Thermo Scientific Konelab PRIME 60
and
Konelab PRIME 30
Fully automated clinical chemistry systems
 For medium sized laboratories as a stand-alone instrument
 For high volume testing as a part of automated workcell
Konelab PRIME 60:
Capacity up to 600 tests/hour
depending on workload
2
Konelab PRIME 30:
Capacity up to 300 tests/hour
depending on workload
WORKCELL Automation
•
•
•
•
3
Single entry point without pre-sorting
Minimizes the need of aliquots
Workload balancing
Centralized control over the system
Continuously expanding test range
• Over 80 carefully validated
methods for
•
•
•
•
•
•
Enzymes
Substrates
Electrolytes
Specific proteins
Drugs of Abuse Tests
Therapeutic Drug Monitoring
• CE marked applications
can be complemented
with user-definable tests
4
Product overview
• Continuous access to samples,
reagents and cuvettes
• On-board capacity of
•
•
•
•
84 routine samples, 6 STAT samples
39 fixed calibrator & control samples
45 reagents in the refrigerated disk
600 cuvette storage positions in PRIME 30,
2100 in PRIME 60
• ISE option: K+, Na+, Cl-,
• also Li+ and Ca2+ as optional extra
• Interface to a sample track system
5
Operational efficiency
• Automated sample pretreatment feature
• Automatic sample clot detection
• Versatile dilution features
• Pre-dilution possibility
• Post-dilution with both high and low
secondary dilution ratios
• Calibrator set made automatically from one
stock calibrator for most specific proteins
• Different sample types can be
analysed at the same time
• Important in drug monitoring
and therapeutic control
• Reflex testing
• Saves time and money when finding out
the specific test to be run
6
Productive, accurate analysis
• User-safe and contamination free
measurement
• Proven, unique, single use
12-cell cuvette
• Cost-effective due to low reaction
volume
• Only 100 to 250 l
• Typically 120 - 200 l
• Flexibility and long walk-away
time
• Cuvette storage enables
up to 4 hours walk-away time
• Continuous loading access without
interrupting testing
7
Advanced design to facilitate routine work
• Integrated workstation with touch
screen
• Enables a working posture with less
physical strain
• Ideal for limited space
• Intuitive graphical user-interface
• Provides fast guidance
• Makes the analyser easy to use
• Available in more than 15 language
versions
8
Safe sample handling
• Error free sample handling
• Automatic sample identification,
direct barcode reading and cup/ tube recognition
• Bidirectional LIS interface for quick data transfer
• Sample tubes
• 5, 7 and 10 ml tubes
• 0.5 and 2 ml sample cups
•
• Calibrators and controls
• Cooled positions
• Possibility to load also into segments
9
Automated sample pretreatment
•
Saves the operator time, e.g. by automating hemolyzation in
HbA1c measurement
•
Improves quality by minimizing operator variation
•
Dedicated sample segment for whole blood samples
•
10
For one segment hemolyzation takes about 10 min,
total turnaround time about 30 min
KUSTI - optional module for point-in-space dispensing
• Making automatically an aliquot
from the primary sample
• Equipped with a 92-positions segment
• While part of automated workcell
requested tests processed
autonomously
• Sample is sent further to
the next analyzer
• Minimizing delays on the sample
conveyor
• Manual sample loading using
segments possible at the same
time
11
Automatic clot detection
• To secure result integrity
• Based on pressure differential technology
• Both in sample and KUSTI dispensers
• The pressure system is calibrated
• By making a series of air aspirations, takes
appr. 5 seconds, no extra solutions needed
• At start up with sample dispenser
• At every water wash with KUSTI
• Operator is alarmed about clot
• All requests are cancelled for that sample
• Extra wash is performed for needles
12
Clot detection in sample dispenser
• Pressure signals of succesful aspirations on sample dispenser
• The pressure dives in an aspiration and returns through a maximum
to the rest level
180
200
160
180
140
160
120
Pressure
OK
140
100
120
80
•
2 - 15 µl
SAMPLE aspirations
60
100
40
80
20
60
0
40
1
17
33
49
65
20
81
97 113 129 145 161 177 193
Time (ms)
Clot
0
1
13
