Alexandra Richardson, PhD, CLP April 2015 Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities. The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton. The two-fold mission of the Foundation is to: ► conduct medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind, and ► transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. 2 Medical Research at Leading Research Institutions U. of Geneva North Carolina State UCSD Salk UT-Austin UT-Southwestern MD Anderson UTHSC-San Antonio Baylor College of Medicine UT-Medical Branch 3 Medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind Medical Research to Develop Cures Cancer Immunotoxins for targeted cancer therapy CNS & Ophthalmology Stem Cell Therapy for Parkinson’s Disease Metabolic Diseases Urocortin peptides for diabetes Avicin to treat Mantle cell Lymphoma Monoclonal antibodies targeting angiogenesis Engineered proteases Modulation of brain stress in neurological diseases GLP-1 combination therapy Genetic disease models for neurological diseases Molecular switches in glucose control Gene therapy and peptide therapeutics for AMD Serum oxysterols as biomarkers of disease Next generation anti-mitotic drugs Fc engineered aglycosylated antibodies 4 Medical Research to Develop Cures 5 Infectious Diseases Autoimmune & Inflammation Cardiology Endometriosis Vaccines for Dengue and Chinkungunya Engineered proteases Urocortin peptides and gene therapy for congestive heart failure Small molecules targeting SRC Vaccines and diagnostics for Ehrlichioses Fc engineering of aglycosylated antibodies OCT-TPL diagnostics of human vascular plaques OCT Image Guided Laser knife for diagnosis and treatment Leaders in Innovation and Technology Stem Cell Therapy Examples Gene Therapy Neuropeptides Protein Engineering, Antibodies and Immunotoxins 6 Transforming Research Into Products Mission Two: To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. • Collaborations • Spin-out companies • Licensing 7 Portfolio of Start-up Companies 8 Some of Our Other Licensees 9 Marketed Products Exparel DepoDur • Morphine liposome injectable suspension • Post-operative pain Depocyt • Cytarabine liposomes injectable suspension • Lymphomatous and solid tumor meningitis Attrius Retcam AccuPlex 4 SCA6 Diagnostic tests FIA 10 • bupivacaine liposome injectable suspension • Pain • Cardiac PET Imaging • Medical imaging systems for private practices • Neonatal and pediatric imaging system • Wide-field digital imaging system for the hospital and clinic • Ehrlichoisis canine • Assay for canine vector borne diseases • Ataxia diagnostic • Assay for Spinocerebellar ataxia type 6 (SCA6) • Functional Intracellular analysis • Assay for intracellular function of essential micronutrients Clinical Pipeline Candidate compound 11 Indication Partner Development Stage Lenti-D Childhood ALD Pre-clinical Phase I LentiGlobin Betathalassemia Pre-clinical Phase I/II LentiGlobin Sickle cell anemia Pre-clinical Phase I Retinostat AMD Pre-clinical Phase I Urocortin Congestive Heart Failure Pre-clinical Phase I VC-01 Type I Diabetes Pre-clinical Phase I a-TEA Breast cancer Pre-clinical Phase I Phase II/III Phase II Available to Partner A Cancer Research Hospital Advanced Pre-clinical Pipeline Candidate compound 12 Indication Development Stage Encorstat Corneal graft rejection Pre-clinical Avicin Mantle Cell Lymphoma Pre-clinical Dengue tetra vaccine Dengue Fever IND package VEGF-rGel Solid Tumors IND package VEGF-rGel AMD Partner IND IND Available to Partner Advanced pre-clinical Available to Partner Collaboration and Licensing Opportunities 13 • • Urocortins and analogues for Diabetes GLP-1 agonist combination therapies for Diabetes • • • • Alk4-Fc, a Cripto antagonist for Cancer Granzyme B - a potent payload for antibody drug conjugates (ADC) YESS - engineering of proteases Fc engineered antibodies with specific effector function • • • • • • Filaggrin to treat dermatological disorders TEAD gene and peptide therapies for ocular neovascular disease CRFR1 antagonists - therapeutic for early onset AD Stem cell therapy program for Parkinson's Disease Vaccines and Diagnostics for Ehrlichioses OCT guided laser knife for surgery in small spaces Conducting and funding research Transferring research into products One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com arichardson@claytonbiotech.com