Assiut university researches
PRE-OPERATIVE ORAL GABAPENTIN
VERSUS TROPISETRON FOR
PREVENTION OF INTRATHECAL
MORPHINE INDUCED NAUSEA AND
VOMITING AFTER MAJOR ABDOMINAL
CANCER SURGERY
Khaled M. Fares, MD and Sahar A. Mohamed, MD.
Abstract:
ABSTRACT Unfortunately spinal morphine is associated with
high incidence of pruritus and emetic symptoms which can
limit its use. The aim of this study was to compare the efficacy
of preoperative oral Gabapentin versus tropisetron on
postoperative nausea and vomiting after major abdominal
surgery under combined spinal and general anesthesia.
Ninety patients randomly assigned into three groups 30
patients each; group Control received placebo, group
Gabapentin received 600 mg of gabapentin and group
Tropisetron received 5 mg tropisetron orally 2 hours before
surgery. Frequency and severity of PONV, pruritus, pain
severity, time to first request of rescue analgesic and
incidence of side effects were recorded in the 1st 24 hours
postoperative. Incidence of PONV in Gabapentin and
Tropisetron group decreased compared to Control group (p
Key words:
gabapentin; tropisetron; intrathecal morphine; nausea;
vomiting.
Published in:
Journal Of Egyption Society for Management Of Pain,Vol 29
NO 2,