Transporting Your Skin Through
Time
Lori Bush
President of Nu Skin
Our Nu Skin Mission
We strive to be a distinctive resource for all
who aspire to the physical, emotional, or
financial rewards that derive from skin care
product leadership.
Healthy, beautiful skin
On a journey through
time
How will your skin
travel through time?
?
Zoe Diana Draelos, M.D.
Evolution of Skin Care:
The Beginning
• Affordable common soap
– Increased hygiene and fewer skin
infections
– Soap removed too much sebum and
yielded dry skin
Evolution of Skin Care:
The Beginning
• Moisturizers needed to
counteract the drying effect of
soap
– Original moisturizers were
petroleum, lanolin
– Greasy substances prevented
moisture from evaporating from
the skin
Evolution of Skin Care:
The Present
• Refined cleansers that provide
excellent hygiene, but do not
overdry the skin
• Elegant moisturizers that hydrate
and retard moisture loss
• Sunscreens that prevent sunburn
and function to counteract the
aging effects of UV exposure
Present Skin Care Philosophy
• Add to the skin what is missing
• Sophisticated cosmeceutical
moisturizers to add vitamins and
antioxidants (skin care
maintenance)
• Sunscreens to add additional
protection from aging (skin care
prevention)
Future Skin Care Philosophy
• Adding and supplementing the skin for
prevention and maintenance purposes is
important
• The step beyond is removal of substances
that retard optimal skin functioning
• Add the good, remove the bad
Critical Questions
• What should you add to the skin and what
should you remove?
• How do you know what is good and what is
bad?
• How do you remove substances from the
skin that promote aging?
Skin Aging Concepts
• Skin ages due to UV damage, oxidation
• Oxidation by products accumulate
• Skin aging progresses as byproducts
decrease optimal functioning
Satisfied Oxygen Atom
Crippled “Free Radical”
Free Radical Chain Reaction
Antioxidants lose an
electron without
initiating a chain
reaction.
Antioxidants inhibit
lipid bi-layer and cell
membrane breakdown.
Future Skin Care: Adapting New
Technology to Skin
• Rate of tissue aging is slowed
in laboratory by placing tissue
in special transport media
• Transport media contains
substances to remove
byproducts from the tissue
• Tissues age at a slower rate due
to optimal functioning
Evolution of Skin Care:
The Future
• Important active ingredient in
transport media is lactobionic
acid
• Minimize the damaging
effects of:
– Oxygen and other pro-oxidants
– Transitional metals, such as
iron
Evolution of Skin Care:
The Future
• New skin care products utilize transport
media technology to aid in the prevention of
aging
• Active ingredients placed in moisturizers to
hydrate skin
• Adding the good and removing the bad
The Future is Now
• Add to the skin
– sun protection
– skin moisturizers
– skin antioxidants
• Remove from the skin
– sebum and environmental dirt
– damaging byproducts
Barbara Green, R.Ph., M.S.
Evolution of Hydroxyacid Skin Care
AHAs (glycolic acid, lactic acid)
PHAs (gluconolactone)
New
Bionic PHAs
(lactobionic acid)
AHA vs. PHA
glycolic acid
gluconolactone
CH OH
2
O
H
COOH
H
H
C
H
OH
OH
H
H
OH
OH
O
PHA: Gluconolactone
• Polyhydroxy AHA (PHA): full strength anti-aging
benefits
• Natural component of skin; cell nutrient
• Natural antioxidant/chelator
• Highly moisturizing
• Strengthens skin barrier (published study)
• Non-stinging, non-burning
• Suitable for all skin types including sensitive skin
• No increase in sun sensitivity
Gluconolactone - Chelator
• Dairy - prevents milk stone
• Brewery - prevents beer stones
• Foodstuffs - coagulant for tofu
• Humans - acidify urine to allow exchange
of Mg++ for Ca++ in kidney stones
Lactobionic Acid
(Bionic PHA)
• Anti-aging effects (it is an AHA)
• Gentle to skin
• Plumps the skin
• Provides unique skin feel attributes – gel/film
forming property
• Suitable for all skin types, even sensitive skin
• Moisturizing/water binding: 8 hydroxyl groups
Lactobionic Acid Gel
Weight (g) of water absorbed
per mole of substance*
75
65
55
45
35
25
15
5
lactobionic acid
glycerol
gluconolactone
sorbitol
glycolic acid
citric acid
propylene glycol
lactic acid
control
salicylic acid
-5
*After exposure to 100 % relative humidity for four hours.
Lactobionic Acid – Skin Protector!
• Antioxidant
– Medical use - preservative for organs during
transplantation procedures – it traps metals
• Inhibitor of metalloproteinase enzymes (MMPs)
– MMPs degrade skin collagen
– Leads to wrinkles, laxity, visible capillaries
– UV and aging
MMP activity
Cumulative Irritation Study
14 days
Nonirritating!
