X-Linked Conditions: Case Scenarios
This PowerPoint file contains a number of slides that may be useful for teaching of
genetics concepts.
You may use these slides and their contents for non-commercial educational purposes.
This presentation includes:
• A Duchenne muscular dystrophy pedigree showing X-linked inheritance
• A pedigree used to assess risk of DMD in offspring
• A DMD case scenario.
© 2009 NHS National Genetics Education and Development Centre
Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk
DMD Pedigree
The X chromosome carrying the disease-causing mutation can be tracked through the family
© 2009 NHS National Genetics Education and Development Centre
Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk
“Will I have a boy with Duchenne Muscular Dystrophy?”
© 2009 NHS National Genetics Education and Development Centre
Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk
Jason’s family tree
Jason, aged 3 yrs referred to a paediatrician by his GP
•Later walking than older siblings
•Difficulty running and riding tricycle
•Always climbs up stairs on all fours
Rachel
14.3.74
Tony
26.9.73
Susie
3.6.95
© 2009 NHS National Genetics Education and Development Centre
Fay
7.1.98
Jason
15.11.99
Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk