Carmelo CARLO-­‐STELLA, M.D. Curriculum Vitae PERSONAL DATA Birthplace Citizenship Office address CURRENT APPOINTMENTS University Hospital EDUCATION 1975 1981
1986 1993 TRAINING 1981-­‐1984 1985 1986-­‐1987 1988 Capo d'Orlando (ME), Italy, January 13, 1958 Italian IRCCS Istituto Clinico Humanitas Humanitas Cancer Center Dipartimento di Onco-­‐Ematologia Via Manzoni, 56 -­‐ 20089 Rozzano (Milano) Tel: 02 8224 4577 -­‐ Fax: 02 8224 4590 E-­‐mail: carmelo.carlostella@unimi.it Associate Professor of Medical Oncology University of Milano, School of Medicine Head, Hematology and Cancer Therapeutics Unit Department of Oncology and Hematology Humanitas Cancer Center Humanitas Clinical and Research Center High School Diploma Medical Doctor, Magna cum Laude, University of Pavia, Pavia, Italy Specialization in Internal Medicine, University of Pavia, Italy Specialization in Hematology, University of Parma, Parma, Italy Residency in Internal Medicine, University of Pavia, Pavia, Italy Research Fellow in Hematology, University of Frankfurt School of Medicine, Frankfurt, Germany Post-­‐Doctoral Training Award in Hematology of the IRCCS Policlinico San Matteo, Pavia, Italy Post-­‐doctoral Research Fellow in Hematology, University of Frankfurt School of Medicine, Frankfurt, Germany 2
1988-­‐1989 Post-­‐Doctoral Training Award in Hematology of the IRCCS Policlinico San Matteo, Pavia, Italy APPOINTMENTS 1989-­‐1998 Assistant Professor of Hematology University of Parma School of Medicine, Parma, Italy 1999-­‐2005 Assistant Professor of Medical Oncology University of Milano School of Medicine, Milano, Italy 1999-­‐2011 Active Staff in Oncology, “Cristina Gandini” Medical Oncology Unit Fondazione IRCCS Istituto Nazionale Tumori, Milano 2005-­‐2011 Director, Hematopoietic Stem Cell Manipulation Unit Fondazione IRCCS Istituto Nazionale Tumori, Milano 2006-­‐present Associate Professor of Medical Oncology University of Milano School of Medicine, Milano, Italy 2011-­‐present Head, Hematology and Cancer Therapeutics Unit Department of Oncology and Hematology Humanitas Cancer Center Humanitas Clinical and Research Center PROFESSIONAL SOCIETIES 1983-­‐present Italian Society of Hematology (SIE) 1984-­‐present Italian Society of Experimental Hematology (SIES) 1989-­‐present International Society of Experimental Hematology (ISEH) 1993-­‐present American Society of Hematology (ASH) 1993-­‐present European Hematology Association (EHA 1994-­‐present International Society for Cellular Therapy (ISCT) OTHER PROFESSIONAL ACTIVITIES Consultative 1994-­‐1998 Board Member of the Italian Society of Experimental Hematology 1997-­‐1998 Vice-­‐President of the Italian Society of Experimental Hematology 2002 Member of the National Committee of the Italian Health Ministry on “Collection, Manipulation and Clinical Use of Hematopoietic Stem Cells” -­‐ 2002-­‐present Co-­‐Principal investigator in international clinical trials in onco-­‐
hematology area according to ICH-­‐GCP principles 2003-­‐present Consultant of CME program of the Italian Health Department 3
2005-­‐2011 Member of Gruppo Italiano Trapianto di Midollo (GITMO) 2005-­‐2011 Member of Stem Cell Committee of the GITMO 2006-­‐present Member of Stem Cell Committee of the Italian Society of Hematology (SIE) Reviewer of proposals for “Cell-­‐based regenerative medicine” to German Federal Ministry of Education and Research (BMBF) 2008 2011 2011-­‐2013 Editorial 1994-­‐1996 1994-­‐1996 1997-­‐1999 1998-­‐2004 2000-­‐2002 2000-­‐2003 2004-­‐present 1995-­‐present 2006-­‐present 2006-­‐present Member, Ethical Committee for Animal Experimentation Fondazione IRCCS Istituto Nazionale Tumori, Milano Member, Michelangelo Foundation for Advances in Cancer Research and Treatment, Milano Experimental Hematology, Editorial Board Member Haematologica, Advisory Board Member Haematologica, Editorial Board Member Bone Marrow Transplantation, Editorial Board Member Haematologica, Associate Editor