SUNGIL PHARMA
A concern of
A effervescent tablet disinfectant
Good Effervescent !
Long Lasting !
High Effectiveness !
Very Convenient !
Varied Application !
Features of Aquagard-T
• Good Effervescent !
• Long Lasting !
• High Effectiveness !
• Very Convenient !
• Varied Application !
Aquagard-T…
• Aquagard-T is a effervescent tablet disinfectant.
• Aquagard-T is a very powerful disinfectant
containing sodium dichloroisocyanurate (NaDCC)
widely applied for the sterilization of drinking water,
or fighting against infectious diseases, or act as
disinfectant in raising livestock, poultry and fish.
Aquagard-T…
• Aquagard-T is an oxidising compound which releases
chlorine to produce hypochlorous acid and hypochlorite
ion in the presence of water.
It is generally considered that the lethal action on
organism is due to chlorination of cell protein or
enzyme systems by nonionised hypochlorous acid,
causing hydrolysis of peptidic chains of cellular
membranes of pathogenic germs. Chlorine-releasing
substances are bactericidal to most gram-positive and
gram-negative bacteria, bacterial spores and viruses.
NaDCC
(Sodium Dichloroisocyanurate)
(Structural formula of NaDCC)
NaDCC
(Sodium Dichloroisocyanurate)
Hypochlorous acid
+ 2H2O
+ 2HOCl
germicidal activity
H+ + OClHypochlorite ion
(Hydrolysis of NaDCC)
Aquagard-T : NaDCC
(Sodium Dichloroisocyanurate)
• The germicidal activity of hypochlorous acid is 80
times higher than hypochlorite ion.
• The presence of HOCl in solution of chlorine
containing compound
100
HOCl, %
80
60
40
pH of NaOCl
solutions
pH of Aquagard-T
solutions
20
0
4
5
6
7
pH
8
9
10
Chlorine containing
compound

Chlorine used widely as a disinfectant and bleaching agent

Inorganic compound Sodium hypochlorite (NaOCl)
Calcium hypochlorite (CaOCl)
Chloline dioxide (ClO2)
unstable, less germicidal activity

Organic compound Sodium dichloroisocyanurate (NaDCC)
very stable, predominantly germicidal activity
Features of Aquagard-T

Good effervescent high technique for making effervescent
tablets

Long lasting

High effectiveness broad spectrum disinfectant (active to
spore forming bacteria, naked virus)

Very convenient
easy to handle and safe
Varied application used widely for disinfection of poultry,
pig, cattle and sheep, livestock houses
and facilities, drinking water

