The Role of the Ratio of Omega 6s to
Omega 3s in Optimal Health
The superior Marine Lipid Complex
Essential Fatty Acids
 Required by the human body to manufacture
and repair cell membranes
 Protect cells from inflammation
 Cannot be made in sufficient quantities
therefore must be obtained from food
 Two types:
 Alpha-linolenic acid (Omega-3)
 Linoleic acid (Omega-6)
Omega 6 and 3
Fish /Marine
Oils
Walnuts
Omega 3/Omega 6 Imbalance
 Changes in food
manufacturing processes
have resulted in high
amounts of Omega 6
 Hydrogenated oils
 High-fructose corn
syrup
 Genetically engineered
corn and soy products
Omega 3/Omega 6 Ratio
Western Diet
1
Recommended Diet
Omega 3
1
Omega 6
20
1
Inflammatory Pathways
Omega3 Foods
Walnuts
Flaxseed
Green Vegetables
Linoleic Acid (LA)
Pro-Inflammatory
Omega6 Foods
Corn Oil
Soy Oil
Safflower Oil
Arachidonic Acid (AA)
Alpha- Linolenic- Acid (ALA)
EPA/DHA Fish/ Animal Sources
COX1
COX2
5LOX
PGG2
5-HPETE
PGH2
Leucotriene A4
Anti-Inflammatory
Prostaglandins (PG2)
Prostaglandins (PG3)
Thromboxane (TXA)
Thromboxane (LTB5)
Leucotriene B4
Leucotriene (B5)
Cysteinyl Leucotrienes
Omega 3/6 Imbalance
Leads to Inflammation
 Bodies natural biological protective response of tissue
to harmful stimuli
 Pathogens
 Cell damage
 Irritants
 Chronic inflammation characterized by simultaneous
tissue healing and destruction
Inflammation is the Basis of
Most Degenerative Disease

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
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Asthma
Alzheimer’s
Cardiovascular Disease
Metabolic Syndrome
Osteoarthritis
Rheumatoid Arthritis
Inflammatory Bowel Disease
Dysmenorrhea
Delayed Muscle Soreness
And many more….
Effects of Reducing
Omega-6:Omega-3 Ratio
 In secondary prevention
of cardiovascular
disease, a ratio of 4:1
Omega-6 to Omega-3
fatty acids associated
with 70% decrease in
total mortality
DeLongeril M, er al. Mediterranean alpha-linoleic acid-rich
diet in secondary prevention of coronary heart disease.
Lancet 1994; 343: 1454-9.
Effects of Reducing
Omega-6:Omega-3 Ratio
 Lowering the ratio to 5:1,
resulted in alterations in
5-series leukotriene
excretion in an
asthmatics in
ameliorating
methacholine-induced
respiratory distress
Broughton KS, et al. Reduced asthma symptoms
with omega-3 fatty acid ingestion are related to 5series leukotriene production. Am J Clin Nutr
1997; 65: 1011-17.
Effects of Reducing
Omega-6:Omega-3 Ratio
 Lowering the Omega-6:
Omega-3 ratio by 4:1 by
using 4gm of omega-3
fatty acids produced
inhibition of production
of IL-1β and TNFα
associated with
rheumatoid arthritis
James MJ, Cleland LG. Dietary omega-3 fatty acids
and therapy for rheumatoid arthritis. Semin
Arthritis Rheum 1997; 27: 85-97.
The OMAPREM
Difference
 With 30 years of Clinical
Studies, OMAPREM is
proven to be a Powerful,
Effective Cox-2 and 5Lox
inhibitor.
OMAPREM
 In addition to EPA and DHA,
OMAPREM contains over 30
fatty acids that contribute to
its anti inflammatory
benefits. As well as 4 novel
compounds*
*Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel (Perna
canaliculus)(PCSO-524™)
S. McPhee a , L .D. Hodges a , P.F.A. Wright b , P.M. Wynne c , N. Kalafatis a , D.W. Harney a, T.A. Macrides a,⁎
*Novel anti-inflammatory ω-3 PUFAs from the New Zealand
green-lipped mussel, Perna canaliculus
A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎
COX2
Inflammation
5LOX
Inflammation /
Swelling
OMAPREM Novel
Compounds
 A structurally related family of ω-3 PUFAs was identified in
the most bioactive fractions, which included:
 C18:4
 C19:4
 C20:4
 C21:5
 The novel compounds may be biologically significant as AI
agents, as a result of their in vitro inhibition of
lipoxygenase products of the AA pathway.
*Novel anti-inflammatory ω-3 PUFAs from the New Zealand
green-lipped mussel, Perna canaliculus
A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎
OMAPREM
The Superior Choice
 Purity
 Potency
 Efficacy
 Science
 Partner Program
Fish Oil Source
 May contain man made pollutants if
taken from natural sources
 Heavy Metals
 PCB’s
 Pesticides
 Radiation
 Farm raised fish have lower amounts
of Omega 3s and higher amounts of
Omega 6s due to corn/grain diet
 Bio-magnification
http://www.hsph.harvard.edu/nutritionsource/fish/
Fish Oil Source
 Fish, like salmon, consume smaller
fish or krill that consume the
plankton.