21
41
61
81
101
121
141
161
181
201
The clot message is sent if
in aspiration maximum fails
to reach the rest level or if
the end pressure of the curve
remains too far below the rest
level
Clot detection in KUSTI dispenser
• Pressure signals of a succesful aspiration
• In each sub-aspiration the pressure signal dives to a certain depth, but
returns to the rest level between aspirations
140
120
100
80
Reject line
60
40
20
0
1
14
53
105 157 209 261 313 365 417 469 521 573 625 677 729 781 833 885 937 989 1041 1093 1145 1197 1249 1301 1353
• The clot message is sent
if in aspiration the
pressure dives deeper
than in a successful
aspiration
Convenient reagent handling
• Continuous monitoring possibility
• Flagging of expired reagents
• Determination of vial volume
• Estimation of reagent sufficiency
• Automatic bottle change-over
increases the walk-away time
• Possibility to run QC with
every new bottle
• Used reagent lots can be archived
15
Simultaneous electrolyte measurement
• Direct measurement method used in Konelab
• Generally considered the most accurate ISE method
• Serum, plasma and urine samples
• Direct or by manually pre-diluted urine sample
• Micro volume electrodes for even smaller sample volumes
• Sample volume of only 50 l is sufficient for Na+, K+ and Cl• Additionally 6 l if Li+, Ca 2+ or pH is required
• Maintenance-free electrodes
• Delivered ready-to-use
16
Proactive support
• Minimal user maintenance tasks
• About 5 min daily
• Start up and Stand by procedures
• Maintenance contracts
• 6 and 12 months programs
17
Proven technology and experience
• Konelab analyzers are supported with
• Customized installation
• Product training
• Product & Application support
• After-sales support
• Maintenance contracts
• Technical service
18
Confirmed quality
• Quality system is certified according to
the ISO 9001:2000 standard extended
with the EN ISO 13485:2003
• Konelab Analyzer systems comply with
the requirements of the In Vitro
Diagnostic Medical Device Directive
(IVDMDD)
19
Key benefits of Konelab analyzers
• Easy to use
• Clearly laid out, simple to navigate user interface
• Automation and analyst efficiency
•
•
•
•
•
Once loaded, the analyzer will run without the assistance of the analyst
Automatic dilution of an over range sample
Automated sample pretreatment feature
Reflex test possibility
Clot detection
• Different types of samples can be analysed at the same time
• Important in drug monitoring and therapeutic control
• Productivity
• Low reagent volumes -> low cost per test,
important in expensive tests
• Quick daily start up
• Minimal maintenance
• User-safe and contamination free analysis
• Disposable cuvettes
20
Key benefits of Konelab analyzers
• Carefully selected methods and applications
•
•
•
•
Over 150 CE-marked reagents
Optimized kits serve laboratories of all sizes
Liquid stable and ready for use
System-specific multi-calibrators and controls
• Flexible software
• Easy method set-up
• Special applications to be validated
by the customer or distributor
• Direct electrolyte measurement
• The most accurate ISE method
• Maintenance-free electrodes
delivered ready-to-use
• Full application and technical support
21
One reagent line to be used in all Konelab analyzers
 -1-Antitrypsin
Apolipoprotein A1 and B
Ceruloplasmin
Complement C3 and C4
C-reactive protein
Cystatin C
High Sensitive CRP
HbA1c
Haptoglobin
IgA, G and M
Lipoprotein (a)
Microalbuminuria
Myoglobin
Orosomucoid
Prealbumin
Rheumatoid factors
Transferrin
TDM
Electrolytes
Na, K, Cl
Ca, pH
Albumin
Antistreptolysin O
DoA (DAT)
ACP
ALP
ALT/GPT
AST/GOT
Amylase
Cholinesterase
Dibucaine
CK
CK-MB
Gamma-GT
-HBDH
LDH
Lipase
Specific Proteins
Enzymes
Substrates
22
Albumin
Total and Direct Bilirubin
Carbon Dioxide
Calcium
Cholesterol
HDL and LDL Cholesterol
Creatinine
Glucose
Iron
Magnesium
Phosphorus
Total Protein
Triglycerides
U/CSF Protein
Urea
Uric Acid
Amphetamine
Barbiturates
Benzodiazepines
Cannabinoids
Cocaine Metabolite
Opiates
Cotinine
Ethyl Alcohol
Methadone
Propoxyphene
Carbamazepine
Phenobarbital
Phenytoin
Theophylline
Valproic Acid
Lithium
Konelab PRIME 60 and PRIME 30
Operational efficiency and
accurate results!
23