CLINICAL INDICATIONS: This is a __-year-old patient who underwent a complete investigation at the University of California, San Francisco, Bariatric Surgery Center and fulfilled the Bariatric Surgery Center criteria and the National Institutes of Health criteria to undergo surgery for morbid obesity. The patient was offered the laparoscopic versus open Roux- en-Y gastric bypass. The preoperative investigation can be found in the UCSF Bariatric Surgery chart. The patient was informed in detail about the medical and surgical alternatives for the treatment, and the morbidity and the mortality associated with the procedure. The patient understood and signed informed consent and was brought to the operating room in stable condition. FINDINGS: Morbid obesity, body mass index (BMI) of __. PROCEDURE: The patient was prepped and draped in the usual sterile fashion and administered general anesthesia with endotracheal intubation. A Foley catheter was inserted. An arterial line, two large-bore peripheral intravenous lines and an orogastric tube were placed by the Anesthesia Team. Subcutaneous heparin and antibiotics IV were administered. The patient had all extremities padded and protected, and was safely secured to the operative table. A first trocar was inserted in a supraumbilical 10 mm incision into the peritoneal cavity under direct visualization. Pneumoperitoneum was then obtained at 15 mmHg. Reinsertion of the camera was then accomplished, and visualization and inspection of the whole abdominal cavity did not demonstrate any abnormalities. Two additional 10- 12 mm trocars were inserted under direct vision, one in the right side of the abdomen approximately 7 cm lateral to the supraumbilical trocar in the lateral aspect of the rectus muscle sheath and the other 10-12 mm trocar was inserted under direct vision in the left side of the abdomen, also in a paramedian position about 10 cm above the umbilical trocar. Two 5 mm trocars were then inserted under direct vision, one in the left subcostal area at the level with the anterior axillary line and the other in a right paramedian position. An additional 5 mm trocar was inserted in the subxiphoid area under direct vision, and through that trocar was inserted a grasper which was attached to the left crus of the diaphragm to accomplish the retraction of the left lobe of the liver. The patient was placed in Trendelenburg position. The greater omentum was then retracted superiorly toward the supramesocolic aspect of the abdomen. The Treitz angle was identified and located. The first loop of jejunum was then run for about 30 cm from the Treitz angle and divided with an Endo GIA white load of 45 mm. The mesentery of that proximal jejunal loop was then divided with another firing of a gray load of a 45 mm Endo GIA. Hemostasis was reviewed and obtained. The distal portion of the jejunal loop was run for 150 cm and was apposed with the proximal jejunal loop to create a lateral-lateral jejunojejunostomy. This was accomplished by opening a hole in the antimesenteric portion of the proximal and the distal jejunum using the Harmonic Scalpel. Then, a 60 mm white load Endo GIA stapler was inserted in each opening, approximated and fired, creating a jejunojejunostomy. The stapler was then removed, and the entrance site of the stapler was closed by using a 60 mm white load Endo GIA stapler. Two additional seromuscular stitches were placed at the crotch and as an antikinking stitch proximally using 2-0 Ti-Cron. A running suture of 0 Ti- Cron was placed in the mesenteric defect to approximate the mesenteric defect that was created, closing it properly. Then, attention was directed to divide the greater omentum. This was accomplished by using the Harmonic Scalpel to a point close to the transverse colon. Then, patient was placed in reverse Trendelenburg and the stomach was displaced and inspected. A small window just at the level of first gastric vein about 5 cm from the gastroesophageal junction was created to access the lesser sac by using the Harmonic Scalpel. Then, an Endo GIA 45 mm blue load was inserted in the lesser curvature window, and the stomach was transected approximately 5 cm from the gastroesophageal junction horizontally. Then, two loads of a 60 mm stapler blue load Endo GIA were inserted to create a small gastric pouch and divide the stomach vertically. Complete division of the His angle was inspected and was accomplished by firing an additional 45 mm blue load Endo GIA stapler. Hemostasis was reviewed and obtained. The anvil of the circular 25 mm stapler was inserted using the device called Oroanvil, inserted by the anesthesiologist through the patient's mouth. After the distal portion of the device appeared just above the horizontal staple line of the stomach, we created a small opening with the Harmonic scalpel, removing the tube that connected to the anvil proximally. We then pulled the tube through left lower quadrant trocar to exteriorize the anvil. We then divided the holding suture and disconnected the anvil from the tube that was removed and discarded. The anvil was in good position in the gastric pouch. We dilated the RLQ incision to insert a wound protector device and introduced the EEA stapler through it. We then brought the Roux loop in an antecolic fashion through the greater omentum window created previously and introduced the EEA stapler through an opening in the stapled portion of the Roux loop. The stapler introducer was then advanced and exteriorized through the antimesenteric portion of the bowel and connected to the anvil in the gastric pouch. The gastric pouch and the Roux loop were then approximated with care to apposition it properly and fired to create the gastrojejunostomy. The EEA stapler was then removed and the open portion of the Roux loop was closed by firing a 60 mm Endo GIA white load. The wound protective device was removed and a trocar re-inserted. The extra intestine stapled off when closing the Roux loop was removed from the abdomen. Three sutures between the anterior aspect of the Roux loop in the seromuscular and the gastric pouch in an interrupted fashion were placed to create a second row for the gastrojejunostomy. An orogastric tube was passed through by the anesthesiologist through the gastrojejunostomy. We clamped the jejunum just distal to the gastrojejunostomy and inflated the gastric pouch and the gastrojejunostomy with 60 cc of methylene blue in increments of 10 cc using the orogastric tube. No leaks or extravasation was noted after careful inspection of all aspects of the anastomosis and gastric pouch. The anesthesiologist then suctioned out the methylene blue solution and removed the orogastric tube. We then placed 5 cc of fibrin glue in the posterior and anterior aspects of the gastrojejunal anastomosis and gastric pouch staple line. We then inserted a #19 Blake drain in the superior portion of the abdomen, exteriorizing it through the left upper quadrant. All the trocars were then removed under direct vision. The pneumoperitoneum was deflated. The skin was closed using staples. A dressing was applied. The drain was sutured to the abdominal wall with a 2-0 nylon suture. At the end of the procedure, the sponge, instrument and needle counts were correct. The patient was then extubated, awakened from anesthesia, and transported to the recovery room in stable condition.