European network on applications of Atomic Force
Microscopy to NanoMedicine and Life Sciences
AFM4NanoMed&Bio TD1002
Action Chair: Pierre Parot
Rapporteur: Pavle Andjus
Science Officer: Magdalena Radwanska
Start date: 13/12/2010
End date: 12/12/2014
COST is supported by
the EU RTD Framework Programme
ESF provides the
COST Office through an EC contract
Scientific background
COST is supported by
the EU RTD Framework Programme
2
ESF provides the
COST Office through an EC contract
What is Atomic Force Microscopy?
Photodiode
laser
Feedback
Cantilever tip
sample
Force
piezo
Distance
Scan mode
Force mode
Strength
• High signal to noise ratio (S/N)
• Measurement in physiological conditions (liquid)
• Possibility of coupling with other imaging and functional methods
COST is supported by
the EU RTD Framework Programme
ESF provides the
COST Office through an EC contract
Challenges in AFM for Clinical research
Weakness
• Complex instrument to manipulate
• Upmost importance of the preparation of the sample
• Need to improve speed, sensitivity and normalization
Membrane
proteins
COST is supported by
the EU RTD Framework Programme
ESF provides the
COST Office through an EC contract
Why a COST Action now?
Need:
to establish equitable communication between physics and life sciences
to train young scientists in this transdisciplinary domain
to include manufacturers and R&D for improving machines
COST is supported by
the EU RTD Framework Programme
ESF provides the
COST Office through an EC contract
COST Action TD 1002 Website
First WG meeting, Lamorlaye France, 10-13 May 2011
COST is supported by
the EU RTD Framework Programme
ESF provides the
COST Office through an EC contract
Objectives based on the MoU
COST is supported by
the EU RTD Framework Programme
7
ESF provides the
COST Office through an EC contract
Objectives based on the MoU
•
- Promote the federation and integration of the European community of scientists involved in
applying AFM to NanoMed&Bio.
•
- Reinforce exchanges of scientific experiences specialized on biological applications.
•
- Gather the knowledge to develop AFM into a tool for clinical diagnosis;
•
- Explore novel applications of AFM in NanoMed&Bio, pharmaceutical, environmental and
food industry.
•
- Provide rigorous training for students and young scientists to efficiently master AFM
operations in NanoMed&Bio.
•
- Support Short-Term Scientific Missions of young investigators or students among physics
and biomedical laboratories.
Physics
1980’s
COST is supported by
the EU RTD Framework Programme
Biophysics
1990’s
8
Biology
Medicine
2000’s
2020
ESF provides the
COST Office through an EC contract
COST Action expected results
• - The Action will efficiently transfer and continuously
update knowledge from AFM researches to medical
researchers and clinicians.
• - The Action will maintain the leadership of the
European AFM groups in AFM technique
developments and applications.
• - The Action will allow the concerted European
standardization of laboratory and clinical methods
including the rules and regulations of safety and
security related to public health.
COST is supported by
the EU RTD Framework Programme
9
ESF provides the
COST Office through an EC contract
Action/Network structure
COST is supported by
the EU RTD Framework Programme
10
ESF provides the
COST Office through an EC contract
ACTION_TD1002
AFM4NanoMed&Bio
13/12/2010 – 12/12/2014
European network on applications of Atomic Force
Microscopy to NanoMedicine and Life Sciences
BMBS
TDP
Participating countries: AT BE CH DE DK ES FI FR GR HR HU IR IT IL LU NL PL PT UK
Chair of the Action: Pierre Parot, FR, parot@cea.fr
COST Science Officer: Magdalena Radwanska Magdalena.Radwanska@cost.eu
Action website: www.afm4nanomed&bio.org
Kickoff Meeting took place on December 13th 2010 Next Meeting: August 2011 PARIS
The main objective of the Action is to further develop and transfer
the biophysical achievements of Atomic Force Microscopy to NanoMedicine and clinical research.
Management Committee (MC) Chair: Pierre Parot Vice-Chair: Hans Oberleithner Task Group Coordinator: Jean-Luc Pellequer
Working Group Coordinators
Physician Scientist
with Medical Project
AFM newcomer
WG 1
Imaging from molecules to cells Fundamental WG that uses the basic strength
Simon
Scheuring
of AFM: High Resolution Imaging
WG 2
Salvatore
Cannistraro
AFM
Hospital
AFM lab
WG 3
Dynamic Force spectroscopy on Molecules and Cells WG promoting
fundamental research based on the piconewton force sensitivity of AFM.
Peter
Schöen
NanoMedicine Nanodiagnosis Nanosensing
WG 4
Environmental Nanotoxicology and Nanoparticles Applied WG that evaluates
Applied WG that uses AFM
with additional techniques: fluorescence, Raman, ion measurements…
Training Center
Physician Scientist
with AFM data
AFM trained
Vesna
Svetličić
WG 5
Ricardo
Garcia
COST is supported by the EU RTD
COST is supported by
Framework Programme
the EU RTD Framework Programme
the use of AFM as a tool in nanoecology and nanotoxicology and health risk assessment
New Instrumentation and Techniques
Special WG in relation with manufacturers
concerning the specifications of standardized AFM Machines for clinical applications.
The Council of the European Union
provides the COST Secretariat
ESF provides the COST Office
through a European Commission contract ESF provides the
COST Office through an EC contract
What sort of COST would you like?
and for Whom?
• COST Action management should be oriented to junior
researchers.
• Could COST rules be formally changed in that way?
• What COST could do to help COST Actions reaching successful
FP proposal?
• Who can in COST office help us to participate to the preparation
of FP calls.
• Could COST imagine to increase the number of TD Actions?
COST is supported by
the EU RTD Framework Programme
12
ESF provides the
COST Office through an EC contract