free available chlorine is present for 5
days in Aquagard-T solutions
Microbiocidal activity of
various disinfectants
Very
Resistant
Very Sensitive
Sensitive
Resistant
Septic bacteria
Enveloped virus
(HC, TGE,
ILT, IB, ND)
Non-enveloped virus
(Enterovirus,
Adenovirus, FMD,
IBD, Reo)
(Pasteurella sp)
Spore forming
bacteria
(B. anthracis,
Clostridium)
Weak Disinfectants
Intermediate Disinfectants
Strong Disinfectants
surfactant,
cresol, phenol,
chlorine, iodine,
quaternary ammonium
chloride
ortho, alcohol
Aldehydes,
ethylene oxide
Microbiocidal activity of
Aquagard-T
Microbials
NaDCC* (ppm)
Staphylococcus aureus
1.12
Escherichia coli
0.83
Salmonella typhi
0.83
Klebsiella pneumoniae
2.36
Serratia marcescens
1.14
Yersinia enterocolitica
0.72
Pseudomonas aeruginosa
2.00
Saccharomyces cerevisiae
72.0
Candida albicans
45.9
* Total available chlorine
Bactericidal activity of
Aquagard-T
Phenol coefficiency of Aquagard-T against bacteria
Test strains
Phenol coefficiency
Staphylococcus aureus 209P
28.5
Salmonella pullorum 9-25
25.5
Erysipelothrix rhusiopathiae
16.3
Erysipelothrix rhusiopathiae fujisawa
16.3
Bactericidal activity of
Aquagard-T
Effectiveness of Aquagard-T against spore forming bacteria
Spore
Disinfectants
Bacillus
subtilis
ATCC9372
Bacillus
(natto) BN
strain
B. Cereus
RIMD
0206001
Cl. Perfringens
Type B
NCTC3182
Aspergillus
oryzae
Aquagard-T
1:152(5)
1:57(15)
1:380(5)
1:950(15)
1:3,800(15)
1:3,420(15)
Iodine
1:10(30)
<1:10(30)
1:10(15)
<1:10
1:1,000(15)
Benzalkonium
chloride
1:150(5)
1:100(5)
1:50(5)
1:100(5)
<1:10
1:1,500(15)
Amphoteric
surfactant
1:50(15)
1:20(5)
1:25(15)
1:10(5)
<1:50(15)
<1:10
1:1,000(15)
Chlorhexidine
1:200(5)
1:300(15)
1:100(15)
1:10(5)
<1:50(15)
<1:10
1:1,200(15)
Effective dilution rate, ( ) : Exposure time
Bactericidal activity of
Aquagard-T
The sporicidal activity of disinfectants
Test strains
NaDCC
NaOCl
Remarks
Bacillus cereus
17.2
1,060
>62 times
Bacillus subtilis
30.9
1,510
>49 times
Virucidal activity of Aquagard-T
Virucidal activity against poultry viruses
Adenovirus
IBD virus
ILT
virus
ND
virus
NaDCC
○
○
○
○
Iodine
×
○
○
○
Benzalkonium
chloride
×
×
○
○
○ : inactivated, × : not inactivated
Virucidal activity of Aquagard-T
Virucidal activity against pig viruses
FMD
virus
Adeno JE
virus virus
TGE
virus
Aujeszky’s
disease
virus
Rota
virus
HC
virus
NaDCC
○
○
○
○
○
○
○
Iodine
○
×
×
×
○
×
○
○ : inactivated, × : not inactivated
Fungicidal activity of
Aquagard-T
Test fungi
MIC (mcg/ml) of
Aquagard-T
Candida albicans
2.6
Candida krusei
26.3
Aspergillus niger
263.2
Aspergillus fumigatus
263.2
Penicillium citrinum
263.2
Trichophyton verrucosum
263.2
Microsporum canis
263.2
Trichophyton mentagrophytes
263.2
The efficacy test scope
Total bacterial colony counts on foot bath in entrance of farm
Chlorine
contents or
dilution rate
0
1
3
5
Aquagard-T
418ppm
-
-
-
2.0×103
NaOCl
418ppm
-
-
2.4×105
1.7×105
Quaternary ammonium
chloride
1:200
-
-
7.0×102
8.3×105
Iodine
1:250
-
-
4.0×101
7.0×103
Orthodichlorobenzene
1:250
-
2.0×103
7.0×103
8.7×103
Control
-
-
5.0×104
2.0×108
3.2×107
Disinfectants
Elapsed days (day)
Unit : CFU/ml, - : <1×101CFU/ml
Bactericidal activity
• Method : According to regulation of NVRQS
• Experiment : Research Institute for Veterinary Science in
Konkuk Univ.
• Results :
Condition
Disease
Light water
Organic
substance
Salmonella spp.
1:7,200
1:540
Brucella spp.
1:3,500
1:400
Streptococcus spp.
1:8,000
1:720
Virucidal activity
• Method : According to regulation of NVRQS
• Experiment : Research Institute for Veterinary Science in
Gyeongsang National Univ. and Cheonbuk National Univ.
• Results :
Disease
Condition
Light water
Organic substance
Hog cholera virus
1:12,000
1:1,000
PRRS virus
1:12,500
1:750
New castle virus
1:9,000
1:1,000
Avian Influenza Virus
1:15,000
1:500
Avian Pneumovirus
1:700
1:50
Inclusion Hepatitis virus
1:500
1:100
Composition of Aquagard-T
• Each tablet (13g) contains
5g of Sodium dichloroisocyanurate
(= 3g of available chlorine)
and
Component A
(effervescent agent)
Component B
(pH controlling agent)
Application of Aquagard-T
• Disinfection of virus and bacteria in livestock housing,
farms (floor, wall), facilities and equipment, the
animal body
• Drinking water treatment
• Teat dip or spray (mastitis prevention)
• Disinfection of pathogen
– General bacteria (Salmonella spp.), Brucella spp.,
Streptococcus spp. and so on.
