Necrosis
TAMMY DO
TRAUMA RESEARCH ASSOCIATES PROGRAM
8.24.2012
Necrosis
 Premature death of cells/death of body tissue
 Apoptosis vs. Necrosis
 Caused by:
 Infections
 Toxins
 Trauma
 Ischemia
Causes
 Ischemia
 Thrombosis/embolism
 Infection/Disease
 Fungal/bacterial
 Diabetes
 Chemicals
 Poisons/toxins
 venom
 Trauma
Necrotic Wound from Spider Bite
Types of Necrosis
 Coagulative
 Liquefactive
 Caseous
 Fatty
 Fibrinoid
 Gangrenous
 Aseptic
Coagulative Necrosis
 Caused by ischemia
 Denaturation of




structural proteins
Enzymatic digestion of
cells
Architecture of tissue
preserved
Occurs in organs like
heart, spleen, kidney
Does not occur in brain
Liquefactive Necrosis
 Necrotic tissue digested
by enzymes into liquid
 Associated with abscess
formation
 Commonly seen in brain

ischemia
 Fungal or bacterial
infection

Not in brain
Caseous Necrosis
 Necrotic tissue is
crumbly and cheese-like
 Typically caused by
tuberculosis


Syphilis
fungal
Fat Necrosis
 In response to trauma
 Lipases break down fats
 React with calcium:
saponification
 Chalky white deposits
 Most commonly seen in
pancreas and breasts

Acute pancreatitis
Fibrinoid Necrosis
 Caused by deposition of
fibrin or fibrin-like
materials
 Vasculitis
Gangrenous Necrosis
 Considerable mass of
necrosis
 Types of gangrene



Dry
Wet
Gas
 Dry Necrosis





Form of coagulative
Caused by ischemia
Autoamputation
Distal parts of limbs
Dry, shrunken, black
Gangrenous Cont.
 Wet



Moist tissue and organs
Characterized by bacterial
infection
Dark, swollen, foul odor
 Gas


Bacterial infection that
produces gas within tissue
Deadly
Gangrenous Cont.
Aseptic Necrosis
 Avascular necrosis or
osteonecrosis
 Necrosis of bone
 Lack of blood supply to
bone
 Medications, trauma,
ischemia,
hypercoagulable blood,
alcoholism
Treatment
 Depends on the extent of damage
 Restoration of blood flow
 Maggot Therapy
 Debridement
 Amputation
Sources
 http://onlinemedicinefacts.com/pathology/caseous
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necrosis-liquefactive-necrosis-and-fibrinoid-necrosis
http://www.symptomsbook.com/Facts-Therapy-PicturesDiagnosed-Information-Diagnosis-Herceptin-Treatednecrosis-Diagnosed-Diagnosis.htm
http://www.medicinenet.com/aseptic_necrosis/article.htm
http://www.nlm.nih.gov/medlineplus/ency/article/00226
6.htm
http://www.mayoclinic.com/health/avascularnecrosis/DS00650
http://library.med.utah.edu/WebPath/CINJHTML/CINJ0
29.html