academic foundation (f2) post in psychiatry

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ACADEMIC FOUNDATION YEAR 2 POSTS IN Vascular Surgery/Medicine
Academic Unit of Vascular Molecular Medicine
LIGHT Laboratories
Clarendon Road
University of Leeds
Leeds LS2 9LT
Professor Peter Grant, Professor of Medicine
Professor Julian Scott, Professor of Vascular Surgery
Description of the Academic Unit
The Academic Unit is multi-disciplinary and has one Professor of medicine
(Professor PJ Grant) and one Professor of Vascular Surgery (Professor DJA
Scott), with senior academic staff in diabetes and vascular biology.
The major interest of the Academic Unit is the study of genetic and
environmental determinants of thrombotic vascular disorders; ischaemic heart
disease, abdominal aortic aneurysm, peripheral vascular disease,
cerebrovascular disease, venous thromboembolism and the vascular
complications of diabetes mellitus. Extensive facilities exist for both clinical
and laboratory based research activities. Professor Peter Grant is Head of the
Academic Unit. Principal investigators in the Academic Unit are Dr Ramzi
Ajjan (Senior Lecturer & DOH Clinician Scientist), Dr Eleanor Scott (Senior
Lecturer), Dr Lucinda Summers (Senior Lecturer), Dr Robert Ariens (Reader),
Dr Angela Carter (University Research Fellow), Dr Richard Pease and Dr
Helen Phillipou. Mr Max Stickland is the Academic Unit Coordinator.
The Academic Unit is supported by the MRC, British Heart Foundation, Stroke
Association, Health Service Association and the Sir Jules Thorn Charitable
Trust .The Academic Unit has well equipped laboratories with dedicated
laboratories for DNA / RNA work, PCR and cell biology. There are also
facilities for the measurement of circulating haemostatic proteins, protein
purification and functional analysis. Major laboratory equipment includes a
Transgenomic WAVE machine for the detection of novel polymorphisms,
ABI310 automated flourescent sequencer, Applied Biosystems 7700 real time
PCR machine, a BioCad Sprint for protein analysis and a laser scanning
confocal microscope. Current clinical and scientific research projects include
transcriptional regulation of haemostasis and insulin resistance,
characterisation of polymorphic variants in the beta3 integrin gene and the
RAGE promoter. Other studies include recombinant expression of fibrinogen
and Factor XIII and the role of Factor X and EPR1 in vascular disease. We
are also investigating the Glyoxalase system and glycation in diabetes
mellitus, the role of the Factor XIII A and B subunits in vascular disease,
complement system in ischaemic heart disease, heritability of haemostatic
factors in twins and families, haemostatic factors in South Asians and the role
of insulin resistance in peripheral vascular disease.
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Overview of F2 Post in Academic Vascular Surgery/Medicine
The Academic Post in Vascular Surgery/medicine is one of the four month
attachments in an FY2 programme which also includes Vascular Surgery at
Bradford and Diabetes Medicine at the Leeds General Infirmary. The
Academic Vascular Surgery/Medicine placement consists of 5 PAs of
academic work and 5 PAs of clinical work per week. The academic
component aims to develop a range of vascular surgery/diabetes clinical
research and teaching skills. The clinical component is in vascular
surgery/diabetes, closely linked to relevant aspects of the academic
component.
In addition, there are teaching sessions throughout the year for all trainees
who do an academic placement during their F2 year. These focus on generic
research skills.
Outline of the Post
Prior to starting the placement
After appointments successful applicants will be invited to visit the Academic
Unit to discuss their forthcoming placement. This will enable us to match you
with the most suitable academic supervisor, and to begin planning the specific
areas to cover during your placement.
Teaching sessions throughout the F2 year
Together with other trainees who undertake an academic F2 placement, you
will have regular teaching sessions on generic research skills throughout the
F2 year.
Components of the F2 Post:

Vascular Surgery, Bradford Royal Infirmary

Leeds General Infirmary (Diabetes Medicine Professor Grant)

