
33. Nyati, M.K., et al., The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy
in an intrahepatic colon cancer model Gene Therapy, 2002. 9(13): p. 844-849.
34. Laxman, B., et al., Noninvasive real-time imaging of apoptosis. Proc Natl Acad Sci U S A, 2002. 99(26):
p. 16551-5.
35. Iyer, M., et al., Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter
genes in living mice. Molecular Therapy, 2002. 6(4): p. 555-62.
36. Edinger, M., et al., Advancing animal models of neoplasia through in vivo bioluminescence imaging. Eur
J Cancer, 2002. 38(16): p. 2128-36.
37. Echchannaoui, H., et al., Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus
pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. Journal of
Infectious Disease, 2002. 186(6): p. 798-806.
38. Contag, C.H. and B.D. Ross, It's not just about anatomy: in vivo bioluminescence imaging as an
eyepiece into biology. Journal of Magnetic Resonance Imaging, 2002. 16(4): p. 378-87.
39. Bhaumik, S. and S.S. Gambhir, Optical imaging of Renilla luciferase reporter gene expression in living
mice. Proceedings of the National Academy of Scienses of the United States of America, 2002. 99(1):
p. 377-82.
40. Adams, J.Y., et al., Visualization of advanced human prostate cancer lesions in living mice by a targeted
gene transfer vector and optical imaging. Nature Medicine, 2002. 8(8): p. 891-7.
41. Iyer, M., et al., Two-step transcriptional amplification as a method for imaging reporter gene
expression using weak promoters. Proc Natl Acad Sci U S A, 2001. 98(25): p. 14595-600.
42. Rehemtulla, A., et al., Rapid and quantitative assessment of cancer treatment response using in vivo
bioluminescence imaging. Neoplasia, 2000. 2(6): p. 491-5.
43. Contag, C.H., et al., Use of reporter genes for optical measurements of neoplastic disease in vivo.
Neoplasia, 2000. 2(1-2): p. 41-52.
44. Sweeney, T.J., et al., Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad
Sci U S A, 1999. 96(21): p. 12044-9.
45. Edinger, M., et al., Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia,
1999. 1(4): p. 303-10.
46. Zhao, H., et al., Characterization of coelenterazine analogs for measurements of Renilla luciferase
activity in live cells and living animals. Mol Imaging, 2004. 3(1): p. 43-54.
47. Zhang, J., et al., In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK
ligand gene promoter in intraosseous prostate cancer. Prostate, 2004. 59(4): p. 360-9.
48. Zhang, J., et al., In vivo visualization of aging-associated gene transcription: evidence for free radical
theory of aging. Exp Gerontol, 2004. 39(2): p. 239-47.
49. Zhang, G.J., et al., Bioluminescent imaging of Cdk2 inhibition in vivo. Nat Med, 2004. 10(6): p. 643-8.
50. Zeamari, S., et al., In vivo bioluminescence imaging of locally disseminated colon carcinoma in rats. Br
J Cancer, 2004. 90(6): p. 1259-64.
51. Yoshimitsu, M., et al., Bioluminescent imaging of a marking transgene and correction of Fabry mice by
neonatal injection of recombinant lentiviral vectors. Proc Natl Acad Sci U S A, 2004. 101(48): p. 1690914.
52. Xie, X., et al., The EZC-prostate model: noninvasive prostate imaging in living mice. Mol Endocrinol,
2004. 18(3): p. 722-32.
53. Walensky, L.D., et al., Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science,
2004. 305(5689): p. 1466-70.
54. Verra, N.C., et al., Human telomerase reverse transcriptase-transduced human cytotoxic T cells
suppress the growth of human melanoma in immunodeficient mice. Cancer Res, 2004. 64(6): p. 215361.
55. Uhrbom, L., E. Nerio, and E.C. Holland, Dissecting tumor maintenance requirements using
bioluminescence imaging of cell proliferation in a mouse glioma model. Nat Med, 2004. 10(11): p.
