The first Russian-Chinese Agricultural Forum
«The status and prospects of the Russian-Chinese cooperation in agriculture»
1 July 2014.
Solagift – the world manufacturer of high
technology products from the conifer green
foliage - an export resource of Tomsk Region.
The Solagift story
2003 – construction of the production facility for conifer needles
extraction in Semiluzhki,Tomsk Region.
2004 – installation and bringing the carbon dioxide extraction line to
production capacities. Launching of СО2 – extracts of ТМ
«SibEX ®» on the Russian market.
2006 – Cooperation agreement between «Solagran» Ltd and
«SIBEX» Ltd.
2007- 85% shares of «Sibex» belong to «Solagran» Ltd. Start of
upgrading plan implementation.
2008 – start-up of the world’s first commercial production of
polyprenols (20 March). Making and defence of the businessplan for construction of the GMP-certified factory in the Special
Economic Zone in Tomsk.
2010 – launching of Ropren® on the pharmaceutical market of
Russia (February). Structural reorganization of the Russian
companies into the holding company Solagran Son with 100%
capital transfer to Solagran Ltd (May). Purchase of the
production facility in Vyshny Volochyok, Tver Region
(September).
2011 – a project participant of Skolkovo Innovation Center
2012 – registration of the trademarks in Asia Pacific, Middle East and
European Economic Community.
2013 – 10 million rubles budget subsidy for creation of Innovation
Center in the Special Economic Zone in Tomsk.
2014 - The winner of the All-Russian contest «Regions – sustainable
development»
CORPORATE STRUCTURE (Russia)
Management company «Solagran Son» LLC, Tomsk
Production complexes
Biotech LLC
Production of
CGNC and
provitamin complex
Vyshny Volochyok,
Tver Region.
SIBЕХ LLC
Production of
polyprenol
concentrates and
СО-2-extracts,
Tomsk
Solagift LLC
Manufacture of
finished dosage
forms and
pharmaceutical
substances,
Tomsk, SEZ
Scientific group
Exclusive distributor
Darius LLC
Skolkovo
Biofar LLC
Solana Biotech
St. Petersburg
Tomsk
Company’s technologies
The carbon dioxide extraction workshop.
Original patented technology, which enables to
extract biologically active substances from the
plant by using liquid carbon dioxide supercritical
fluid extraction processes. No organic solvents
and high temperatures used in the process.
No chemical disruption of biologically active
substances.
The workshop of organic extraction and
preparatory chromatography. The technology
enables the suite of compounds of conifer green
foliage to retain their biological activity and
function. The first world’s production of
polyprenols under the technology of multistage
selective extraction and preparatory
chromatography.
Substances – core family of BIOEFFECTIVES
The company manufactures 11 basic substances - Bioeffectives. The process enables the live elements of
conifer needles to be extracted without disruption of their biologically active properties.
Stage I processing
stage II processing
Bioeffective® A
Coniferous wax
Bioeffective® R
Bioeffective® N
Essential oils
Bioeffective® V
Green conifer
needles
Bioeffective® P
Natural green
needles
aqueous extract
Bioeffective® I
Liquid
CO2- extraction
Bioeffective® E
Bioeffective® S
Bioeffective® B
Polyprenols - Bioeffective R
Concentrations of dolichols in various human tissues, μg/g
Polyprenols are naturally occurring precursors of dolichols
Which are found in all key organs and soft tissues of
human body. Dolichols are essential in protecting cellular
membranes, stabilizing cell proteins and supporting the
body’s immune system. They also act as coenzymes in
The synthesis of polysaccharides and in protein –
carbohydrate metabolism.
Tissue
Concentration, μg/g
spleen
85-165
liver
465-1226
kidney
240-760
lungs
80-100
Polyprenols are present in trees and plants, whereas
dolichols are found in animals. Ingested polyprenols are
metabolized by the liver into dolichols which then are
involved in the dolichol-phosphate cycle.
ovary
1493-3226
heart
240-270
cerebrum
430-680
Live conifer needles are one of the richest and most
widely available sources for polyprenol extraction in the
world.
hypophysis
Bioeffective R is a 95-98% concentrate of polyprenols.
The compound consists of a series of homologues each
containing 13-18 isoprene units (65-90 carbon units)
in the molecular chain.
bowels
1400-6058
230-320
adrenal gland
1270
thyroid gland
1145
pancreatic gland
943
Prostate gland
268
Pharmaceutical properties of polyprenols
The pharmacological activity of polyprenols is based on their substitutive effect in the case of
dolichol deficits, or deficiencies in the dolichol-phosphate cycle, which are observed with chronic
inflammatory, degenerative and oncological diseases.
Hepatoprotective – lower cytolysis and cholestasis
markers, fibrosis index
Hypolipidemic – lowering cholesterol, triglycerides,
atherogenic factor
Neuroprotective and nootropic Improvement of memory and attention, regression of the
symptoms of polyneuropathy
Antioxidant – increased activity of antioxidant
enzymes.