Vascular Surgery/Medicine (LIGHT)
You will meet with your academic supervisor at the start of your placement to
review your learning portfolio and the academic opportunities of the
placement. You will then agree on a set of academic objectives for the
placement. You will receive feedback from your supervisor during the
placement about these, and towards the end of the placement will have an
appraisal meeting. You will also undertake assessments of academic
competencies in the course of your placement.
Activities during the academic placement:
These will be coordinated by your academic supervisor, and provided by a
range of members of the Academic Unit, accompanied by relevant selfdirected learning.
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Research skills
1. Vascular Surgery/medicine research skills. This will involve developing the
generic research skills learned during the F2 year, and focusing on their
applications in vascular surgery/medicine research.There are also regular
research seminars held by the Academic Unit.
2. Research Training. During the attachment you will trained in a variety of
software packages; ( excel, access, SPSS and reference manager). This will
enable you to undertake simple database management and statistical
analysis of a variety of data sets. Other research skills will include study
design and paper/grant writing, analysis and critique. In the laboratory you will
be taught cell culture, ELISA, DNA preparation, PCR, confocal microscopy,
Mass Spectrometry and a variety of tests of fibrin structure and function.
3. A research project. This will either be a short project, e.g. involving analysis
of data already available from a research study, or will involve making a
contribution to an ongoing study. Specific opportunities will depend on the
status of studies at the time of the placement, but examples include
performing a review of literature evidence or clinical protocols of particular
relevance to the study. Some projects may involve sequential trainees taking
over where their predecessor left off on a project. Where appropriate, you will
be encouraged to write up your research project for publication.
Teaching skills
In order to begin to develop your teaching skills, you will take part in the
teaching of behavioural sciences to first year undergraduate medical students.
This will primarily involve taking part in the facilitation of small group teaching
sessions. You will have clear guidance concerning the teaching materials and
your role, and will be supervised during the process. For further support, you
may also be paired with a more senior psychiatric trainee. There will be
further opportunities to develop teaching skills during the clinical component
of your placement, as outline below.
Clinical component
This will be in vascular surgery and diabetes, and supervised by Professor
Scott and Professor Grant. It will cover the clinical and generic foundation
competencies and will be closely linked to the academic component. There
will be F2-level clinical feedback, appraisal and assessment, as documented
in the Foundation Curriculum (www.mmc.nhs.uk).
Academic mentorship
If you wish to continue into specialist training in academic vascular
surgery/medicine, we can facilitate academic mentorship. This is coordinated
by Professor DJA Scott and Professor Grant.
Applicants are welcome to contact Professor Scott and Professor Grant for
more information about this placement. (d.j.a.scott@leeds.ac.uk,
p.j.grant@leeds.ac.uk).
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APPENDIX
Contact address
LIGHT Laboratories
Clarendon Way
University of Leeds
Leeds
LS2 9JT
Tel: 0113 343 7721
The Leeds Institute of Genetics, Health and Therapeutics (LIGHT) is the
first biomedical facility in the University of Leeds. The research mission
of LIGHT is to perform internationally competitive translational research
into complex diseases (cardiovascular illness, diabetes,
neurodegenerative diseases and cancer) and to improve the delivery of
patient care
The Institute comprises the Centre for Epidemiology and Biostatistics, Medical
Physics, groups from Biological Sciences and a research grouping on
Diabetes and Cardiovascular Research including: Molecular Vascular
Medicine, the British Heart Foundation Heart Research Centre and the
Cardiovascular Research Institute at Leeds (CRISTAL). LIGHT ultimately
aims to conduct novel scientific research that has both patient and public
health benefit. Research is carried out using core skills in genomics,
proteomics, cell biology, molecular pharmacology, epidemiology, biostatistics,
bioinformatics, clinical medicine and imaging.
The multidisciplinary approach has a foundation in the basic understanding of
normal and abnormal cell function at the molecular and cellular level.
Mechanistic research thus provides an understanding of key events in the
disease process which can be translated into biomarkers for application either
in population or clinical-based studies.

At the population level novel biomarkers of exposure, susceptibility and
disease can be incorporated into aetiologic studies and provide new
opportunities to evaluate public health intervention strategies.