3
2.5
Mean
Scores
0.1% SLS
2
1.5
Lactobionic acid 4% +
Gluconolactone 8%
cream
0.9% NaCl
1
0.5
0
1 2 3 4 5 6 7 8 9 10 11 12 13 14
Day
n = 24
Atopic Dermatitis with PHA Regimen
Before
After
Antioxidant Effects
ANTHRALIN
HYDROQUINONE
BANANA PEEL
Most
Effective
oxalic acid
oxalic acid
oxalic acid
ascorbic acid
citric acid
gluconolactone
Very
ascorbic acid
citric acid
gluconolactone
lactobionic acid
ascorbic acid
citric acid
gluconolactone
lactobionic acid
lactobionic acid
tartaric acid
Effective
Anti-oxidant effects on Banana Peel
(72 hours)
PHAs
prevent
oxidative
browning
Gluconolactone
Lactobionic Acid
AHAs vs. PHAs
Anti-aging Effects
AHA vs. PHA Anti-Aging Study
PHA Regimen : 14% daily PHA
AHA Regimen : 16% daily AHA
Mean Relative % Improvement
(compared to baseline)
Week 12PHA n=30
Week 12AHA n=27
50
40
30
X
20
10
y
rit
Cl
a
wn
es
s
lo
Sa
l
M
ot
tle
d
Pi
gm
nt
Fi
rm
ne
ss
gh
ne
ss
Ro
u
re
Si
ze
Po
rin
W
Fi
ne
Li
ne
s
kl
es
0
Note: All attributes significantly improved from baseline (p<0.05)
X: AHA regimen significantly better than PHA regimen
AHA vs. PHA Anti-Aging Study
Irritation Assessment
Means (0-3 Scale)
(mild) 1
0.75
Baseline
Week 6
Week 12
+X
*
*
0.5
*
*
+X
+X
+X
0.25
* significant improvement from baseline (p<0.05)
+ significant worsening from baseline (p<0.05)
X burning, stinging significantly worse than PHA regimen
St
in
gin
g-P
HA
HA
St
in
gin
g-A
g-P
HA
ni
n
Bu
r
ng
-A
HA
Bu
rn
i
PH
A
ma
he
Er
yt
Er
yt
he
ma
-
AH
A
(none) 0
n=27 (AHA)
n=27 (PHA)
PHA Serum
Anti-aging Effects
Facial Clinical Evaluation - PHA Serum
Mean Relative % Improvement
(compared to baseline)
80
Week 6
60
Week 12
40
20
ot
tl
ed
Pi
gm
nt
ne
ss
M
Sa
llo
w
ne
ss
R
ou
gh
xi
ty
La
ze
Si
Po
re
ri
n
W
ne
Li
ne
s
kl
es
0
Fi
Percent %
100
All attributes significantly improved at Weeks 6 and 12 from baseline (p<0.05)
Facial Clinical Evaluation
Percent %
280
Mean Relative % Improvement
(compared to baseline)
260
Week 12
PHA
serum
240
220
200
Clarity
Significantly improved at Weeks 6 and 12 from baseline (p<0.05)
Total Skin Thickness (Plumping)
Mean Relative % Improvement
(compared to baseline)
12
*
PHA
Serum
Percent %
9
6
Untreated
3
0
*Significantly increased skin thickness over untreated (p<0.05)
Fine Lines
Softened
Before
PHA Regimen
Study
12 weeks
After
PHA Regimen Study – 12 weeks
Smoother, brighter
Before
After
PHA Benefits to Aging Skin
• Anti-aging effects
– Smoother, brighter complexion, reduced
appearance of fine lines and wrinkles, increased
clarity
• Anti-oxidant/chelator
• Moisturizing
• Gentle enough for sensitive skin
Jan Lephart
Senior Director of Nu Skin
Research and Development
Tru Targeted Treatments
Tru Targeted Treatments
Biological
Aging
Mechanical
Aging
Environmental
Aging
NEW!
Nu Skin
Tru Face Revealing Gel
Nu Skin Tru Face Revealing Gel
• Addresses biological and
environmental aging
• Features patented polyhydroxy
acid technology
•Lactobionic Acid AND Gluconolactone
• Extremely gentle yet powerful
Nu Skin Tru Face Revealing Gel
• Delivers powerful antioxidants
• Chelates excess iron, reducing potential oxidative damage
• Moisturizes, draws water to skin
• Minimizes appearance of pore size
• Reduces visible effects of photoaging
• Improves skin texture and radiance
Nu Skin Tru Face Revealing Gel
• Helps restore youthful cell renewal
• Reveals a smoother, softer
complexion
• Perfect for even sensitive, irritable
skin
Nu Skin Tru Face Line Corrector
• Treats mechanical aging
• Features pro-collagen peptide
• Softens and improves the appearance of
moderate to deep lines and wrinkles
• Clinical study showed significant wrinkle
improvement in 91% of participants
Nu Skin Tru Face Skin Perfecting Gel
• Combats environmental aging
• Features Kelpadelie, a marine algae extract
that is milder to skin than Retinol
• Improves and maintains skin clarity and
restores skin radiance
Tru Targeted Treatments
Tru Face Revealing Gel - Patented PHA Technology
Tru Face Line Corrector - Pro Collagen Peptide
Tru Face Skin Pefecting Gel - Kelpadelie Algae
Transporting Your Skin Through
Time