Immunomodulatory – prolonged interferon inducing
action
Antidepressant - reduction of depressive symtoms,
fast and pronounced spectrum of antidepressant activity
against various depressive disorders
Burn and wound healing - reduces healing time of
wounds and burns, stimulates the process of complete
epithelialization at early stages.
Oncoprotective -
ability to inhibit carcinogenesis
and initiate the induction of apoptosis of cancer cells.
-
Gemoprotective
Prevents the pathological changes
in the cellular composition of the bone marrow, provides
gemosupressive effects of chemotherapy
Adrenotropic -
reduces inflammatory process,
improves the functional condition of the prostate gland,
increases testosterone levels.
Geroprotective – prevents the development of
Alzheimer’s and Parkinson’s diseases
Anti-ischemic - significantly reduces the incidence
of myocardial infarction, improves coronary blood flow.
Protects the brain from metabolic asidosis, prevents the
development of energy disturbances.
Pharmaceutical properties of polyprenols
in vivo
Endocrine
system
Immune
system
Brain
Liver
R
Neuro - immuno - hormone
regulation
Ropren ( BIOEFFECTIVE R) – the first Russian innovative
pharmaceutical of a new type.
Positioning: Modern tissue protector and stimulator
of reparative regeneration.
Advantages: shows a wide range of biological properties
and hepatoprotective effect in treatment of patients
with chronic disorder of the hepatobiliary system.
It has a short dosage schedule and convenient form of
release; it is obtained from natural raw material ; it has a
complex action and restores the essential biochemical
processes in liver, pancreatic gland and nervous tissue.
Estimated reserves and polyprenols content in tree species within the
forestry of Tomsk Region.
(Report of the TPU Research Institute under the Government contract № 373
of 21 November 2013 )
Health improving and prophylactic mission of Solagift Ltd. in
new products (TM BIOEFFETIVE and TAIGA)
Bioeffectives
with cell sap of fir
5 kinds
Phytococktails
6 kinds
Creams
Bio active additive
«TAIGA» 3 kinds
«Taiga healer» 3 kinds
Bioeffectives based on oil
fraction of silver fir extract
5 kinds
Biologically active
additives based on
polyprenols and conifer
extracts 6 kinds
Application of substances from conifer green foliage in
agriculture
«Growth promotants» are biological growth promotant for
plants enhancing germination and accumulation of dry
biomass of crops.
Use of «Growth promotants for plants”» in agriculture provides:
 active germination of seeds of vegetable and grain crops
 stimulation of growth for cereal crops ( wheat, rye) pea, onion, cucumber,
carrot, cabbage, and increase of crop yield
Increases resistance to diseases (fungicidal and bactericidal properties)
 economical consumption - 3 - 10 g/ha
«Feed additives» are natural biological growth promotant
of animals and is recommended for use in pig breeding,
poultry farming and cattle raising.
Use of «Growth promotant» in agriculture :
 boosts the body weight gain of broiler chickens by 7,7%.
 Increases safety of animals up to 100% (mortality in the control group
was 12,5%)
 Improves zootechny performance due to lower feed consumption per
a kilogram of obtained meat.
 is an alternative to the use of antibiotics in the treatment and
prevention activities
The site of the Special Economic Zone in Tomsk – development prospects
of highly competitive biotechnological products.
General view of
administrative and
production complex
«SOLAGIFT»
Future production
of substances in
SEZ in Tomsk
The site of the Special Economic Zone in Tomsk – development prospects
of highly competitive biotechnology products
Production of substances:
Name
Yearly capacity, kg
Provitamin concentrate (PVC)
Plant waxes
silbiol
polyprenols
Chlorophyll carotene paste
Balsamic paste
Sodium chlorophyllin
37 313
5 500
17 670
2 750
1000
1000
600
Production of liquid dosage forms and biologically active additives:
Name
Годовая мощность, тыс. флаконов
СО2-extract of Siberian silver fir, oil fraction
2000
СО2-extract of Siberian silver fir, water fraction
440
Ropren
1500
Production of solid and soft dosage forms:
Name
Годовая мощность
Tablets, including coated tablets
7,9 million units
capsules
23 million units
ointment
142,86 thousand tubes
suppository
2,32 million units
Pharmcluster of Tomsk Region – a tool for company potential
commercialization.
Project: «Growth of integrated structure for the development of innovative
medicines based on natural and synthetic raw materials» .
Time: 2014 - 2018.
Project goal: To ensure conditions for continuous production, development and
commercialization of new medical products and technologies starting from
fundamental research to commercial manufacture of products and their further
launch on the Russian and global markets.
OLEOPREN
GEPA
OLEOPREN
CARDIO
OLEOPREN
NEURO