Practical Implications of
Sleep Neurochemistry
LASM November 2011
Kevin R. Hargrave, MD
CNS Clinic, Lafayette LA
Practical Implications of Sleep Neurochemistry
• Intro comments
(3-15)
• Rx’s: top 5 in U.S. and most common of CNS clinic pt’s (16-27)
• Anatomy of sleep related neuronal centers/circuits
(28-49)
– Wake circuitry
– Sleep NREM circuitry
– REM circuitry
• Brain Chemistry and sleep stages
(49-89)
– Wake neurochemicals
– NREM neurochemicals
– REM neurochemicals
• Conditions (sleep d.o.’s) and tidbits thereof
(90-105)
• Drugs (effects on sleep)
(106-130)
‘Sleep’
According to Dr. Dement,
Sleep: Two essential features
a. Perceptual wall bw conscious mind and outside world
b. Immediately reversible
And the brain “puts itself to sleep”
According to Freud, from his 1905 book Interpretation of Dreams,
dreams represent
“the royal road to a knowledge of the part the
unconscious plays in mental life”
As late as 1970, the practice of medicine ended
when the patient fell asleep.
Practical Implications of Sleep Neurochemistry
•Anatomy
•Brain Chemistry
(brain anatomy as it pertains to sleep)
(W, NR, R and their
Nchem’s
•Conditions
•Drugs
(sleep d.o.’s)
(Rx’s and their effects on sleep)
Sleep/Wake Neuroanatomy:
SCN (anterior hypothalamus)
Sleep Review Sept 2011
Sleep/Wake Neuroanatomy
http://courses.washington.edu
fly
Neurochemistry of Sleep and Wakefulness. Monti et al.
Genes Dev. 2010 Jun 15;24(12):1220-35.
.
Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069
©2006 by American Physiological Society
.
Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069
©2006 by American Physiological Society
pubs.niaaa.nih.gov