Annals of Hematology, Advisory Board Member Annals of Hematology, Section Editor, Experimental Hematology Stem Cells, Editorial Board Member Current Stem Cell Research & Therapy, Editorial Board Member Recent Patents on Anti-­‐Cancer Drug Discovery, Editorial Board Member World Journal of Stem Cells, Editorial Board Member 2009-­‐2012 GRANTS 1996 -­‐ 1998 Principal Investigator “Selection of BCR/ABL negative progenitors with tyrosine kinase inhibitors or growth factor-­‐driven amplification” -­‐ Supported by Italian Association for Leukemias (AIL) 1996 -­‐ 1998 Head, Research Unit “Selection of BCR/ABL negative progenitors with tyrosine kinase inhibitors or growth factor-­‐driven amplification” -­‐ Supported by Italian Association for Cancer Research (AIRC) 1998 -­‐ 2002 Principal Investigator “Marrow stromal cell therapy using culture-­‐expanded and genetically-­‐engineered mesenchymal stem cells” -­‐ Supported by Italian Association for Cancer Research (AIRC) 4
2001 – 2003 2006 – 2007 2006 – 2008 2009 – 2010 2010 – 2013 2009 -­‐ 2011 2011 -­‐ 2012 Head, Research Unit “Stem cell biology: models for nuclear transfer and ex vivo expansion for research and therapy” – Ricerca Finalizzata, Supported by Italian Health Ministry Head, Research Unit “Stem cells and regenerative cell therapy. GMP production and characterization of mesenchymal stem cells for clinical use in regenerative and immunomodulating cell therapy” – Ricerca Finalizzata, Supported by Italian Health Ministry Head, Research Unit “Somatic cell theray of human cancer using CD34+ cells transduced with an adenovector encoding TRAIL” – Ricerca Finalizzata, Supported by Italian Health Ministry Principal Investigator “Rational combinations of molecularly targeted agents in lymphoproliferative disorders” – Ricerca Finalizzata, Supported by Italian Health Ministry Head, Research Unit “Cell therapy with TRAIL-­‐armed, genetically engineered or phenotypically redirected, effectors“ – Special Project Clinical Molecular Oncology 5‰, supported by Italian Association for Cancer Research (AIRC) Head, Research Unit “Eterogeneità funzionale di cellule staminali emopoietiche CD34+” – Progetto di Interesse Nazionale (PRIN), supported by Ministry of Education, University and Research Head, Research Unit “NEPENTE -­‐ NEtwork lombardo di eccellenza PEr lo sviluppo di farmaci di origine Naturale diretti alla modulazione del microambiente tissutale per la prevenzione e TErapia dei tumori e delle malattie neurodegenerative” – Supported by Regione Lombardia RESEARCH FIELDS 1. Stem Cell Purging 1.1 In vitro pharmacological purging of leukemic stem cells 2. Clinical use of growth factors 2.1 Use of growth factors to mobilize hematopoietic stem/progenitor cells 3. Tumor Xenografts in Immunodeficient Mice 3.1 Intratumor homing of normal human hematopoietic stem/progenitor cells 3.2 Preclinical models to evaluate the therapeutic efficacy of new drugs 4. Gene transfer into human hematopoietic stem/progenitor cells 4.1 Use of adenovirally-­‐transduced hematopoietic stem/progenitor cells as vehicles for the systemic delivery of anticancer molecules 5. Treatment of human malignancies 5.1 Clinical protocols for high-­‐dose therapy of human chemosensitive tumors 5.2 Clinical use of peripheral blood progenitor cells following myeloablative therapy 5.3 Clinical use of anti-­‐lymphoma monoclonal antibodies 5
5.4 Phase I/II clinical trials using molecularly targeted agents for the treatment of relapsed/refractory lymphoma PUBLICATIONS (1987 – 2014) More than 150 full papers published in peer-­‐reviewed journals, including Blood, Journal of Clinical Oncology, Journal of Clinical Investigation, Cancer Research, Clinical Cancer Research, etc.. Total Impact Factor: >800. Total Citation Index: >3,500. Bibliometric indices according to ISI Web of Science: • Sum of the times cited: 4,490 • Total Impact Factor: >850 • H-­‐Index: 31 Milano, May 13, 2014 Carmelo Carlo-­‐Stella, M.D.