General Presentation v.2
Introduction
Biochemize S.L. is a biotechnological company focused in the
design and development of processes based on biocatalysis.
Our technological platform lies in the use of enzymes or
microorganisms to perform chemical reactions able to substitute
manufacturing processes based on classical organic chemistry.
General Presentation v.2
Location
We are located in Terrassa, at 20 km from Barcelona.
Our office and laboratories are part of the facilities of the Technology
Centre of our associate partner Leitat.
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Our Technology
Biochemize S.L. develops bioprocesses using biocatalysts (enzymes or
microorganisms) in single or multiple transformation steps.
Our technological platform P2B (Platform to Biochemize) is capable to
perform high throughput screening of biocatalysts, reaction conditions,
suitable substrates and products obtained.
The screening can be done in a short period of time and renders
information about different possible bioprocesses and conditions that could
be further developed at a larger scale.
General Presentation v.2
P2B – Platform To Biochemize
P2B is the key to determine quickly with low risk and at very small scale
if a conceptual biotransformation is technologically viable.
Once the succeeding biocatalysts or bioprocesses have been identified,
Biochemize S.L. investigates at lab scale the experimental conditions
which can lead to the highest yields.
Two approaches can be followed:
P2B Bioprocess
Development of bioprocesses suitable to substitute
established synthetic procedures up to an industrial scale
already
P2B Discovery
Perform biotransformations that can lead to a (new) chemical entity
with improved features compared to the starting molecule
General Presentation v.2
P2B – Platform To Biochemize
The information obtained from P2B-Bioprocess allows estimations of
productivity, costs and risks needed to confirm whether the process is
feasible at industrial scale.
P2B
Screening of
biocatalysts &
conditions
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Lab Scale
Catalyst selection
& conditions
optimization
Feasibility
Estimation of
Productivity,
Costs & Risks
Industrialization
Products & Services
Biochemize S.L. offers the following contract research services to
customers:
Technical Assessments and Consulting
Development of biotechnology processes
Obtaining building blocks
Support in discovery of new chemical entities
General Presentation v.2
Products & Services
Technical Assessments and Consulting
We offer theoretical evaluations and consulting to verify the feasibility of
substituting chemical synthetic processes by biotechnology.
(Experimental work is also possible)
The assessments include estimations of yields,
engineering needs, costs, risks, regulatory aspects, etc.
Biochemize S.L. has a worldwide network of contacts: suppliers of
biocatalysts, manufacturers, analytical services, researcher, advisors, etc.
We offer consulting and contact extension possibilities to customers
through our own network.
General Presentation v.2
Products & Services
Development of biotechnology processes
Substitution of processes based on synthetic organic chemistry by
biotechnology.
A Bioprocess can be more efficient,
costs saving or less contaminant
A
B
C
D
A Bioprocess can be highly selective.
Sometimes allows reducing synthetic pathways
(e.g. protection/deprotection steps)
The development ranges from theoretical design to industrial scale-up and
implementation. This latter phase is carried out by the customer under the
support and supervision of Biochemize S.L.
General Presentation v.2
Products & Services
Obtaining of building blocks
Building blocks obtained by biotechnology can be used as alternative
source of reagents, starting materials and intermediates for chemical
synthesis.
Building blocks can help to reduce synthesis steps of current processes or
skipping reagents or intermediates hazardous, unstable, or complex to be
obtained.
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Products & Services
Support in discovery of new chemical entities
Synthesis of potential new chemical entities
through biotechnology approaches.
Biocatalysts can be used to obtain new lead, lead
optimization, me-too and me-better compounds
by modification of already available structures.
Strategy especially interesting for molecules of
natural origin and/or complex structure.
Biotechnological transformations can be applied to obtain a new molecule
without complex synthetic processes or avoiding the use of synthetic
reagents that can deeply change the original structure.
Biochemize S.L. can perform High Throughput Screening through the P2B
technology.
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Operations
Biochemize S.L. offers the most outstanding and up to date technology
options, while maintaining an industrial scope.
If necessary, many operations can be outsourced to other companies and
research centres under our direction and supervision.
We have a powerful network of contacts in biocatalysis and
bioprocessing. Several partnership agreements have been established.
Advisors
Analytical Services
Biocatalyst Suppliers
Bioprocessing Services
Biotransformation Experts
Enzyme Screening
Enzyme Immobilization
Genetic Engineering
Manufacturers
Research & Development
Scaling-Up Services
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Austria
Bulgaria
China
Denmark
Ireland
Italy
Korea
Netherlands
Spain
United Kingdom
United States
Operations
Biochemize S.L. is able to perform many biocatalyzed transformations. Our
most recent experience is based on the following reactions:
OH
O
R CH2 OH
Y
R
H
R
O
O
R C
N
OH
R
R
O-R' Ester
Formation
& hydrolysis
Transamidation
Transesterification
O
R
Amide
Formation, Hydrolysis,
Hydration & dehydration
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Aldol
reaction
X
Oxidation
& Reduction
Nitrile
Formation
& hydrolysis
O
N
R'
R''
Project Management
Biochemize S.L. follows a project management approach which comprises
several development phases:
P2B
Bioprocess
Theoretical
Evaluation
PHASE I
P2B
Discovery
Bibliography
Assessment
Experimental
Exploratory
Research
Technology
Development
PHASE II
PHASE III
PHASE IV
Biotransform.
Screening
Biocatalyst
Selection &
Reproduction
Compound
Characteriz.
Scale-Up
Industrial
Implement.
PHASE V
Small Scale
Production
Each phase is not planned nor quoted until the previous phase is not
completed and the results presented.
Control of Risks and Costs:
The customer decides the project continuation at each phase depending on
results and conclusions obtained so far.
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Why contracting Biochemize?
We offer the most outstanding and up to date technology options.
Industrial scope guaranteed: productivity, costs and risks are the key
drivers of our evaluations.
Our technology platform (P2B) is a powerful tool for fast, low risk and
small scale proof of concept verifications.
We increase the success possibilities through the P2B platform and our
network of contacts.
Project management based on a development by phases approach.
The customer controls the risks and costs associated to the project
development.
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Contact
Jaume Mir
Founder
CEO and Commercial Director
E-mail:
jmir@biochemize.com
Telephone:
++34 686 441 120
Address:
C/. de la Innovació, 2
(Leitat Centre Tecnològic)
88225 – Terrassa
(Barcelona) SPAIN
General Presentation v.2
General Presentation v.2