1257-60.
56. Tseng, J.C., et al., Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol, 2004.
22(1): p. 70-7.
57. Troy, T., et al., Quantitative comparison of the sensitivity of detection of fluorescent and
bioluminescent reporters in animal models. Mol Imaging, 2004. 3(1): p. 9-23.
58. Smith, M.C., et al., CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res,
2004. 64(23): p. 8604-12.
59. Shah, N.P., et al., Overriding imatinib resistance with a novel ABL kinase inhibitor. Science, 2004.
305(5682): p. 399-401.
60. Shachaf, C.M., et al., MYC inactivation uncovers pluripotent differentiation and tumour dormancy in
hepatocellular cancer. Nature, 2004. 431(7012): p. 1112-7.
61. Scatena, C.D., et al., Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the
study of metastatic human prostate cancer. Prostate, 2004. 59(3): p. 292-303.
62. Sato, A., B. Klaunberg, and R. Tolwani, In vivo bioluminescence imaging. Comp Med, 2004. 54(6): p.
631-4.
63. Sarraf-Yazdi, S., et al., Use of in vivo bioluminescence imaging to predict hepatic tumor burden in mice.
J Surg Res, 2004. 120(2): p. 249-55.
64. Rehemtulla, A., N. Taneja, and B.D. Ross, Bioluminescence detection of cells having stabilized p53 in
response to a genotoxic event. Mol Imaging, 2004. 3(1): p. 63-8.
65. Ray, P., et al., Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res,
2004. 64(4): p. 1323-30.
66. Rapisarda, A., et al., Schedule-dependent Inhibition of Hypoxia-inducible Factor-1{alpha} Protein
Accumulation, Angiogenesis, and Tumor Growth by Topotecan in U251-HRE Glioblastoma Xenografts.
Cancer Res, 2004. 64(19): p. 6845-6848.
67. Qiu, Z., et al., Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide
gene therapy for neuroblastomas compared to herpes simplex virus VP22. J Virol, 2004. 78(8): p.
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68. Ponomarev, V., et al., A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent,
and nuclear noninvasive imaging. European Journal of Nuclear Medicine and Molecular Imaging, 2004.
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69. Pichler, A., J.L. Prior, and D. Piwnica-Worms, Imaging reversal of multidrug resistance in living mice
with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A, 2004.
101(6): p. 1702-7.
70. Paulmurugan, R., et al., Molecular imaging of drug-modulated protein-protein interactions in living
subjects. Cancer Res, 2004. 64(6): p. 2113-9.
71. Moriyama, E.H., et al., Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIXmediated photodynamic therapy. Photochem Photobiol, 2004. 80(2): p. 242-9.
72. Mocanu, J.D., et al., Combined in vivo bioluminescence and fluorescence imaging for cancer gene
therapy. Mol Imaging, 2004. 3(4): p. 352-5.
73. Mitsiades, C.S., et al., Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a
therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer
Cell, 2004. 5(3): p. 221-30.
74. Mandl, S.J., et al., Multi-modality imaging identifies key times for annexin V imaging as an early
predictor of therapeutic outcome. Mol Imaging, 2004. 3(1): p. 1-8.
75. Liang, Q., et al., Noninvasive imaging of transcriptionally restricted transgene expression following
intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene. Mol
Imaging Biol, 2004. 6(6): p. 395-404.
76. Liang, Q., et al., Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus
receptor-epidermal growth factor (sCAR-EGF) fusion protein. Molecular Imaging and Biology, 2004.
6(6): p. 385-94.
77. Kung, A.L., et al., Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor
pathway. Cancer Cell, 2004. 6(1): p. 33-43.
78. Kim, Y.J., et al., Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a
tri-fusion reporter gene. Molecular Imaging and Biology, 2004. 6(5): p. 331-40.
79. Iyer, M., et al., Noninvasive imaging of enhanced prostate-specific gene expression using a two-step
transcriptional amplification-based lentivirus vector. Molecular Therapy, 2004. 10(3): p. 545-52.
