ICABR Conference
Kelly Fleming
20 June, 2013
Monsanto Company Confidential
1
Notes
Certain statements contained in this presentation are “forward-looking statements,” such as statements concerning
the company’s anticipated financial results, current and future product performance, regulatory approvals, business
and financial plans and other non-historical facts. These statements are based on current expectations and currently
available information. However, since these statements are based on factors that involve risks and uncertainties, the
company’s actual performance and results may differ materially from those described or implied by such forwardlooking statements. Factors that could cause or contribute to such differences include, among others: continued
competition in seeds, traits and agricultural chemicals; the company’s exposure to various contingencies, including
those related to intellectual property protection, regulatory compliance and the speed with which approvals are
received, and public acceptance of biotechnology products; the success of the company’s research and development
activities; the outcomes of major lawsuits; developments related to foreign currencies and economies; successful
operation of recent acquisitions; fluctuations in commodity prices; compliance with regulations affecting our
manufacturing; the accuracy of the company’s estimates related to distribution inventory levels; the company’s
ability to fund its short-term financing needs and to obtain payment for the products that it sells; the effect of
weather conditions, natural disasters and accidents on the agriculture business or the company’s facilities; and other
risks and factors detailed in the company’s most recent reports on Forms 10-Q and 10-K. Undue reliance should not
be placed on these forward-looking statements, which are current only as of the date of this presentation. The
company disclaims any current intention or obligation to update any forward-looking statements or any of the factors
that may affect actual results.
Monsanto Imagine and the Vine Design, Channel, Channel Bio, D&PL, Deltapine, DEKALB, DEKALB and Winged Ear
Design, When Performance Counts, Asgrow, Asgrow and Design, Acceleron, Acceleron and Design, Apex, BioDirect,
Biotech Yield Endorsement, BYE, Bollgard, Bollgard II, Bollgard and Design, Bollgard II and Design, Corn States
Triangle Design, Cotton States, Cotton States and Design, Discovering, Delivering, Yielding., EarthMap Solutions and
Design, Growing Yield Sustainably, Our Science Your Success and Design, Processor Preferred, Produce More,
Conserve More, Roundup, Roundup PowerMax, Roundup Pro, Roundup ProMax, Roundup Ready, Roundup Ready 2
Yield, Roundup Powerful Performance and Design, Roundup Ready Rate and Design, Roundup Rewards, Roundup
Technology, Roundup WeatherMax, SmartStax, SmartStax and Design, Vistive, Vistive and Design, YieldGard,
YieldGard Rootworm and Design, YieldGard Corn Borer and Design, YieldGard Plus and Design, YieldGard VT,
YieldGard VT and Design, YieldGard VT Triple, YieldGard VT Rootworm/RR2, VT Double PRO, VT Triple PRO, Genuity,
Genuity and Design and Genuity Icons, Seminis, Seminis Vegetable Seeds and Design and De Ruiter are trademarks
and service marks owned by Monsanto Company and its wholly owned subsidiaries. All other trademarks are the
property of their respective owners.
© 2010 Monsanto Company. All Rights Reserved.
Monsanto Company Confidential
2
It All Adds up to a Doubling in Global Grain Demand
Corn
Wheat
Soybeans
Cotton
Rice
3,000
2,500
2,000
+28%
+102%
+125%
1,500
1,000
+40%
500
0
TODAY
PEOPLE
Monsanto Company Confidential
Source: IHS Global Insights, Agriculture Division
GLOBAL
MEAT
GDP
CONSUMPTION
+76%
2000 2010 2015 2020 2030
GLOBAL GRAIN DEMAND (M
MT)
3
Our R&D Engine
is Evolving to Deliver
Tomorrow’s Products
as Systems Applied On-Farm
1
Product concepts
based on farmers’
needs
2
3
R&D Engine
Products
Diseases, Pests,
and Weeds
Crop Residues
Seed Selection
Plant Population
Nutrients
Genes, Germplasm, Chemistries
Monsanto Company Confidential
Seed + crop management
4
Biologicals Complement our
Systems Approach to
Increasing Yield
1 Emerging Trends
Reducing Agricultural Inputs with
More Sustainable Solutions
Green / Sustainable
Healthier Dietary
Habits
Regulatory Pressure
on Some Chemistry
Breeding
Biotechnology
Biologicals
Highest yielding
genetics for target
environment
Complementary
agronomic and
yield enhancing
traits
Plant Health
Extended Disease
Protection
Mid Season Insect
control
Bio-Nutrients
Monsanto Company Confidential
Chemistry
Traits &
Germplasm
provide platform
for Ag chemistry
Products
Agronomics
Farm management
practices and
optimizing genetic
placement on
the farm
5
What are Biologicals?