– Foot and Mouth Disease virus, Hog Cholera virus, PRRS virus,
Newcastle Disease virus, Avian Influenza Virus, Avian
Pneumovirus, Inclusion Body Hepatitis virus and so on
Use of Aquagard-T
(Bacteria)
Recommended Dilution Rate
Low
Contamination Group
High
Contamination Group
Disinfection Target
Livestock building, the
surface of the animal's
body, equipment, General
automobiles
The Floor of the Livestock
building, Manure,
the body of the animal
(dead or alive),
Automobiles/Vehicles
General Bacteria
(Salmonella spp.)
1:7,200
(1tablet per 93L of water)
1:540
(1tablet per 7L of water)
Brucella spp.
1:3,500
(1tablet per 45L of water)
1:400
(1tablet per 5L of water)
Streptococcus
spp.
1:8,000
(1tablet per 104L of water)
1:720
(1tablet per 9.3L of water)
* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant
against general bacteria and specific pathogen.
Use of Aquagard-T
(Virus)
Recommended Dilution Rate
Low Contamination Group
High Contamination Group
Livestock building, the surface
of the animal's body, equipment,
General automobiles
The Floor of the Livestock
building, Manure, the body of
the animal (dead or alive),
Automobiles/Vehicles
Hog Cholera virus
1:12,000
(1 tablet per 156L of water)
1:1,000
(1 tablet per 13L of water)
PRRS virus
1:12,500
(1 tablet per 163L of water)
1:750
(1 tablet per 9.7L of water)
ND virus
1:9,000
(1 tablet per 117L of water)
1:1,000
(1 tablet per 13L of water)
Avian Influenza
Virus
1:15,000
(1 tablet per 195L of water)
1:500
(1 tablet per 6.5L of water)
Avian
Pneumovirus
1:700
(1 tablet per 9L of water)
1:50
(1 tablet per 650ml of water)
Inclusion body
hepatitis virus
1:500
(1 tablet per 6.5L of water)
1:100
(1 tablet per 1.3L of water)
Disinfection Target
* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant
against general bacteria and specific pathogen.
Use of Aquagard-T
(Water Treatment)
• Dissolve Aquagard-T in water tank every other day or
every day if necessary.
• Dilute 1 tablet per 500 ~ 750 L of drinking water
according to water quality and farm condition.
Use program for poultry
• Poultry houses and facilities
- Thorough cleaning with water
- Spray Aquagard-T solution not less than 2 times
before placement of chicks.
- Spray Aquagard-T solution during growing
period if necessary.
Use program for poultry
• Foot bath
- For disinfect boots by dipping before entering each
house, replace the Aquagard-T solutions every 5 days
or sooner when soiled by heavy use.
• Transport
- For prevention of disease transmission through
trucks and crates by disinfecting them with Aquagard-T.
- Use in wheel baths and renew every 5 days or
according to volume of traffic.
Use program for dairy
• Dairy houses and facilities
- Thorough cleaning with water
- Spray Aquagard-T solution, eliminate all bacteria,
viruses and fungi.
Use program for dairy to prevent
Mastitis
• Preparation of disinfection
– Dissolve 1 Aquagard-T tablet per
1L of water and move to dipping
cup or sprayer for disinfection.
• Prior to milking
- Clean milk starts with clean teats.
- Teat and udder spraying will remove
all bacteria, viruses and fungi.
• After milking
- Teat dip or spraying will
decontaminate the teats and prevent
mastitis
Use program for Milking
Dipping method
Spray method
1) Disinfection prior to milking
- Removal of contaminant on teat
4) Massage and final
cleaning
- With clean and disinfected towel
2) Removal of disinfectant
- With clean and disinfected towel
5) Attaching the
milking mashing
- Vacuum-blocking
3) Prior to milking
- More than 5 times
6) Disinfection after milking
- Prevention of teat canal
Package of Aquagard-T
• 10 tablets / plastic container
• 100 tablets (1.3kg) / plastic container
• 2,000 tablets / carton
Storage and shelf-life of
Aquagard-T
• Storage
Keep under cool and dry conditions and
protect from light
• Shelf-life
24 months after manufacturing
Efficacy Test Report
Effect of Aquagard-T on E. Coli in Water
Precautions of Aquagard-T
• Keep out of reach of children.
• Do not dissolve in strong alkali (over pH 10) or
acidic (below pH 3) solution.
• Do not exceed the recommended dosage.
• For 5 days, from before 2 days to after 2 days of
vaccination, do not disinfect drinking water.
• Do not place near fire or strong inflammables.
• Do not place in metallic vessel more than 2 hours.
• In case of drink diluted solution, immediately seek
for medical advice.
SUNGIL PHARMA
A concern of