Steve Holmes, PhD
Director, Therapeutic Targets
Kymab Limited
I am in the Biotechnology industry
DNA
A code
Organised into genes
>30,000 in each of us
Each gene
Can be translated
Into a specific
protein
Proteins are large
and complex
and carry out the body’s
functions
Most biological medicines
are PROTEINS
1
Biologics : Some of the Molecules used in Medicine
Biologics. Some of the Molecules
MW ca. 18,500
-Interferon
Aspirin MW 180
Insulin
MW ca. 6,000
IgG Monoclonal Antibody
MW ca. 160,000
Pharmaceutical Product Sales
Total Sales $Billion
Top 10 - Sales $Billion
600
70
60
500
50
400
40
Biologic Drugs
Conventional Drugs
300
30
200
20
100
10
0
0
2000
2008
2014
2000
2008
2014
• By 2014 Biologics are expected to account for 75% ($50Bn) of the revenues
from the top 10 best selling drugs
• Five of the Top 10 are predicted to be monoclonal antibodies
Mechanism of Action of Monoclonal Antibodies
Unique binding
function
Effector function
Monoclonal Antibody
Clinical use of Monoclonal Antibodies
Rheumatoid Arthritis – Disease Reversal
Clinically Approved anti-TNF
Monoclonal Antibodies for RA
Remicade
Humira
A day in the life of Steve Holmes
►Research ideas for monoclonal antibody therapy for
Amyotrophic lateral sclerosis
IP, literature and competition searches
Review list of experts in field
►Prepare for meeting with Contract Manufacturing
Organisation
►Attend antibody research group meeting
►Attend management meeting
►Telecon with Wellcome Trust
►Prepare project plan for new monoclonal
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Early clinical Late clinical
trials
trials
Approval
What is my job in the cycle?
What skills are required to do my job?
• Ideas
• Immunology, biochemistry, molecular biology
• Research
• Antibody generation, antibody engineering, cell line
development and manufacturing
• Development
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Early clinical Late clinical
trials
trials
Approval
What skills are required to do my job?
How did I gain the skills?
• Immunology, biochemistry, molecular biology
Post-Doc (3 years)
Assistant Professor (4 years)
On job training
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
What skills are required to do my job?
Early clinical Late clinical
trials
trials
Approval
How did I gain the skills?
• Immunology, biochemistry, molecular biology
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Academia
Biotech. and Pharma. industry
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
What skills are required to do my job?
Early clinical Late clinical
trials
trials
Approval
How did I gain the skills?
• Immunology, biochemistry, molecular biology
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Academia
Biotech. and Pharma. industry
30+ Patents
60+ Publications
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
What skills are required to do my job?
Early clinical Late clinical
trials
trials
Approval
How did I gain the skills?
• Immunology, biochemistry, molecular biology
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Pharma and Biotech industry
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
What skills are required to do my job?
Early clinical Late clinical
trials
trials
Approval
How did I gain the skills?
• Immunology, biochemistry, molecular biology
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
Biotech industry
30+ Patents, 60+ publications
Kymab: Therapeutic monoclonal antibody company
Life cycle: idea to clinic
~8 years
Ideas
Research
Development
Early clinical Late clinical
trials
trials
4 mAbs
What skills are required to do my job?
Approval
Bosatria
How did I gain the skills?
• Immunology, biochemistry, molecular biology
• Antibody generation, engineering, cell
line development and manufacturing
• Disease biology expertise
• Clinical trials
• IP, Fund raising, Bus. Dev.
• Years of experience
• Track record
30+ years
Monoclonal antibodies in clinical trials
Domantis – sold to GSK for £230M
Biotechnology Industry
Salary, Career path and career progression/promotion opportunities
BSc
PhD
0 – 4 years experience
0 – 4 years experience
~£18K - £35K
~£20K - £50K
Career Path
Science Career
Career Opportunities
Research Associate
Marketing/Sales
Scientist
Patent attorney
Senior Scientist
Business Dev./CBO
Director
CEO
CSO
Consultant
Found own company