Comparison of Optical Coherence Tomography and Fluorescence Assessments of Decay underneath Dental Sealants Gregory Chan Mentor: Petra Wilder-Smith The efficacy of optical coherence tomography (OCT) and fluorescence-based imaging modalities at detecting decay underneath dental sealants was qualitatively and quantitatively evaluated. Sealant was applied onto healthy, demineralized, and carious teeth. The OCT and fluorescence images of each of the three categories of teeth were compared for the ability to identify decay. A clear contrast was visible in the OCT images between healthy, demineralized, and carious teeth, with statistical significance. Fluorescence detected heavy decay but there was no discernment between healthy and demineralized teeth, either qualitatively or quantitatively. This study demonstrates the capability of optical coherence tomography to diagnose tooth demineralization and decay under dental sealants.