A.J. Plechner DVM Lecture Two Lecture Two April 7, 2015 Dr. Plechner A modern day animal with an EI imbalance. Demodectic mange is a common disease. Inflammatory Bowel syndrome After hormone supplementation and immune regulation Irish setter with EI imbalance Irish setter with EI imbalance Two weeks after adrenal-thyroid supplementation and nomallizing IgA, IgG and IgM. Genetic EI imbalance passed from mother to son Mother Son 3 weeks after correction of adrenalthyroid immune system. (mother) In 1971, clinical studies show an 8 week old golden retriever male puppy with a severe, generalized pyoderma. Blood tests indicated a low cortisol, low T3T4, deregulated IgA, IgG, IgM In one week. In two weeks, T3T4 and IgA,IgG & IgM were remeasured. All had increased and the puppy looked better. What happened? Why would a steroid increase the IgG, IgA, IgM? After researching endocrine cycles, a biochemist friend was asked to develop a total estrogen test. Upon developing this test it demonstrated that high adrenal estrogen, causes deregulation of IgA, IgG & IgM with the case studies tested. After adrenal thyroid immune regulation, the puppy appeared like this! Lecture One showed this basset hound puppy with an EI imbalance This is the puppy after adrenalthyroid-immune regulation Animal cancer patients have an EI imbalance with loss of control of the immune system. A cancer patient Splenic mass Splenic mass – 5 days later. Excised mass – Hemangiosarcoma As with the hemangiosarcoma patient, a patient with a typical cancer EI makeup has: Deficient or bound cortisol. High adrenal estrogen. Deficient or bound T3T4 Deregulated IgA, IgG & IgM Three other related canines developed Hemangiocarsomas. The lesions were excised and EI replacement done. All three are still alive three years later which has never happened before. One to six month of life before death usually occurs. Six of their offspring had the exact same EI imbalance. They were corrected with EI therapy to help avoid the same cancer. Replacement EI therapy usually avoids cancer development or at least slows down its development until very late in life. Can you predict an EI imbalance? Yes! A six to eight week old animal can be tested for Cortisol, T3T4 and total estrogen! The IgG, IgA & IgM will vary due to vaccination procedures. At this time, a new owner may decide to either not take the animal or fund its EI imbalance for life. Can you prevent the EI imbalance? Yes! It is not to say that you cannot breed two animals, it only says they may not have an EI compatibility. You can mix and match and breed parents with different EI imbalances and produce an average without an imbalance. Example – a female Brittany spaniel, a national field trial champion named CeCe, had low cortisol, high adrenal estrogen, suppressed T3T4 and deregulated B & T cells, not only did she stop running and could not become pregnant, she developed “Valley Fever” due to her suppressed T cells. EI therapy corrected the above. CeCe was good enough as a national field trial champion that the owners decided to breed her. The male that was picked was “Sundance”, he had a high cortisol, more normal adrenal estrogen, and a normal thyroid. CeCe had a litter – the offspring appeared normal, I was given one of the puppies and chose to name her Murphy’s law! At 7 months her EI levels and littermates levels were normal. If you identify the EI imbalance in parents you can breed it out. The imbalance is in their offspring. We need to have healthy animals so that young people like this can become Veterinarians.