Mentored Professional Enrichment Experience Applicant: Andrew Mitchelson Name of Project/Experience: Patient Demographics and Risk Factors in Pediatric Distal Humeral Supracondylar Fractures Location where Project/Experience will take place: Southern Illinois University School of Medicine Department of Surgery, Division of Orthopedics 747 N. Rutledge, Springfield IL 62794 Mentor Name and Contact Information: Khaled J. Saleh, BSc, MD, MSc, FRCS(C), MHCM SIU School of Medicine, Division of Orthopaedics, P.O. Box 19679, Springfield, IL ksaleh@siumed.edu 217-545-8865 Brooke Robinson, MPH SIU School of Medicine, Division of Orthopaedics, P.O. Box 19679, Springfield, IL brobinson@siumed.edu 217-545-1387 RATIONALE Elbow fractures are common in the pediatric population, accounting for 65% of all pediatric fractures. Of those, 60% are manifest as supracondylar humeral fractures 1. The modified Gartland system further classifies supracondylar humeral fractures into one of 3 or 4 types. The classification type of each fracture is based upon degree of displacement, extent of periosteal injury, neurovascular involvement, and degree of stability 2. Treatment options include immobilization unaccompanied by other reductive intervention, closed reduction with pin fixation, and open reduction with pin fixation 2. Some literature already exists examining patient demographics and supracondylar humeral fractures. One study has indicated an average age of supracondylar humeral fracture occurrence around six years 3. Despite historic trends, there may be a female sex predilection in these fractures 4. However, the findings of existing studies with regard to sex demographics vary. Demographic information that is not currently available with regard to supracondylar humeral fractures includes patient ethnicity, body mass index (BMI) trends, overall demographic trends (age, sex, ethnicity, BMI) specific to the modified Gartland classification system, and overal demographic trends in relation to treatment approaches. Indentification of significant risk factors for the occurrence and severity of pediatric supracondylar fractures will ultimately effect the treatment algorithm of these patients. These fractures, despite being comparitively common, are associated with significant complications. Knowledge of a significant risk factor-severity-complication relationship will increase suspicion of complications in at-risk populations. Additionally, such knowledge will aid in determining the most appropriate treatment approach to address potential complications and to minimize their occurrence. GOALS Research goals for this MPEE project are: 1. To examine patient ethnicity in incidence of supracondylar humeral fractures 2. To examine body mass index in incidence of supracondylar humeral fractures 3. To examine trends in patient demographics and fracture classification (according to the modified Gartland system of classification) 4. To examine trends in patient demographics and treatment approaches 5. To determine whether or not risk factors exist as predictors of supracondylar humeral fracture severity. Personal goals for this MPEE project are: 6. To gain exposure to the field of orthopedic surgery (through research, interactions with attending and resident surgeons, and clinical experiences) 7. To begin to develop my capacity for clinical and translational research 8. To build a foundation for continued research and an evidence-based practice METHODS This project will begin with a review of all distal humeral supracondylar fractures treated by SIU orthopedic surgeons over the last five years. We will request a report from SIU SOM Information Resources that will show all of the patients who have ICD-9 codes 81241 and 81251 beginning January 2007 through January 2012. Based on preliminary clinic data, we estimate that our sample size will be approximately 500 patients. This sample size is consistent with previously published epidemiological studies on pediatric supracondylar humeral fractures 3,4. From the patient list, we will retrospectively review each of the patients’ charts to collect age, sex, ethnicity, body mass index, fracture classification, and treatment. We will enter this data into an excel spreadsheet. ANALYSIS Once we have collected the data from Centricity and entered it into an excel spreadsheet, the data will be imported into a statistical program, either SPSS or SAS. We will work with a statistician using the statistical program to compute descriptive statistics and uni- and multivariate analyses. Analysis will examine the trends between specific demographics, injury types, and treatment approaches. Univariate and mulitvariate analysis will be conducted, focusing on the association between patient demographics and severity of disease (fracture pattern on plane radiographs and surgical procedure). Statistical analysis will determine whether there is a statistically significant correlation between patient demographics/risk factors and fracture severity. We hypothesize that there will be a significant difference in prevalence of supracondylar fractures based on gender, ethnicity, and BMI values. We also hypothesize that certain demographics will predispose patients to the severity of their injury. Completion of my personal goals will be determined by my level of involvement within the Division of Orthopedics, my participation in research and clinical activities, and my hopeful appeciation for the role of research in clinical practice. SUPPORT 1. Do you request support funds? Yes No 2. Would you be able to participate if a scholarship is not available? Yes No REFERENCES 1 Kasser JR, Beaty JH. Supracondylar fractures of the distal humerus. In: Beaty JH, Kasser JR, Wilkins KE, Rockwood CE, editors. Rockwood and Wilkins’ fractures in children. 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p 543-89. 2 Omid R, Choi PD, Skaggs DL. Supracondylar humeral fractures in children. J Bone Joint Surg Am. 2008 May;90(5):1121-32. 3 Cheng JC, Lam TP, Maffulli N. Epidemiological features of supracondylar frac- tures of the humerus in Chinese children. J Pediatr Orthop B. 2001;10:63-7. 4 Farnsworth CL, Silva PD, Mubarak SJ. Etiology of supracondylar humerus frac- tures. J Pediatr Orthop. 1998;18:38-42.