Stem Cell Therapy in Dogs
A New Treatment for a New Decade
Presented by
Vet-Stem
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What are Stem Cells?
Stem Cells are primitive cells present in almost every tissue
•
Self Renewing
•
Able to become different
tissue types
•
Signal other cells to come
in and rescue and repair
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What Do Adult Stem Cells Do?
10 million cells die in your
body every minute of
every day.
Your stem cells replace
them so you can
continue living.
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Embryonic vs Adult Stem Cells
Embryonic Stem Cells
•
•
•
•
Intended to form whole animal - not for repair
Can form tumors – UNPREDICTABLE
Ethical dilemma
Maybe someday
Adult Stem Cells – many sources
•
•
•
•
Intended for self repair
No ethical dilemma
Do not form tumors when injected
Available now
Gruen L and Grabel L, Stem Cell 2006;24;2162-2169.
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Why Fat as Stem Cell Source?
•
High healing cell count – No culturing
required
•
1000 times more stem cells than bone
marrow
•
Family of healing cells
•
Rapid, Easy to access
•
Over 1700 peer reviewed papers published
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What Do Stem Cells Do?
• Reduce Inflammation
• Reduce pain
• Differentiation into tissue
• Home in on injury sites
• Induce healing-regeneration
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The Injury Response Cascade
Magnitude
Inflammation
“Regeneration”
Fibrosis
QUICK
FIX
Acute Injury
Time
Scar Complete
Courtesy of Dr.Caplan, Case Western Reserve
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Magnitude
Stem Cells in Injury Response
“Regeneration”
Inflammation
Fibrosis
Time
Acute Injury
Stem Cells
Scar Reduced
Courtesy of Dr. Caplan, Case Western Reserve
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Annie
Annie 9 yr LabX
Chronic elbow arthritis
Drugs not controlling pain
Stem Cell Therapy
Able to jump in and out of car;
took 2 hour run in the woods
90 days after stem cell therapy
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Harley
Harley 6 yr Rat terrier
Pain in hips & knees since 6
months old
Pain killer medications
(NSAIDS) for 12 months &
still painful
Wouldn’t play ball or go up
stairs
2 weeks after stem cells–
Dramatic pain reduction
Plays ball and climbs stairs
Now NSAID free for >36
months
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Blinded Clinical Trial Participant
Cinnamon 10 yr Standard Poodle
Arthritis in both hips
Unable/unwilling to take medications
Owners considering euthanasia-got a new puppy
30 days after stem cell therapy he was playing, jumping, running
and taking long walks
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Got Fat?
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Why Use Vet-Stem?
• Began treating horses in 2003
•
Experienced-Over 3,500 horses & 2,000
dogs
•
Safety-your pet’s own cells
•
Strict quality standards
•
Peer-reviewed, published controlled studies
•
Global leader in veterinary stem cell therapy
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Safety Profile*
Horses: 7/3,359 (0.2%) Only local swelling/pain
Dog:
2/1,695 (0.1%) Only local swelling/pain
*probable adverse events, through 6/1/09
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Quality Standards
• Written standard operating
procedures
• Independent Quality
Assurance Unit
• Routine audits of all
procedures
• Sample release criteria
• Formal training systems
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Service Overview
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Vet-Stem Adipose Processing Lab
1. Immediate use
3. Lifetime supply
by culture
2. Frozen for future
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Current Supported Uses
Dogs/Cats
•
•
•
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Osteoarthritis
Polyarthritis
Tendonitis
Ligament injury
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Ideal Stem Cell Case
Pet w/ lameness or pain due to arthritis or a partial
tear of a ligament or tendon
Pet does not require surgery – surgery first, if needed
No other major diseases (liver, kidney, heart)
No major spinal disease (spondylosis, spinal arthritis)
Not-responsive or can’t tolerate pain killers
Realistic expectations
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Cruciate Ligament Disease & Stem Cells
• Surgery – always have surgery when required
• With surgery – helps to reduce inflammation
and scar tissue
• After surgery – helps to treat inflammation
and encourage cartilage repair
• Chronic ACL inflammation and synovitis is a
good case
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Storm
Storm 9yr Catahoula Leopard Dog Mix
Arthritis in both hips and right stifle
Unable/unwilling to take medications
3 weeks after treatment started showing improvement
Later his left stifle was treated after surgical repair
Storm and owners happy that he is doing extremely well
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Real World Dog OA Cases
Average Veterinary Scores of Dogs in Regards to
Pain, Lameness, and Range of Motion
2008 Commercial Clinical Data*
3.5
Veterinary
Scale:
5=Extreme
(considering
euthanasia)
4=Severe
3=Moderate
2=Mild
1=Normal
Veterinary Score
3.0
2.5
2.0
*Voluntary
responses from
commercial
cases.
1.5
1.0
Day 0
30
60
90
Pain
(N=141, pre-tx)
Day 0
30
60
90
Day 0
Lameness
(N=146, pre-tx)
30
60
90
Range Of Motion
(N=141, pre-tx)
24
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Conclusion:
According to a 2009 Owner Survey
• Greater than 33% of dogs discontinued the use of
NSAIDs completely
• Greater than 28% of dogs decreased their
dependency on NSAIDs
At 90 and 246 days after treatment
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Malibu
Before and After Video
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Media Coverage of
Veterinary Medicine
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Questions?
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