GIT diseases
•
– diffuse labial, gingival or mucosal swelling
– „cobblestoning“ of buccal mucosa and gingiva
– aphtous ulcers
– mucosal tags
– angular cheilitis
– oral granulomas
•
– oral signs are present in periods of exacerbation of disease
– aphtous ulceration or superficial hemorrhagic ulcers
– angular stomatitis
– pyostomatitis vegetans, pyostomatitis gangrenosum cobblestoning of the gut mucosa pystomatitis vegetans

GIT diseases
•
– reduction of the pH of the oral cavity below
5,5 – enamel damage
– damage of the dentin – higher sensitivity (to temperature..), caries
•
– jaundice
– petechiae or gingival bleeding (hemostasis disorder)

Hematologic diseases
•
– folate and vit. B12 deficiency
– iron deficiency
– glossitis
• red colour
• athrophic papilae
• recurrent aphthae
– candidal infection
– angular stomatitis
– oral pain

Hematologic diseases
•
– gingival hypertrophy
– petechiae
– mucosal ulcers
– hemorrhage
Treatment of leukemia
– reactivation of herpes simplex virus – oral mucosistis

Angular cheilitis
• Iron-deficiency anemia
Intraoral burning
• Iron-deficiency anemia
• Pernicious anemia
Hemorrhage
• Pyostomatitis vegetans
• Scurvy
• Ulcerative colitis
Candidiasis
• Crohn's disease (steriod therapy)
• Iron-deficiency anemia
• Pyostomatitis vegetans (steriod therapy)
• Ulcerative colitis (steroid therapy Aphthous ulcers
• Crohn's disease
• Pernicious anemia
• Ulcerative colitis

Labial swelling
• Crohn's disease
Erosion of enamel and dentin
• Anorexia nervosa/bulimia
• Gastroesophageal reflux
Gingivitis
• Anorexia nervosa/bullimia
• Crohn's disease
• Scurvy
Glossitis
• Crohn's disease
• Iron-deficiency anemia
• Pernicious anemia
• Ulcerative colitis
Ulcerations and erosions
• Crohn's disease
• Iron-deficiency anemia
• Pernicious anemia
• Pyostomatitis vegetans
• Ulcerative colitis

Connective-tissue diseases
•
– autoimmune disease
– men : women - 1 : 9, 50 years and older
Main signs
– sicca syndrome
– keratoconjuctivitis sicca
– xerostomia
Oral signs
– decrease in saliva
• xerostomia
– dry, red, wrinkled mucosa
• difficulty in swalloving and eating
• disturbance in taste and speech
• increased dental caries
• infections
• atrophy of the papilae
• candidiasis

Connective-tissue diseases
•
– vasculitis of medium and large arteries
Oral signs
– swelling of papilae on the surface of the tongue (strawbery tongue)
– intense erythema of the mucosal surfaces
– cracked, cherry red, swolen and hemorrhagic lips

Connective-tissue diseases
•
– diffuse sclerosis of the skin, GIT, heart muscle, lungs, kidney
Oral signs
– pursed lips – dificult to open the mouth
– esophafeal sclerosis  gastroesophageal reflux – damage of enamel
– pale, rigid mucosa
– teleangiectasias
– decreased mobility of tongue
– salivary hypofunction
Limited mouth opening and decreased tongue mobility
Gingival retraction

Connective-tissue diseases
•
– autoimmune disease
Oral signs
– ulcerations
– oral lesions of lichen planus – painfull
– petechiae
– damage of salivary glands xerostomia ulcer lichen planus lesions

Pulmonary diseases
•
Oral signs
– disorder of salivary glands
– swelling lips
– gingivitis
– dryness

Pulmonary diseases
•
Oral signs
– multiple, nodular, painles ulcerations of the gingiva, bucal mucosa, labial mucosa and palate
– tumorlike swelling of salivary glans
– swelling of the tongue
– xerostomia
– facial nerve palsy

Cutaneous diseases
•
Oral signs
– fissured tongue
– small white papules
– red and white plagues
– bright red patches
•
– hyperpigmentation, papillomatosis
Oral signs
– gingival hyperplasia
– gingiva, tongue, lips - papilomas

Endocrine diseases
•
Oral signs
– xerostomia caused decreased salivation and increased glucosa level in saliva
• gingivitis
• oral infections
• candidiasis
– higher incidence of caries
– bilateral enlargement of parotid glands
– altered taste
– burning mouth syndrome bilateral parotid gland enlargement gingivitis hyperplasia

Endocrine diseases
•
Oral signs
– candidiasis
– upper lip twitching
•
Oral signs
– loss of the lamina dura surrounding the roots of the teeth
– decrease of trabecular density
– osseous lesions „brown tumor“

Endocrine diseases
•
Oral signs
– fatty tissue deposition – „moon face“
– osteoporosis  pathological fractures of the mandible, maxilla or alveolar bone
– delayed healing of fractures and also sof tissue injuries
•
Oral signs
– „bronzing“ hyperpigmentation of the skin
– oral mucosal melanosis – buccal mucosa, tongue hyperpigmentation moon face

Renal diseases
• Uremic stomatitis
– rare
– in undiagnosed and untreated chronic renal failure
– irritation and chemical injury of mucosa by ammonia or ammonium compounds
Signs
– painful plagues and crusts – bucal mucosa, the floor or dosrum of the tongue, floor of the mouth
– Type I
• generalized or localized erythema
• exudate
• pain, burning, xerostomia, halitosis, gingival bleeding, candidiosis
– Type II
• ulceration
• secondary infection
• anemia