An efficient pipeline from medical images to numerical simulations
MEET THE FACULTY CANDIDATE
POSTER SESSION GUIDELINES
Image segmentation and morphological analysis
Characterize the geometry of vascular
structures.
Aorta-R Iliac
145.5º
Aorta-L Iliac
150º
Software: VMTK (www.vmtk.org).
Ongoing project: classify subject-specific
morphologies of the infrarenal aorta; relevance
of local morphology to the measured flow
patterns.
R Iliac-L Iliac
64.5º
Left: Magnetic Resonance Angiography of the infrarenal aorta of
a healthy male subject; reconstruction of the vessel lumen by
means of a level set-based segmentation.
Right: Centerline-based calculation of the angles between the
aorta and iliac arteries at the bifurcation point.
Tiziano Passerini, PhD
Department of Mathematics and Computer Science
Emory University
tiziano@mathcs.emory.edu
WSS
Statistical identification and classification of
morphological & fluid-dynamics features
of the arterial system.
s
R
Publications:
Passerini, Sangalli, Vantini, Piccinelli, Bacigaluppi, Antiga,
Boccardi, Secchi, Veneziani, “An Integrated Statistical
Investigation of Internal Carotid Arteries of Patients affected by
Cerebral Aneurysms”, CVET, 2012.
s
Partners:
Dr. S.Vantini, Dr. L.Sangalli, P.Secchi (Politecnico
di Milano); M.Piccinelli (Emory Radiology); Dr.
A.Veneziani (Emory Math&CS)
C
The three plots show
the values of wall
shear stress (WSS),
radius (R) and
curvature (C)
computed in the
internal carotid
artery of 52 patients,
as functions of the
spatial location
along the artery (s).
The features of the
curves are
statistically
associated to the
presence, position
and rupture status of
cerebral aneurysms
in the brain.
Store, classify, query large and complex data sets.
Project:
AneuriskWeb (ecm2.mathcs.emory.edu/aneuriskweb),
a public, free repository of medical images, vascular geometries,
hemodynamics simulations. The database can be browsed or
queried based on geometric and hemodynamic features.
Partners: M.Piccinelli (Emory Radiology), Dr. L.Antiga (Orobix), Dr. A.Veneziani (Emory Math&CS)
2. Posters may be taped or tacked to the board. Push pins will be available during poster session set up. Any
other means of fixation must be supplied by the author.
High performance and cloud computing:
evaluating the cost-effectiveness of on-demand
computing facilities.
Patient data
(medical images,
diagnostics…)
1. Poster session materials can be one or more of the following:
a. thin cardboard or regular paper of the text of the actual paper printed in large font
b. photos and graphics
c. thin cardboard or regular paper copies of a Power Point Presentation.
3. No three dimensional items which cannot be attached by means of tape or push pins will be allowed. Due to
space restrictions, no tables will be provided. The cork boards are attached to their own stands.
Partners:
J.Slawinski, U.Villa, Dr. A.Veneziani,
Dr. V.Sunderam (Emory Math&CS)
Image
segmentation
and morphological
analysis
Data mining
knowledge
extraction
Flow in a cylindrical nozzle with conical collector and sudden
expansion. Reynolds number in the throat: 3500.
Direct numerical simulation with second order tetrahedral finite
elements. Mesh refinement based on the nozzle diameter.
Computer
simulations
Database
1. Posters will be located designated by a sign on the poster board. Poster locations are determined by
alphabetical order. Please display your poster only in the designated location.
Total runtime (in hours)
2. Posters will be presented Wednesday, October 24 from 3:30pm to 5:30pm.
All posters will be in Exhibit Hall A2 on the first level of the Georgia World Congress Center.
Cost vs time of a3. benchmark
CFD simulation on different
4. All posters must be set up between 1:30pm and 3:00pm prior to the start of the Meet the Faculty Candidate
computing platforms.
Session. Puma, Ellipse and Lonestar (traditional
computing clusters);
EC2
and byRockhopper
(on-demand
HPC
5. All posters
must be removed
6:00pm. If author does not remove
the poster by this specific
time, BMES will
remove the poster and does not accept any responsibility for the poster.
cloud-computing facilities). For each platform we report the
number of computing cores yielding the fastest computation. T*
is the average computing time across platforms. On demand
facilities can be extremely cost-efficient.
Ongoing project: FDA’s benchmark
(Computational Round Robin #1: Nozzle)
Partners: U.Villa, Dr. A.Veneziani (Emory
Math&CS); Dr. A.Quaini, Dr. S.Canic (U Houston)
Mathematical models
Geometrical multiscale models for the
cardiovascular system;
Reduced models for the dynamics of
vascular networks.
Pressure dynamics in the human physiological right arm, modeled by
means of a 1D blood flow model. Numerical solver based on the LifeV
library.
