RLUH Lower GI Investigation pathways in clinical practice This guidance proposes to clarify the investigation algorithm for patients presenting with Lower GI symptoms. It essentially prescribes the demise of the Barium Enema and devises a rational plan for the employment of CT-Colonography, Flexible Sigmoidoscopy and Colonoscopy. Aims Improve quality of care for patients with lower GI symptoms and provide an evidence-based and high quality service Reduce the rate of missed colorectal cancers/advanced colorectal polyps by replacing double contrast barium enema with a more accurate investigation (CT colonography). Reorganise colonoscopy service to provide the best evidence-based service and improve the appropriateness of referral for colonoscopy NOTES applying to ALL tests! ALL patients referred for these investigations MUST be able to tolerate bowel prep and MUST be agile enough to climb on and move on an examination couch – if in doubt please discuss with Endoscopist or Radiologist!. Special considerations for bowel prep apply for patients with diabetes or renal failure. Abdominal pain on its own is NOT an indication for any of these investigations Irritible Bowel Syndrome does not require investigation except as new onset sypmptom >45 years (see NICE http://guidance.nice.org.uk/CG61) Please use other referral form to ensure patient gets onto database! Please see NICE guidance Patients who have had an MI should NOT have endoscopy for 3 months or CT-Colonography for 6 weeks. Exceptional circumstances should be discussed with a Radiologist or Endoscopist whom you should name in your referral. This document has been agreed October 2009 by: Dr. Martin Lombard, Clinical Director Gastroenterology Dr. Mark Hughes, Clinical Director Radiology Mr. Paul Rooney, Lead Clinician Colorectal Cancer In consultation with Drs. Keith Leiper, Sanchoy Sarkar & Paul O’Toole . Indications for CT Colonography: Group 1: Investigation of weight loss or any palpable mass thought to be related to colon – CT colonography may give additional information in this group. Group 2: Patients with a distal cancer identified on Flexible Sigmoidoscopy or Limited colonoscopy to exclude metachronous tumours Group 3: Patients with incomplete colonosocopy for any reason (anticipate <10%, includes where indication for colonoscopy is diagnostic or surveillance except in IBD) could have same day colonography without the need to re-prep and return – not always possible but worth discussing with CT on the day!. Group 4: Age >45, change in bowel habit and abdominal pain (IBS type symptoms). Please see NICE guidance on this issue at: http://guidance.nice.org.uk/CG61 Group 5: Patients with a major aversion to endoscopy where serious colonic disease needs exclusion or some patients who are have multiple comorbidities or are anticoagulated but consider first whether they would be fit for any further intervention. Note patients in this category with iron deficiency or a history of bleeding should be considered for colonoscopy rather than colonography. Indications for CT Colonography: A patient in whom a colonic tumour is suspected but they are not capable or agile enough for bowel prep. PLEASE consider first whether investigation will add anything and what outcomes are possible if a positive diagnosis is made If in doubt please discuss with a Radiologist!. Indications for Colonoscopy: Group 6: Diarrhoea which is persistent >6 weeks as predominant symptom (regardless of age) except if patients have elevated endoscopic risk or aversion (see Group 5 above) Group 7: Patients with confirmed iron deficiency anaemia (low HB and Low ferritin, except if patients have elevated endoscopic risk or aversion (see Group 5 above) Group 8: Polyps/other abnormality detected by CTC or flexible sigmoidoscopy Group 9: patients who have had previous polyps or cancer who may be on the surveillance system but who present with interval symptoms Group 9: Screening and surveillance as per BSG and local guidelines for colonoscopic surveillance should be registered on the databse Note: Young patients (guide age <45yrs) who warrant lower bowel investigation for any reason should have colonoscopy in preference to colonography because of the longer terms risks of radiation exposure Indications for Flexible sigmoidoscopy: All bright red rectal bleeding, in the absence of diarrhoea, change of bowel habit, weight loss or pain, or significant family history should go to OAFs. Patients presenting with symptoms who require exclusion or assessment of inflammatory bowel disease should have flexible sigmoidoscopy unless a full bowel assessment is required Patients with localised rectal symptoms (Proctalgia, tenesmus etc) should only require flexible sigmoidoscopy Note that abdominal pain on its own is not an indication for endoscopic tests References Cotton PB, Durkalski VL, Pineau BC, et al. Computed tomographic colonography (virtual colonoscopy): a multicenter comparison with standard colonoscopy for detection of colorectal neoplasia. JAMA. 2004;291:1713-9. Gluecker TM, Johnson CD, Harmsen WS, et al. Colorectal cancer screening with CT colonography, colonoscopy, and double-contrast barium enema examination: Prospective assessment of patient perceptions and preferences. Radiology 2003;227:378–84. Pickhardt PJ, Hanson ME, Vanness DJ et al. Unsuspected extracolonic findings at screening CT colonography: clinical and economic impact. Radiology. 2008 ;249:151-9. Rex DK, Rahmani EY, Haseman JH, et al. Relative sensitivity of colonoscopy and barium enema for detection of colorectal cancer in clinical practice. Gastroenterology 1997;112:17–23. Rockey DC, Paulson E, Niedzwiecki D, et al. Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison. Lancet 2005;365:305–11. Taylor SA, Halligan S, Burling D, et al. Intra-individual comparison of patient acceptability of multidetector-rowCT colonography and double-contrast barium enema. Clin Radiol 2005;60:207–14. Taylor SA, Halligan S, Saunders BP, et al. Acceptance by patients of multidetector CT colonography compared with barium enema examinations, flexible sigmoidoscopy, and colonoscopy. AJR Am J Roentgenol 2003;181:913–21 Toma J, Paszat LF, Gunraj N, et al. Rates of new or missed colorectal cancer after barium enema and their risk factors: A population-based study. Am J Gastroenterol 2008 Oct 1. [Epub ahead of print] Winawer SJ, Stewart ET, Zauber AG, et al. National Polyp Study Work Group. A comparison of colonoscopy and double-contrast barium enema for surveillance after polypectomy. N Engl J Med 2000;342:1766–72.