80. Hollingshead, M.G., et al., A potential role for imaging technology in anticancer efficacy evaluations.
Eur J Cancer, 2004. 40(6): p. 890-8.
81. Fei, P., et al., Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.
Cancer Cell, 2004. 6(6): p. 597-609.
82. Douma, S., et al., Suppression of anoikis and induction of metastasis by the neurotrophic receptor
TrkB. Nature, 2004. 430(7003): p. 1034-9.
83. Doubrovin, M., et al., Multimodality in vivo molecular-genetic imaging. Bioconjugate Chemistry, 2004.
15(6): p. 1376-88.
84. Chen, X., P.S. Conti, and R.A. Moats, In vivo near-infrared fluorescence imaging of integrin alphavbeta3
in brain tumor xenografts. Cancer Research, 2004. 64(21): p. 8009-14.
85. Blankenberg, F.G., et al., Tumor imaging using a standardized radiolabeled adapter protein docked to
vascular endothelial growth factor. The Journal of Nuclear Medicine, 2004. 45(8): p. 1373-80.
86. Stathopoulos, G.T., et al., Nuclear Factor-{kappa}B Affects Tumor Progression in a Mouse Model of
Malignant Pleural Effusion. Am. J. Respir. Cell Mol. Biol., 2005: p. 2005-0130OC.
87. Silvertown, J.D., et al., H2 relaxin overexpression increases in vivo prostate xenograft tumor growth
and angiogenesis. International Journal of Cancer, 2005. 9999(9999): p. NA.
88. Shu, C.J., et al., Visualization of a primary anti-tumor immune response by positron emission
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89. Schneider, A., et al., Bone turnover mediates preferential localization of prostate cancer in the skeleton.
Endocrinology, 2005. 146(4): p. 1727-36.
90. Schimmelpfennig, C.H., et al., Ex Vivo Expanded Dendritic Cells Home to T-Cell Zones of Lymphoid
Organs and Survive in Vivo after Allogeneic Bone Marrow Transplantation. Am J Pathol, 2005. 167(5):
p. 1321-1331.
91. Sato, M., et al., Functionality of Androgen Receptor-Based Gene Expression Imaging in Hormone
Refractory Prostate Cancer. Clin Cancer Res, 2005. 11(10): p. 3743-3749.
92. Ryan, P.L., et al., Photonic Monitoring in Real Time of Vascular Endothelial Growth Factor Receptor 2
Gene Expression under Relaxin-Induced Conditions in a Novel Murine Wound Model. Ann NY Acad Sci,
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93. Qian, D.Z., et al., In vivo imaging of retinoic acid receptor beta2 transcriptional activation by the
histone deacetylase inhibitor MS-275 in retinoid-resistant prostate cancer cells. Prostate, 2005. 64(1):
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94. Pichler, A., et al., In vivo RNA Interference-Mediated Ablation of MDR1 P-Glycoprotein. Clin Cancer Res,
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95. Peng, W., et al., Tightly-regulated suicide gene expression kills PSA-expressing prostate tumor cells.
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96. Paulmurugan, R. and S.S. Gambhir, Novel Fusion Protein Approach for Efficient High-Throughput
Screening of Small Molecule-Mediating Protein-Protein Interactions in Cells and Living Animals. Cancer
Res, 2005. 65(16): p. 7413-7420.
97. Ohlfest, J.R., et al., Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the
Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing
Intracranial Human Glioblastoma. Molecular Therapy, 2005. 12(5): p. 778-788.
98. Notting, I.C., et al., Whole-body bioluminescent imaging of human uveal melanoma in a new mouse
model of local tumor growth and metastasis. Invest Ophthalmol Vis Sci, 2005. 46(5): p. 1581-7.
99. Nogawa, M., et al., Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo
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Moriyama, Y., et al., In vivo Study of the Inflammatory Modulating Effects of Low Level Laser
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