Geometry and model parameters courtesy of Dr. P. Blanco.
Publications:
Mathematical
models &
analysis
• Alastruey, Passerini, Formaggia, Peiró, “Physical
determinants of the arterial pulse waveform:
theoretical analysis and calculation using the 1-D
formulation”, J Eng Math, 2012.
• Passerini, De Luca, Formaggia, Quarteroni, Veneziani, “A 3D/1D geometrical multiscale model of cerebral vasculature”, J Eng
Math, 2009.
Acknowledgements:
Support from Emory School of Medicine (Dr. W.R.Taylor, Dr. H.Samady)
Support from Emory’s Strategic Initiative “Computational & Life Sciences”
Support from The Brain Aneurysm Foundation (PI: Dr. A.Veneziani)
OSI (healthy,
simulated amputation
Poster Session Hours & Location
Verification and validation of the
CFD methodology.
Hypothesi
s
OSI (healthy,
baseline
4. It is highly recommended that you bring multiple copies of your abstract submission and CV to provide to
interested parties. Attendees will receive a list of candidates however the submissions will be available online in advance and for a short period after the Annual Meeting.
Numerical methods
Partners: Dr. P.Blanco (LNCC, Brazil), Dr. L.Grinberg (Brown University), M.Piccinelli (Emory
Radiology), Dr. A.Veneziani (Emory Math&CS).
Testing of hypotheses / Device design
OSI (difference,
Amputation - Baseline
proximal
distal
Velocity streamlines
at the systolic peak
in baseline
conditions and in
two different
simulated postsurgical scenarios.
The flow distribution
in the sovra-aortic
branches and flow
stagnation at the
aortic valve are
sensitive to the
cannula placement.
Poster Materials
2. Overlapping papers or posters will not be accepted. Any poster larger than the allotted
4 ft TALL by x 8 ft WIDE in an overlapping situation will be removed.
• Slawinski, Passerini, Villa, Veneziani, Sunderam, “Experiences
with target-Platform Heterogeneity in Clouds, Grids, and On
Premise Resources”, Proc. IPDPS-HCW 2012.
• Passerini, Slawinski, Villa, Veneziani, Sunderam, “Experiences
with a computational fluid dynamics code on clouds, grids, and
on-premise resources”, submitted, JPDC 2012.
Numerical
methods
Sample data
from the
database.
Velocity
streamlines in a
giant aneurysm
of the internal
carotid artery.
In red: the
aneurysm neck.
Computer simulations
Publications:
s
Database
Cost of the computing
1. All posters should be flat when unrolled and be able to completely fit within and be affixed to a 4 ft TALL by x
8 ft WIDE
resource (in
$) cork board.
Software: LifeV (www.lifev.org)
mathcs.emory.edu/~tiziano
Partners: M.Piccinelli, Dr. J.Oshinski (Emory
Radiology); Dr. A. Veneziani (Emory Math&CS);
A.Smolensky, Dr. W.R. Taylor (Emory
Cardiology).
Data mining and knowledge
extraction
Poster Size
Oscillatory shear index on the wall of
the infrarenal aorta of a healthy
subject in baseline conditions and
after simulated left above knee
amputation (inflation of a pressure
cuff at the left thigh). OSI increases
on the frontal and left sides of the
distal arterial wall, suggesting a
possible flow-induced localization of
vascular diseases (e.g. aortic
abdominal aneurysm).
Parametric study on the positioning of the cannula in left ventricular
assist device (LVAD) patients, and its effects on blood features.
Sensitivity analysis of blood flow patterns to local morphological features (angle between bifurcating arteries)
and systemic conditions (increased peripheral resistances).
Partners: Dr. A.Veneziani (Emory Math&CS), M.Piccinelli (Emory
Radiology); Dr. D.Gupta (Emory Cardiology)
Partners: A.Smolensky, Dr. W.R.Taylor (Emory Cardiology); M.Piccinelli, Dr. J.Oshinski (Emory Radiology); Dr.
A.Veneziani (Emory Math&CS)
Find fluid dynamics parameters that can be predictors of pathological
events: study the wall shear stress as a marker of endothelial dysfunction in
the coronary circulation.
Post treatment
Radius (mm)
Pre treatment
Radius (mm)
TAWSS
(dyn/cm2)
In patients with left coronary artery disease,
arterial segments with endothelial
dysfunction (ED) show significantly lower
time average wall shear stress (TAWSS)
with respect to those with normal endothelial
function. A sign of ED is a reduced radius
after acetylcholine injection.
Partners:
M.Piccinelli (Emory Radiology);
M.Corban, Dr. H.Samady (Emory
Cardiology); Dr. A.Veneziani
(Emory Math&CS); Dr. L.Timmins,
Dr. D.Giddens (Georgia Tech)