At the clinical level novel biomarkers and imaging technology may
improve diagnosis and prognosis whilst advances in understanding
molecular mechanisms also provides new targets for research into
more effective therapies; in collaboration with external partners, the
Institute is interested in developing new pharmaceutical agents for the
management and prevention of complex diseases.
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The LIGHT Laboratories Building
Examples of current research topics include the study of the underlying
pathology of Alzheimers disease; genetic, lifestyle and environmental risk
factors for cancer and cardiovascular disease; genetic and environmental
determinants of fibrin structure/function in relation to diabetes and
cardiovascular disease; the genetic basis of premature coronary artery
disease and magnetic resonance imaging to improve diagnosis and
management of ischaemic heart disease; the cellular and molecular aetiology
of infertility. Many of these projects are part of the cross-cutting research
themes that build upon the core skills of the constituent groups within LIGHT
(see the Research page).
Overall therefore LIGHT conducts basic and applied research that will
alleviate morbidity and mortality from chronic diseases. It does this through
provision of an improved scientific rationale for both prevention strategies in
populations and improved treatment and disease management in the clinic.
This research activity is underpinned by a number of important infrastructural
developments.
The impressive new LIGHT Laboratories are a £10m SRIF funded initiative,
which sit at the core of the Institute. Opened in October 2004, the building
contains a mixture of clinicians and basic scientists from the Faculties of
Medicine and Health and Biological Sciences working in collaboration. The
LIGHT Laboratories are situated next to the Medical School, adjacent to the
Leeds General Infirmary and opposite the Faculty of Biological Sciences,
providing a major opportunity for cross-Faculty collaboration. Further
infrastructure funding has provided state-of-the-art equipment, including a
Microarray Facility, which is run under a service provision arrangement (for
further details click here), a proteomics suite which has allowed participation
in the Human Proteome Organisation (HUPO) clinical proteomics initiative
and an MRI facility.
The Institute also has access to a number of national and regional disease
registers of cancer, diabetes and paediatric intensive care admissions, which
facilitate clinical and population-based research. In addition, LIGHT is
involved in some large population studies including the UK Women's Cohort
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Study, a genetic study of families with early heart disease and the newly
launched Born in Bradford mother-child birth cohort.
http://www.borninbradford.nhs.uk/
LIGHT is also the focus for a number of broader collaborative ventures across
the University. For example, the Interdisciplinary Centre for Obesity, Nutrition
and Health (ICON-Health) is led from within LIGHT and the Institute is a
collaborative partner in the Centre for Bioinformatics, in the Faculty of
Mathematics. LIGHT also leads the Leeds Environmental Health Network
(LEHnet) that advises the UK Environment Agency and encompasses
members from civil engineering, geography, the Environment Centre as well
as LIGHT.
Academic Staff; Vascular Molecular Medicine.
Name
Phone
Title
ABBAS, Afroze
37708
Dr
medaa@medphysics.leeds.ac.uk
ADAMSON,
Penny
37741
Dr
medpja@medphysics.leeds.ac.uk
AJJAN, Ramzi
37475
Dr
r.ajjan@leeds.ac.uk
ARIENS, Robert
37734
Dr
r.a.s.ariens@leeds.ac.uk
BAILEY,
Kristian
37708
-
medkb@medphysics.leeds.ac.uk
BALDO, Omer
37708
Dr
medob@medphysics.leeds.ac.uk
BALMFORTH,
Tony
37767
Dr
a.j.balmforth@leeds.ac.uk
BOOTHBY,
May
37709
Mrs
m.boothby@leeds.ac.uk
BROWN, Jane
37709
Mrs
j.m.y.brown@leeds.ac.uk
CARTER,
Angela
37765
Dr
medamca@leeds.ac.uk
CORDELL, Paul
37742
Dr
p.a.cordell@leeds.ac.uk
FEELY Morgan
37760
Dr
m.p.feely@leeds.ac.uk
FUTERS,
Simon
37744
Dr
t.s.futers@leeds.ac.uk
GRANT, Peter
37721
Prof
p.j.grant@leeds.ac.uk
HOUSEMAN,
37721
Mrs
n.j.houseman@leeds.ac.uk
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Email
Nikki
JOHNSON,
Anne
37702
Ms
a.b.johnson@leeds.ac.uk
KAIN, Kirti
37745
Dr
k.kain@leeds.ac.uk
KEARNEY,
Mark
37764
Prof
m.t.kearney@leeds.ac.uk
McCORMACK,
Lynn
37748
Dr
l.mccormack@leeds.ac.uk
MOSS Marcus
37708
Mr
medmam@medphysics.leeds.ac.uk
MWAMBINGU,
Tom
37708
Dr
medtm@medphysics.leeds.ac.uk
PEASE,
Richard
37740
Dr
r.j.pease@leeds.ac.uk
PHILIPPOU,
Helen
37768
Dr
h.philippou@leeds.ac.uk
PHOENIX,
Fladia
37708
Miss
medfp@medphysics.leeds.ac.uk
RENNIE, Libby
37702
Miss
meder@medphysics.leeds.ac.uk
RICE, Penny
37702
Ms
p.j.rice@leeds.ac.uk
SCALES,
Andrea
37719
Mrs
a.scales@leeds.ac.uk
SCOTT Julian
37735
Prof
d.j.a.scott@leeds.ac.uk
SCOTT,
Eleanor
37762
Dr
e.m.scott@leeds.ac.uk
SHEFTA, Jahan
37708
Ms
medjss@medphysics.leeds.ac.uk
SMITH, Kerrie
37708
Miss
k.a.smith@leeds.ac.uk
SOMANI, Riyaz
37708
Dr
r.somani@leeds.ac.uk
STANDEVEN,
Kristina
37743
Dr
k.f.standeven@leeds.ac.uk
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STICKLAND,
Max
37733
Mr
m.stickland@leeds.ac.uk
SUMMERS,
Lucinda
37737
Dr
l.k.m.summers@leeds.ac.uk
SUNDERLAND,
Richard
37708
Mr
medrjs@medphysics.leeds.ac.uk
SURR, Jessica
37708
Miss
medjs@medphysics.leeds.ac.uk
-
Dr
lipbun.tan@leedsth.nhs.uk
VARDY, Emma
37708
Dr
e.r.l.c.vardy@leeds.ac.uk
WHEATCROFT,
Stephen
37723
Dr
s.b.wheatcroft@leeds.ac.uk
TAN, Lip-Bun
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