 Fish also can absorb industrial
contaminates (like mercury) by
eating smaller fish.
 The farther up the food chain the
higher the level of contaminates
http://www.hsph.harvard.edu/nutritionsource/fish/
Krill- Sustainability
 National Geographic Magazine has
warned about the 80 percent drop in
krill populations over the last few
decades
 This drop could potentially harming
already depleted whale and other
marine mammal populations
 Without krill, most of the life forms in the
Antarctic would disappear.
http://animals.nationalgeographic.com/animals/invertebrates/krill.html
OMAPREM Purity
 Green lipped mussels
 Sustainably farmed in the pristine
waters of New Zealand’s
Marlborough Sound.
 Evolved to have extraordinary
antioxidant content due to ozone
deficiency
 Blue Ocean Institute, ranked New
Zealand Green-lipped mussels as one
of the top two ‘eco-friendly seafoods’
in the world.*
*http://www.purenzgreenshell.com/aquaculture/quality-assurance/sustainability.cfm
Marine Oil Extraction Process
 Cold press
 Distillation
 Supercritical fluid
extraction
Marine Oil Extraction Process
 Cold press and distillation processes result in bound
forms of essential fatty acids
 Triglyceride
 Ethyl esters
 More metabolic processing required by the body in
order for absorption
Marine Oil Extraction Process
Extraction Processes
• Free Fatty Acids - easily absorbed and
have been shown to have superior
bioavailability*
• Triglyceride form- have a triglyceride
“backbone” to the grouping of Fatty
Acids
• Ethyl Easter- The Fatty acids are
grouped together. The body must add
the triglyceride backbone for
absorption
Free Fatty
Acids
Triglyceride
Ethyl Easter
HUMAN ABSORBTION OF FISHOIL FATIY ACIDS AS TRIACYLGLYCERLS, FREE ACIDS, OR
ETHYLESTERS
Tarry D. Lawson andBronwynG. Hughes
Fatty Acid Absorption
Ethyl Easter
Form
Triglyceride
Form
• Enzymes
convert Ethyl
Easter back into
Triglyceride
Form
Glycerolysis
Free Fatty
Acid Form
PCSO-524
Lipolysis
• Lipases free
the fatty acids
from
Triglycerides
forming
Micelles that
contain Free
Fatty Acids
• Intestinal
Barrier
Diffusion
Across
Plasma
Membrane
Fatty Acids
Reformed into
Triglycerides
• Particles
called
lipoproteins
or
chylomicrons
• Bioavailable
Released into
capillaries
then blood
stream
OMAPREM Extraction Process
 SFE (CO2) Patented Supercritical Fluid Extraction
 Dissolves nonpolar lipids from freeze dried mussel
powder using combination of pressure and low
temperature
 Process process high quantity of Free Fatty Acids
OMAPREM Extraction Process
 Removes marine proteins 
 Remove heavy metals 
no allergy
no toxins
 Provides free fatty acid form for easy absorption into
the bloodstream
OMAPREM: Potency
OMAPREM Potency
Bioavailability
The PCSO-524 oil used in
OMAPREM has been shown to have
17 to 22 times more free fatty acid
form DHA and EPA, in addition
there are 4 novel fatty acids with
greater bioactivity then standard
fish oils.
*Convance –Certificate of Analysis 594817-0 10-jul-2012, 594835-0,594836-0
Multiple Fatty Acids Multiple
Benefits
Lauric acid
• PCSO-524tm contains novel fatty acids
in addition to 30+ fatty acids that can
reduce inflammation many times
better than other anti-inflammatory
supplements.
Caprylic acid
ALA
Stearic acid
• The array of fatty acids offers many
unique properties not found in any
other marine source
Docosapentaenoic acid
(DPA)
Eicosatetraenoic acid (ETA)
Linolenic acid
Nervonic acid
Fish Oils contain
little more than
these Fatty Acids
DHA
EPA
Smaller & Superior
One tiny capsule of OMAPREM is as powerful as 20 fish oil.
Bioavailability of free fatty acid 5-10 times more in a much smaller quanitity
Kataoka et al. Future Cardiol 2013; 9(2): 177-186.
OMAPREM: Science
Efficacy
*Studies Available Upon Request
Arthritis
 50 patients older than 50 years
 Patients treated with PCSO-524™ showed a statistically
significant improvement of both their pain symptoms related to
osteoarthritis and improved quality of their daily lives (p = 0.05)
 Conclusion: Reduction of pain was statistically evident at four
weeks among the subjects who took capsules that contained
PCSO-524™.
