Cancer Research Center of Toulouse
UMR1037 Inserm - Université Toulouse III Paul Sabatier - CNRS
Recife 2014
1-what is it ?
2-who are we ?
3-our mission, our results
4-our project
Oncopole of Toulouse: a priority of Midi Pyrénées
Institut Universitaire du Cancer - Oncopole of Toulouse
an innovating architecture
to inspirate multidisciplinary research
8700 m2 of total floor space
5200 m2 research teams
(incl. 3549 m2 for 21 modules of 184 m2 )
800 m2 administration
2700 m2 facilities
(incl. 2100 m2 animal facility).
a highly attractive scientifico-medical environment
Purpan Hospital
• Team 07 P. Brousset
• Team 08 S. Manenti/C. Récher
• Team 09 J.J. Fournié
• Protéomics (2/2)
• Biological ressources collection
• Administration
Claudius Regaud Institute
• Team 03 G. Favre
• Team 11 E. Moyal/C. Toulas
• Team 12 M. Poirot/S. Silvente-Poirot
Rangueil Hospital
• Team 04 T. Levade
• Team 05 H. Prats
• Team 06 S. Pyronnet/C. Bousquet
• Team 10 L. Buscail/P. Cordelier
• Protéomics (1/2)
• Gene vectors
LBCMCP
• Team 01 A. Besson
IPBS/CNRS
• Team 02 J.S. Hoffmann/C. Cazaux
Who are we ?
18 research teams, 250 persons, 80 PhD students & graduates
10 core technological platforms 13,000 cages animal facility
Our Core technological platforms
(transgenesis, cryoconservation, genotyping , small animal imaging, …)
Mouse Facility
CREFRE
Experimental Histopathology
(CREFRE, CUC, IFR150)
(UMS006)
Omics
(genomics, transcriptomics, proteomics, MS)
(CRCT,CUC, IFR150)
Mab production & protein ingeneering
(CRCT)
Gene vectors
(CRCT)
Cell Imaging
(CRCT, IFR150)
Bioinformatics
(CUC, CRCT)
Flow cytometry & cell sorting
(CRCT)
Analytical Pharmacology
(CUC)
Biological Resources Collection
(CRCT, CUC)
2012: More than 200 people dedicated to cancer research
Staff: positions
Staff: functions
Others: 6
Master
students:
17
PostDoctoral
fellows: 19
Others: 19
Trainees: 17
Researchers
: 39
Teachers @
University:
13
Permanents
: 105
PhD
students: 47
Hospital
practitioners
: 28
Contractuals
: 72
Technicians:
44
Leading institutions, leading research
Positions
Functions
49%
Others
(AHU…): 6
M1 & M2:
Post- 17
Others: 19
26%
Trainees: 17
Doctoral
fellows: 19
Permanents:
105
Contractuals:
72
CR/DR: 39
PU,
MCU: 13
14%
PhD
students:
47
PH, PU-PH,
MCU-PH:
28
6%
5%
Technicians
: 44
Our Missions , Our results
Our missions
I. Promote an outstanding fundamental research on cancer
II. Accelerate discovery of new drugs, technologies and treatments
III. Promote scientific, medical & clinical education of students & staff
IV. Accelerate access to new clinical trials at IUC
V. Promote economical development
(pharma, biotech & other companies )
Our results: 5-year indicators of CRCT
22 million €
contracts
21901
~1000 publications
~260 graduates
217
457
142
119
81,9
524
40 patents
3 start-up companies
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Dept 1- Molecular biology of cancer cells
 CDKi as tumor suppressors & oncogenes
 genetic instability of tumor cells
 rhoGTPases regulating cancer cell signaling
Departements
&
thèmes de recherche
Dept 2- Tumor Biology
 metabolism
 angiogenesis & lymphangiogenesis
 translational control of tumor response to stress
Dept 3- Hematology & Immunology
 oncogenesis of T cell lymphoma & leukemia
 signaling of Acute Myeloid Leukemia
 immunotherapy of B lymphomas
+ new projects
Dept 4- Experimental Therapeutics
 biomarkers & biotherapies,
 therapeutic innovation
 tumor radioresistance
Our project
Grandes Questions en Oncologie
Mécanismes Oncogéniques
Microenvironnement, Métabolisme, Evolution Tumorale
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Cancer Cell Metabolism
Clonal & Microenvironmental Coevolutions
Evolution Clinique & Biomarqueurs Prédictifs
Innovations Therapeutiques
N
N
Biological Drugs
Oligonucleotides
Synth peptides
Gene therapy
Natural products
OCH3
HO
H 3C
CH3
O
H 3C
N
CH3
N
O
S
O
OH
O
H 3 CO
mAbs
O
NH
HO
O
Ecteinascidin
743
O
O
O
H 3C
O
NH
OH
CH 3
H3C
CH 3
CH 3
H
O
O
OH
O
O
O
O
OH
CH3
N
H
N
N
H 3C
O
N
CH3
New Chemical Entities (Tki, …)
Recomb proteins
O
H
N
Innovations Technologiques
Understand better to defeat cancer
… and let’s score the goal together !