Definition
Key Segments
Foliar or seed treatment
products which are:
Foliar or seed treatment
products which are:
Based on or containing a
living organism
Microbials
• Pesticides
• Plant Health/Inoculants
BioDirect™ Technology—
RNA
May be used to complement
or replace Ag chemistry
products
Driven By
1
2
Sustainable/
Green Trends
Healthier Dietary
Habits
Plant Growth Regulators
May have a shorter, cheaper
regulatory cycle than Ag
chem products
Pheromones
Beneficial Insects
Monsanto Company Confidential
3
Scientific
Advances
Improved Plant
Testing
6
Global Ag Biologicals Industry Primarily Supports Fruit and
Vegetable Crops
Row Crops >
of Biologicals
Focused on
Row Crops
>
15%
Trees,
Vines,
Orchard,
Fruits
Vegetables >
Monsanto Company Confidential
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For Monsanto, Biologicals = BioDirect™ Technology+ Microbials
Biologicals Research Focus
™
TECHNOLOGY
Weed
Management
Insect
Management
Virus
Control
Seed
Treatment
Monsanto Company Confidential
+
Microbials
Bee
Health
Delivery Methods
Foliar
Applications
Pest Control Plant Vigor &
Yield
Disease
Control
IFS
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New BioDirect™ Technology is Next Step in Evolution
of Technologies for Solving Farmers’ Challenges
Evolution: AG Platforms Driving Yield
NEW
Genomics
Monsanto’s
leading genomics
and agronomics
systems capability
are key catalysts:
data and insight
enables multiple,
complementary
R&D platforms
Next Inflection Point
NEW
AG Biologicals
Integrated Farming Systems℠ (IFS)
Advanced Breeding
AG Biotechnology
Synthetic Agricultural Chemicals
1980s
1990s
2000s
2010s
BioDirectTM Monsanto’s Biological Ag Solutions Technology
Creating potential breakthrough AG biological products with BioDirectTM technology
Monsanto Company Confidential
9
Gene
BioDirect ™ is Based on New Applications of RNAi Technology
RNAi is
A Natural
Mechanism to
Control the
Expression of
a Gene
RNA
DNA
Protein Produced
“Transfers information from gene to
construct a protein”
“Trigger”
When cells make RNAi it specifically
targets an RNA
Gene
X
RNA
DNA
Monsanto Company Confidential
RNA
broken up
Protein
Protein not produced
10
Early Testing Indicates BioDirect™ Technology
Has Potential To Be Step Change In Weed Control
BioDirectTM Technology Glyphosate-Resistant Weed Control Targets Resistant Weeds
Glyphosate-Resistant (GR) Palmer Pigweed
Control Field Trials
Glyphosate-Resistant Waterhemp
Lab Trials – 2012
Tunica, Mississippi – 2012
GR Palmer pigweed sprayed
with glyphosate alone
GR Palmer pigweed
sprayed with BioDirect™
Technology + glyphosate
Untreated
Check
Glyphosate
Only
Glyphosate +
BioDirectTM
Technology
Non-transgenic weed control topical technology designed to complement glyphosate
chemistry to target glyphosate-resistant weeds and provide broader spectrum of control
Complementary to Monsanto’s other weed control platforms
Monsanto Company Confidential
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Initial Testing Indicates BioDirect™ Technology Could Provide
Significant New Source of Protection Against Insect Pests
BioDirectTM Insect Control Technology
Colorado Potato Beetle Lab Trials*
Mexican Bean Beetle Lab Trials*
Monsanto Research – 2012
Lab Trials – 2012
Untreated plants
Plants protected with
BioDirect™ Technology
Untreated plants
Plants protected with
BioDirect™ Technology
Non-transgenic insect control topical technology designed as a new source to control insects for
potential opportunity across a spectrum of crops
Leverages Monsanto’s core capability in genomics, using genome sequences to identify more
precise, effective tools for pest control
Monsanto Company Confidential
* Photo of plants depict plants grown and treated in lab environment
12
Initial Testing Indicates BioDirect™ Technology
Could Reduce The Symptoms Of Viruses
BioDirectTM Virus Control Technology
Virus Control in Pepper Lab Trials*
Virus Control in Tomato Lab Trials*
Monsanto Research – 2012
Lab Trials – 2012
Untreated plants
Plants protected with
BioDirect™ Technology
Untreated plants
Plants protected with
BioDirect™ Technology
Non-transgenic virus control topical technology designed as a new tool to potentially reduce
the impacts of viruses
Leverages Monsanto’s core capability in genomics, using genome sequences to identify more
precise, effective tools for virus control
Monsanto Company Confidential
* Photo of plants depict plants grown and treated in lab environment
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Bee Health Focus
Varroa Genomics, Viral Sequencing
• Establish complete and annotated genomics database of phoretic and brood mites
• Viral sequencing used to select targets
BioDirect Technology
Proof of Concept
• Substantial and reproducible Varroa gene silencing by feeding
Field Testing Analytics
• Analytical methods Virus and Varroa field data assessment developed,
field trial completed
Varroa Delivery Methods
Monsanto Company Confidential
• Delivery to Varroa by feeding bees shown
• Formulations and application methods are being developed
• Field study with Dr. Jamie Ellis (UF) initiated
14
BioDirect™ Technology
Monsanto is investing in a new R&D platform called Agricultural Biologicals.
BioDirect ™ is the first AG biological technology
we have in discovery.
BioDirect™ technology uses
molecules found in nature
and are selected to be
effective and specific for
their intended target.
BioDirect™ technology is
expected to further support
farmer and consumer
demand for sustainable
agricultural practices.
We’re just beginning to explore this technology, but believe potential pest
control products (weed, insect, and virus) will expand farmers’ choices.
Monsanto Company Confidential
15
Microbials Offer Additional Biological Solutions for Agriculture
Microbial Products Are Emerging in Row Crops
New Technologies Are Enabling Discoveries to Expand Agricultural
Impact of Microbial Biologicals
 Genomic analysis of microbe-plant communities
 Enhanced screening and analytics to discover high performance microbial
agents
 High-resolution Field Testing
 Status: Building increased microbial field testing
capacity for potential in-licensing opportunities and
internal discovery research via Agradis acquisition
Monsanto Company Confidential
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Thank you
Monsanto Company Confidential
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