 Practitioners can expect quicker long-term results with less risk
of side effects for their osteoarthritis patients when they
recommend products that contain PCSO-524™, compared with
fish oil.
Szechinski J et al. Measurement of pain relief resulting from the administration of Perna
canaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer
from osteoarthritis of hip and/or knee joints. Reumatologia 2011; 49: 244-252.
Visual Analog Scale (Arthritis)
Week 0
Week 4
Week 8
Week 12
0.00
10.00
89%
20.00
30.00
40.00
50.00
60.00
70.00
PCSO-524
Fish Oil
Quality of Life – Health
Assessment Questionnaire
Fish oil
Mean
-91%
Week
p < 0,05
Rheumatoid Arthritis
 12 week drug monitoring study evaluated the effects



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
of PCSO-524™ on 50 adult men and women suffering
from inflammatory rheumatoid arthritis
21 of the 34 subjects (64%) reduced or terminated
current drug therapy
13 patients did not require further therapy
38 % of all subjects were regarded as being free from
disorders
Number of subjects suffering from severe pain was
significantly decreased from 60% (at baseline) to 25
% (at 3 months)
A significant positive effect was observed for all
investigated parameters
Gruenwald J et al. Efficacy and tolerability of mussel-Lyprinol omega-3-complex on
inflammatory rheumatoid disorders. PhytoPharm Research.
Inflammatory Bowel Disease
 The effect of pretreatment with PCSO-524™ on
experimentally induced inflammatory bowel disease
(IBD) in mice
 Body weight and disease activity index (DAI) scores
were recorded daily
 Treatment significantly reduced body weight loss, DAI
scores, crypt area losses, and cecum and colon weights,
compared with control
Tenikoff D et al. Stabilized lipid extract of New Zealand green-lipped mussel: a potential
preventative treatment modality for inflammatory bowel disease. J Gastroenterol 2005; 40:
361-365.
Asthma
 Forty-six patients with atopic asthma received
two capsules of lipid extract (PCSO-524™) or
placebo b.i.d. for 8 weeks
 Significant decrease in daytime wheeze
concentration of exhaled H2O2
 Increase in morning PEF in the lipid extract
group compared to the placebo group
 No reported significant side effects
Emelyanov A, et al. Treatment of asthma with lipid extract of New Zealand greenlipped mussel: a randomized clinical trial. Eur Respir J 2002: 20: 596-600.
Athletic Performance DOMS
 PCSO-524®, derived from the New Zealand green-
lipped mussel on DOMS after a 30 km training run.
 One group was supplemented with 400 mg per day of
PCSO-524® for 11 weeks, the other group with an olive
oil placebo.
 Conclusion: Pain sensations experienced by distance
runners following a 30 km run were reduced by
supplementation with the marine oil complex PCSO524®, an effect which was greater in lesser trained
runners
No Known Side Effects Just
Side Benefits
 Pharmaceutical Options like
 Codeine Based Pain Relievers
 Cortisone
 Immune Modulators
 NSAIDs (COX1, COX2)
 Create Side Effects Like
 Cartilage deterioration, osteonecrosis, nerve damage, adrenal
suppression, hyperglycemia
 Immune suppression
 Addiction
 GI bleed, stroke, MI, renal failure
The OMAPREM Advantage
• OMAPREM has been shown to be up to
100 times more
effective than other fish oils
• OMAPREM contains complex of 30+ different fatty
(Including EPA and DHA) acids. This array of fatty acids are
unique to the green lipped mussel.
• The fatty acids in OMAPREM are up to 22 times more free
form than fish oil therefore easier for the body to absorb.
•
•
•
•
0 known side effects
0 Drug to Drug interaction
0 Contaminants
0 to Lose!
OMAPREM: Partner Program
Benefit Your Patients and Your
Practice
First Quarter
Second Quarter
Third Quarter
Fourth Quarter
First Year Total
$3,150
$8,625
$13,800
$18,975
$44,550
Fifth Quarter
Sixth Quarter
Seventh Quarter
Eighth Quarter
Second Year Total
$24,150
$29,325
$34,500
$39,675
$ 127,650
Chart based on 1 patient a day, a total of 25 patients each month.
Ongoing Additional Quarterly Incentive
Profit Per Bottle
150-225 Bottles sold per quarter $1 extra per bottle
226-300 Bottles sold per quarter $2 extra per bottle
301-up Bottles sold per quarter $3 extra per bottle
$20 per 60 ct. bottle ($64.95 retail)
$10 per 30 ct. bottle ($39.95 retail)
For More Information
www.OMAPREM.com!
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OMAPREM’s Key Points for Patients
 OMAPREM is a step in the
right direction with
improving your overall
health and well being
 OMAPREM’s top rated
customer service staff is
ready to assist you
Take Advantage of the
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Call our customer service line (800-725-0376). It is our
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